The document evaluates the automatic exposure control (AEC) systems from four major CT scanner manufacturers in terms of their ability to reduce radiation dose while maintaining image quality. By scanning an anthropomorphic chest phantom with and without AEC activated on 16- and 64-slice CT scanners, the authors found that:
1) Tube current modulation dynamics were similar between GE and Toshiba systems and between Philips and Siemens systems.
2) Radiation dose was reduced by 35-60% with AEC activated, but image noise generally increased, especially in low-dose regions like the lungs.
3) Image noise became more uniform along the scanning direction with AEC activated compared to a fixed tube current.
Implementation of an audit and dose reduction program for ct matyaginLeishman Associates
This document summarizes an audit and dose reduction program implemented for CT scans. It found that CT radiation exposure has increased significantly in recent decades and now accounts for a large percentage of medical radiation exposure. By modifying scan protocols and settings to optimize dose while maintaining image quality, they were able to reduce CT radiation doses at their hospital below international reference levels for most common CT exams. Areas like brain perfusion CT still require further dose optimization. Recording detailed dose information in imaging records was also implemented.
Features of new installed linac Trilogy At Dr Ziauddin Hospital KarachiRahim Gohar
This document provides an overview of the features and capabilities of a new Trilogy linear accelerator installed at Dr. Ziauddin Hospital's radiation oncology department. It describes the linac's engineering, its ability to perform treatments using 3D-CRT, IMRT, VMAT, electrons, and SRS. It also discusses the linac's imaging modalities for treatment planning and verification. Key treatment techniques like IMRT, VMAT, and IGRT are summarized in terms of how they are planned and delivered using the linac and its integrated treatment planning system.
Image Guided Radiation Therapy (IGRT) uses imaging technologies to reduce uncertainties in radiation therapy delivery and improve targeting accuracy. IGRT involves acquiring images of the treatment area to capture position and guide corrections. Technologies include 2D kV/MV imaging, 2.5D tomotherapy, and 3D kV-CBCT and MVCT. Future directions include 4D imaging during treatment and combined MR-Linac systems. The clinic plans to implement IGRT starting with basic 2D/3D CBCT capabilities and work towards standardized protocols, automated corrections, and quality assurance programs.
This document discusses the radiation exposure risks associated with computed tomography (CT) scans. It notes that while no large epidemiological studies of cancer risks from CT scans have been reported, studies of atomic bomb survivors receiving similar radiation doses to organ doses from CT scans have shown a small increased risk of cancer. The document estimates that 0.4-2.0% of cancers in the US may be attributable to radiation from CT scans. It also notes that the risks are greater for children than adults. The document concludes that the cancer risks associated with CT scans are based on real data from atomic bomb survivors and not just models or extrapolations.
This document discusses the use of pre-treatment imaging protocols for motion estimation in radiation therapy. It describes how advances in radiation therapy techniques have increased risks due to precision, and how accuracy can be achieved through reliable patient immobilization, treatment planning correlation, and pre-treatment quality assurance using daily imaging protocols. Daily imaging allows for tighter treatment margins and accounts for tumor and anatomical changes during treatment. The document then reviews different tumor motion issues and protocols based on anatomical sites, as well as imaging modalities and techniques used to better define targets and enable image-guided radiation therapy.
Robust breathing signal extraction from cone beam CT projections based on ada...Wookjin Choi
This document summarizes a research paper that proposes a novel method for extracting breathing signals from cone beam CT projections without using external markers. The method uses an adaptive filtering technique to enhance weak oscillating structures in the Amsterdam Shroud image generated from the projections. A two-step optimization approach is then used to reveal the large-scale regularity of the breathing signals. Evaluation on 5 patient data sets found the new algorithm outperformed existing methods by extracting less noisy signals with errors of only -0.07±1.58 breaths per minute compared to reference signals. While results are promising, the study had a small data set and image quality remains limited.
This document discusses the use of electronic portal imaging (EPI) to verify patient positioning accuracy during external beam radiation therapy. It analyzes EPI data from 57 esophageal cancer patients treated over two years. The mean displacement between planned and actual patient positions was 2.05mm left-right, 2.79mm superior-inferior, and 3.09mm anterior-posterior. These values are below the 5mm tolerance limit, indicating EPI provides sufficient targeting accuracy. Regular EPI allows correction of setup errors and helps ensure the tumor receives the planned radiation dose while minimizing risks to healthy tissues.
Implementation of an audit and dose reduction program for ct matyaginLeishman Associates
This document summarizes an audit and dose reduction program implemented for CT scans. It found that CT radiation exposure has increased significantly in recent decades and now accounts for a large percentage of medical radiation exposure. By modifying scan protocols and settings to optimize dose while maintaining image quality, they were able to reduce CT radiation doses at their hospital below international reference levels for most common CT exams. Areas like brain perfusion CT still require further dose optimization. Recording detailed dose information in imaging records was also implemented.
Features of new installed linac Trilogy At Dr Ziauddin Hospital KarachiRahim Gohar
This document provides an overview of the features and capabilities of a new Trilogy linear accelerator installed at Dr. Ziauddin Hospital's radiation oncology department. It describes the linac's engineering, its ability to perform treatments using 3D-CRT, IMRT, VMAT, electrons, and SRS. It also discusses the linac's imaging modalities for treatment planning and verification. Key treatment techniques like IMRT, VMAT, and IGRT are summarized in terms of how they are planned and delivered using the linac and its integrated treatment planning system.
Image Guided Radiation Therapy (IGRT) uses imaging technologies to reduce uncertainties in radiation therapy delivery and improve targeting accuracy. IGRT involves acquiring images of the treatment area to capture position and guide corrections. Technologies include 2D kV/MV imaging, 2.5D tomotherapy, and 3D kV-CBCT and MVCT. Future directions include 4D imaging during treatment and combined MR-Linac systems. The clinic plans to implement IGRT starting with basic 2D/3D CBCT capabilities and work towards standardized protocols, automated corrections, and quality assurance programs.
This document discusses the radiation exposure risks associated with computed tomography (CT) scans. It notes that while no large epidemiological studies of cancer risks from CT scans have been reported, studies of atomic bomb survivors receiving similar radiation doses to organ doses from CT scans have shown a small increased risk of cancer. The document estimates that 0.4-2.0% of cancers in the US may be attributable to radiation from CT scans. It also notes that the risks are greater for children than adults. The document concludes that the cancer risks associated with CT scans are based on real data from atomic bomb survivors and not just models or extrapolations.
