Therapeutic exercises are planned physical movements intended to remediate or prevent impairments, enhance function, reduce risk, and optimize health and well-being. They involve movement prescribed to correct impairments and restore function. The most common therapeutic exercises fall into four groups: strengthening exercises, endurance exercises, flexibility exercises, and balance/coordination exercises. Therapeutic exercise is a core skill of physiotherapy and includes aerobic conditioning, agility training, coordination exercises, range of motion exercises, and more. Factors like a patient's health status, goals, motivation, and support system influence the expected outcomes of therapeutic exercise.
The document discusses exercise guidelines and benefits for various medical conditions. It provides guidelines for moderate and vigorous aerobic exercise for adults, as well as reasons some people do not exercise. It then outlines strategies to motivate patients using 3M's (mentioning, modeling, motivation). The FITT principle for exercise prescription and risk stratification for exercise are also covered. Specific conditions discussed include hypertension, obesity, pregnancy, osteoporosis, and depression.
Physical activity in people with disabilities and elderly peopleKarel Van Isacker
This document discusses physical activity for disabled and elderly people. It defines physical activity and exercise, and explains the health benefits of physical activity, including reduced risk of heart disease, diabetes, obesity, and hip fractures. It recommends that physical activity programs for the elderly and disabled include aerobic exercise, strength training, and flexibility training, along with guidelines for frequency, duration and intensity. Barriers to physical activity for these groups are addressed, as well as ways to motivate participation through social support, alternative activities, and tracking progress. Environmental and medical factors to consider with exercise programs are also outlined.
The document provides an overview of nutrition, physical activity, exercise, and general guidelines for healthy eating and exercise. It discusses:
1) How genetics and lifestyle factors like diet, physical activity, and medicine influence health status, with lifestyle accounting for 70% of life expectancy.
2) The leading causes of death in the US are largely preventable through lifestyle changes that address risk factors like physical inactivity, poor diet, smoking, and excess alcohol.
3) General guidelines for a healthy diet include balancing calories with activity, choosing nutritious foods moderate in fat and sugars, and high in fruits/veggies.
4) General exercise guidelines recommend 150 minutes of moderate exercise or 75 minutes of
Exercise Oncology Transforming Research to Practice shareableAndrewChongaway
PPT discussing available research in exercise and rehabilitation with the oncology population. Takes a look at the pitfalls of exercise programming in the oncology population as well as ideas to promote appropriate exercise programming in the rehab and wellness settings.
This document provides an overview of muscular strength and endurance training. It defines muscular strength as the maximal force produced by a muscle in one repetition, usually with high resistance and low repetitions (1-10 reps). Muscular endurance is defined as the ability of a muscle to exert sub-maximal force over an extended period of time, using low to moderate resistance and high repetitions (15-25 reps). Guidelines for improving muscular fitness include training major muscle groups 2-3 times per week, with 2-4 sets of 8-12 repetitions. Long-term training can improve the heart, lungs, circulation, blood, blood pressure, skeleton and muscles. Delayed onset muscle soreness and contraindicated exercises for certain populations
This document provides an overview of physical fitness assessments. It defines physical fitness as the ability to carry out daily tasks without undue fatigue. Components of physical fitness include body composition, muscular strength and endurance, cardiorespiratory fitness, flexibility, agility, balance, coordination, reaction time, power, and speed. The document describes methods for assessing each component, such as BMI, pushups, sit-and-reach tests. It recommends that adults engage in moderate exercise for 30 minutes daily to improve health and reduce disease risk. Precautions are discussed to prevent cardiac events during exercise.
The document discusses exercise guidelines and benefits for various medical conditions. It provides guidelines for moderate and vigorous aerobic exercise for adults, as well as reasons some people do not exercise. It then outlines strategies to motivate patients using 3M's (mentioning, modeling, motivation). The FITT principle for exercise prescription and risk stratification for exercise are also covered. Specific conditions discussed include hypertension, obesity, pregnancy, osteoporosis, and depression.
