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TUBERCULOSIS OF GENITAL TRACT
INCIDENCE
 0.75-1%
 5% in all female pelvic infections
 Occurs in 10% cases of pulmonary tuberculosis
 Mostly effects-reproductive age group
INC TREND….
 Inc in population with overall rise in tuberculosis cases
 HIV infection with inc incidence of pulmonary and
extrapulmonary forms of tuberculosis including drug
resistant forms.
SOURCE
 Sec to focus elsewhere in body
 Direct innoculation over vulva,vagina during sexual
intercourse with a partner suffering from tuberculous
lesions of genitilia
MODE OF SPREAD
 Blood stream
 7%-bovine org
 1-2%-ascends through the genital tract
OBSTETRIC HISTORY
 Only about 10% have children
 Rest r infertile
BACTERIOLOGY
 human tubercle bacilli
 Bovine organisms account for only a small no of cases
PATHOLOGY
FALLOPIAN TUBE
 Tuberculous endosalphingitis
 Tuberculous exosalphingitis
 Interstitial tubercular salphingitis
Tuberculous endosalphingitis
 Tube- thickened, enlarged, tortuous
 5%- fimbrial end is pouting, everted, open
 Periodic spill of tubal exudate - frequent exacerbations
 After HSG –with oil contrast –in the wall of flare up
 Caseation in wall of tube, collection of cheesy material –
 pyosalphinx
 Dense adhesions
 Contents-sterile
 But liable to recurrent attacks by pyogenic organisms
wrong diag -subacute,recurrent PID
 Sometimes endosalphinx - hyperplastic oedematous
pattern- ectopic preg
 Mucosa- granulomatous lesion with chr inflam infiltration
 Caseation –late stage
TUBERCULOUS EXOSALPHINGITIS
 Direct extension from adjacent organs
 Peritoneal surface –miliary tubercules
 Ampullary portion-dilated
 Fimbrial end-open,pouting
 TOBACCO – POUCH APP
 FROZEN PELVIS
 Trauma,Fistula-attempt to separate adhesions
INTERSTITIAL TUBERCULOUS
SALPHINGITIS
 TUBE –thickened
 Only on HPE- confirmed
 Diagnosis-
 Histopathology- caseation, gaint cells, clusters of epithelial cells
,lymphocytic infiltration
 Early- several sections need to be studied before tubercles
detected
 Late- typical gaint cells
 DD-
 oil granuloma after HSG
 Catgut reaction in case of prev sx foreign body reac
 Sarcoidosis
 Fungus infection
OVARY
 Appear normal
 30%-tubercles on surface, adhesions with tube
uterus
 70%
 Uterus appear normal, end-gaint cells
 Advanced cases- caseating material collects in uterine
cavity- pyometra
 Common- postmenopausal
 Ashermanns syndrome- hypo,amenorrhoea
 Abscess in myometrium- rare
cervix
 Descending type
 Rarely-ascending type
 App- ulcer/red papillary erosion bleed on touch
Vulva & vagina
 Ulcer-shallow,undermined edges
 Heals with scar formation at one end,spreads slowly to
other organs
 Painful ulcers
SYMPTOMS
INFERTILITY
 Often the only symp-35-60%
 In half- h/o tb in past/contact
 Due to blocked tubes
 Poor quality of ova may be responsible
Menstrual disorders
 40%-menorrhagia
 10%-amenorrhoea-sec
 Young women-twenties-sec amenorrhoea, pelvic ex-
adnexal swelling-suspect
 PMB
 Ashermanns- amenorrhoea
pain
 25-40% chr pelvic pain
 Severe pain- uncommon(sec infec)
 Sec infec- pain,nausea,vomitings,fever
Vaginal discharge
 Blood stained discharge
 Post coital bleeding
 Leucorrhoea
Abdominal mass
 Usually mass is immobile
 A doughy feel –tb peritonitis
FISTULA FORMATION-
 Following sx for abscess
CLINICAL SIGNS
 General cond- good mostly
 Tb peritonitis- abd doughy
 Tb encysyed cyst- immobile,sometimes tender
-tymphanic on percussion
 Pelvic adnexal mass- small,fixed
-frozen pelvis
HSG in asymptomatic-
 Lead pipe app
 Beading & variation in filling density
 Calcification of tube
 Cornual block
 Jagged fluffiness of tubal outline
 Vascular and lymphatic invasion of dye
 Tobacco-pouch and dilated distal end of tubes due to
hydro/pyosalphinx
 In proven case CI-spred the infection
 PID fail to respond, recurrent infec without
polymorphonuclear leucocytosis
 Healed extragenital lesion suff from infertility, menstrual
disorders,pelvic mass –suspect
 Cx ulcer- mimic ca
INVESTIGATIONS
 Aim-
 To identify prim lesion
 Confirm genital lesion
 Blood- wbc,ESR raised….
