This document is a research paper presented to Air Force 2025 that examines the capabilities required for interdiction missions in the year 2025. It discusses that interdiction will still rely on precision employment and information dominance, which stem from accuracy, lethality, target detection/identification, and cycle time. The paper outlines that future interdiction systems will need to delay, disrupt, destroy, or divert both personnel and materiel across a range of environments and scenarios, requiring improvements in accuracy measured in centimeters rather than meters, as well as variable levels of lethality and faster target detection and engagement times. Technologies like nanotechnology, nonlinear modeling, and expanded use of the electromagnetic spectrum are identified as enabling future interdiction capabilities.