Physical activity in people with disabilities and elderly peopleKarel Van Isacker
This document discusses physical activity for disabled and elderly people. It defines physical activity and exercise, and explains the health benefits of physical activity, including reduced risk of heart disease, diabetes, obesity, and hip fractures. It recommends that physical activity programs for the elderly and disabled include aerobic exercise, strength training, and flexibility training, along with guidelines for frequency, duration and intensity. Barriers to physical activity for these groups are addressed, as well as ways to motivate participation through social support, alternative activities, and tracking progress. Environmental and medical factors to consider with exercise programs are also outlined.
The document provides an overview of nutrition, physical activity, exercise, and general guidelines for healthy eating and exercise. It discusses:
1) How genetics and lifestyle factors like diet, physical activity, and medicine influence health status, with lifestyle accounting for 70% of life expectancy.
2) The leading causes of death in the US are largely preventable through lifestyle changes that address risk factors like physical inactivity, poor diet, smoking, and excess alcohol.
3) General guidelines for a healthy diet include balancing calories with activity, choosing nutritious foods moderate in fat and sugars, and high in fruits/veggies.
4) General exercise guidelines recommend 150 minutes of moderate exercise or 75 minutes of
Exercise Oncology Transforming Research to Practice shareableAndrewChongaway
PPT discussing available research in exercise and rehabilitation with the oncology population. Takes a look at the pitfalls of exercise programming in the oncology population as well as ideas to promote appropriate exercise programming in the rehab and wellness settings.
This document provides an overview of muscular strength and endurance training. It defines muscular strength as the maximal force produced by a muscle in one repetition, usually with high resistance and low repetitions (1-10 reps). Muscular endurance is defined as the ability of a muscle to exert sub-maximal force over an extended period of time, using low to moderate resistance and high repetitions (15-25 reps). Guidelines for improving muscular fitness include training major muscle groups 2-3 times per week, with 2-4 sets of 8-12 repetitions. Long-term training can improve the heart, lungs, circulation, blood, blood pressure, skeleton and muscles. Delayed onset muscle soreness and contraindicated exercises for certain populations
This document provides an overview of physical fitness assessments. It defines physical fitness as the ability to carry out daily tasks without undue fatigue. Components of physical fitness include body composition, muscular strength and endurance, cardiorespiratory fitness, flexibility, agility, balance, coordination, reaction time, power, and speed. The document describes methods for assessing each component, such as BMI, pushups, sit-and-reach tests. It recommends that adults engage in moderate exercise for 30 minutes daily to improve health and reduce disease risk. Precautions are discussed to prevent cardiac events during exercise.
This document provides an overview of cardiovascular fitness and training principles. It defines cardiovascular fitness as the body's ability to transport and use oxygen. It recommends aerobic exercise 3-5 days per week at a moderate or vigorous intensity for 30-60 minutes. It also describes measuring exercise intensity using heart rate training zones. The document outlines both short-term benefits during exercise and long-term health benefits of cardiovascular training. It provides guidelines for special populations and key points about cardiovascular fitness.
This document discusses physical well-being and the importance of physical activity. It notes that physical activity benefits many body systems like the heart, muscles, bones, and immune system. It provides physical activity guidelines for adults and children, recommending at least 30 minutes per day of moderate activity for adults, or 20 minutes of vigorous activity 3 times per week, and 60 minutes per day for children. The document also discusses different aspects of physical fitness like cardiorespiratory endurance, muscular strength and endurance, flexibility, and body composition.
The document discusses the importance of physical fitness, health, and wellness for law enforcement officers. It notes that over half of American adults do not engage in recommended physical activity levels and about a quarter do not exercise at all. The document emphasizes that physical fitness through aerobic exercise and strength training can improve officers' health, safety, job performance, and reduce injury risks.