 -periodic examination is of value
 Montoux test-
 positive test-sensitised by tuberculoprotein
 negative excludes tb
 Chestxray-healed/active pulmonary infection
 Diagnostic uterine curretage-
 Done-week preceeding menstruation
 Tubercles likely to come to the surface
 Material sent in two portions-
 1)formol saline-HPE to detect gaint cell system
 Histology-detect tubercles in 10%
 FP-chr lesions(talk/catgut granuloma),sarcoidosis
 FN-improper timing of uterine curretage/less incidence of
uterine infection
 2)normal saline-
 Culture in L-J medium
 Identification of AFB by ziel-neelsens stain
 Nucleic acid amplification
 Guinea pig inoculation
 A positive culture-suggestive
 A positive innoculation test-diagnostic
 Bacteriologic test-if positive-type the bcilli,report their
drug sensitivity
 Nucleic acid amplification(16S ribosomal DNA)-
 PCR-identify in endometrium,menstual blood
 Sensitivity-85-90%
 Detect- 10 org in clinical specimens compared to 10,000
for smea positivity
 Genital tb- always paucibacillary
First day menstrual discharge
 Collected by pipette
 Subjected to nucleic acid amplification, culture, guinea pig
innoculation
 Positive-tb
 Negetive-not rule out tb
 Sputum,urine- culture for tb
 Lymohnode biopsy- neck in lymphadenitis
 Biopsy- lesion in cx,vagina,vulva
 HSG-
 Proved case-CI –reactivation of lesion
 Routine work up in investigation of infertility may reveal –
 b/l tubal block
 Coiling of tubes/calcified shadow of places
 Tubal diverticula/fluffiness of tubal outline
 Uterine cavity- irreg outline. honeycomb app/uterine
synaechiae
 Imaging-
 usg-abd,pelvis,CT/MRI helpful when there is mass/ascites
 Doesnot confirm the diagnosis
Laproscopy
 -absence of endometrial evidence
 Identify tubercles on peritoneal surgace
 Nodular app of tubes
 Biopsy from tubercles can be taken
 Aspiration of fluid-culture
 Accidentally discovered during diag lap for infertility
DIAGNOSIS
 The physician should Be conscious of entity
 Suspect and exclude genital tb in –
1. Unexplained infertility/amenorrhoea
2. Recurr episodes of pelvic infections,not responding with
usual course of antibiotics
3. Presence of pelvic mass with nodules in the POD
DD
Pelvic mass-
 pyogenic tubo-ovarian mass
 Pelvic endometriosis
 Adherent ovarian cyst
 Chr disturbed ectopic pregnancy
TREATMENT
 GENERAL
 Chemotherapy
 surgery
general
 Pulmonary tb perse –no need of admission
 Except in acute exacerbations
 Imp body resistence
 Regular diet
 Correct anaemia
 until infectn is controlled, husband should use condom
during intercourse- prevent urogenital tb
chemotherapy
 INTIAL PHASE-
 4 drugs are used for 2 mnths-
 red bacterial population
 prevent emergence of drug-resistence
 Drugs-
 Isoniazid
 Ehambutol
 Rifampicin
 Pyrazinamide
 Ethambutol-prev treated/immunocompromised
 Continuation phase-
 Treatment is continued for a period of further 4mnths
with isoniazid,rifampicin
 About a yr of treatment,diagnostic endometrial
curretage is to be done….
