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Effect of Vitamin P
Vitamin eX*
Deficiency Disorders and RWA
Dr Paul T Francis, MD
Assoc. Prof.
Community Medicine
Amrita Institute of Medical Sciences, Kochi, India
paultfrancis@gmail.com
*eXercise
Contents
• Health benefits of regular PAeX
• Health problems due deficiency of PAeX
• Recommended PAeX dosage for different
age groups
Vitamin
• “Vitamin" coined in 1911 by the Warsaw-
born biochemist Casimir Funk for a ‘vital’
‘amine’
• Later the ‘e’ was removed
• Usually not synthesized by the body
Vitamin eX
• An essential ingredient in our daily life,
being ignored at a great cost to our health in
the modern times
Physical activity, Exercise, Physical
fitness
• Physical Activity is any bodily movement
produced by skeletal muscles, which results in
energy expenditure
• Exercise is a subset of physical activity that is
planned, structured, and repetitive and has as a
final or an intermediate objective the improvement
or maintenance of physical fitness.
• Physical fitness is a set of attributes that are either
health or skill-related.
Physical fitness
Skill related -
Power
Agility
Balance
Health related –
Cardiorespiratory endurance
Body composition
Physical fitness
Skill related -
Power
Agility
Balance
Physical fitness
Skill related -
Power
Agility
Balance
Health related –
Cardio-respiratory endurance
Body composition
Physical fitness
Skill related -
Power
Agility
Balance
Mary Kom
Gymnast on a balance beam
MET (Metabolic Equivalent)
• I MET is equal to the energy expended by
body at rest (3.5mLO2/kg/min or 1Cal/kg/hr) –
Basal Met Rate/Resting Met rate
• The energy expenditure during PAeX is
considered as multiples of MET
• Sedentary < 1.6 MET
• Low intensity 1.6 < 3 MET
• Moderate intensity 3<6 MET
• Vigorous intensity 6<9 MET
‘Aerobic’ exercise
• Aerobic activity, also called endurance activity, improves
cardiorespiratory fitness. Examples: brisk walking,
running, bicycling, jumping rope, and swimming.
• Aerobic exercise stimulates heart and muscles to use more
Oxygen
• In anaerobic exercise the metabolism is only 50%
anaerobic – intense exertion - Sprint, Weight lifting
• 1. ‘Explosive Efforts’ (duration up to 6 s)
• 2. ‘High Intensity Efforts’ (efforts comprised between >6 s to 1
min)
• 3. ‘Endurance Intensive Efforts’ (for exercise bouts longer than 1
min)
Clean and jerk
Svetlana
Nikolayevna
2012 olympics
161 kgs
Aerobic exercise
Sedentary behaviour/physical
Inactivity
• Sedentary - characterized by much sitting
and little physical exercise
• an independent risk factor for NCDs
• Fourth leading risk factor for global
mortality
• Responsible for 6% of deaths globally –
around 3.2 million deaths per year
• Around 31% of the world’s population is
not meeting the minimum physical activity
PAeX
Pioneering study
on PA
by JN Morris in 1950s
compared mortality
of London bus
Drivers and Conductors
Physiological effects of PAeX
• Acute exertion & Exercise training
• Heart – ejection vol, size, Resting rate (-)
• Skeletal muscle – size, capillaries,
mitochondria, Glycogen and TG deposits,
fat acids are used more
• Blood – vol,
• Fat – HDL, TG (-)
Effects
• BP – acute exertion +, shortly after –
• Acute effects
• Immune system – decrease in immune
response few hours
• Blood coagulation – transient increase in
platelet aggregation
Benefits of Physical
activity/Exercise
• PAeX profoundly affects the body and the
benefits are innumerable – the whole body
benefits
• Reduction in the whole spectrum of NCDs
- 31% reduction in mortality
Important benefits of PAeX
• Reduces blood pressure
• Reduces serum cholesterol
• Increases muscle and bone strength
• Prevents colon and breast cancer
• Reduces depression, dementia
Benefits of PA/eX
• Better sleep, less mental stress
• Better immunity – less communicable
diseases!