The document outlines general principles for exercise prescription, including the FITT principle of frequency, intensity, time, and type. It recommends at least 150 minutes per week of moderate exercise or 75 minutes of vigorous exercise. Exercise should involve rhythmic activities using large muscle groups. Strength, flexibility, and balance training are also recommended components. Progression should be gradual and individualized based on a person's health, goals and tolerance.
The role of Exercise to prevent of Non-Communicable Diseases (NCDs). Recommended Weekly Allowance. Frequency, Duration, and Intensity of Physical Activity/Exercise to be Healthy, Happy and Young
This document discusses the benefits of exercise and fitness programs. It outlines that regular exercise strengthens the cardiovascular system, improves balance, reduces stress and anxiety by increasing happy chemicals in the brain, improves self-confidence, increases brainpower and memory, strengthens muscles and bones, reduces the risk of heart disease, and prevents obesity. A fitness program incorporates physical activities to target functional, skill-related, and health-related fitness goals.
Chapter 11 EXERCISE FOR HEALTH AND FITNESSEarlene McNair
This document discusses the benefits of exercise and components of physical fitness. It outlines the key health benefits of exercise, including reduced risk of premature death, improved cardiorespiratory health, disease prevention, and improved psychological well-being. It then describes the five components of physical fitness - cardiorespiratory endurance, muscular strength, muscular endurance, flexibility, and body composition. The document provides guidance on developing an exercise routine, including frequency, intensity, time, type and progression for different types of exercise.
Regular physical activity provides significant health benefits for those with diabetes, including improved blood glucose control, lipid profile, blood pressure, and weight management. The Canadian Diabetes Association recommends a minimum of 150 minutes per week of aerobic exercise and 3 sessions per week of resistance exercise. However, most people with diabetes do not meet these targets. Healthcare professionals play an important role in promoting physical activity by assessing patients' current activity levels, advising on exercise prescriptions, and assisting with goal setting and follow up to help patients adopt and maintain regular physical activity.
This document defines physical fitness and its components. It discusses two main types of fitness: health-related fitness and skill-related fitness. Health-related fitness includes cardiorespiratory endurance, muscular endurance, body composition, and flexibility. Skill-related fitness includes agility, coordination, speed, power, and reaction time. Exercise is defined as planned physical activity to improve fitness, while physical activity is any bodily movement from muscle contraction. Several tools to monitor and assess physical activity and fitness are also outlined, including the PAR-Q+, IPAQ, and methods to monitor exercise intensity like the talk test and heart rate.
This document provides information on physical fitness and exercise. It defines key terms like physical activity, exercise, and physical fitness. It recommends that adults get at least 30 minutes of moderate physical activity most days of the week to promote health. It also discusses the health benefits of exercise and lists the components of physical fitness like cardiorespiratory endurance and muscular strength. Finally, it provides guidelines for developing an effective exercise program and training safely and gradually over time.
This document defines key terms related to physical fitness and exercise. It discusses the importance of aerobic, anaerobic, stretching, and balance exercises. It outlines the phases of an exercise program and basic principles of exercise including progression, overload, specificity, individuality, reversibility, variation, rest and recovery, and the FITT principle. The FITT principle recommends exercising a minimum of 3-5 days per week, at a moderate to vigorous intensity for 30-60 minutes, including cardio, strength, and flexibility training.
This document discusses the psychological benefits of exercise. It outlines several common benefits such as improved mood, reduced stress, increased self-esteem, and improved body image. It also examines specific psychological variables like depression, anxiety, stress, and mood states. The literature shows that both aerobic and anaerobic exercise can positively impact these mental health factors. Overall, the document advocates that personal trainers promote both the physical and psychological advantages of exercise to their clients.