 Positive- treatment contd..
 Negetive- endometrium is examined at interval of six
mnths…
patient must be considered cured –
 At least 2 reports including histological and
bacteriological examination becomes negetive
 Majority of pts respond well to chemotherapy
 Multidrug resistent tb-
 Infection with myc tb that is resistant to 2 or more
agentsincluding isoniazid
 HIV negative patients who r MDR have high mortality
rate
 Such patients treated with-5 drug regimens(CDC)
DRUG Daily oral
dose
Nature Toxicity Comments
Isoniazid 5mg/kg
Max-300mg
Bactericidal Hepatitis,perip
heral
neuropathy
Check LFT,
Combine
pyridoxine
50mg daily
Rifampicin 10mg/kg
Max-600mg
Bactericidal Hepatic
dysfunction,
Orange
discolouration
urine,febrile
reaction
avoid- ocp
Monitor liver
enzymes
Pyrizinamide 20-25mg/kg
Max-2gm
Bactericidal Hepatitis,huper
uricaemia,GI
upset,arthralgia
LFT,
Active against
intracellular
dividing forms
Ethambutol 15-20mg/kg
Max-2.5gm
Bacteriostatic Visual
disturbances,op
tic neuritis,loss
of visual activity
Ophthalmosco
pic prior to
therapy
Itermittentdose shedule
 Treatment should be supervised by DOTS provider
 RNTCP &DOTS-
 Isoniazid-15mg/kg-3 times a week for 6 mnths
 Pyrazinamide-30mg/kg-3 times a week for first 2 mnths
only
 Ethambutol-30mg/kg-3 times a week-2mnths only
 Rifampicin-600mg-3 times a week for 6mnths
 Drugs in resistent cases-
 Capreomycin-15-30mg/kg
 Kanamycin-15-30mg/kg
 Ethionamide-15-30mg/kg
 Para-aminosalicylic acid-150mg/kg
 cycloserine-15-20mg
SURGERY
INDICATIONS-
 Unresponsiveness of active disease in spite of adequate
anti-tubercular tx
 Tubercular pyosalphinx
 Ovarian abscess
 Pyometra
 Persistent menorrhagiachr pelvic pain causing
deteriorating health status
CI-
 presence of active tb in extragenital region
 favourable respose with dec in mass size
 Accidental discovery of tubercular tubo ovarian mass on
laprotomy in young pt.-abdomen is closed after taking
tissue for biopsy
Precautions-
 Anti-tb tx shold be started at least 6wks prior to sx
 Continued 6wks after sx
Types of surgery-
 TAH+BSO –rare today
 Hypertrophied vulva-vulvectomy
 Removal of adnexal mass in young woman
 Drainage of pyometra
 Fistula repair
 Tuboplasty-CI
 Any sx on tube will reactivate diseaSe
 Fertility cannot be restored when tubal walls are
damaged
PROGNOSIS
 90%-cured
 only 10%-fertiliy restored
 Of these who conceived 50% -tubal preg
 20-30%-abort
 Only 2%-live births
 INVITRO FERTILIZATION-
 Sucessfully tx r offered .