This document discusses the use of pre-treatment imaging protocols for motion estimation in radiation therapy. It describes how advances in radiation therapy techniques have increased risks due to precision, and how accuracy can be achieved through reliable patient immobilization, treatment planning correlation, and pre-treatment quality assurance using daily imaging protocols. Daily imaging allows for tighter treatment margins and accounts for tumor and anatomical changes during treatment. The document then reviews different tumor motion issues and protocols based on anatomical sites, as well as imaging modalities and techniques used to better define targets and enable image-guided radiation therapy.
Robust breathing signal extraction from cone beam CT projections based on ada...Wookjin Choi
This document summarizes a research paper that proposes a novel method for extracting breathing signals from cone beam CT projections without using external markers. The method uses an adaptive filtering technique to enhance weak oscillating structures in the Amsterdam Shroud image generated from the projections. A two-step optimization approach is then used to reveal the large-scale regularity of the breathing signals. Evaluation on 5 patient data sets found the new algorithm outperformed existing methods by extracting less noisy signals with errors of only -0.07±1.58 breaths per minute compared to reference signals. While results are promising, the study had a small data set and image quality remains limited.
This document discusses the use of electronic portal imaging (EPI) to verify patient positioning accuracy during external beam radiation therapy. It analyzes EPI data from 57 esophageal cancer patients treated over two years. The mean displacement between planned and actual patient positions was 2.05mm left-right, 2.79mm superior-inferior, and 3.09mm anterior-posterior. These values are below the 5mm tolerance limit, indicating EPI provides sufficient targeting accuracy. Regular EPI allows correction of setup errors and helps ensure the tumor receives the planned radiation dose while minimizing risks to healthy tissues.
This document provides information about dose reduction techniques in CT scanning. It discusses how CT scan technology has advanced but also leads to higher radiation doses compared to other modalities. Various techniques can help reduce dose like adjusting acquisition parameters such as tube current, voltage, and scan length. Equipment designs with features like iterative reconstruction and dual-layer detectors can also help lower dose. Selecting the appropriate scan protocol tailored to the clinical task is important to optimize image quality while keeping radiation exposure as low as reasonably achievable.
Patient positional correction stategies in radiotherapyBiplab Sarkar
This document discusses strategies for correcting positional errors in radiation therapy. It begins by defining setup error and gross error. Non-image based correction strategies are then described, including using skin marks, lasers, and table indices to identify gross errors. Image-based corrections are also discussed, including online strategies that correct errors before treatment and offline strategies that correct after multiple fractions to reduce systematic errors. The document covers various protocols for offline corrections including no-action level, expanding action level, and shrinking action level approaches. Finally, the document discusses rotational errors and challenges incorporating them into current margins and planning systems.
This document discusses the clinical implementation of volumetric modulated arc therapy (VMAT) at UT M.D. Anderson Cancer Center. It provides an overview of VMAT, the advantages it offers over other radiation therapy techniques, and the steps taken to configure the accelerator, treatment planning system, and quality assurance processes for VMAT delivery. Key aspects covered include accelerator prerequisites, TPS commissioning, patient-specific quality assurance using films and ion chambers, monthly constancy checks, and tips for rapid arc treatment planning for prostate cases.
IGRT is a radiation therapy process that uses imaging to ensure accurate patient positioning and alignment. Frequent imaging during treatment, such as with CBCT, allows corrections to be made for set-up errors and organ motion. This improves the precision of radiation delivery to the target volume while reducing doses to healthy tissues, leading to better treatment outcomes and fewer side effects.
This document discusses the capabilities of dual energy CT, including direct angiography and bone removal with plaque highlighting. Dual energy CT can directly visualize arteries and branching vessels by removing bone based on differentiating iodine and bone through spectral analysis. This allows dual energy CT to be used for angiographic applications as a minimally invasive alternative to digital subtraction angiography. Examples given include carotid and aortic angiography to assess conditions like aneurysms. Dual energy CT also enables characterization of plaques and assessment of endoleaks after endovascular procedures.
This document provides an overview of Intensity Modulated Radiotherapy (IMRT). It discusses the shift from conventional to conformal radiotherapy using improved imaging and planning techniques. IMRT allows customization of radiation dose distributions through non-uniform beam intensities achieved using dynamic multileaf collimators or compensators. The clinical implementation of IMRT requires treatment planning and delivery systems. IMRT offers advantages over conventional radiotherapy for many cancer types and its use has increased substantially in recent decades.
This document discusses image-guided radiation therapy (IGRT) and its evolution and applications. It begins by defining IGRT as external beam radiation therapy using imaging prior to each treatment fraction to verify patient positioning. IGRT allows for reduction of safety margins by compensating for set-up errors and organ motion. The document then reviews the history of IGRT from early portal imaging to modern cone-beam CT and other volumetric imaging techniques. It provides examples of IGRT protocols and clinical outcomes for sites such as prostate, lung, liver, and central nervous system tumors.
Dual energy imaging and digital tomosynthesis: Innovative X-ray based imaging...Carestream
Dual-energy (DE) imaging and digital tomosynthesis (DT) have been around for a few decades, but recent advancements in digital detectors have made this technology increasingly promising in clinical use. For more information about Carestream's imaging portfolio, visit www.carestream.com/medical or http://www.carestream.com/blog/2016/03/15/dual-energy-imaging-and-digital-tomosynthesis/
This document summarizes the work completed during a medical physics rotation focused on imaging for treatment planning and verification. Key tasks included:
- Performing quality assurance tests on the electronic portal imaging device (EPID) including measurements of image uniformity, signal-to-noise ratio, and modulation transfer function at varying imaging parameters.
- Analyzing contrast-to-noise ratio, signal-to-noise ratio, and dose dependence using phantoms imaged with the EPID.
- Validating calculations of the EPID's modulation transfer function.
- Ensuring proper alignment of the EPID with the radiation isocenter using reticule alignment tests at different gantry angles.
- Observing clinical treatments for sites
Basic information about Elekta and its familiar with xvi and Iviewgt protocols and there import and defining the Target area clip box registration along with HEXAPOD 6Dof couch & Apex Dmlc setup
VMAT (Volumetric Modulated Arc Therapy) was first proposed in 1995 as a form of rotational IMRT. It involves delivering radiation therapy with the linear accelerator gantry rotating continuously around the patient. Intensity modulation is achieved through continuous movement of the MLC leaves as they shape the beam during rotation. VMAT can produce dose distributions similar to IMRT but with fewer monitor units and faster treatment times. Recent advances in treatment planning and linear accelerator control systems now allow for effective clinical implementation of VMAT with either single or multiple full arcs.
