One of the key aims of the document is to enable general practice and primary care services to play a stronger role at the heart of an integrated community-based health system. This will mean patients having access to a broader range of services from primary care within their own homes and communities, with general practice taking on a more central coordinating role and delivering comprehensive care in collaboration with other services. For patients with long-term conditions, the goal is to ensure they can access all the necessary support and care from primary care services. The document discusses how the Primary Care Commissioning CIC can help clinical commissioning groups and practices develop new models of general practice through programs that facilitate discussions, share expertise, and provide project support.
Realising the Value Stakeholder Event - Workshop:Let's think in terms of beha...Nesta
Workshop B - Let's think in terms of behaviour: What changes do we want to see?
Participants will be shown how the Behavioural Insights Team approach projects in terms of targeting specific behaviours to change. Participants will then work together to do just this for the Realising the Value programme, thinking about what changes they would like to see amongst people, patients and practitioners. This will help form outcome measures for the RtV programme and will give participants a new way of thinking about making tangible change happen in their own organisations.
Realising the Value Stakeholder Event -Workshop: How does the system support Nesta
Workshop D - How does the system support communities/individuals and how could it do it better?
The levers and drivers that national bodies put in place and how these are used locally have a significant impact on working in partnership with communities and patients. These levers and drivers include regulation, targets, outcomes measures, financial flows, annual contracting cycles, clinical standards, workforce training and revalidation etc.
This workshop will draw upon your experience and evidence to address two questions:
How these levers and drivers get in the way of working in partnership with patients and communities?
What is the best blend of approaches to support commissioners and providers locally to harness the energy of patients and communities
Integrating Family Planning and Ongoing Environment Activities in Lake Victor...JSI
APHA International Health Poster Session - Climate Change and Health
Population, Health, Environment (PHE) programs are built on the principle that there is value added in providing integrated services in fragile eco-systems. Typically, PHE projects address several technical areas (health, environment, livelihoods, and family planning [FP]) and integrate staff, operation costs, training and monitoring. While excellent short-term gains are possible, long-term sustainability once donor funding ends is problematic. The Lake Victoria Basin in East Africa is particularly fragile, suffering from over-population, over-fishing, poor land utilization and acute poverty. There are many community-based organizations (CBOs), and healthy (though inconsistent) amounts of donor funding, with many focused on one technical area. The Advancing Partners & Communities (APC) Project, funded by USAID, tested a new integration model through a grant to Kenya’s Nyanza Reproductive Health Society. The model was designed to identify CBOs already undertaking environmental or youth efforts who were interested in adding on community-based FP. APC provided in-kind inputs: training and other minor support, without separate project staff and office infrastructure. Results were mixed. Finding interested groups was difficult because community organizations were used to full service funding. Of the four organizations which volunteered, three were successful in bringing FP to rural areas where previously unavailable, resulting in over 5,500 new FP users collectively. One organization successfully linked FP using agricultural analogies (the benefits of seedling spacing as well as birth spacing). The project can be deemed a qualified success. More support was needed than anticipated, and time and resource constraints forced the project to end before ultimate proof of concept. One key lesson learned is the need to link early to government sources of contraceptives to ensure an ongoing supply. However, given sustainability concerns and duplication of donor effort, the project clearly points to advantages of exploring new models which do not add staff or infrastructure.
Realising the Value Stakeholder Event - Workshop:Let's think in terms of beha...Nesta
Workshop B - Let's think in terms of behaviour: What changes do we want to see?
Participants will be shown how the Behavioural Insights Team approach projects in terms of targeting specific behaviours to change. Participants will then work together to do just this for the Realising the Value programme, thinking about what changes they would like to see amongst people, patients and practitioners. This will help form outcome measures for the RtV programme and will give participants a new way of thinking about making tangible change happen in their own organisations.
Realising the Value Stakeholder Event -Workshop: How does the system support Nesta
Workshop D - How does the system support communities/individuals and how could it do it better?
The levers and drivers that national bodies put in place and how these are used locally have a significant impact on working in partnership with communities and patients. These levers and drivers include regulation, targets, outcomes measures, financial flows, annual contracting cycles, clinical standards, workforce training and revalidation etc.
This workshop will draw upon your experience and evidence to address two questions:
How these levers and drivers get in the way of working in partnership with patients and communities?
