2022 Undergraduate Research Symposium: Vivian Truong
Young adults (18-25) have the highest prevalence (29.4%) of any mental illness and the lowest rate of receiving mental health services (38.9%; NIMH). WSU CAPS provides Wayne State students with an online mental health screening opportunity. The numbers of screenings were of interest for this project.
COVID-19 has been shown to negatively impact students’ social and academic engagement, as a result, screening usage during the pandemic was expected to increase. Additionally, the literature on gender and racial/ethnic disparities in mental health service utilization suggest that screening tools may be used less by men and underrepresented minorities. We also expected gender and racial disparities in use, despite the anonymity provided by online screening.
We examined screening use during the pandemic from 3/15/2020 to 6/15/2021 in comparison with pre-pandemic use from 3/15/2018 to 6/15/2019. It is found that the rate of screening is slightly elevated during the pandemic. Secondly, the rate of screening use among different demographic groups, specifically racial/ethnic groups, and gender groups during the fall of 2020 was explored. Of the 897 screenings that were completed, White completed more than 50% of them. Black students were less likely to be screened (12.2% versus 14.8%, p < .01), as were Hispanic students (3.3% versus 5%, p < .001).
Surprisingly, Asian students were more likely to complete the screening (16% versus 10.2%, p < .001). Students who identified as male were highly underrepresented among those who completed the screenings (17.5% versus 40.7% of students).
Summary of findings from qualitative study that examined circumstances prompting HIV testing among trans women in Indiana. This presentation was delivered at the Association of Nurses in AIDS Care Conference in Atlanta, GA in November 2016. The paper, HIV testing and entry to care among trans women in Indiana was published in the Journal of the Association of Nurses in AIDS Care: http://dx.doi.org/10.1016/j.jana.2017.05.003
Hi52Hlth: Using Mobile Technology to Access Healthcare for TeensYTH
Hi52Hlth is a mobile application (app) created to engage adolescents and young adults in the search for resources in the Houston area. The app allows the user to search for locations of clinics and community organizations with directions, articles and videos on HIV/AIDS, ability to ask questions directly to health avatars ("Tiff" and "Ty"), PEP (Post-Exposure Prophylaxis) and PrEP (Pre-Exposure Prophylaxis) information, and a frequently asked questions section.
National studies have demonstrated that LGBTQ adolescents are disproportionately impacted by negative health outcomes including STDs, HIV, and unplanned pregnancy. In 2014, Essential Access Health surveyed LAUSD school-based Wellness Centers; gaps in current knowledge and practice related to inclusive clinical care of LGBTQ patients were identified. In 2016, we implemented staff trainings to improve LGBTQ-inclusive services. Based on training evaluation, areas for further technical assistance were identified, and used to develop online training resources. This presentation will discuss tools and best practices for implementing trainings on inclusive care.
Georgia State School of Public Health Ph.D. student Rachel Culbreth discussed her research into HIV and other diseases among young people living in slum communities in Kampala, Uganda, during the APHA 2016 annual meeting in Denver. This is her presentation.
Summary of findings from qualitative study that examined circumstances prompting HIV testing among trans women in Indiana. This presentation was delivered at the Association of Nurses in AIDS Care Conference in Atlanta, GA in November 2016. The paper, HIV testing and entry to care among trans women in Indiana was published in the Journal of the Association of Nurses in AIDS Care: http://dx.doi.org/10.1016/j.jana.2017.05.003
Hi52Hlth: Using Mobile Technology to Access Healthcare for TeensYTH
Hi52Hlth is a mobile application (app) created to engage adolescents and young adults in the search for resources in the Houston area. The app allows the user to search for locations of clinics and community organizations with directions, articles and videos on HIV/AIDS, ability to ask questions directly to health avatars ("Tiff" and "Ty"), PEP (Post-Exposure Prophylaxis) and PrEP (Pre-Exposure Prophylaxis) information, and a frequently asked questions section.
National studies have demonstrated that LGBTQ adolescents are disproportionately impacted by negative health outcomes including STDs, HIV, and unplanned pregnancy. In 2014, Essential Access Health surveyed LAUSD school-based Wellness Centers; gaps in current knowledge and practice related to inclusive clinical care of LGBTQ patients were identified. In 2016, we implemented staff trainings to improve LGBTQ-inclusive services. Based on training evaluation, areas for further technical assistance were identified, and used to develop online training resources. This presentation will discuss tools and best practices for implementing trainings on inclusive care.