Intensity Modulated Radiation Therapy (IMRT) is an advanced mode of high-precision radiotherapy that uses computer-controlled linear accelerators to deliver precise radiation doses to a malignant tumor or specific areas within the tumor by reducing radiation dose to the nearby normal tissues.
This document discusses preliminary dosimetric analysis of target motion effects in 4D tomotherapy and outlines several challenges and potential solutions:
1) Contouring targets across multiple respiratory phases is time-consuming; research consoles can help by propagating contours and creating average images.
2) Planning and dose computation across phases is complex; multiple plans must be evaluated to assess potential underdosing.
3) Initial QA using dynamic phantoms shows dose shifts near targets, underscoring the need for 4D evaluations and potentially larger margins.
4) Further investigations of 4D imaging, planning, dose computation and adaptive techniques are needed to fully account for respiratory motion effects in tomotherapy.
The Role of Computers in Medical PhysicsVictor Ekpo
The document discusses the various roles of computers in medical physics. It describes how computers are used for tasks like data conversion, database management, image display, processing and analysis. Computers aid in areas such as radiodiagnosis, radiotherapy treatment planning, dosimetry and various medical imaging modalities. They provide benefits like speed, automation, accuracy and ability to store and share large amounts of data. Overall, the integration of computers has greatly enhanced the field of medical physics.
The document discusses the use of Tomotherapy for radiation treatment planning and delivery. It provides examples of how Tomotherapy allows for:
1) Highly conformal radiation plans that sculpt dose around complex tumor target shapes while minimizing dose to nearby organs.
2) Daily image guidance that enables adjustment of targets to account for changes in patient anatomy and tumor size during treatment.
3) Delivery of simultaneous integrated boosts to multiple tumor sites.
This document discusses various techniques for arc therapy including tomotherapy, intensity modulated arc therapy (IMAT), and volumetric modulated arc therapy (VMAT). It provides details on:
- The history and basic concept of arc therapy which involves continuous radiation delivery from a rotating source.
- Techniques like tomotherapy which uses fan beams and helical delivery, and IMAT/VMAT which modulates dose rate and leaf speed during single or multiple full gantry rotations.
- The planning process for these techniques including inverse planning with direct aperture optimization to determine optimal leaf positions and weights to achieve conformal dose distributions while satisfying delivery constraints.
This document discusses the importance of treatment verification in radiotherapy and outlines the process. It notes that even small errors can have negative consequences so treatment verification is essential to ensure the right dose is delivered to the right area. The key aspects of treatment verification are machine setup, monitor units, patient positioning and imaging by comparing images to references. Errors can be systematic from planning or random from daily variations; various methods are described to reduce errors and ensure treatments are accurately delivered.
This document discusses various modern radiation therapy techniques including IMRT, IGRT, MVCBCT, and KVCBCT. It provides background on 2D and 3D conformal radiation therapy. IMRT uses intensity modulated beams and inverse planning to improve dose distribution. IGRT uses imaging before and during treatment for precise targeting. MVCBCT and KVCBCT provide volumetric imaging using megavoltage and kilovoltage sources, with KVCBCT offering better soft tissue contrast. Errors in patient positioning can be detected and corrected using these image-guided techniques.
This study investigated generating improved 3D treatment plans for telecoabalt machines without MLC by using locally available materials like universal shielding blocks. The study aimed to see if plans similar to IMRT could be created on telecoabalt to help poor patients who cannot afford linear accelerator treatment but need advanced techniques. Two case studies are presented where improved 3D plans were created for telecoabalt that provided dose coverage and sparing of normal tissues comparable to IMRT plans. The conclusion is that 3DCRT/IMRT type plans are feasible on telecoabalt with careful planning using field-in-field techniques and custom shielding blocks.
This document provides information about dose reduction techniques in CT scanning. It discusses how CT scan technology has advanced but also leads to higher radiation doses compared to other modalities. Various techniques can help reduce dose like adjusting acquisition parameters such as tube current, voltage, and scan length. Equipment designs with features like iterative reconstruction and dual-layer detectors can also help lower dose. Selecting the appropriate scan protocol tailored to the clinical task is important to optimize image quality while keeping radiation exposure as low as reasonably achievable.
Patient positional correction stategies in radiotherapyBiplab Sarkar
This document discusses strategies for correcting positional errors in radiation therapy. It begins by defining setup error and gross error. Non-image based correction strategies are then described, including using skin marks, lasers, and table indices to identify gross errors. Image-based corrections are also discussed, including online strategies that correct errors before treatment and offline strategies that correct after multiple fractions to reduce systematic errors. The document covers various protocols for offline corrections including no-action level, expanding action level, and shrinking action level approaches. Finally, the document discusses rotational errors and challenges incorporating them into current margins and planning systems.
This document discusses the clinical implementation of volumetric modulated arc therapy (VMAT) at UT M.D. Anderson Cancer Center. It provides an overview of VMAT, the advantages it offers over other radiation therapy techniques, and the steps taken to configure the accelerator, treatment planning system, and quality assurance processes for VMAT delivery. Key aspects covered include accelerator prerequisites, TPS commissioning, patient-specific quality assurance using films and ion chambers, monthly constancy checks, and tips for rapid arc treatment planning for prostate cases.
IGRT is a radiation therapy process that uses imaging to ensure accurate patient positioning and alignment. Frequent imaging during treatment, such as with CBCT, allows corrections to be made for set-up errors and organ motion. This improves the precision of radiation delivery to the target volume while reducing doses to healthy tissues, leading to better treatment outcomes and fewer side effects.
This document discusses the capabilities of dual energy CT, including direct angiography and bone removal with plaque highlighting. Dual energy CT can directly visualize arteries and branching vessels by removing bone based on differentiating iodine and bone through spectral analysis. This allows dual energy CT to be used for angiographic applications as a minimally invasive alternative to digital subtraction angiography. Examples given include carotid and aortic angiography to assess conditions like aneurysms. Dual energy CT also enables characterization of plaques and assessment of endoleaks after endovascular procedures.
This document provides an overview of Intensity Modulated Radiotherapy (IMRT). It discusses the shift from conventional to conformal radiotherapy using improved imaging and planning techniques. IMRT allows customization of radiation dose distributions through non-uniform beam intensities achieved using dynamic multileaf collimators or compensators. The clinical implementation of IMRT requires treatment planning and delivery systems. IMRT offers advantages over conventional radiotherapy for many cancer types and its use has increased substantially in recent decades.