What is the best blend of approaches to support commissioners and providers locally to harness the energy of patients and communities
Integrating Family Planning and Ongoing Environment Activities in Lake Victor...JSI
APHA International Health Poster Session - Climate Change and Health
Population, Health, Environment (PHE) programs are built on the principle that there is value added in providing integrated services in fragile eco-systems. Typically, PHE projects address several technical areas (health, environment, livelihoods, and family planning [FP]) and integrate staff, operation costs, training and monitoring. While excellent short-term gains are possible, long-term sustainability once donor funding ends is problematic. The Lake Victoria Basin in East Africa is particularly fragile, suffering from over-population, over-fishing, poor land utilization and acute poverty. There are many community-based organizations (CBOs), and healthy (though inconsistent) amounts of donor funding, with many focused on one technical area. The Advancing Partners & Communities (APC) Project, funded by USAID, tested a new integration model through a grant to Kenya’s Nyanza Reproductive Health Society. The model was designed to identify CBOs already undertaking environmental or youth efforts who were interested in adding on community-based FP. APC provided in-kind inputs: training and other minor support, without separate project staff and office infrastructure. Results were mixed. Finding interested groups was difficult because community organizations were used to full service funding. Of the four organizations which volunteered, three were successful in bringing FP to rural areas where previously unavailable, resulting in over 5,500 new FP users collectively. One organization successfully linked FP using agricultural analogies (the benefits of seedling spacing as well as birth spacing). The project can be deemed a qualified success. More support was needed than anticipated, and time and resource constraints forced the project to end before ultimate proof of concept. One key lesson learned is the need to link early to government sources of contraceptives to ensure an ongoing supply. However, given sustainability concerns and duplication of donor effort, the project clearly points to advantages of exploring new models which do not add staff or infrastructure.
This webinar follows on from the RiPfA Family Group Conferencing with Adults workshop (London, June 2017). The webinar content will be drawn from the workshop and is intended as a recap for those who attended, or as an overview for those who did not attend but would like to find out more about this subject. We strongly encourage you to book a training room to screen the webinar and use it as a space to discuss how you might develop a similar service in your area.
The webinar will:
Provide a brief introduction to the origins, principles and processes of FGCs with adults.
Provide an overview of FGCs within the context of legislative frameworks which support adult social care (eg, the Care Act 2014; Making Safeguarding Personal 2010).
Provide an overview of the research/evidence base on the effectiveness of adult FGCs.
Share practice ideas for setting up an FGC service, or for further developing an FGC service which has already begun*.
Share ideas for developing a simple framework to measure the effectiveness of adult FGCs in your organisation*.
*These ideas will support the development of a RiPfA resource looking at evaluating the impact of a family group conference service with adults (to be published in October 2017).
Aimed at: All those involved in adult family group conferences, including senior leaders, managers and coordinators who already run or are looking to set up a family group conference service for adults.
Empowering and enabling charities to become trusted partners in the commissio...CharityComms
Charlie Peel, Neurological Commissioning Support
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
What your organisation needs to know about personal health budgets, communica...CharityComms
Jaimee Lewis, Think Local, Act Personal
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
Are We There Yet Outcomes Framework Debra MooreDebra Moore
Presentation given to the National Clinical Leads and Modern Matrons Annual Conference (Mental Health and Learning Disability) outlining the Confirm & Challenge (6C\'s) Model and Outcomes Framework
The view from the frontline - achieving success and improving patient/public ...CharityComms
Jane Harris - associate director of communications, Rethink
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
A Nova Scotia based province wide research study on the role of career service workers in supporting clients with mental health issues/illnesses. Funded by CERIC and sponsored by Nova Scotia Career Development Association this research is the ground work for creating a guide to improve employment outcomes, address stigmatizing beliefs and discriminatory policies.
John Isitt, Resonant Media
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
Supporting staff who are carers - meeting the 5YFV for the nhs, pop up uni, 1...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
Ending homelessness through employment and housing requires a focused effort aimed at building linkages with the mainstream workforce system, using innovative, proven strategies and advocating for the necessary resources and supports. Homeless jobseekers with barriers to employment are disadvantaged in the best of times. In the current economy, agencies need better tools and skilled practice. In this pre-conference session, we will help participants make use of new the Community Employment Pathway guidebook provided by the Department of Housing and Urban Development (HUD) to create training and job opportunities, explore how hopeFound has combined a Housing First, work first program using motivational interviewing as a cornerstone practice. Speakers also addressed the need for local and national advocacy for financial resources, employment encouraging policies, and access to mainstream services.
The slides from the ELFT QI open morning on 23 December 2015 - suitable for those wanting to learn more about the approach to quality improvement at East London NHS Foundation Trust
This webinar follows on from the RiPfA Family Group Conferencing with Adults workshop (London, June 2017). The webinar content will be drawn from the workshop and is intended as a recap for those who attended, or as an overview for those who did not attend but would like to find out more about this subject. We strongly encourage you to book a training room to screen the webinar and use it as a space to discuss how you might develop a similar service in your area.
The webinar will:
Provide a brief introduction to the origins, principles and processes of FGCs with adults.
Provide an overview of FGCs within the context of legislative frameworks which support adult social care (eg, the Care Act 2014; Making Safeguarding Personal 2010).
Provide an overview of the research/evidence base on the effectiveness of adult FGCs.
Share practice ideas for setting up an FGC service, or for further developing an FGC service which has already begun*.
Share ideas for developing a simple framework to measure the effectiveness of adult FGCs in your organisation*.
*These ideas will support the development of a RiPfA resource looking at evaluating the impact of a family group conference service with adults (to be published in October 2017).
Aimed at: All those involved in adult family group conferences, including senior leaders, managers and coordinators who already run or are looking to set up a family group conference service for adults.