Georgia State School of Public Health Ph.D. student Rachel Culbreth discussed her research into HIV and other diseases among young people living in slum communities in Kampala, Uganda, during the APHA 2016 annual meeting in Denver. This is her presentation.
Ian's UnityHealth 2019 grand rounds suicide preventionIan Dawe
At the end of this presentation, you will :
1. Knowledgeably describe the problem of suicide in our
clients as an issue beyond just the traditional targets of our
medical interventions,
2. Understand concepts of quality and process improvement
as they relate to implementation of suicide prevention
strategies in hospital and community settings,
3. Become a champion of the Project Nøw approach to improve
care and outcomes for individuals at risk of suicide in
healthcare systems locally, provincially and nationally.
Theodoros F. Katsivas, M.D., M.A.S., of UC San Diego Owen Clinic, presents "San Diego Primary Care Providers' Attitudes to HIV and HIV Testing" at AIDS Clinical Rounds
Prevalence and characteristics of adults with fetal alcohol spectrum disorder...BARRY STANLEY 2 fasd
Results
We identified a high rate of FASD (17.5, 95% CI [9.2, 25.8%]) in this sample, and this rate could have been as high as 31.2%
with confirmation of prenatal alcohol exposure. Most participants in this study presented with significant neurodevelopmental and cognitive deficits in at least two domains of functioning, irrespective of diagnosis, with only five of 80 participants (6.3%) demonstrating no cognitive impairment.
Join us as we discuss best practices for integrating HIV prevention (e.g. HIV testing, PrEP and linkage to care) into primary care within the context of enhancing clinical workforce development.
Panelists:
• Marwan Haddad, MD, MPH, AAHIVS, Medical Director, Center for Key Populations, Community Health Center, Inc.
• Jeannie McIntosh, APRN, FNP-C, AAHIVS, Family Nurse Practitioner, Center for Key Populations, Community Health Center, Inc.
2023 Undergraduate Research Symposium: Taral Patel and Sophie Habashy
Asthma negatively affects the quality of life of those who suffer from it, with the acknowledgment that the African American/Black community is disproportionately afflicted by the disease. Research suggests that increased atmospheric particulate matter among other pollutants is correlated with higher rates of reported asthma symptoms and hospitalizations.
The present study describes the methodology of cross-referencing Environmental Protection Agency (EPA) reported daily particulate matter 2.5 (PM2.5) with participant laboratory visits with the goal of allowing researchers to assess the effect of this pollutant with concurrent reports of psychosocial and asthma measures. Part of this data comes from the Asthma in the Lives of Families Today study which investigated psychosocial predictors of asthma-related health among African American children from the Detroit area between 2011-2018. Determining PM2.5 levels on lab visit days was conducted in multiple steps. Firstly, participants' zip codes were used to determine their geographical census block (i.e., GEOID). Next, GEOIDs were matched to the most closely located EPA PM2.5 sites of the twelve stationed in Wayne County.
After the EPA site was matched to the participant, the PM2.5 measurement on the day of each participant's ALOFT visit was identified. This methodological approach provided a clear air pollution reference on the date of lab visits, allowing ALOFT researchers to investigate its specific and subsequent impact on child asthma health.
2023 Undergraduate Research Symposium: Lane Belden and Bex Watson
The term folkhemmet or “the people’s home” is a Swedish political term that has enjoyed a wide usage amongst various political parties along with the development of the modern Swedish state over the past century. This project aims to define the term and describe its usage through the analysis of both primary and secondary sources.
The term is explored as a uniquely Swedish cultural phenomenon, with both populism and collectivism being explored as avenues to account for the seemingly contradictory usage of the term by opposing political parties. A timeline of the term is created to demonstrate its shifting associations.
More Related Content
Similar to WSU CAPS Resource: Mental Health Screening Utilization
Ian's UnityHealth 2019 grand rounds suicide preventionIan Dawe
At the end of this presentation, you will :
1. Knowledgeably describe the problem of suicide in our
clients as an issue beyond just the traditional targets of our
medical interventions,
2. Understand concepts of quality and process improvement
as they relate to implementation of suicide prevention
strategies in hospital and community settings,
3. Become a champion of the Project Nøw approach to improve
care and outcomes for individuals at risk of suicide in
healthcare systems locally, provincially and nationally.
