The ulnar nerve arises from the brachial plexus and supplies sensation to the palmar side of the hand and medial 1.5 fingers as well as muscles in the forearm and hand. It is most commonly injured at the elbow or wrist, which can cause sensory loss, muscle weakness or wasting, and deformities like claw hand. Surgical exploration and repair or nerve transposition are often used to treat ulnar nerve injuries.
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
Lumbar spinal canal stenosis is one of the difficult topic of spine. All the information are taken from Campbell's operative orthopedics Thirteen edition and from internet. I also took help from the lectures of renowned orthopedics professors of Bangladesh.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
Lumbar spinal canal stenosis is one of the difficult topic of spine. All the information are taken from Campbell's operative orthopedics Thirteen edition and from internet. I also took help from the lectures of renowned orthopedics professors of Bangladesh.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
4th year medical student's seminar presentation under supervision of orthopedic lecturer. Reference is from Dr. Sameh Doss Textbook of upper and lower limb, and also other multiple websites.
Detailed Hand surgical anatomy by mohamed abdelhadyMohamed Abdelhady
Detailed Hand surgical anatomy including bones , blood and nerve supply and special structures eg flexor retiniculum , extensor compartments and anatomical snaff box
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. The ulnar nerve arises from the medial
cord of the brachial plexus (C8 and T1),
Gives off no cutaneous or motor
branches in the axilla or in the arm.
It enters the forearm from behind the
medial epicondyle
3. In the distal third of the forearm, it gives
off its palmar and posterior cutaneous
branches.
The palmar cutaneous branch supplies
the skin over the hypothenar eminence
The posterior branch supplies the skin
over the medial third of the dorsum of
the hand and the medial one and a half
fingers.
4. Not uncommonly, the posterior branch
supplies two and a half instead of one
and a half fingers.
NB: It does not supply the skin over the
distal part of the dorsum of these fingers.
5. Entering the palm by passing in front of
the flexor retinaculum,
The superficial branch of the ulnar nerve
supplies the skin of the palmar surface of
the medial one and a half fingers
, including their nail beds
6.
7. Muscles supplied:
Flexor carpi ulnaris
Flexor digitorum profundus(medial half)
Muscles of the hypothenar eminence
Adductor policis
Third and fourth lumbricals
Interossei
Palmaris brevis
8.
9. Mainly the type of nerve trauma
depends on the mechanism of injury:
Neuropraxia
Axonotemesis
Neurotemesis
10. The ulnar nerve is most commonly injured at
the elbow, where it lies behind the medial
epicondyle,
The injuries at the elbow are usually
associated with fractures of the medial
epicondyle.
At the wrist, where it lies with the ulnar artery
in front of the flexor retinaculum.
The superficial position of the nerve at the
wrist makes it vulnerable to damage from
cuts and stab wounds
11. Injuries of the ulnar nerve at elbow:
Motor:
The flexor carpi ulnaris and the medial half of the
flexor digitorum profundus muscles are paralyzed.
The paralysis of the flexor carpi ulnaris can be
observed by asking the patient to make a tightly
clenched fist.
Normally, the synergistic action of the flexor carpi
ulnaris tendon can be observed as it passes to the
pisiform bone;
the tightening of the tendon will be absent if the
muscle is paralyzed.
12. The profundus tendons to the ring and little fingers will
be functionless,
The terminal phalanges of these fingers are therefore
not capable of being markedly flexed.
Flexion of the wrist joint will result in abduction, owing
to paralysis of the flexor carpi ulnaris.
The medial border of the front of the forearm will
show flattening owing to the wasting of the
underlying ulnaris and profundus muscles.
The small muscles of the hand will be paralyzed,
except the muscles of the thenar eminence and the
first two lumbricals, which are supplied by the median
nerve.
13. The patient is unable to adduct and abduct the fingers
and consequently is unable to grip a piece of paper
placed between the fingers.
It is impossible to adduct the thumb because the
adductor pollicis muscle is paralyzed.
If the patient is asked to grip a piece of paper between
the thumb and the index finger, he or she does so by
strongly contracting the flexor pollicis longus and flexing
the terminal phalanx (Froment's sign).
The metacarpophalangeal joints become hyperextended
because of the paralysis of the lumbrical and interosseous
muscles, which normally flex these joints.
The interphalangeal joints are flexed, owing again to the
paralysis of the lumbrical and interosseous muscles, which
normally extend these joints through the extensor
expansion.
14. The flexion deformity at the interphalangeal joints of
the fourth and fifth fingers is obvious because the first
and second lumbrical muscles of the index and
middle fingers are not paralyzed.
In long-standing cases the hand assumes the
characteristic claw deformity (main en griffe).
Wasting of the paralyzed muscles results in flattening
of the hypothenar eminence and loss of the convex
curve to the medial border of the hand.
Examination of the dorsum of the hand will show
hollowing between the metacarpal bones caused by
wasting of the dorsal interosseous muscles.
15. Sensory:
Loss of skin sensation will be observed
over the anterior and posterior surfaces
of the medial third of the hand and the
medial one and a half fingers.
16. Vasomotor Changes
The skin areas involved in sensory loss are
warmer and drier than normal because
of the arteriolar dilatation and absence
of sweating resulting from loss of
sympathetic control
17. Injury of ulnar nerve at wrist:
Motor:
The small muscles of the hand will be
paralyzed and show wasting, except for the
muscles of the thenar eminence and the
first two lumbricals.
The clawhand is much more obvious in
wrist lesions because the flexor digitorum
profundus muscle is not paralyzed, and
marked flexion of the terminal phalanges
occurs.
18. Sensory:
The main ulnar nerve and its palmar cutaneous
branch are usually severed
The posterior cutaneous branch, which arises
from the ulnar nerve trunk about 2.5 in. (6.25
cm) above the pisiform bone, is usually
unaffected.
The sensory loss will therefore be confined to
the palmar surface of the medial third of the
hand and the medial one and a half fingers
and to the dorsal aspects of the middle and
distal phalanges of the same fingers.
19. Vasomotor and trophic changes:
These are the same as those described
for injuries at the elbow. It is important to
remember that with ulnar nerve
injuries, the higher the lesion, the less
obvious the clawing deformity of the
hand.
20.
21. Surgical management & Medical mx:
Exploration and suture of the divided nerve
Anterior transposition of nerve at the elbow
joint
Metacarpophalengeal flexion can be
improved by extensor carpi radialis longus to
intrinsic tendon transferes or
Looping a slip of flexor digitorum supeficialis
around the opening of the flexor
sheath(Zancolli procedure)
Admistration of analgesics if nerve lesion is
associated with fracture
22. Index abduction can be improved by
transfering extensor policis brevis or
extensor indicis to interosseous insertion
on the radial side of the finger.
23. faradism
Ift
Passive movements, can be auto
assisted
Hydrotherapy
Electro diagnosis
Tens
24. If there is no recovery after nerve
division,hand function is significantly
impaired
Grip strength is lost because the primary
metacarpophalangial flexors are lost
Pinch is poor because thumb adduction
and index finger abduction is weakened.
25. Apley’s othopaedic textbook
Snell’ clinical anatomy
www.physiopedia.com
Cleveland clinic journal of medicine
www.pubmed.com
Essential physical medicine and
rehabilitation.