Components of Physical Fitness BSC 6 SEm Fit & Exs Mgt.pptxChandanRaj58
This document discusses the importance of measuring different components of physical fitness, including cardiorespiratory fitness, body composition, muscle fitness, and flexibility. It describes the health benefits of improved cardiorespiratory fitness and the health risks of obesity and eating disorders. The purposes of fitness testing are also outlined, including diagnosis of strengths/weaknesses, monitoring training progress, and program evaluation. Principles of fitness development like overload and individuality are also covered.
Physical fitness refers to the body's ability to function efficiently and carry out daily tasks and activities while maintaining good health. It has two main components: specific fitness, which focuses on skills for particular activities or sports, and general fitness, which aims for total health and well-being. Physical fitness provides many benefits such as reducing stress, building strong bones and muscles, maintaining a healthy weight, and improving cardiovascular health. It can be developed through aerobic activities like running and swimming that strengthen the heart and lungs, as well as strength and flexibility exercises. Factors like heredity, lifestyle, nutrition, and exercise habits all impact a person's level of physical fitness.
Basic principles of Exercise designs for healthy and special populations, based on American College of Sports Medicine Guidelines. Target audience: Fitness trainers and health professionals. This lecture was delivered at Chennai in February 2014 in an international seminar organized by Madras Diabetes Research Foundation and Florida International University.
Exercise Is Medicine: How a Medical Fitness Center Differs from a Health ClubMercy Medical Center
During his presentation on 2/25/14, Eldon Jones, director of health & fitness at Mercy Medical Center in Canton, Ohio, explains how exercise often is as effective as medication in treating certain chronic serious health conditions, including heart disease, diabetes and more.
Eldon also covered how a medical fitness center differs from a tradition gym or health club.
Other topics covered in the presentaton:
* The importance of prescribing exercise
* US Physical Activity Guidelines
* Cardiac rehabilitation and how it works
* Components of ExRx for risk factor reduction
* FITT principle
* Stages of conditioning
* Strength training
Concept understanding of Fitness, Exercise, and Nutrition. This presentation was prepared for the parents of Lourdes School of Mandaluyong. This is part of their RESPIRE program.
AM I PHYSICALLY FIT OR IS IT FAR FROM THE TRUTH
what physical fitness
component of physical fitness
skill related physical fitness
exercise prescription
principle of exercises
theory of fit
warmup and cool down
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
This document provides an overview of cardiovascular fitness and training principles. It defines cardiovascular fitness as the body's ability to transport and use oxygen. It recommends aerobic exercise 3-5 days per week at a moderate or vigorous intensity for 30-60 minutes. It also describes measuring exercise intensity using heart rate training zones. The document outlines both short-term benefits during exercise and long-term health benefits of cardiovascular training. It provides guidelines for special populations and key points about cardiovascular fitness.
This document discusses physical well-being and the importance of physical activity. It notes that physical activity benefits many body systems like the heart, muscles, bones, and immune system. It provides physical activity guidelines for adults and children, recommending at least 30 minutes per day of moderate activity for adults, or 20 minutes of vigorous activity 3 times per week, and 60 minutes per day for children. The document also discusses different aspects of physical fitness like cardiorespiratory endurance, muscular strength and endurance, flexibility, and body composition.
The document discusses the importance of physical fitness, health, and wellness for law enforcement officers. It notes that over half of American adults do not engage in recommended physical activity levels and about a quarter do not exercise at all. The document emphasizes that physical fitness through aerobic exercise and strength training can improve officers' health, safety, job performance, and reduce injury risks.
The document outlines general principles for exercise prescription, including the FITT principle of frequency, intensity, time, and type. It recommends at least 150 minutes per week of moderate exercise or 75 minutes of vigorous exercise. Exercise should involve rhythmic activities using large muscle groups. Strength, flexibility, and balance training are also recommended components. Progression should be gradual and individualized based on a person's health, goals and tolerance.