Theodoros F. Katsivas, M.D., M.A.S., of UC San Diego Owen Clinic, presents "San Diego Primary Care Providers' Attitudes to HIV and HIV Testing" at AIDS Clinical Rounds
Prevalence and characteristics of adults with fetal alcohol spectrum disorder...BARRY STANLEY 2 fasd
Results
We identified a high rate of FASD (17.5, 95% CI [9.2, 25.8%]) in this sample, and this rate could have been as high as 31.2%
with confirmation of prenatal alcohol exposure. Most participants in this study presented with significant neurodevelopmental and cognitive deficits in at least two domains of functioning, irrespective of diagnosis, with only five of 80 participants (6.3%) demonstrating no cognitive impairment.
Join us as we discuss best practices for integrating HIV prevention (e.g. HIV testing, PrEP and linkage to care) into primary care within the context of enhancing clinical workforce development.
Panelists:
• Marwan Haddad, MD, MPH, AAHIVS, Medical Director, Center for Key Populations, Community Health Center, Inc.
• Jeannie McIntosh, APRN, FNP-C, AAHIVS, Family Nurse Practitioner, Center for Key Populations, Community Health Center, Inc.
Similar to WSU CAPS Resource: Mental Health Screening Utilization (20)
2023 Undergraduate Research Symposium: Taral Patel and Sophie Habashy
Asthma negatively affects the quality of life of those who suffer from it, with the acknowledgment that the African American/Black community is disproportionately afflicted by the disease. Research suggests that increased atmospheric particulate matter among other pollutants is correlated with higher rates of reported asthma symptoms and hospitalizations.
The present study describes the methodology of cross-referencing Environmental Protection Agency (EPA) reported daily particulate matter 2.5 (PM2.5) with participant laboratory visits with the goal of allowing researchers to assess the effect of this pollutant with concurrent reports of psychosocial and asthma measures. Part of this data comes from the Asthma in the Lives of Families Today study which investigated psychosocial predictors of asthma-related health among African American children from the Detroit area between 2011-2018. Determining PM2.5 levels on lab visit days was conducted in multiple steps. Firstly, participants' zip codes were used to determine their geographical census block (i.e., GEOID). Next, GEOIDs were matched to the most closely located EPA PM2.5 sites of the twelve stationed in Wayne County.
After the EPA site was matched to the participant, the PM2.5 measurement on the day of each participant's ALOFT visit was identified. This methodological approach provided a clear air pollution reference on the date of lab visits, allowing ALOFT researchers to investigate its specific and subsequent impact on child asthma health.
2023 Undergraduate Research Symposium: Lane Belden and Bex Watson
The term folkhemmet or “the people’s home” is a Swedish political term that has enjoyed a wide usage amongst various political parties along with the development of the modern Swedish state over the past century. This project aims to define the term and describe its usage through the analysis of both primary and secondary sources.
The term is explored as a uniquely Swedish cultural phenomenon, with both populism and collectivism being explored as avenues to account for the seemingly contradictory usage of the term by opposing political parties. A timeline of the term is created to demonstrate its shifting associations.
2023 Undergraduate Research Symposium: Morgan Grougan
Amidst the ever-expanding cosmos of scientific literature, the quest for tools that can deftly extract and analyze data from publications has grown increasingly vital. Enter LoA (Librarian of Alexandria), a Linux-Python tool that harnesses the power of artificial intelligence to scour chemistry-related papers, meticulously extracting invaluable textual measurements and data into structured Excel files.
This approach engenders the formation of an expansive, high-quality dataset, poised to train predictive models in assessing the properties of chemicals, proteins, and other compounds, with a predominant emphasis on the field of chemistry. LoA's sophisticated AI algorithms artfully decipher and extract essential information from intricate scientific documents. Although the tool currently focuses on extracting text, plans for future iterations include deciphering images and delving into deeper analysis. LoA's potential transcends the realm of chemistry, with prospective applications in diverse scientific disciplines such as materials science, biology, and pharmacology, by tailoring the extraction process to the domain at hand.