This document discusses image-guided radiation therapy (IGRT) and its evolution and applications. It begins by defining IGRT as external beam radiation therapy using imaging prior to each treatment fraction to verify patient positioning. IGRT allows for reduction of safety margins by compensating for set-up errors and organ motion. The document then reviews the history of IGRT from early portal imaging to modern cone-beam CT and other volumetric imaging techniques. It provides examples of IGRT protocols and clinical outcomes for sites such as prostate, lung, liver, and central nervous system tumors.
Dual energy imaging and digital tomosynthesis: Innovative X-ray based imaging...Carestream
Dual-energy (DE) imaging and digital tomosynthesis (DT) have been around for a few decades, but recent advancements in digital detectors have made this technology increasingly promising in clinical use. For more information about Carestream's imaging portfolio, visit www.carestream.com/medical or http://www.carestream.com/blog/2016/03/15/dual-energy-imaging-and-digital-tomosynthesis/
This document summarizes the work completed during a medical physics rotation focused on imaging for treatment planning and verification. Key tasks included:
- Performing quality assurance tests on the electronic portal imaging device (EPID) including measurements of image uniformity, signal-to-noise ratio, and modulation transfer function at varying imaging parameters.
- Analyzing contrast-to-noise ratio, signal-to-noise ratio, and dose dependence using phantoms imaged with the EPID.
- Validating calculations of the EPID's modulation transfer function.
- Ensuring proper alignment of the EPID with the radiation isocenter using reticule alignment tests at different gantry angles.
- Observing clinical treatments for sites
Basic information about Elekta and its familiar with xvi and Iviewgt protocols and there import and defining the Target area clip box registration along with HEXAPOD 6Dof couch & Apex Dmlc setup
VMAT (Volumetric Modulated Arc Therapy) was first proposed in 1995 as a form of rotational IMRT. It involves delivering radiation therapy with the linear accelerator gantry rotating continuously around the patient. Intensity modulation is achieved through continuous movement of the MLC leaves as they shape the beam during rotation. VMAT can produce dose distributions similar to IMRT but with fewer monitor units and faster treatment times. Recent advances in treatment planning and linear accelerator control systems now allow for effective clinical implementation of VMAT with either single or multiple full arcs.
Intensity Modulated Radiation Therapy (IMRT) is an advanced mode of high-precision radiotherapy that uses computer-controlled linear accelerators to deliver precise radiation doses to a malignant tumor or specific areas within the tumor by reducing radiation dose to the nearby normal tissues.
This document discusses preliminary dosimetric analysis of target motion effects in 4D tomotherapy and outlines several challenges and potential solutions:
1) Contouring targets across multiple respiratory phases is time-consuming; research consoles can help by propagating contours and creating average images.
2) Planning and dose computation across phases is complex; multiple plans must be evaluated to assess potential underdosing.
3) Initial QA using dynamic phantoms shows dose shifts near targets, underscoring the need for 4D evaluations and potentially larger margins.
4) Further investigations of 4D imaging, planning, dose computation and adaptive techniques are needed to fully account for respiratory motion effects in tomotherapy.
The Role of Computers in Medical PhysicsVictor Ekpo
The document discusses the various roles of computers in medical physics. It describes how computers are used for tasks like data conversion, database management, image display, processing and analysis. Computers aid in areas such as radiodiagnosis, radiotherapy treatment planning, dosimetry and various medical imaging modalities. They provide benefits like speed, automation, accuracy and ability to store and share large amounts of data. Overall, the integration of computers has greatly enhanced the field of medical physics.
The document discusses the use of Tomotherapy for radiation treatment planning and delivery. It provides examples of how Tomotherapy allows for:
1) Highly conformal radiation plans that sculpt dose around complex tumor target shapes while minimizing dose to nearby organs.
2) Daily image guidance that enables adjustment of targets to account for changes in patient anatomy and tumor size during treatment.
3) Delivery of simultaneous integrated boosts to multiple tumor sites.
This document discusses various techniques for arc therapy including tomotherapy, intensity modulated arc therapy (IMAT), and volumetric modulated arc therapy (VMAT). It provides details on:
- The history and basic concept of arc therapy which involves continuous radiation delivery from a rotating source.
- Techniques like tomotherapy which uses fan beams and helical delivery, and IMAT/VMAT which modulates dose rate and leaf speed during single or multiple full gantry rotations.
- The planning process for these techniques including inverse planning with direct aperture optimization to determine optimal leaf positions and weights to achieve conformal dose distributions while satisfying delivery constraints.
This document discusses the importance of treatment verification in radiotherapy and outlines the process. It notes that even small errors can have negative consequences so treatment verification is essential to ensure the right dose is delivered to the right area. The key aspects of treatment verification are machine setup, monitor units, patient positioning and imaging by comparing images to references. Errors can be systematic from planning or random from daily variations; various methods are described to reduce errors and ensure treatments are accurately delivered.
This document discusses various modern radiation therapy techniques including IMRT, IGRT, MVCBCT, and KVCBCT. It provides background on 2D and 3D conformal radiation therapy. IMRT uses intensity modulated beams and inverse planning to improve dose distribution. IGRT uses imaging before and during treatment for precise targeting. MVCBCT and KVCBCT provide volumetric imaging using megavoltage and kilovoltage sources, with KVCBCT offering better soft tissue contrast. Errors in patient positioning can be detected and corrected using these image-guided techniques.
This study investigated generating improved 3D treatment plans for telecoabalt machines without MLC by using locally available materials like universal shielding blocks. The study aimed to see if plans similar to IMRT could be created on telecoabalt to help poor patients who cannot afford linear accelerator treatment but need advanced techniques. Two case studies are presented where improved 3D plans were created for telecoabalt that provided dose coverage and sparing of normal tissues comparable to IMRT plans. The conclusion is that 3DCRT/IMRT type plans are feasible on telecoabalt with careful planning using field-in-field techniques and custom shielding blocks.
Dr. Tao Peng is the CEO and founder of Breadtrip, a travel destination information and products company. He has a Ph.D from Melbourne University and previously worked at McKinsey and founded a startup in Australia. Breadtrip launched in 2012 and has grown to 1.5 million registered users who share photos and stories from 180 countries. The name Breadtrip comes from the fairy tale of Hansel and Gretel using breadcrumbs to find their way home.
This document provides information about search engine marketing (SEM). It defines SEM as using internet marketing to promote websites and increase visibility on search engine results pages. The goal is to increase revenues while lowering costs. This is done by building brand awareness and offerings. The document discusses types of search engines and their market shares. It also covers search engine optimization (SEO), local SEO, pay-per-click (PPC) advertising, and evaluating search results. Additional topics include content marketing, integrating SEO with social media and public relations, and optimizing for different devices like desktop, mobile, and tablets.