The role of Exercise to prevent of Non-Communicable Diseases (NCDs). Recommended Weekly Allowance. Frequency, Duration, and Intensity of Physical Activity/Exercise to be Healthy, Happy and Young
This document discusses the benefits of exercise and fitness programs. It outlines that regular exercise strengthens the cardiovascular system, improves balance, reduces stress and anxiety by increasing happy chemicals in the brain, improves self-confidence, increases brainpower and memory, strengthens muscles and bones, reduces the risk of heart disease, and prevents obesity. A fitness program incorporates physical activities to target functional, skill-related, and health-related fitness goals.
Chapter 11 EXERCISE FOR HEALTH AND FITNESSEarlene McNair
This document discusses the benefits of exercise and components of physical fitness. It outlines the key health benefits of exercise, including reduced risk of premature death, improved cardiorespiratory health, disease prevention, and improved psychological well-being. It then describes the five components of physical fitness - cardiorespiratory endurance, muscular strength, muscular endurance, flexibility, and body composition. The document provides guidance on developing an exercise routine, including frequency, intensity, time, type and progression for different types of exercise.
Regular physical activity provides significant health benefits for those with diabetes, including improved blood glucose control, lipid profile, blood pressure, and weight management. The Canadian Diabetes Association recommends a minimum of 150 minutes per week of aerobic exercise and 3 sessions per week of resistance exercise. However, most people with diabetes do not meet these targets. Healthcare professionals play an important role in promoting physical activity by assessing patients' current activity levels, advising on exercise prescriptions, and assisting with goal setting and follow up to help patients adopt and maintain regular physical activity.
This document defines physical fitness and its components. It discusses two main types of fitness: health-related fitness and skill-related fitness. Health-related fitness includes cardiorespiratory endurance, muscular endurance, body composition, and flexibility. Skill-related fitness includes agility, coordination, speed, power, and reaction time. Exercise is defined as planned physical activity to improve fitness, while physical activity is any bodily movement from muscle contraction. Several tools to monitor and assess physical activity and fitness are also outlined, including the PAR-Q+, IPAQ, and methods to monitor exercise intensity like the talk test and heart rate.
This document provides information on physical fitness and exercise. It defines key terms like physical activity, exercise, and physical fitness. It recommends that adults get at least 30 minutes of moderate physical activity most days of the week to promote health. It also discusses the health benefits of exercise and lists the components of physical fitness like cardiorespiratory endurance and muscular strength. Finally, it provides guidelines for developing an effective exercise program and training safely and gradually over time.
This document defines key terms related to physical fitness and exercise. It discusses the importance of aerobic, anaerobic, stretching, and balance exercises. It outlines the phases of an exercise program and basic principles of exercise including progression, overload, specificity, individuality, reversibility, variation, rest and recovery, and the FITT principle. The FITT principle recommends exercising a minimum of 3-5 days per week, at a moderate to vigorous intensity for 30-60 minutes, including cardio, strength, and flexibility training.
This document discusses the psychological benefits of exercise. It outlines several common benefits such as improved mood, reduced stress, increased self-esteem, and improved body image. It also examines specific psychological variables like depression, anxiety, stress, and mood states. The literature shows that both aerobic and anaerobic exercise can positively impact these mental health factors. Overall, the document advocates that personal trainers promote both the physical and psychological advantages of exercise to their clients.
Components of Physical Fitness BSC 6 SEm Fit & Exs Mgt.pptxChandanRaj58
This document discusses the importance of measuring different components of physical fitness, including cardiorespiratory fitness, body composition, muscle fitness, and flexibility. It describes the health benefits of improved cardiorespiratory fitness and the health risks of obesity and eating disorders. The purposes of fitness testing are also outlined, including diagnosis of strengths/weaknesses, monitoring training progress, and program evaluation. Principles of fitness development like overload and individuality are also covered.