Like the ancient Library of Alexandria, LoA aspires to become a beacon of knowledge, a comprehensive instrument for navigating the vast ocean of human intellect. As it is presented at an undergraduate research symposium, this innovative tool embodies the potential for revolutionizing scientific research, opening doors to interdisciplinary applications, and illuminating the path to discoveries yet unimagined. Embracing the beauty of imperfection, LoA continues to evolve, a testament to the resilience and adaptability that characterizes the boundless realm of scientific inquiry.
2023 Undergraduate Research Symposium: Carly Ghanem
The standard treatment for lower back pain has been interbody fusion: Transforaminal Lumbar Interbody Fusion (TLIF). The invasive nature leads to muscle detachment and damaged nerves. To address these issues, minimally invasive (MI) TLIF techniques have been developed.
While MI TLIFs show decreased blood loss and complication rates relative to open TLIF, surgery times and long-term outcomes are reported to be similar. Oblique lateral lumbar interbody fusion (OLLIF) is a MI lumbar spinal fusion through a single 10-15 mm incision, with a faster surgery time and easier approach. Anesthesia, surgery times, and blood loss were recorded for all patients that entered into the EMR. Because no suction is used in OLLIF procedures, blood loss was measured by weighing sponges and subtracting dry weight.
To monetize the cost per minute for a hospital, a published reference was utilized and adjusted with the consumer price index. These values were reported in aggregate and stratified, based on spinal level(s) of surgery. Mann-Whitney U-tests were utilized to test the null hypothesis that the OLLIF and TLIF groups have the same or identical mean distributions for age, BMI, blood loss, and uncensored time duration variables. Data analyses were performed using IBM SPSS. A shorter length of stay than TLIF by 58.5% across all surgeries studied was found.
The trend of shorter lengths of stay remained consistent when surgeries were stratified based on the spinal level(s) involved. OLLIF also had a lower surgical admission cost than TLIF, with a difference of $6,701 versus $11,583. These findings suggest that OLLIF may be a more cost-effective and efficient alternative to TLIF for treating lower back pain, particularly for hospitals with limited resources.
2023 Undergraduate Research Symposium: Kira Jonatzke
Under favorable environments, the worm C. elegans undergoes four different larval stages before becoming a fertile adult. However, when environments are harsh, such as under high temperatures or high population density and low food availability, C. elegans enters a different developmental program, known as dauer.
Dauers are developmentally arrested, highly resistant to stress and live long. Thus, when environments improve, dauers exit to the last larval stage and become fertile adults. Recently, we serendipitously discovered that the Mos1 transposon insertion site ttTi5605 produced more dauers at high temperatures, when compared to wild-type animals. This Mos1 insertion site is situated between two genes, the predicted glucose transporter FGT-2 and the F14E5.8 gene of unknown function.
Thus, the Mos1 transposon insertion might alter the expression of FGT-2 and/or F14E5.8, which potentially suggests a role for at least one of these proteins in regulating the switch to the dauer program.
2023 Undergraduate Research Symposium: Lexi Soltesz
A central health issue for those with a chronic spinal cord injury (SCI) above the sixth thoracic vertebrae is autonomic dysfunction. Autonomic dysfunction results in significant increases and decreases in blood pressure and negatively affects health-related quality of life.
This uncontrolled blood pressure also negatively impacts cognitive function and adherence to rehabilitation programs. Additionally, the lesion itself impairs motor function thereby resulting in decreased physical activity and impaired mitochondrial function. Moreover, autonomic dysfunction can lead to an increased risk of stroke, and therefore increased mortality. Mild intermittent hypoxia (MIH), an experimental protocol in which participants experience lower oxygen, in a controlled and repetitive sequence, has been shown to improve blood pressure control in humans.
Our study aims to investigate the impact of MIH on autonomic dysfunction during in-lab provocation and during in-home testing. Likewise, we will also investigate the impact of MIH on mitochondrial and microvascular function and motor function. Our preliminary data shows that MIH may improve autonomic dysfunction which may be explained by improvements in baroreceptor and/or mitochondrial and endothelial function. As evidenced by our preliminary data, MIH is a promising potential protocol for improving health-related quality of life in those with SCI.
2023 Undergraduate Research Symposium: Mahmoud Teran
The development of memories, including those throughout extinction learning, require neuroplasticity for encoding and retrieval to occur. As environmental factors can affect gene expression, epigenetic changes can play a critical role in the development of memory formation and updating and ultimately manifesting in behavioral changes reflective of the learning.
