Over 600,000 Americans are diagnosed with deep vein thrombosis (DVT) annually, with 300,000 developing post-thrombotic syndrome and 120,000 experiencing recurrent venous thromboembolism. While anticoagulation is the gold standard for treating DVT, it does not resolve clots or rapidly relieve symptoms and does not prevent post-thrombotic syndrome. Pharmacomechanical thrombectomy using the Trellis catheter isolates clots for localized thrombolysis, reducing bleeding risks compared to systemic thrombolysis. Studies show the Trellis technique achieved over 80% clot lysis in under 90 minutes with no bleeding complications and 100% patency after 1 month.