• Secondary prevention
• Better prognosis, survival and quality of life for
those with NCD
How much PAeX is required to keep us
healthy?
A program of regular exercise that includes
cardiorespiratory, resistance, flexibility, and
neuromotor exercise training beyond
activities of daily living to improve and
maintain physical fitness and health is
essential for most adults
American College of Sports Medicine. Position Stand. Quantity and Quality of Exercise for
Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in
Apparently Healthy Adults: Guidance for Prescribing Exercise. 2011
Basal Metabolic Rate
• About 60% of energy is used for BMR
• EE beyond that routine EE is required to
provide health benefits.
Relevant for
• Cardio-respiratory health (coronary heart
disease, cardiovascular disease, stroke and
hypertension).
• Metabolic health (diabetes and obesity).
• Musculoskeletal health (bone health,
osteoporosis).
• Cancer (breast and colon cancer).
• Functional health and prevention of falls.
• Depression.
PAeX
• Three factors combine to form the ‘exercise
dose’
• Frequency
• Duration
• Intensity
Recommended Weekly Allowance
• Adequacy of PAeX is measured by the
Total time/Energy Expenditure accumulated
over a period of one week
• Lot of flexibility in doing PAeX
RWA
• Even small amount helps
• Benefit is dose related
• Doesn’t require expensive equipment or
facilities
RWA
• For three age groups
• 5-17 yrs
• 18-64 yrs
• >65 yrs
Children 5-17
• 60 minutes moderate to vigorous every day
• More health benefits if the duration is increased
• Vigorous intensity activity and Muscle bone
strengthening activities should be included at least
3 times a week
• PA - play, games, sports, transportation, or
planned exercise
5-17 yrs
• This one hour should be beyond the
physical activity accumulated in the
course of normal daily non-recreational
activities
Adults 18-64 yrs
• 150 minutes of moderate intensity activity
or
• 75 minutes of vigorous intensity activity or
• An equivalent combination of moderate and
vigorous activity per week
• Plus - Strength training of major muscle
groups 2 times a week
Adults 18-64yrs
• Duration if doubled, will give maximum
benefits
• Beyond that is uncertain
• PA - Recreational, transportation (e.g
walking or cycling), occupational (i.e.
work), household chores, sports/games or
planned exercise
Distribution over a week
• 30 mts – M x 5 days
• 25 mts – V x 3 days
Minimum duration of a bout - 10 minutes
Combination
• 30mts x 4MET = 120 MET/day x 5 = 600
• 15m x 8M = 120 MET x 3 days = 360
+ 30m x 4M = 120 x 2 d = 240
• One day rest per week is needed
• Can you do the entire quantity in one day?