The purpose of the current project is to show the utility of Positron Emission Tomography (PET), a functional, molecular imaging technique that employs radioactive substances to measure specific markers in the brain. As part of our efforts to understand the neurobiological mechanisms of fear learning and the role of epigenetic changes using PET, images of the brains were collected before and after extinction learning of acquired long-term fear (LTF) memories induced by shock tone pairings made every 30 seconds over 38 min.
PET images were collected by injecting the radiotracer [18F]TFAHA, a substrate for class IIa histone deacetylases (HDACs). The resulting accumulation of the breakdown product of [18F]TFAHA could be considered as a proxy for class IIa HDAC expression changes before and after LTF memory. HDAC activity is directly related to gene expression changes through deacetylation of histone lysine residues. This results in a closed chromatin conformation and prevents the binding of RNA polymerase II and ultimate gene transcription and protein synthesis.
This can then be manifested and seen as behavioral change. Our preliminary analysis of PET images results indicate a significant interaction effect between pre-to-post class IIa HDAC expression-activity, sex, and shock condition. Additional PET image analysis is anticipated to show the extent of HDAC activity in both the sexes following LTF.
2022 Undergraduate Research Symposium: Christina Kort
There are five developmental factors discussed throughout the review that are applicable to adolescents during the pandemic. This involves the incorporation of nutrition and exercise health, in which a lack of physical activity or appropriate eating habits may be hindering growth.
Learning experiences have been altered to a digital platform and have deeply affected students' motivation and cognitive engagement. Forming strong social connections with friends and members of the community is another way to help ensure that developing brains are progressing. In some cases, the home environment may be negatively impacting the ability to complete work or achieve personal space. Taking some time away or setting boundaries around family may be crucial for growth.
The last aspect necessary for adolescents to sustain positive development consists of a daily structure. Staying active in recreational activities is a good way to ensure structure and can greatly benefit the other factors related to forming new bonds and getting physical exercise.
2022 Undergraduate Research Symposium: Mary Tooma
Graduate co-author: Emily Graham LeRose
This research was conducted to investigate the underlying etiological cause(s) and/or psychosocial contributions to suicidal ideation as highly self-reported among individuals with a developmental stutter.
A comprehensive literature review was completed to explore two of the hypothesized components thought to increase risk for suicidal ideation in this population; genetic heritability of suicidal ideation and the presence of co-morbid mental health disorders arising as a result of having a stutter (i.e., depression, anxiety, etc.). Additionally, an empirical review was completed for recommendations to improve overall outcomes in therapy for individuals who stutter.
Results from this investigation of the literature found the most empirical support for a connection between high rates of co-morbid mental health disorders and suicidal ideation in individuals who stutter. Additionally, a therapeutic approach titled "Attachment-Based Family Therapy" has been shown to be highly effective in treating individuals, particularly adolescents, who experience suicidal ideation and depression.
2022 Undergraduate Research Symposium: Justin Ahrens
Graduate co-author: Maddy Denison
The main goal of this project is to use IrIII complexes to monitor cytochrome P450 (CYP) activity. CYP P450 metabolism determines how quickly drugs are excreted from the body and what kind of dose is required for pharmaceuticals to be effective.
Existing probes for CYPs are non-fluorescent, but when CYPs metabolize them, they are “turned on” and fluoresce. Even though these probes are able to monitor metabolism, once they are metabolized and “turned on” they cannot be reversed or turned off. Therefore, this is no current way to monitor dynamic changes in CYP activity continuously over time.
The Kodanko laboratory is addressing this unmet need by developing IrIII complexes that are reversible sensors of CYP enzymes. A chiral resolution strategy with enantioenriched ligands was used to prepare four analogs of IrIII complexes with different stereochemistry. These complexes were evaluated as emissive sensors in human liver hepatocytes to establish which IrIII complex is the lead compound for sensing CYP in living cells. Results from this multi-disciplinary study will be reported.
2022 Undergraduate Research Symposium: Bahea Nasser
My research is overall in the issue of the mass incarceration rate of people with serious mental illness. My research goes into detail about the factors and causes of this problem, re-offending, deinstitutionalization, other important information, and how people with serious mental illness in the criminal justice system receive inadequate treatment.
2022 Undergraduate Research Symposium: Tareq Murshed
Accounting has had major developments and throughout the years it has went from pen and paper to paperless.