书友会期期精彩不断,热门话题信手拈来,让人获益匪浅。云里雾里之后,让我们拨开这片云雾,本期不如看看背后的故事-讲述互联网背后的UED。
User Experience Design,简称UED。UED是进行产品策划的主力之一,他们用自己的知识、经验、设计能力拿出设计方案。ED不只是互联网专家,还是行业专家。能够用自己的互联网知识来设计出行业专家想实现的操作,而付诸以商业营销。
The document provides an overview of the NGSP Group's research at Swinburne University of Technology, including three key areas:
1) Data management in cloud computing focusing on storage, placement, and replication strategies.
2) Performance management of scientific workflows, addressing temporal quality of service, constraints, monitoring, and violation handling.
3) Security and privacy protection in the cloud, particularly developing noise obfuscation techniques to protect indirect private information during normal cloud service processes.
The Melukat ceremony is a purification ritual performed by Balinese Hindus to cleanse energies. It takes place over 2-4 weeks, involving offerings to priests and dressing in traditional clothes. On the day of the ritual, a High Priest uses dry rice, flowers, and holy water along with incantations to cleanse participants. The expected results include good luck, energy, awareness of spirits, and spiritual dreams, though the author notes experiencing rice in unwanted places.
The document is a collection of images and captions from various Flickr users advocating for social and political change in Spain. Some key themes represented are criticism of austerity measures, calls for unity and collective action, and encouragement for continued protest. The captions suggest rallying people to keep fighting for their goals and standing up against policies they disagree with.
This document discusses various techniques for optimizing radiation dose in thoracic computed tomography (CT) scans. It begins with an introduction to the growth of CT technology and increasing use of CT exams. It then covers conventional techniques like using indication-specific protocols, limiting scan passes and length, optimizing patient positioning, and adjusting tube current, potential, and rotation time. Contemporary techniques discussed include iterative reconstruction, high pitch scanning, automatic tube potential selection, and organ-based dose modulation. The document emphasizes that chest CT is important but doses should be optimized to get necessary information while keeping radiation exposure as low as reasonably possible.
This document discusses two techniques for detecting breast cancer using bioimpedance:
1. A mobile electrical impedance tomography IC that can detect breast cancer in 3D through non-invasive surface impedance measurements. It has high sensitivity and can detect tumors as small as 5mm.
2. A fiber optic bioimpedance spectroscopy system that combines fiber optic and bioimpedance methods to differentiate between normal, low metastatic, and high metastatic breast cell types through statistical analysis of their optical and impedance spectral signatures. It shows potential for non-invasive cancer progression monitoring.
The document summarizes new technologies in the CARESTREAM Touch Prime Ultrasound System, including SynTek Architecture and Smart System Control (SSC). SynTek Architecture uses parallel beamforming and GPU processing for improved image quality and frame rates compared to conventional serial approaches. SSC automatically optimizes over 25 imaging parameters in real-time for optimized images with minimal user interaction. The system also features Smart Flow imaging which visualizes blood flow in all directions independent of angle. Smart Flow Assist further automates Doppler measurements for improved workflow efficiency. Overall, the advanced technologies combined with an intuitive interface provide enhanced ultrasound imaging performance and automation.
The document summarizes new technologies in the CARESTREAM Touch Prime Ultrasound System, including SynTek Architecture and Smart System Control (SSC). SynTek Architecture uses parallel beamforming and GPU processing for improved image quality and frame rates compared to conventional serial line-by-line acquisition. SSC automatically optimizes over 25 imaging parameters in real-time for optimal images with limited user interaction. The system also features Smart Flow imaging for angle-independent Doppler without steering needs, and Smart Flow Assist for automated spectral Doppler measurements. These technologies aim to improve imaging performance, workflow efficiency, and diagnostic confidence.
Parsons and Robar, Volume of interest CBCT and tube current modulation for i...David Parsons
This document describes a study investigating volume of interest (VOI) cone-beam CT (CBCT) using a dynamic blade collimation system and tube current modulation. The system uses a four blade dynamic collimator that can track an arbitrary VOI defined in treatment planning. Measurements showed VOI CBCT improved contrast-to-noise ratio by a factor of 2.2 compared to full-field CBCT for the same dose. Dose was reduced to 15-80% within the central axis plane and less than 1% out of plane compared to full-field CBCT. Incorporating tube current modulation further increased contrast-to-noise ratio by 1.2, providing a total improvement of 2.6
ThompsonEtal2013.pdfAccurate localization of incidental fi.docxherthalearmont
ThompsonEtal2013.pdf
Accurate localization of incidental findings on the computed
tomography attenuation correction image: the influence
of tube current variation
John Thompsona,c, Peter Hogga, Samantha Highamb and David Manninga,d
This observer performance study assessed lesion
detection in the computed tomography attenuation
correction image, as would be produced for myocardial
perfusion imaging over a tube current (mA) range. A static
anthropomorphic chest phantom containing simulated
pulmonary lesions was scanned using the four available
mA values (1, 1.5, 2 and 2.5) on a GE Infinia Hawkeye 4.
All other computed tomography acquisition parameters
remained constant throughout. Twenty-seven cases
showing zero to four lesions were produced for a
free-response receiver-operating characteristic method.
Image observations were completed using our novel
web-based ROCView software under controlled conditions.
The Jackknife alternative free-response receiver-operating
characteristic (JAFROC) figure of merit was used for
significance testing, wherein a difference in lesion
detection performance was considered significant
at P values less than 0.05. Twenty readers with varying
computed tomography experience (0–24 years) evaluated
108 images using an ordinal scale to score confidence.
The JAFROC analysis showed that there was no
statistically significant difference in performance between
mA values (P = 0.439) for this sample of observers.
In conclusion, no significant difference in lesion detection
performance was seen between the mA values. This
suggests that there is no value in using anything other
than the lowest mA value for the investigation of incidental
extracardiac findings. Nucl Med Commun 34:180–184 �c
2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Nuclear Medicine Communications 2013, 34:180–184
Keywords: computed tomography acquisition parameters,
dose optimization, free-response receiver-operating characteristic,
tube current
aUniversity of Salford, bPennine Acute Hospitals NHS Trust, Greater
Manchester, cUniversity Hospitals of Morecambe Bay NHS Foundation Trust,
Barrow-in-Furness and dLancaster University, Lancaster, UK
Correspondence to John Thompson, BSc (Hons), MSc, Nuclear Medicine
Department, Furness General Hospital, Dalton Lane, Barrow-in-Furness,
Cumbria LA14 4LF, UK
Tel: + 44 1229 870870 x54388; fax: + 44 1229 491036;
e-mail: [email protected]
Received 31 July 2012 Revised 28 September 2012
Accepted 29 October 2012
Introduction
Computed tomography (CT) has improved the sensitivity
and specificity of many nuclear medicine techniques
through the provision of additional anatomic information or
by providing a high-quality attenuation correction (AC)
map [1,2]. The use of AC is strongly recommended in some
patients undergoing certain procedures, most notably in
those undergoing myocardial perfusion imaging [3,4]. Within
this patient group there is also potential for the discove ...