 40%-success- provided endometrium normal
VULVAL TUBERCULOSIS
 Painful,tender ulcer
 Confirmation-biopsy
 Medical rx-same
 Unresponsive-vulvectomy
CERVICAL TUBERCULOSIS
 Mucopurulent discharge,post coital bleed
 p/s-ulcerated /hypertrophic growth which bleed on touch
 Cervical cytology-
 Multinucleated gaint cells,epitheloid cells,dyskaryotic cells
 ATT
 Unresponsive-hystrectomy

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Tuberculosis of genital tract

  • 2. INCIDENCE  0.75-1%  5% in all female pelvic infections  Occurs in 10% cases of pulmonary tuberculosis  Mostly effects-reproductive age group
  • 3. INC TREND….  Inc in population with overall rise in tuberculosis cases  HIV infection with inc incidence of pulmonary and extrapulmonary forms of tuberculosis including drug resistant forms.
  • 4. SOURCE  Sec to focus elsewhere in body  Direct innoculation over vulva,vagina during sexual intercourse with a partner suffering from tuberculous lesions of genitilia
  • 5. MODE OF SPREAD  Blood stream  7%-bovine org  1-2%-ascends through the genital tract
  • 6. OBSTETRIC HISTORY  Only about 10% have children  Rest r infertile
  • 7. BACTERIOLOGY  human tubercle bacilli  Bovine organisms account for only a small no of cases
  • 9. FALLOPIAN TUBE  Tuberculous endosalphingitis  Tuberculous exosalphingitis  Interstitial tubercular salphingitis
  • 10. Tuberculous endosalphingitis  Tube- thickened, enlarged, tortuous  5%- fimbrial end is pouting, everted, open  Periodic spill of tubal exudate - frequent exacerbations  After HSG –with oil contrast –in the wall of flare up  Caseation in wall of tube, collection of cheesy material –  pyosalphinx  Dense adhesions
  • 11.  Contents-sterile  But liable to recurrent attacks by pyogenic organisms wrong diag -subacute,recurrent PID  Sometimes endosalphinx - hyperplastic oedematous pattern- ectopic preg  Mucosa- granulomatous lesion with chr inflam infiltration  Caseation –late stage
  • 12. TUBERCULOUS EXOSALPHINGITIS  Direct extension from adjacent organs  Peritoneal surface –miliary tubercules  Ampullary portion-dilated  Fimbrial end-open,pouting  TOBACCO – POUCH APP  FROZEN PELVIS  Trauma,Fistula-attempt to separate adhesions
  • 13. INTERSTITIAL TUBERCULOUS SALPHINGITIS  TUBE –thickened  Only on HPE- confirmed
  • 14.  Diagnosis-  Histopathology- caseation, gaint cells, clusters of epithelial cells ,lymphocytic infiltration  Early- several sections need to be studied before tubercles detected  Late- typical gaint cells  DD-  oil granuloma after HSG  Catgut reaction in case of prev sx foreign body reac  Sarcoidosis  Fungus infection
  • 15. OVARY  Appear normal  30%-tubercles on surface, adhesions with tube
  • 16. uterus  70%  Uterus appear normal, end-gaint cells  Advanced cases- caseating material collects in uterine cavity- pyometra  Common- postmenopausal  Ashermanns syndrome- hypo,amenorrhoea  Abscess in myometrium- rare
  • 17. cervix  Descending type  Rarely-ascending type  App- ulcer/red papillary erosion bleed on touch
  • 18. Vulva & vagina  Ulcer-shallow,undermined edges  Heals with scar formation at one end,spreads slowly to other organs  Painful ulcers
  • 20. INFERTILITY  Often the only symp-35-60%  In half- h/o tb in past/contact  Due to blocked tubes  Poor quality of ova may be responsible
  • 21. Menstrual disorders  40%-menorrhagia  10%-amenorrhoea-sec  Young women-twenties-sec amenorrhoea, pelvic ex- adnexal swelling-suspect  PMB  Ashermanns- amenorrhoea
  • 22.