2022 Undergraduate Research Symposium: Hanna Alfasih
This research is about the misuse of analgesics and how they have contributed to the opioid epidemic.
2022 Undergraduate Research Symposium: Dorian Mersinllari
This PowerPoint shows how can CRNAs better help/ understand their patients? It was a project for my English class and I think it's really good at explaining how nurses should be treating their patients and how it would help their relationship with them. It's a 13-slide PowerPoint that includes a synthesis map and six good sources. I also had to record myself presenting it which includes information outside of what you see on the PowerPoint.
2022 Undergraduate Research Symposium: Ma'ldah Sheikh
The male gaze is a point of view in literary and digital media. It is from the viewing pleasure and perspective of heterosexual men. This form of content is predominantly characterized by the objectification and sexualization of women and other minority groups. The female gaze is meant to oppose the male gaze in cinema, but there are many controversies pertaining to this within the film discourse community.
Many theorists debate that there is no such thing as the female gaze, while others argue that even with the existence of the female gaze, the male gaze can never truly be reversed.
2022 Undergraduate Research Symposium: Shane Tinsley
Introduction: Disease-specific health awareness (HA) campaigns have rapidly developed as an important avenue to improve patient education and ideally outcomes. Our study objective was to understand the impact of urological HA months on engaging public search interests in the United States.
Methods: We utilized Google Trends to examine public health interest in urologic conditions during monthly awareness campaigns over a 17-year period (2004-2021). Relative Search Volume (RSV) during the annual HA campaign months relative to non-health awareness (NHA) campaign months was calculated. Differences between HA-RSV and NHA-RSV months were compared using t-test.
Results: Although small increases in public interest were noted for certain diseases (prostate cancer in November, testicular cancer in April and erectile dysfunction), there was interestingly a comparative decrease in RSV for other diseases (bladder cancer, prostate cancer in September, testicular cancer in November, kidney cancer, benign prostate hyperplasia and male infertility) in their respective HA months; however, none of these differences were statistically significant (p > 0.05).
Conclusion: Our study did not find a significant difference in public interest of any urological diseases during their respective HA campaign months. This highlights the critical need for further research to investigate potential improvements in campaign methodology during dedicated HA months to better achieve their goals of increased public health engagement.
2022 Undergraduate Research Symposium: Avery Bacheller
My research abstract explains the importance of adolescent suicide by breaking down statistics, defining the discourse community, citing and explaining sources that help build a good argument for my thesis. All of these combined help me to spread awareness and information regarding adolescent suicide.
2022 Undergraduate Research Symposium: Taha Kader
Family physicians are crucial to providing appropriate medical care in rural areas. Family physicians tackle various roles such as maternity and emergency care in these areas. However, there aren't nearly enough family physicians in these areas, and something needs to be done.
2022 Undergraduate Research Symposium: Samaah Saifullah
Graduate co-author: Kelsey L. Canada
Automated hippocampal subfield segmentation methods have led to exponential growth in the literature. Although automated segmentation is perfectly reliable, deviations from anatomical definitions are common and weaken their validity.
To address the lack of guidance for quality control (QC) of automated segmentation methods, we developed a taxonomy of errors and two-step protocol for 1) identification and 2) manual correction. Raters examined segmentations from a customized atlas to identify errors in six categories with severity ratings; only major severity errors are manually corrected in order to minimize introducing human error.
The QC procedure was developed and cross-validated with an independent sample on two MRI scanners. Raters had excellent agreement in QC decisions between- and within-raters on all regions, manual corrections introduced less than 3% error and were unrelated to participant demographic.
The feasible and reliable QC procedure allows confident interpretation of hippocampal subfield segmentations, and potential applications to other brain regions.
2022 Undergraduate Research Symposium: Neel Patel and Mariana Sierra
The Kristen Rat Sarcoma (KRAS) protein, encoded by the KRAS gene, is a signal transducer that plays a crucial role in regulating cell proliferation. KRAS mutations have been known to cause lung, colorectal, and pancreatic cancers. Previously, KRAS was considered an “undruggable” target. However, with better understanding of the protein’s biology paired with advanced new technologies, the FDA approved the first KRAS inhibitor (sotorasib) for lung cancer patients with the KRASG12C mutation in 2021, expressing the recent interest of targeted drugs for KRAS.