1) CT dose index (CTDI) measures radiation output of CT scanners. Modern measures include CTDI100, CTDIvol, and dose length product (DLP).
2) Automatic exposure control (AEC) modulates tube current based on patient attenuation to maintain consistent image quality while reducing dose.
3) Dose reduction techniques in CT include AEC, bowtie filters, iterative reconstruction, prospective gating, and dynamic collimation.
This document discusses cone-beam computed tomography (CBCT) and its applications in dental practice. CBCT provides sub-millimeter resolution images of the maxillofacial skeleton in a fraction of the time and radiation dose of conventional CT. It allows reconstruction of 3D volumetric data into multiplanar reformatted images. Specific applications discussed include implant planning, pathology assessment, temporomandibular joint imaging, and orthodontics. Advanced display modes like curved planar reformation and volume rendering provide familiar views useful for clinical evaluation and measurement.
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2. M. Söderberg & M. Gunnarsson626
Acta Radiol 2010 (6)
is properly optimized, it can reduce the radiation dose
to the patient by about 20–40% while still producing an
image of sufficient quality for confident diagnosis (8).
AEC systems have a number of benefits: better control
of the dose absorbed by the patient, improved consis-
tency of image quality among patients, reduction of
certain image artifacts, and reduced load on the X-ray
tube, which increases its lifetime (9). Several reports
have demonstrated the efficacy of AEC systems by
using homogeneous phantoms and performing clinical
work (9–17). However, few studies have investigated
3D AEC systems in terms of dose versus image quality
using anthropomorphic phantoms (18–21).
The purpose of this study was to evaluate the poten-
tial for reducing radiation exposure to the patient
while maintaining adequate image quality using the
AEC systems from four different CT manufacturers:
GE Healthcare (Milwaukee, Wisc., USA), Philips
Medical Systems (Best, The Netherlands), Siemens
Medical Solutions (Erlangen, Germany), and
Toshiba Medical Systems (Tokyo, Japan).
Material and Methods
AEC is a technique that performs automatic modulation
of the tube current in the x-y plane (angular modula-
tion), along the scanning direction (z-axis; longitudinal
modulation), or both (combined modulation; Table 1)
(22–24). The modulation is performed according to the
patient’s size and shape, and the attenuation of the body
parts being scanned. The operator selects an indicator
of the image quality that is required and then the system
adjusts the tube current to obtain the predetermined
image quality with improved radiation efficiency.
AEC systems
The combined tube current modulation system from
GE is AutomA 3D (9, 25, 26), which consists of
two parts: AutomA provides longitudinal AEC and
SmartmA provides angular AEC. The two parts can
be used separately or in concert. The image quality
is specified in terms of a selected noise index (NI),
defined as the standard deviation (SD) of pixel values
in the central region of an image of a uniform water
phantom. Based on each patient’s attenuation values
measured on the scan projection radiograph (SPR), the
tube current is adjusted to preserve the same level of
noise in each image. The system allows the operator to
define the range within which the tube current can be
modulated by selecting minimum and maximum mA
limits.
The Philips AEC system, DoseRight, has three parts:
Automatic Current Selection (ACS), which provides
patient-based AEC; D-DOM, which provides angular
AEC; and Z-DOM, which provides longitudinal AEC
(9, 25, 27). Currently, it is not possible to use all three
tube current modulation tools together; instead, ACS
can be applied with Z-DOM or with D-DOM. To set the
required image quality level, the Philips system uses
a reference image concept. The operator chooses a
protocol-specific mAs value and, based on each patient’s
attenuation information from the SPR, the mAs is auto-
matically adjusted to achieve approximately the same
noise level as in a predefined reference patient (start
value: 33 cm in diameter).
The Siemens system uses a combined tube current
modulation system called CARE Dose 4D (9, 25, 28).
The system works with automatic tube current modu-
lation according to the patient’s size and attenuation
changes together with real-time, online, controlled
tube current modulation during each tube rotation.
The image quality is defined by the operator-selected
image quality reference mAs value and the adapta-
tion strengths (weak, average or strong). From the SPR
the algorithm determines whether the patient sections
are slim or obese relative to an internally stored X-ray
attenuation of a standard sized patient. Based on the
preselected adaptation strengths the extent of change in
tube current (image quality and radiation dose) can be
controlled. The tube current will be weak, average or
strong decreased for slim sections and weak, average
or strong increased for obese sections. By default the
adaptation strengths are set by the manufacturer to
average decrease for slim and average increase for
obese sections.
Table 1. Automatic exposure control (AEC) techniques available in the modern CT systems
Parameter
AEC modulation
Angular Longitudinal Combined
Principle The tube current is adjusted during
each gantry rotation, according to
the size, shape, and attenuation of
body region being scanned
The tube current is adjusted along the scanning
direction of the patient, according to the size and
attenuation of the anatomic region being scanned
and the predetermined image quality
The tube current is adjusted both
during each gantry rotation and for
each slice position
Direction x, y z x, y, z
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Toshiba uses a combined system called Sure
Exposure 3D (9, 25, 29). The image quality is speci-
fied in terms of selected SD of CT numbers measured
in a patient-equivalent water phantom. Attenuation
information from the SPR of each patient is used
to map the selected image quality to tube current
values. The system makes use of the frontal and lat-
eral patient diameter and the detector intensities to
account for the oscillating tube current modulation
during each gantry rotation. The system allows the
operator to define the range within which the tube
current can be modulated by selecting minimum and
maximum mA limits.
Phantom
An anthropomorphic chest phantom (Chest Phantom
PBU-X-21, Kyoto Kagaku Co. Ltd, Kyoto, Japan) was
used (Fig. 1). The phantom is based on a skeleton of
a 160 cm tall male and consists of epoxy resins, ure-
thane, calcium hydroxyapatite, and other substances to
achieve variations in contrast in the phantom images
similar to those from a human body.
During CT acquisitions, the phantom was centered
as in a routine clinical CT examination, that is, supine
position with the sagittal midline and mid-thickness of
the phantom at the isocenter of the gantry. The scan-
ning direction was chosen according to the recommen-
dations of the individual system manufacturers.
