This document summarizes genomic variation and individual genome sequencing. It discusses the rising number of subjects with genome sequences available, from 14,201 in 2007 to over 1 million in 2015. It also provides information about genomic analysis tools from NCBI including the SAM format, genome browsers, E-Utilities, Entrez Direct, and upcoming APIs. Finally, it advertises upcoming hackathons in January and March for developing tools and apps to work with NCBI genomic data and APIs.