In clinical trials, sotorasib proved ineffective for pancreatic and colorectal cancers with the G12C mutation. Irrespective of mutant identity, oncogenic KRAS requires activation by the guanine nucleotide exchange factor (GEF) Son of Sevenless 1 (SOS1), highlighting an exploitable vulnerability with broad therapeutic applicability. The goal of this study is to develop novel pan-KRAS inhibitors by targeting the KRAS-SOS1 interactions through computational modeling. To start, we applied Gaussian accelerated molecular dynamics (GaMD) simulation, an advanced conformational sampling method, to collect the nature of the KRAS protein motion in solution. Then, the clustering analysis method was used to assemble KRAS conformational structures into ten groups for later virtual screening and docking simulations.
We aim to address 20 to 30 compounds to later be experimentally assessed for their (1) ability to disrupt the KRAS-SOS1 interactions and (2) cytotoxicity in KRAS mutation-bearing cell lines. The work will provide insights in the drug efficacy of KRAS inhibitors and give rise to a novel set of KRAS candidates to be used in clinical oncogenic treatments.
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WSU CAPS Resource: Mental Health Screening Utilization
1.
2. WSU CAPS Resource:
Mental Health
Screening Utilization
By: Vivian Truong, Jeffrey Kuentzel*
Department of Psychology, WSU CAPS
3. Young adults (18-25) have the highest prevalence (29.4%) of any mental illness and the lowest
rate of receiving mental health services (38.9%; NIMH). WSU CAPS provides Wayne State
students with an online mental health screening opportunity. The numbers of screenings
were of interest for this project. COVID-19 has been shown to negatively impact students’
social and academic engagement, as a result, screening usage during the pandemic was
expected to increase. Additionally, the literature on gender and racial/ethnic disparities in
mental health service utilization suggest that screening tools may be used less by men and
underrepresented minorities. We also expected gender and racial disparities in use, despite
the anonymity provided by online screening.
We examined screening use during the pandemic from 3/15/2020 to 6/15/2021 in
comparison with pre-pandemic use from 3/15/2018 to 6/15/2019. It is found that the rate of
screening is slightly elevated during the pandemic. Secondly, the rate of screening use among
different demographic groups, specifically racial/ethnic groups, and gender groups during the
Fall of 2020 was explored. Of the 897 screenings that were completed, White completed
more than 50% of them. Black students were less likely to be screened (12.2% versus 14.8%, p
< .01), as were Hispanic students (3.3% versus 5%, p < .001). Surprisingly, Asian students were
more likely to complete the screening (16% versus 10.2%, p < .001). Students who identified
as male were highly underrepresented among those who completed the screenings (17.5%
versus 40.7% of students).
Abstract
4. Introduction: College &
Mental Health
• 1st onset of mental health and/or exacerbation of mental health
• 75% of mental disorders first onset by the age of 24
• Highest prevalence: 29.4%
• Lowest rate of receiving mental health services: 38.9%
• Adults: 26-49: 45.4%; 50+: 47.2%
• > 65% of American high schoolers attend post-secondary education
• Emergence of adulthood identity development
• Social & personal growth development
• Adapt & balance new responsibilities
5. Introduction: COVID-19 &
Mental Health
• COVID-19
• Disruption in routines & academic settings
• Lack of resources for successful learning
• Tools: computers, Wifi
• Learning Assistant: peer mentors, office hours
• Academic environment: quiet time
• Yi et al: meta-analysis
• 39% prevalence for depression
• 36% prevalence for anxiety
• Li et al
• Bangladeshi college students
• 28.5% feel stressed
• 33.3% showed signs of anxiety
• 46.92% showed symptoms of depression
• Cao et al: GAD-7
• 24.9% experience anxiety due to pandemic & the lack of protective
factors
• 69% at high- & medium-risk categories
6. Introduction: Ethnic Groups &
Mental Health
• Stigmatization of mental health
• Lack of help-seeking behaviors
• Exacerbation of symptoms
• Decrease quality of life & self-esteem
• Exacerbation of overall health
• 1/5 U.S. adults live with mental illness (~ 51.5 million people)
• Only 44.8% receive mental health services
• Patterns of stigma & discrimination is most salient in ethnic groups
• Asian & Pakistan communities: embarrassment & defaming family reputation
( Knifton et al, 2010)
• African American & Latino: embarrassment & other’s reaction (DeFreitas et
al, 2018)
• Latino communities: exacerbation of mental health of caretakers of
individuals living with
7. Introduction: Gender &
Mental Health
• Male mental health service utilization: 36.8% (National Institute of Mental
Health)
• Masculine norms : strong, independent, & emotionally inexpressive
• Rejects femineity & weakness
• Decrease & avoidance in help-seeking behaviors fulfill societal
expectation
• Suicide rate in men: 3.6x higher than women
• Leading cause of death for men from 10 – 35 years old
• Female mental health service utilization: 49.7%
• At higher risk for depression than men
• Unrecognized male-specific symptoms
• Substance abuse
• Aggression
• Risk-taking
8. Purpose
• Examine the rate of mental health
screenings in Wayne State student
before and during the pandemic
• Examine the rate of mental health
screening disparities between
different demographics compared to
the Wayne State student body
9. Hypothesis
• COVID-19 causes an increase in screener usage due to
changes in routine, and prolonged isolation.