Empowering and enabling charities to become trusted partners in the commissio...CharityComms
Charlie Peel, Neurological Commissioning Support
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
What your organisation needs to know about personal health budgets, communica...CharityComms
Jaimee Lewis, Think Local, Act Personal
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
Are We There Yet Outcomes Framework Debra MooreDebra Moore
Presentation given to the National Clinical Leads and Modern Matrons Annual Conference (Mental Health and Learning Disability) outlining the Confirm & Challenge (6C\'s) Model and Outcomes Framework
The view from the frontline - achieving success and improving patient/public ...CharityComms
Jane Harris - associate director of communications, Rethink
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
A Nova Scotia based province wide research study on the role of career service workers in supporting clients with mental health issues/illnesses. Funded by CERIC and sponsored by Nova Scotia Career Development Association this research is the ground work for creating a guide to improve employment outcomes, address stigmatizing beliefs and discriminatory policies.
John Isitt, Resonant Media
Changing the game: positioning your charity to succeed in the new health service market conference
www.charitycomms.org.uk/events
Supporting staff who are carers - meeting the 5YFV for the nhs, pop up uni, 1...NHS England
Expo is the most significant annual health and social care event in the calendar, uniting more NHS and care leaders, commissioners, clinicians, voluntary sector partners, innovators and media than any other health and care event.
Expo 15 returned to Manchester and was hosted once again by NHS England. Around 5000 people a day from health and care, the voluntary sector, local government, and industry joined together at Manchester Central Convention Centre for two packed days of speakers, workshops, exhibitions and professional development.
This year, Expo was more relevant and engaging than ever before, happening within the first 100 days of the new Government, and almost 12 months after the publication of the NHS Five Year Forward View. It was also a great opportunity to check on and learn from the progress of Greater Manchester as the area prepares to take over a £6 billion devolved health and social care budget, pledging to integrate hospital, community, primary and social care and vastly improve health and well-being.
More information is available online: www.expo.nhs.uk
Ending homelessness through employment and housing requires a focused effort aimed at building linkages with the mainstream workforce system, using innovative, proven strategies and advocating for the necessary resources and supports. Homeless jobseekers with barriers to employment are disadvantaged in the best of times. In the current economy, agencies need better tools and skilled practice. In this pre-conference session, we will help participants make use of new the Community Employment Pathway guidebook provided by the Department of Housing and Urban Development (HUD) to create training and job opportunities, explore how hopeFound has combined a Housing First, work first program using motivational interviewing as a cornerstone practice. Speakers also addressed the need for local and national advocacy for financial resources, employment encouraging policies, and access to mainstream services.
The slides from the ELFT QI open morning on 23 December 2015 - suitable for those wanting to learn more about the approach to quality improvement at East London NHS Foundation Trust
These slides are from a presentation at the Think Local Act Personal conference on 26th November 2014. The slides and short film provide an introduction to the Coalition for Collaborative Care and its vision for a better deal for people with long-term conditions.
A brief overview of the support aavailable in the General Practice Forward to help practices implement changes that will release time for care. Presenation to Lincolnshire LMC 25/05/17
Gary Kent of NewKey and Jacqui Hendra of Devon County Council describe how the use of Individual Service Funds has promoted trust, flexibility and a focus on outcomes in health and social care.
This presenation is a case study of how Hertfordshire is building a multi-agency commissioning approach to sport and physical activity. It looks at how we have used advice, support and funding from CLOA (www.cloa.org.uk) and Sport England, and work across a range of agencies, to build our approach. The presentation is developed for the East of England Local Government Association and CLOA joint seminar on 5th December. A range of documents and strategies and tools sit behind it.
The Care Act 2014 introduces new responsibilities for councils in relation to prevention, the provision of information and advice and the promotion of well being, as well as giving new rights to carers, introducing a care spending cap for self-funders and a minimum eligibility threshold for care and support.
Impact and celebration event - implementing the city-wide Mental Health Frame...NHS Improving Quality
Jenny Thornton from Leeds Mental Health Framework discusses implementing the city-wide Mental Health Framework. Slides from the impact and celebration event held in Leeds on 3 March 2015.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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3. General practice – the hub of care
Integrated community
based health and
social care
Integrated community
based healthcare
Integrated
general practice
4. Transforming primary care
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practice
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primary care
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commissioning
Practices
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CCGs
Area teams
The first important aspect about the potential for collaboration is how practices can work together to provide more effective of efficient services. What areas could they do better by working together? Are there admin and support services that would be better provided together? Can they develop policies and procedures together?Are there any aspects of contract management and claims that would be more efficient?Are there any services that may be provided together to improve patient access and free up resources in practices?What can general practice do together to look at more efficient and effective ways of providing services? Can practices share their existing work load in more effective ways to continue to provide services for patients?
The first important aspect about the potential for collaboration is how practices can work together to provide more effective of efficient services. What areas could they do better by working together? Are there admin and support services that would be better provided together? Can they develop policies and procedures together?Are there any aspects of contract management and claims that would be more efficient?Are there any services that may be provided together to improve patient access and free up resources in practices?What can general practice do together to look at more efficient and effective ways of providing services? Can practices share their existing work load in more effective ways to continue to provide services for patients?