  • 23. pain  25-40% chr pelvic pain  Severe pain- uncommon(sec infec)  Sec infec- pain,nausea,vomitings,fever
  • 24. Vaginal discharge  Blood stained discharge  Post coital bleeding  Leucorrhoea
  • 25. Abdominal mass  Usually mass is immobile  A doughy feel –tb peritonitis FISTULA FORMATION-  Following sx for abscess
  • 26. CLINICAL SIGNS  General cond- good mostly  Tb peritonitis- abd doughy  Tb encysyed cyst- immobile,sometimes tender -tymphanic on percussion  Pelvic adnexal mass- small,fixed -frozen pelvis
  • 27. HSG in asymptomatic-  Lead pipe app  Beading & variation in filling density  Calcification of tube  Cornual block  Jagged fluffiness of tubal outline  Vascular and lymphatic invasion of dye  Tobacco-pouch and dilated distal end of tubes due to hydro/pyosalphinx  In proven case CI-spred the infection
  • 28.  PID fail to respond, recurrent infec without polymorphonuclear leucocytosis  Healed extragenital lesion suff from infertility, menstrual disorders,pelvic mass –suspect  Cx ulcer- mimic ca
  • 29. INVESTIGATIONS  Aim-  To identify prim lesion  Confirm genital lesion
  • 30.  Blood- wbc,ESR raised….  -periodic examination is of value  Montoux test-  positive test-sensitised by tuberculoprotein  negative excludes tb  Chestxray-healed/active pulmonary infection
  • 31.  Diagnostic uterine curretage-  Done-week preceeding menstruation  Tubercles likely to come to the surface  Material sent in two portions-  1)formol saline-HPE to detect gaint cell system  Histology-detect tubercles in 10%  FP-chr lesions(talk/catgut granuloma),sarcoidosis  FN-improper timing of uterine curretage/less incidence of uterine infection
  • 32.  2)normal saline-  Culture in L-J medium  Identification of AFB by ziel-neelsens stain  Nucleic acid amplification  Guinea pig inoculation  A positive culture-suggestive  A positive innoculation test-diagnostic  Bacteriologic test-if positive-type the bcilli,report their drug sensitivity
  • 33.  Nucleic acid amplification(16S ribosomal DNA)-  PCR-identify in endometrium,menstual blood  Sensitivity-85-90%  Detect- 10 org in clinical specimens compared to 10,000 for smea positivity  Genital tb- always paucibacillary
  • 34. First day menstrual discharge  Collected by pipette  Subjected to nucleic acid amplification, culture, guinea pig innoculation  Positive-tb  Negetive-not rule out tb
  • 35.  Sputum,urine- culture for tb  Lymohnode biopsy- neck in lymphadenitis  Biopsy- lesion in cx,vagina,vulva
  • 36.  HSG-  Proved case-CI –reactivation of lesion  Routine work up in investigation of infertility may reveal –  b/l tubal block  Coiling of tubes/calcified shadow of places  Tubal diverticula/fluffiness of tubal outline  Uterine cavity- irreg outline. honeycomb app/uterine synaechiae
  • 37.
  • 38.
  • 39.
  • 40.
  • 41.