• Patterns of stigma and fear of discriminations
associated with mental health results in a decreased in
screening utilization by ethnic groups.
• Socialization of men into masculinity norms, which
decrease self-help seeking behaviors, demonstrating a
decrease in screening utilization
10. Methodology/Experimental
• Participants: Deidentified data provided by Wayne State Students
• Screenings provided by WSU CAPS Department for WSU students
• Use total number of screenings pre-pandemic (3.15.2018 –
6.15.2019) and during the pandemic (3.15.2020-6.15.2021)
• Rate of screenings across different demographic groups (Racial &
Gender)
• Fall of 2020: August 30,2020 – December 14, 2020
12. Results
0.00% 10.00% 20.00% 30.00% 40.00% 50.00% 60.00% 70.00%
Non-resident Alien
Other
Native Hawaiian/ Pacific
Islander
American Indian/ Alaska Native
Hispanic, Latino, or Spanish
Origin
Asian
Black/ African American
White
Demographics of screeners vs total WSU population
Mental Health Screening WSU
WSU Enrollment Total: 26,251
Mental Health Screening Total: 897 Chi-Square Exact Sig.
(2-sided)
Chi-Square Exact Sig.
(1-sided)
White 15,241 58.10% 494 55% 0.079 0.040
Black/ African American 3,897 14.80% 104 12% 0.007 0.004
Asian 2,668 10.20% 144 16% <0.001 <0.001
Hispanic, Latino, or Spanish Origin 1,447 5.50% 26 3% <0.001 <0.001
American Indian/ Alaska Native 68 0.3% 2 0% N/A N/A
Native Hawaiian/ Pacific Islander 15 0.10% 0 0% N/A N/A
Other 596 2.40% 61 7% N/A N/A
Non-resident Alien 1155 4.60% N/A N/A N/A N/A
13. Results
0% 10% 20% 30% 40% 50% 60% 70% 80%
Other
Male
Female
Demographics of screeners vs total WSU population
Mental Health Screening WSU
WSU Enrollment Total: 26,251 Mental Health Screening Total: 879 Chi-Square Exact Sig. (2-
sided)
Chi-Square Exact Sig. (1-
sided)
Female 15,573 59.3% 670 74.69% <0.001 <0.001
Male 10,678 40.7% 157 17.50% <0.001 <0.001
Other 0 0% 70 7.80% N/A N/A
14. Discussion
• Increased in screening utilization during pandemic
• Interruption in routines, academic settings & general fear of the
pandemic
• Blacks/ African American, Hispanics have lower rate of completing
the screening
• Except for Asian
• Number of screenings by white: close to expected
• Stigmatization of mental health
• Students may not know about the resource
• Males have lower rate of completing the screening
15. Limitations
• Missing data
• Self-report
• Limited to those who knows about the screening
• 3% of Wayne State population for the demographic
review
• Bigger samples more representative of the whole
student body
16. What Now?
• More advertisement of available mental
health services provide by WSU CAPS,
closing the gap of disparities among
ethnic groups and men
• Establish mental-health-related
workshops
• Mental Heath Day, at least once a
month
17. Acknowledgments
I want to thank Dr. Kuentzel
for mentoring me, as well as
UROP for funding this project.
Editor's Notes
Hello everyone, my name is Vivian Truong, and my research will examine the utilization of mental health screening that is provided by the Wayne State Counseling and Psychological Services Department