Testing approach
Measurements were performed using 16- and 64-slice
CT scanners from each manufacturer (Table 2).
Because the method for adjusting the tube current dif-
fers among the individual systems, it was not practical
to use a common standard protocol for all systems.
Furthermore, for a given manufacturer, the system
operation differed depending on whether a 16- or
64-slice scanner was used; therefore, an individual
protocol was created for each examination by modi-
fying an existing standard clinical thorax protocol for
each CT scanner.As many scanning parameters as pos-
sible were set equal for all examinations (Tables 2 and
3). The SPR view was as regularly performed on the
respective CT scanner (Table 2). Image quality param-
eters used for the various AEC systems were typical
for a routine adult thorax CT protocol (Table 4). All
tests were performed in helical scan mode with a com-
bined AEC system activated and inactivated (fixed
mAs), with the exception of the Philips system, which
currently has no combined AEC system. Instead, their
longitudinal AEC system Z-DOM was used together
with ACS, as recommended for a thorax scan by
Philips. The manually selected tube load values (AEC
off) for Philips and Siemens were set as the manufac-
turers recommend (Table 5). These two AEC systems
also use the mAs value (AEC off) as an indicator of the
image quality when the AEC system is activated. GE
and Toshiba AEC systems do not use an mAs value as
an input for the tube current modulation. The selected
tube load values (AEC off) for GE and Toshiba were
instead selected with the purpose to be clinically rel-
evant for a thorax CT protocol (Table 5).
Fig. 1. The anthropomorphic chest phantom (Chest Phantom PBU-X-
21, Kyoto Kagaku Co. Ltd, Kyoto, Japan).
Table 2. Individual scanning parameters for thorax protocol and used scan projection radiograph (SPR) views
Manufacturer Model Collimation (mm) Pitch Kernel SPR
General Electric LightSpeed 16 16 0.625 0.938 Standard Lateral frontal
LightSpeed VCT 64 0.625 0.984 Standard Frontal lateral
Philips Brilliance CT 16 16 0.75 1.063 Standard B Frontal
Brilliance CT 64 Power 64 0.75 1.078 Standard B Frontal
Siemens SOMATOM Sensation 16 16 0.75 1 B31f Frontal
SOMATOM Sensation 64 64 0.6 1 B31f Frontal
Toshiba Aquilion 16 16 0.5 0.938 FC10 Frontal lateral
Aquilion 64 64 0.5 0.828 FC10 Frontal lateral
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Details of the radiation dose were obtained for each
CT scan from the DICOM image information.The dose
reduction (DR) was calculated from the dose length
product (DLP) values using equation 1:
DR
DLP DLP
DLP
.100%AEC off AEC
AEC off
(1)
To characterize the tube current modulation
(dynamic) of each AEC system, the mean mAs value
for each image slice was plotted for the image slices.
This made it possible to study how the tube current
varied along the z-axis of the anthropomorphic chest
phantom.
Image quality evaluation
To evaluate how the AEC systems affected image
quality, the image noise values from scans performed
with the AEC system activated were compared to those
obtained with the AEC system inactivated. Images
from GE, Philips, and Siemens systems were evalu-
ated on a Syngo Multimodality Workplace (Siemens
Medical Solutions, Erlangen, Germany). Since the
Syngo Multimodality Workplace could not read images
fromToshiba these were evaluated using Sante DICOM
Viewer Pro 2.1 (Santesoft, Athens, Greece). All images
were evaluated by the same operator to avoid bias.
Circular regions of interest (ROIs) of 0.5 cm2
were
placed in the spine region of the chest phantom; this
region is uniform and available throughout the phantom
(Fig. 2). The SD of the CT numbers was used as a mea-
sure of the image noise. The SDs for the image slices
are presented graphically.
The mean SD ( ) of the CT numbers in the spine
throughout the chest phantom was calculated, as was
the standard deviation ( ) of the measured SD values.
To evaluate whether the image noise became more uni-
form when the AEC systems were activated as com-
pared to inactivated, the coefficient of variation (Cv
)
was calculated using equation 2:
C = .100%v (2)
Results
Dynamics of tube current modulation
Figs. 3 and 4 illustrate the dynamics of tube current
modulation of eachAEC system in 16- and 64-slice CT,
respectively, and show that the tube current increased
for the shoulder region and decreased through the low
attenuating lung region. Through the denser abdomen,
the mean tube current increased again. The character-
istics and dynamic range of the modulation depend on
the image quality settings, which are unique for each
system. However, as shown in Figs. 3 and 4, the char-
acteristics of the AutomA 3D are similar to those of
the SureExposure 3D and the characteristics of the
ACS Z-DOM are similar to those of CARE Dose
4D. GE and Toshiba AEC systems are both based on a
selected noise reference value and Philips and Siemens
AEC systems are both based on a selected mAs value.
Philips and Siemens AEC systems show greater tube
current increases in the shoulder region relative to the
increases in the abdomen region than do the GE and
ToshibaAEC systems.The SiemensAEC system shows
the greatest range of tube current modulation. The mAs
drops from 100% in the shoulders to 16% (Sensation
16) and 18% (Sensation 64) in the diaphragm.
Table 3. General scanning parameters for thorax protocol
Settings Thorax protocol
Tube voltage (kV) 120
Rotation time (s) 0.5
Slice width (mm) 5
Increment (mm) 5
Filter Standard
FOV (mm) 400
Matrix 512 512
FOV, field of view.
Table 4. Image quality parameters for each manufacturer’s automatic exposure control (AEC) system
Manufacturer AEC system Slice Image quality Various
General Electric AutomA 3D 16 NI 12, Min mA 10, Max mA 200 Plus mode
64 NI 12, Min mA 10, Max mA 200 Plus mode
Philips ACS Z-DOM 16 200 mAs/slice ST: Body
64 200 mAs/slice ST: Body
Siemens CARE Dose 4D 16 Average/Average, Q. Ref. mAs 100
64 Average/Average, Q. Ref. mAs 100
Toshiba SureExposure 3D 16 SD 10, Min mA 10, Max mA 500 QDS
64 SD 10, Min mA 10, Max mA 500 QDS
NI, noise index; ST, scanning type; Q. Ref., quality reference; SD, standard deviation; QDS, quantum denoising system.
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5. Evaluation of automatic exposure control in CT systems 629
Acta Radiol 2010 (6)
Dose reduction
The dose reduction achieved with the AEC system in
use was determined relative to the dose delivered with
the AEC system inactivated. The dose savings ranged
from approximately 35% to 60%, depending on the
system and the AEC settings (Table 5).