  • 42.  Imaging-  usg-abd,pelvis,CT/MRI helpful when there is mass/ascites  Doesnot confirm the diagnosis Laproscopy  -absence of endometrial evidence  Identify tubercles on peritoneal surgace  Nodular app of tubes  Biopsy from tubercles can be taken  Aspiration of fluid-culture  Accidentally discovered during diag lap for infertility
  • 43. DIAGNOSIS  The physician should Be conscious of entity  Suspect and exclude genital tb in – 1. Unexplained infertility/amenorrhoea 2. Recurr episodes of pelvic infections,not responding with usual course of antibiotics 3. Presence of pelvic mass with nodules in the POD
  • 44. DD Pelvic mass-  pyogenic tubo-ovarian mass  Pelvic endometriosis  Adherent ovarian cyst  Chr disturbed ectopic pregnancy
  • 47. general  Pulmonary tb perse –no need of admission  Except in acute exacerbations  Imp body resistence  Regular diet  Correct anaemia  until infectn is controlled, husband should use condom during intercourse- prevent urogenital tb
  • 48. chemotherapy  INTIAL PHASE-  4 drugs are used for 2 mnths-  red bacterial population  prevent emergence of drug-resistence  Drugs-  Isoniazid  Ehambutol  Rifampicin  Pyrazinamide  Ethambutol-prev treated/immunocompromised
  • 49.  Continuation phase-  Treatment is continued for a period of further 4mnths with isoniazid,rifampicin  About a yr of treatment,diagnostic endometrial curretage is to be done….  Positive- treatment contd..  Negetive- endometrium is examined at interval of six mnths…
  • 50. patient must be considered cured –  At least 2 reports including histological and bacteriological examination becomes negetive  Majority of pts respond well to chemotherapy
  • 51.  Multidrug resistent tb-  Infection with myc tb that is resistant to 2 or more agentsincluding isoniazid  HIV negative patients who r MDR have high mortality rate  Such patients treated with-5 drug regimens(CDC)
  • 52. DRUG Daily oral dose Nature Toxicity Comments Isoniazid 5mg/kg Max-300mg Bactericidal Hepatitis,perip heral neuropathy Check LFT, Combine pyridoxine 50mg daily Rifampicin 10mg/kg Max-600mg Bactericidal Hepatic dysfunction, Orange discolouration urine,febrile reaction avoid- ocp Monitor liver enzymes Pyrizinamide 20-25mg/kg Max-2gm Bactericidal Hepatitis,huper uricaemia,GI upset,arthralgia LFT, Active against intracellular dividing forms Ethambutol 15-20mg/kg Max-2.5gm Bacteriostatic Visual disturbances,op tic neuritis,loss of visual activity Ophthalmosco pic prior to therapy
  • 53. Itermittentdose shedule  Treatment should be supervised by DOTS provider  RNTCP &DOTS-  Isoniazid-15mg/kg-3 times a week for 6 mnths  Pyrazinamide-30mg/kg-3 times a week for first 2 mnths only  Ethambutol-30mg/kg-3 times a week-2mnths only  Rifampicin-600mg-3 times a week for 6mnths
  • 54.  Drugs in resistent cases-  Capreomycin-15-30mg/kg  Kanamycin-15-30mg/kg  Ethionamide-15-30mg/kg  Para-aminosalicylic acid-150mg/kg  cycloserine-15-20mg
  • 55. SURGERY INDICATIONS-  Unresponsiveness of active disease in spite of adequate anti-tubercular tx  Tubercular pyosalphinx  Ovarian abscess  Pyometra  Persistent menorrhagiachr pelvic pain causing deteriorating health status
  • 56. CI-  presence of active tb in extragenital region  favourable respose with dec in mass size  Accidental discovery of tubercular tubo ovarian mass on laprotomy in young pt.-abdomen is closed after taking tissue for biopsy
  • 57. Precautions-  Anti-tb tx shold be started at least 6wks prior to sx  Continued 6wks after sx
  • 58. Types of surgery-  TAH+BSO –rare today  Hypertrophied vulva-vulvectomy  Removal of adnexal mass in young woman  Drainage of pyometra  Fistula repair  Tuboplasty-CI  Any sx on tube will reactivate diseaSe  Fertility cannot be restored when tubal walls are damaged
  • 59. PROGNOSIS  90%-cured  only 10%-fertiliy restored  Of these who conceived 50% -tubal preg  20-30%-abort  Only 2%-live births  INVITRO FERTILIZATION-  Sucessfully tx r offered .  40%-success- provided endometrium normal
  • 60. VULVAL TUBERCULOSIS  Painful,tender ulcer  Confirmation-biopsy  Medical rx-same  Unresponsive-vulvectomy
  • 61. CERVICAL TUBERCULOSIS  Mucopurulent discharge,post coital bleed  p/s-ulcerated /hypertrophic growth which bleed on touch  Cervical cytology-  Multinucleated gaint cells,epitheloid cells,dyskaryotic cells  ATT  Unresponsive-hystrectomy