• Weekend warriors
Adults > 65 yrs
• 150 mts of Moderate or 75 mts of vigorous
activity or an equivalent combination of both per
week
• Muscle strengthening exercises at least 2 days a
week
• Adults with poor mobility, should do physical
activity to enhance balance and prevent falls on 3
or more days per week
• Moderate and Vigorous is relative
Adults >65 yrs
• For additional benefits the duration can be
doubled
• Individuals with chronic NCDs should be
active to the level their abilities and health
conditions allow
• PA - recreational, transportation (e.g
walking or cycling), occupational (if the
person is still engaged in work), household
chores, games, or planned exercise
Adults > 65 yrs
• If for health reasons they cannot do the
recommended duration, they must do as
much as possible
Talk test
• Moderate intensity activity - can talk, but
not sing
• Brisk walking
• Vigorous intensity activity - not be able to
say more than a few words without pausing
for a breath
• Jogging
< 5 yrs
• They should probably be more active than
the older children
• However there are not enough studies to
prescribe a minimum recommendation
Disabled
• The recommendations holds good for them
too
• Have to do as much physical activity
possible within the limitations imposed by
the Disability
Obese/overweight
• Overweight people need not despair
• Any PA reduces the risk of mortality for the
given weight
• PA can lead to reduction of body weight
Attaining and maintaining fitness
• 3-6 months of regular exercise is required
for attaining the level of fitness and risk
reduction
• 1-2 weeks after stopping exercise the
beneficial effect may gradually wear away
• The PAeX should be made part of our daily
life
Injuries
• Care should be taken to avoid injuries
• Appropriate place, dress and footwear
needed
• Roads can be really dangerous – vehicles and
dogs (music in ears can be a problem)
• Personal safety - lonely places to be avoided
• With care, benefits far outweigh the risk of
musculoskeletal injuries
Summary
• Physical Inactivity is a major risk factor for many
NCDs
• PAeX is essential to remain healthy and prevent
NCDs
• The basic requirement for an adult is
• 150mts of moderate or 75mts of vigorous intensity
activity or an equivalent combination every week
• Muscle strengthening sessions about 2 days a week
Summary
• Extra PA gives additional benefits
• Minimum duration of a bout should be 10mts
• Even small amount helps
• Those suffering from NCD will have better
prognosis if they do PAeX
Do not forget your weekly dose of vitamin
eX to keep yourself Healthy, Happy and
Young
Thank you
References
1. WHO, Global recommendations on physical activity for health, 2010
2. Physical Activity in the Prevention and Treatment of Disease,
Professional associations for physical activity, 2010, Sweden
3. Taylor RS et al, Exercise-Based Rehabilitation for Patients with
Coronary Heart Disease: Systematic Review and Meta-analysis of
Randomized Controlled Trials, American J of Med: 2004; Volume 116
683
4. Warburton D E.R., Nicol C W, Bredin S S.D, Prescribing exercise as
preventive therapy, CMAJ March 28, 2006;174(7): 961
Vitamin eX (Exercise)

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Vitamin eX (Exercise)

  • 2.
  • 3.
  • 4. Vitamin eX* Deficiency Disorders and RWA Dr Paul T Francis, MD Assoc. Prof. Community Medicine Amrita Institute of Medical Sciences, Kochi, India paultfrancis@gmail.com *eXercise
  • 5. Contents • Health benefits of regular PAeX • Health problems due deficiency of PAeX • Recommended PAeX dosage for different age groups
  • 6. Vitamin • “Vitamin" coined in 1911 by the Warsaw- born biochemist Casimir Funk for a ‘vital’ ‘amine’ • Later the ‘e’ was removed • Usually not synthesized by the body
  • 7. Vitamin eX • An essential ingredient in our daily life, being ignored at a great cost to our health in the modern times
  • 8. Physical activity, Exercise, Physical fitness • Physical Activity is any bodily movement produced by skeletal muscles, which results in energy expenditure • Exercise is a subset of physical activity that is planned, structured, and repetitive and has as a final or an intermediate objective the improvement or maintenance of physical fitness. • Physical fitness is a set of attributes that are either health or skill-related.
  • 9. Physical fitness Skill related - Power Agility Balance Health related – Cardiorespiratory endurance Body composition Physical fitness Skill related - Power Agility Balance Physical fitness Skill related - Power Agility Balance Health related – Cardio-respiratory endurance Body composition Physical fitness Skill related - Power Agility Balance
  • 10. Mary Kom Gymnast on a balance beam
  • 11.