Physical fitness refers to the body's ability to function efficiently and carry out daily tasks and activities while maintaining good health. It has two main components: specific fitness, which focuses on skills for particular activities or sports, and general fitness, which aims for total health and well-being. Physical fitness provides many benefits such as reducing stress, building strong bones and muscles, maintaining a healthy weight, and improving cardiovascular health. It can be developed through aerobic activities like running and swimming that strengthen the heart and lungs, as well as strength and flexibility exercises. Factors like heredity, lifestyle, nutrition, and exercise habits all impact a person's level of physical fitness.
Basic principles of Exercise designs for healthy and special populations, based on American College of Sports Medicine Guidelines. Target audience: Fitness trainers and health professionals. This lecture was delivered at Chennai in February 2014 in an international seminar organized by Madras Diabetes Research Foundation and Florida International University.
Exercise Is Medicine: How a Medical Fitness Center Differs from a Health ClubMercy Medical Center
During his presentation on 2/25/14, Eldon Jones, director of health & fitness at Mercy Medical Center in Canton, Ohio, explains how exercise often is as effective as medication in treating certain chronic serious health conditions, including heart disease, diabetes and more.
Eldon also covered how a medical fitness center differs from a tradition gym or health club.
Other topics covered in the presentaton:
* The importance of prescribing exercise
* US Physical Activity Guidelines
* Cardiac rehabilitation and how it works
* Components of ExRx for risk factor reduction
* FITT principle
* Stages of conditioning
* Strength training
Concept understanding of Fitness, Exercise, and Nutrition. This presentation was prepared for the parents of Lourdes School of Mandaluyong. This is part of their RESPIRE program.
AM I PHYSICALLY FIT OR IS IT FAR FROM THE TRUTH
what physical fitness
component of physical fitness
skill related physical fitness
exercise prescription
principle of exercises
theory of fit
warmup and cool down
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
3. Definition
• The systematic performance or execution
of planned physical movements, postures,
or activities intended to enable the
patient/client to:
Remediate or prevent impairments
Enhance function
Reduce risk
Optimize overall health
Enhance fitness and well-being
4. • In the simplest terms, therapeutic exercise
involves movement prescribed to correct
impairments, restore muscular and
skeletal function and/or maintain a state
of well-being
• Therapeutic exercise is one of the core
skills upon which the profession of
physiotherapy is based.
5.
6. Exercise has been shown to:
• Benefit cardiovascular and respiratory function
• Reduce cardiovascular and respiratory function
• Decrease morbidity and mortality
• Decrease anxiety and depression
• Reduce pain
• Improve cognitive function
• Enhance physical function and independent living in older individuals
• Enhance feelings of well-being
• Reduce risk of falls in older individuals
• Prevent or mitigate functional limitations in older adults
• Enhance performance of work, recreational, and sport activities
7.
8. What is the difference between
physical activity and exercise?
• Physical activity refers to the contraction
of skeletal muscle that produces bodily
movement and requires energy. Exercise
is physical activity that is planned and is
performed with the goal of attaining or
maintaining physical fitness. Physical
fitness is a set of traits that allows an
individual to perform physical activity
9. The U.S. Department of Health and Human
Services published Physical Activity Guidelines in
1996 and more recently in 2018.
• Recommendations for adults include at least 150
minutes a week of moderate-intensity aerobic activity, or
75 minutes a week of vigorous-intensity aerobic activity,
or an equivalent combination of the two. ACSM defines
moderate intensity is defined as 3 to 5.9 metabolic
equivalents (METs), 45-63% VO2 max, or 64-91% of
maximum heart rate. They define vigorous intensity is
defined as greater than 6.0 METs, 64-91% VO2 max, or
77-93% of maximum heart rate (please also refer to
Table 1). Children and adolescents are encouraged to
perform 60 minutes or more of physical activity daily,
including aerobic, muscle-strengthening and bone-
strengthening activities.
10.
11.
12.
