This document describes a case report of a successful treatment of disseminated strongyloidiasis in an immunocompromised patient using subcutaneous ivermectin. A 56-year-old man being treated with corticosteroids developed sepsis and respiratory failure due to strongyloidiasis. Oral ivermectin treatment was ineffective, so the patient was treated with subcutaneous ivermectin, which successfully cured the infection. The patient was removed from life support and discharged from the hospital. While parenteral ivermectin treatment has not been approved, this case suggests it may be an effective salvage therapy for disseminated strongyloidiasis when oral treatment fails or cannot