  • 12. MET (Metabolic Equivalent) • I MET is equal to the energy expended by body at rest (3.5mLO2/kg/min or 1Cal/kg/hr) – Basal Met Rate/Resting Met rate • The energy expenditure during PAeX is considered as multiples of MET • Sedentary < 1.6 MET • Low intensity 1.6 < 3 MET • Moderate intensity 3<6 MET • Vigorous intensity 6<9 MET
  • 13. ‘Aerobic’ exercise • Aerobic activity, also called endurance activity, improves cardiorespiratory fitness. Examples: brisk walking, running, bicycling, jumping rope, and swimming. • Aerobic exercise stimulates heart and muscles to use more Oxygen • In anaerobic exercise the metabolism is only 50% anaerobic – intense exertion - Sprint, Weight lifting • 1. ‘Explosive Efforts’ (duration up to 6 s) • 2. ‘High Intensity Efforts’ (efforts comprised between >6 s to 1 min) • 3. ‘Endurance Intensive Efforts’ (for exercise bouts longer than 1 min)
  • 16. Sedentary behaviour/physical Inactivity • Sedentary - characterized by much sitting and little physical exercise • an independent risk factor for NCDs • Fourth leading risk factor for global mortality • Responsible for 6% of deaths globally – around 3.2 million deaths per year • Around 31% of the world’s population is not meeting the minimum physical activity
  • 17.
  • 18. PAeX Pioneering study on PA by JN Morris in 1950s compared mortality of London bus Drivers and Conductors
  • 19. Physiological effects of PAeX • Acute exertion & Exercise training • Heart – ejection vol, size, Resting rate (-) • Skeletal muscle – size, capillaries, mitochondria, Glycogen and TG deposits, fat acids are used more • Blood – vol, • Fat – HDL, TG (-)
  • 20. Effects • BP – acute exertion +, shortly after – • Acute effects • Immune system – decrease in immune response few hours • Blood coagulation – transient increase in platelet aggregation
  • 21. Benefits of Physical activity/Exercise • PAeX profoundly affects the body and the benefits are innumerable – the whole body benefits • Reduction in the whole spectrum of NCDs - 31% reduction in mortality
  • 22. Important benefits of PAeX • Reduces blood pressure • Reduces serum cholesterol • Increases muscle and bone strength • Prevents colon and breast cancer • Reduces depression, dementia
  • 23. Benefits of PA/eX • Better sleep, less mental stress • Better immunity – less communicable diseases! • Secondary prevention • Better prognosis, survival and quality of life for those with NCD
  • 24. How much PAeX is required to keep us healthy?
  • 25. A program of regular exercise that includes cardiorespiratory, resistance, flexibility, and neuromotor exercise training beyond activities of daily living to improve and maintain physical fitness and health is essential for most adults American College of Sports Medicine. Position Stand. Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults: Guidance for Prescribing Exercise. 2011
  • 26. Basal Metabolic Rate • About 60% of energy is used for BMR • EE beyond that routine EE is required to provide health benefits.
  • 27.
  • 28. Relevant for • Cardio-respiratory health (coronary heart disease, cardiovascular disease, stroke and hypertension). • Metabolic health (diabetes and obesity). • Musculoskeletal health (bone health, osteoporosis). • Cancer (breast and colon cancer). • Functional health and prevention of falls. • Depression.
  • 29. PAeX • Three factors combine to form the ‘exercise dose’ • Frequency • Duration • Intensity
  • 30. Recommended Weekly Allowance • Adequacy of PAeX is measured by the Total time/Energy Expenditure accumulated over a period of one week • Lot of flexibility in doing PAeX
  • 31. RWA • Even small amount helps • Benefit is dose related • Doesn’t require expensive equipment or facilities
  • 32. RWA • For three age groups • 5-17 yrs • 18-64 yrs • >65 yrs
  • 33. Children 5-17 • 60 minutes moderate to vigorous every day • More health benefits if the duration is increased • Vigorous intensity activity and Muscle bone strengthening activities should be included at least 3 times a week • PA - play, games, sports, transportation, or planned exercise
  • 34. 5-17 yrs • This one hour should be beyond the physical activity accumulated in the course of normal daily non-recreational activities
  • 35. Adults 18-64 yrs • 150 minutes of moderate intensity activity or • 75 minutes of vigorous intensity activity or • An equivalent combination of moderate and vigorous activity per week • Plus - Strength training of major muscle groups 2 times a week
  • 36. Adults 18-64yrs • Duration if doubled, will give maximum benefits • Beyond that is uncertain • PA - Recreational, transportation (e.g walking or cycling), occupational (i.e. work), household chores, sports/games or planned exercise
  • 37. Distribution over a week • 30 mts – M x 5 days • 25 mts – V x 3 days Minimum duration of a bout - 10 minutes
  • 38. Combination • 30mts x 4MET = 120 MET/day x 5 = 600 • 15m x 8M = 120 MET x 3 days = 360 + 30m x 4M = 120 x 2 d = 240 • One day rest per week is needed • Can you do the entire quantity in one day? • Weekend warriors
  • 39.