13. • There are several methodologies to exercise
prescription. One of the easier methods is the
Frequency, Intensity, Time, and Type (FITT). The ACSM
also recommends FITT-VP (Frequency, Intensity, Time,
Type, Volume, and Progression). Utilizing these
methodologies parallels writing a traditional medication
prescription. Each component of the prescription
provides a patient with specific information to
incorporate aerobic, resistance, flexibility, and
neuromotor exercise training into a fitness program.
15. Bottom Line Up Front (BLUF)
• Exercise is the best “medicine” around
• Assess physical activity in ALL patients
• Only RARE patients needs GXT before exercise
• GXT pts with symptomatic CV/pulm dz
• The Prescription is: Be “FITT”
– Frequency: 5 days a week (or more)
– Intensity: moderate intensity, 5-6 on 10 scale
– Time: 30 minutes aerobics (10-min chunks OK)
– Type:
• Aerobic activity
• Muscular strengthening activity
• Flexibility activity (in elderly/sick)
• Balance training (if fall risky)
16. Physicians and their Patients
• 47% of primary care physicians include
an exercise history as part of their initial
examination (self report)
• Only 13% of patients report physicians
giving advice about exercise
• Physically active physicians are more
likely to discuss exercise with their
patients
17. ACSM & AHA 2007, HHS 2008
Physical Activity Recommendations
Healthy Adults age 18-64
• Aerobic Physical Activity
– Moderate intensity: 150 minutes/wk, OR
Vigorous intensity: 75 minutes/wk (or a
combo)
– 10 min at least, preferably spread throughout
week
• Muscle Strengthening Activity
– 2 or more days/wk
– 8-10 exercises
– 8-12 reps (one set)
19. Indications for Exercise
• Longevity
• Quality of Life
• Socialization
• Weight control
• Disease prevention
• Disease management
• ….(I could go on)
20. Longevity
The more you exercise, the lower your risk of
death
0
0.2
0.4
0.6
0.8
1
1.2
0 90 180 330 420
Relative
Rick
of
Death
Minutes per Week of Moderate- or Vigorous-Intensity Exercise
Risk of Death
22. Death Prevention:
Attributable Deaths (%) from various
health conditions
Aerobics Center Longitudinal Study (ACLS), Cooper Institute
•40,842 men; 12,943 women
23. Strong Evidence of Benefit
from Physical Activity for…
• Lower risk of:
– Early death
– Heart disease
– Stroke
– Type 2 diabetes
– High blood pressure
– Dyslipidemia
– Metabolic syndrome
– Colon and breast Ca
• Prevention of wt gain
• Wt loss w/dieting
• Improved C-R &
muscular fitness
• Prevention of falls
• Reduced depression
• Better cognitive fxn
(older adults)
24. Moderate evidence for…
• Wt maintenance after loss
• Lower risk of hip fx
• Increased bone density
• Improved sleep quality
• Lower risk lung and endometrial Ca
26. Side effects of exercise
• Slight risk of Musculoskeletal injury
– Increases with duration & intensity
• RARE cardiac events
– FAR outweighed by benefits to heart!
– 25-50% decrease in CVD in exercisers
27. •If we had a pill that conferred
all the benefits of exercise,
physicians would prescribe it to
every patient. Our health care
system would find a way to
make sure that every patient
had access to this “wonder
drug.”
28. Use the
Sports and Exercise Medicine
approach to patients
• Every patient is a potential “athlete” who
needs exercise for HEALTH, not
competition
• Physical activity is a VITAL SIGN--a
STRONG PREDICTOR OF HEALTH
• Every exam is a pre-participation eval
• Conclude exams with activity clearance
and Exercise Rx
39. Muscular Strengthening
• Exercise large muscle groups
• 8-12 reps; should fatigue by last rep
• Rest 2-3 minutes between exercises
• 1 set good, 2 sets better
• Rest day in between
40. What about Older Adults >65,
or those with chronic
diseases?
