1) Stars originate from nebulae of dust and gas. They spend most of their life fusing hydrogen into helium through nuclear fusion in their cores as main sequence stars.
2) When stars have exhausted their hydrogen, their cores collapse and outer layers expand, forming red giants. More massive stars explode as supernovae, leaving behind neutron stars or black holes.
3) The sun is classified as a yellow dwarf star. Its atmosphere consists of the photosphere, chromosphere, and corona. Nuclear fusion in its core provides its energy.
This PowerPoint discusses the Sun at a high school level. It talks about characteristics, solar activities/events, how energy is created, and many more.
Maybe too in-depth for most elementary students, but very good broad coverage for teacher background or more advanced students in elementary or middle school.
This PowerPoint discusses the Sun at a high school level. It talks about characteristics, solar activities/events, how energy is created, and many more.
Maybe too in-depth for most elementary students, but very good broad coverage for teacher background or more advanced students in elementary or middle school.
The sun generates about 400 billion billion
megawatts of power and it has done so for five
billion years. Nuclear fusion – combining lighter
atoms to make heavier ones – is what makes it
possible.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
The sun generates about 400 billion billion
megawatts of power and it has done so for five
billion years. Nuclear fusion – combining lighter
atoms to make heavier ones – is what makes it
possible.
Register to explore the whole course here: https://school.bighistoryproject.com/bhplive?WT.mc_id=Slideshare12202017
What is a solar system?
FORMATION OF SOLAR SYSTEM
Components of the SOLAR SYSTEM
Discovery and exploration
Terminology
Description of the Components of the SOLAR SYSTEM
Farthest Regions
Galactic Context
The Solar System is located in the Milky Way galaxy, a barred spiral galaxy with a diameter of about 100,000 light-years containing about 200 billion stars. Our Sun resides in one of the Milky Way's outer spiral arms, known as the Orion Arm or Local Spur. The Sun lies between 25,000 and 28,000 light years from the Galactic Centre, and its speed within the galaxy is about 220 kilometres per second, so that it completes one revolution every 225–250 million years. This revolution is known as the Solar System's galactic year. The solar apex, the direction of the Sun's path through interstellar space, is near the constellation of Hercules in the direction of the current location of the bright star Vega. The plane of the Solar System's ecliptic lies nearly at right angles (86.5°) to the galactic plane.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
2. The Big Bang
Most acceptable theory
because of its accuracy and
comprehensiveness in
terms of the evidences and
presented facts and
explanations.
Georges Lemaître, first
proposed the theory in
primeval atom, underlies
the basic tenets of Eintein’s
conceptions.
In 1949 radio broadcast, Fred
Hoyle is credited with
coining the term Big Bang.
3. The star’s Life Cycle
All stars originate from clouds of dusts and gases which are
commonly referred to as nebulae.
It is The process of Nuclear fusion that powers a star for most of
its life.
Star first attain the red giant phase, its core collapses into a dense
white dwarf that will soon expel planetary nebula in its outer
layers.
Larger stars can explode in a supernova as their cores collapse
forming an extremely dense neutron star or the commonly
known black hole.
Stars have varying luminosity based on the surface temperature.
4. The Sun
The atmosphere of the sun consists
of three parts .
These includes the photosphere,
chromosphere, and corona.
An extremely hot outermost layer
extending outward from the
chromosphere several million
miles, all of the major features of
the sun can be explained by the
nuclear reactions that make its
energy, the magnetic fields that
are caused by the movements of
the gas, the immense gravity.
5. Stars: The main Sequence
A hot ball gas made up of
entirely gas with hydrogen
fusing into helium, found in
its core.
After fusion, the star send out
energy in space, and there is
a slow contraction
happening to compensate for
the lost energy. This phase is
referred to as the main
sequence.
6. The Life and Death of a star
Most important factor in categorizing a star is its mass. The
star that weighs less than 3 solar masses spends most of its
life being into the main sequence, 90% of all stars are like
this.
If the star is above 3 solar masses, lesser time is required to
be spent in being a main sequence.
7. Energy Making during
normal life
Two protons join together to form
a deuterium nucleus,
commonly known as heavy
water where a positron and a
neutrino are released as by-
products.
The deuterium nucleus is
bombarded by another proton
that gives to a helium-3
nucleus.
8. Main Sequence Star Death
It is only after Ten billion years that a
main sequence star can be converted
approximately 10% of its hydrogen to
helium. Because of the great pressure
at the core of stars fusion occur- in a
fixed volume, increased pressure leads
to increased heat.
The helium core begins to contract,
outer layers expand and cool, glowing
redder. The Star is now called a red
giant. At this point, the Red giant is
made up of mostly carbon. The next
process would be to fuse the carbon
into iron. Great pressure is needed to
undertake this process.
9. Supergiant Star Death
Dies more quickly than a main sequence star because of the
greater mass that pulls the gravity inward in its core
creating tremendous pressure and results to a much faster
fusion rate.
Has pressure needed to fuse carbon into iron, this process
takes energy. When the energy is lost, the star no longer
possesses the balance between outward pressure and gravity
pushing which can result in its violent explosion known as
Supernova.
10. Dwarf Death
Sun is considered a main sequence star, but it is more
classified to as a yellow dwarf.
Red dwarfs are the only active dwarf and its mass ranges
from 1/3 up to 1/12 compared to the mass of the sun.
11. Neutron Stars, Pulsars,
and Black Holes
Black holes. Death of a giant
star results in the formation
of a black hole where the
mass is contained in a single
point, the point at the center
is referred to as Singularity
with a distance having a very
strong gravitational pull that
not even light can pass
through. The distance is
known as Event horizon.
12. Neutron stars and Pulsars
are very dense and spin very
fast, are only 10-15 km in
radius. Form from burnt-out
stars, they do not glow.
Some of it emit radio waves
that pulse on and off. These
stars are called Pulsars.
13. Galaxies
contains the stars, interstellar
media clouds of dust and gases
and remnants.
The Milky Way
most popular one because this is
where the solar syatem is found.
Edwin Hubble and Galileo Galilei
who first made observations in
Milky Way Galaxy in early 16th
and 19th centuries.
Milky Way is a barred spiral galaxy
which is 100,000-120,000 light-
years in diameter. Contains
approximately 200-400 billion
stars. It is estimated to be moving
at a speed of 552 to 630 km per
second. It is estimated to be 13.2
billion years old.
14. Quasars
the term quasar is a short
term from a quasi-stellar
radio source.
It is considered to be a very
high energy containing
distant active nucleus, it
makes it very luminous and
identified as a redshift
source of electromagnetic
energy, radio waves, and
visible light.
Are describe to be composed
of a compact region in the
center of a massive galaxy
surrounding its very massive
collapsed star.
15. Dark Matter
described to be a body that neither emits nor scatters the
light. Existence of dark matter was first postulated by Fritz
Zwicky in 1933 to account for evidence of “missing mass” in
the orbital velocities of galaxies in clusters.