  • 40. Adults > 65 yrs • 150 mts of Moderate or 75 mts of vigorous activity or an equivalent combination of both per week • Muscle strengthening exercises at least 2 days a week • Adults with poor mobility, should do physical activity to enhance balance and prevent falls on 3 or more days per week • Moderate and Vigorous is relative
  • 41. Adults >65 yrs • For additional benefits the duration can be doubled • Individuals with chronic NCDs should be active to the level their abilities and health conditions allow • PA - recreational, transportation (e.g walking or cycling), occupational (if the person is still engaged in work), household chores, games, or planned exercise
  • 42. Adults > 65 yrs • If for health reasons they cannot do the recommended duration, they must do as much as possible
  • 43.
  • 44. Talk test • Moderate intensity activity - can talk, but not sing • Brisk walking • Vigorous intensity activity - not be able to say more than a few words without pausing for a breath • Jogging
  • 45. < 5 yrs • They should probably be more active than the older children • However there are not enough studies to prescribe a minimum recommendation
  • 46. Disabled • The recommendations holds good for them too • Have to do as much physical activity possible within the limitations imposed by the Disability
  • 47.
  • 48. Obese/overweight • Overweight people need not despair • Any PA reduces the risk of mortality for the given weight • PA can lead to reduction of body weight
  • 49.
  • 50. Attaining and maintaining fitness • 3-6 months of regular exercise is required for attaining the level of fitness and risk reduction • 1-2 weeks after stopping exercise the beneficial effect may gradually wear away • The PAeX should be made part of our daily life
  • 51. Injuries • Care should be taken to avoid injuries • Appropriate place, dress and footwear needed • Roads can be really dangerous – vehicles and dogs (music in ears can be a problem) • Personal safety - lonely places to be avoided • With care, benefits far outweigh the risk of musculoskeletal injuries
  • 52. Summary • Physical Inactivity is a major risk factor for many NCDs • PAeX is essential to remain healthy and prevent NCDs • The basic requirement for an adult is • 150mts of moderate or 75mts of vigorous intensity activity or an equivalent combination every week • Muscle strengthening sessions about 2 days a week
  • 53. Summary • Extra PA gives additional benefits • Minimum duration of a bout should be 10mts • Even small amount helps • Those suffering from NCD will have better prognosis if they do PAeX
  • 54. Do not forget your weekly dose of vitamin eX to keep yourself Healthy, Happy and Young
  • 55. Thank you References 1. WHO, Global recommendations on physical activity for health, 2010 2. Physical Activity in the Prevention and Treatment of Disease, Professional associations for physical activity, 2010, Sweden 3. Taylor RS et al, Exercise-Based Rehabilitation for Patients with Coronary Heart Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials, American J of Med: 2004; Volume 116 683 4. Warburton D E.R., Nicol C W, Bredin S S.D, Prescribing exercise as preventive therapy, CMAJ March 28, 2006;174(7): 961

Editor's Notes

  1. For the vast majority of us who is unlikely to get PM grade vit P, there is something else, which is equal or better and can keep us Healthy, happy and young. It is free, available everywhere and anytime and that is Vitamin e X,
  2. Paradoxical effects
  3. Worried about mortality and morbidity numbers/quantify
  4. All of us know about Psychosomatic disorders, effect of mind over body. mostly harmful Here is one instance where body has effect on mind – beneficial