• Aerobic exercise: same
• Strength exercise: same, except 10-15
reps
– Slightly lighter weights
• Flexibility activity 2 days/wk, 10 min
• Balance exercise if at risk for falls,
3x/wk
Nelson ME et al. Physical activity and public health in older adults:
Recommendation from the ACSM and the AHA.
Med Sci Sports Exer 2007;39(8):1435.
41. What about
Children/Adolescents?
• Do 60 minutes or more of physical activity
every day
– Mostly moderate or vigorous
– Vigorous activity at least 3 days/wk
• Strength exercise 3 days/wk
HHS guidelines October 2008
42. Take Home Pearls
• Exercise is the best “medicine” around
• Assess physical activity in ALL patients
• Only RARE patients needs GXT before exercise
• GXT pts with symptomatic CV/pulm dz
• The Prescription is: Be “FITT”
– Frequency: 5 days a week (or more)
– Intensity: moderate intensity, 3-6 on 10 scale
– Time: 30 minutes aerobics (10-min chunks OK)
– Type:
• Aerobic activity
• Muscular strengthening activity
• Flexibility activity (in elderly/sick)
• Balance training (if fall risky)
43. Therapeutic exercise may
include:
• aerobic and endurance conditioning and reconditioning;
• agility training;
• body mechanics training;
• breathing exercises
• coordination exercises;
• developmental activities training;
• movement pattern training;
• neuromotor development activities training;
• neuromuscular education or reeducation;
• perceptual training;
• range of motion exercises and soft tissue stretching;
• relaxation exercises;
• strength, power, and endurance exercises.
44. The most commonly included
exercises fall into 4 groups
• Strengthening exercises, usually performed with heavy resistance
and fewer repetitions.
• Endurance exercises that engage large muscle groups over a longer
period of time, in the area of 50 to 60% VO2Max to achieve greater
cardiovascular endurance.
• Flexibility exercises achieved through stretching and movement.
• Balance and coordination exercises that focus on maintaining an
individual's centre of gravity.
67. Diagnostic classification for the
musculoskeletal system
• Primary prevention/risk for skeletal demineralization
• Impaired posture
• Impaired muscle performance
• Impaired joint mobility,motor function,muscle performance,ROM associated with
connective tissue disfunction
• Impaired joint mobility,motor function,muscle performance,ROM associated with
inflamation
• Impaired joint mobility,motor function,muscle performance,ROM associated with
spinal disorders
• Impaired joint mobility,motor function,muscle performance,ROM associated with
fracture
• Impaired joint mobility,motor function,muscle performance,ROM associated with joint
arthroplasty
• Impaired joint mobility,motor function,muscle performance,ROM associated with
bony and soft tissue surgery
• Impaired joint mobility,motor function,muscle performance,RMO,gait,locomotion and
balance associated with amputation
68. Factors that influence a patients
prognosis/expected outcomes
• Complexity, severity, acuity of the patient’s health condition
• Patient’s general health status and presence of comorbidities and
risk factors
• The patient’s previous level of functioning or disability
• The patient’s living environment
• Patient’s and/or family goals
• Patient’s motivation and adherence and responses to prtvious
interventions
• Safety issuts and concerns
• Extent of support (physical,emothional, social)
69.
70. Independent learning activity
• Critically analyze you own exercise history. Then identify how a
regular regimen of exercise can improve your quality of life.
• Research four health conditions(diseases, injuries or disorder s) that
result in primary impairments of 1) musculoskeletal, 2)
neuromuscular,3) cardiovascular or pulmonary,4) integumentary
systems. Identify characteristic impairments (sight and systems)
associated with each health condition and hypothesize what
activity/functional limitations and participation restrictions are most
likely to develop.
• Using your current knowledge of examination procedures develop a
list of specific tests and measures you would most likely choose to
use when examining the patient whose primary impairments affect
1) musculoskeletal, 2) neuromuscular,3) cardiovascular or
pulmonary,4) integumentary systems.