This document discusses using neuroscience techniques like eye tracking and fMRI to study information science constructs. It outlines two current projects - one using eye tracking to model reading patterns and measure cognitive effort during information searching, and another using fMRI and eye tracking to study neural correlates of information relevance judgments. The eye tracking project analyzes fixation patterns to infer mental states and predicts how measures like reading speed and regressions relate to task characteristics. The fMRI study aims to identify different brain regions activated during relevant vs. non-relevant information searches and low-level word matching. Preliminary analysis of one participant shows differences in activation for an information search vs. word search task.