Noise measurements
The image noise (SD) measurements from the spine
are shown in Figs. 5 and 6. In each of the different
systems, the image noise increased when the AEC
system was used as compared with when constant
tube load was used (AEC off). This noise increase was
more significant in regions where the tube current was
greatly decreased, such as in the lung region. In addi-
tion, different regions in the chest phantom showed
large variations in noise level when constant tube load
was used. Despite the use of tube current modulation,
the level of image noise varied among the different
anatomic regions. However, because the image quality
requirements differ from organ to organ, organ-specific
variations in noise level do not necessarily limit the
diagnostic utility of an image. In the abdominal region,
it is very important to detect low contrast lesions;
therefore, a lower noise level is desirable.
Figs. 5 and 6 show that the measured SD values
were slightly below the selected noise indices (NIs)
in the GE scanners and the selected SD values in the
Table 5. Mean mAs value for the respective scan, estimated dose reduction (DR), and estimated coefficient of variation (Cv
) for respective
CT scanner
Manufacturer Slice AEC setting Mean mAs DLP (mGycm) DR (%) Mean SD SD Cv
(%)
General Electric 16 AEC off 100 508.3 – 6.07 2.02 33.3
AutomA 3D 64 331.9 34.7 8.44 1.41 16.6
64 AEC off 100 403.8 – 7.59 2.54 33.5
AutomA 3D 54 210.6 47.9 10.22 2.39 23.4
Philips 16 AEC off 200 706.8 – 4.97 1.52 30.6
ACS Z-DOM 81 286.6 59.5 7.39 1.92 25.9
64 AEC off 200 605.1 – 4.93 1.45 29.5
ACS Z-DOM 93 296.7 51.0 6.75 1.69 25.0
Siemens 16 AEC off 100 366 – 6.54 1.82 27.8
CARE Dose 4D 59 205 44.0 8.98 2.31 25.8
64 AEC off 100 358 – 8.05 2.22 27.6
CARE Dose 4D 60 204 43.0 10.50 2.55 24.3
Toshiba 16 AEC off 100 769.3 – 5.23 1.60 30.6
SureExposure 3D 44 333.1 56.7 7.92 1.59 20.1
64 AEC off 100 720.4 – 5.32 1.73 32.6
SureExposure 3D 46 293.8 59.2 7.95 1.72 21.6
AEC, automatic exposure control; DLP, dose length product; SD, standard deviation.
Fig. 2. Cross-sectional views showing ROI placement in the spine region of the chest phantom: (A) slice 10, (B) slice 25, (C) slice 50, (D) slice 75.
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Fig. 3. Mean mAs values along the longitudinal axis of the chest phantom for each manufacturer on their respective 16-slice CT scanner, overlaid on
the scan projection radiograph. Philips and Siemens systems report mAs as mAs/pitch.
Fig. 4. Mean mAs values along the longitudinal axis of the chest phantom for each manufacturer on their respective 64-slice CT scanner, overlaid on
the scan projection radiograph. Philips and Siemens systems report mAs as mAs/pitch.
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7. Evaluation of automatic exposure control in CT systems 631
Acta Radiol 2010 (6)
Toshiba scanners. These differences reflect that the
NI/SD settings are only an indicator of image quality
and adjust the tube current so that the detectors
receive similar X-ray fluence rates, that is, the set-
tings regulate the quantum noise in the projection
data. However, image noise also depends on the
reconstruction kernel, reconstructed slice thickness,
and beam filtration.
Because the ROIs were inserted manually in incom-
pletely homogeneous regions, we evaluated whether
region inhomogeneity affected the results. Intra-observer
variability (repeated noise measurements in the spine)
showed that deviation in SD values was 5%. Due to
the quantum statistics, SD measurements in a uniform
phantom would also have resulted in measurement
variability (30).
Table 5 shows the results of the uniformity test
performed by calculating the coefficients of variation
using equation 2. In all systems, the image noise in
the different anatomic regions of the chest phantom
became more uniform when the AEC system was
activated.
Discussion
A clinical CT examination often covers different ana-
tomic regions with variable attenuation values. Because
the tube current is selected based on the region with
the highest attenuation (e.g. shoulder and pelvis) or
the region that requires the highest image quality, the
tube current is usually set to a high level when an AEC
system is not in use. Furthermore, standard protocols
are usually established to generate images of good
quality for average patient sizes. Therefore, if an AEC
system is not used, smaller patients will be exposed
to unnecessarily high doses of radiation and images
of larger patients may be of worse quality. AEC sys-
tems were developed to enable tube current modulation
according to a patient’s shape, size, and attenuation,
and to improve the consistency of image quality among
patients.
There are a number of benefits to using an AEC
system. One is the potential for dose reduction, which
was verified in this study (Table 5). However, it is dif-
ficult to compare the estimated dose reduction values
obtained in this study with values reported in the litera-
ture. The results are strongly dependent on the selected
scanning parameters, the CT scanner/model, and the
specified image quality for the AEC system. Results
from a study performed by PAPADAKIS et al. (31) showed
a 13.9% dose reduction (only angular modulation) for
the thorax and abdomen regions measured using an
adult anthropomorphic phantom. The results of our
study and those from GUTIERREZ et al. (18), which are
Fig. 5. Measured SD (image noise) in the spine region throughout the chest phantom for the respective manufacturer on their 16-slice CT scanner: (A)
GE, (B) Philips, (C) Siemens, (D) Toshiba, when the AEC system was activated and inactivated.
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Acta Radiol 2010 (6)
valid for an anthropomorphic chest phantom repre-
senting a standard male patient, verify that the com-
bination of angular and longitudinal AEC enables
much greater dose reductions, in the range of 35–60%
(Table 5). The results are also in agreement with those of
MULKENS et al. (16) and Rizzo et al. (13) who studied
patient populations. A recent study by PAPADAKIS et al.
(20) performed with an adult anthropomorphic
phantom found a dose reduction of 45.2% in the thorax
and abdomen region. However, in agreement with our
findings, they reported a significant noise increase and
a significant signal to noise ratio decrease.
The results of our study are valid for a phantom
based on a skeleton of a 160 cm tall male. The full body
weight of this person is not determined, but the torso
represents a typical rather lean Asian male. A potential
weakness of the study is that a significant proportion
of the dose reduction seen could simply be due to the
overall small size of the phantom compared with the
size of a standard Western European patient.
Since the calculated dose reductions are based on the
selected mAs value when the AEC systems were inac-
tivated, it is crucial that these values are representative
for a clinical thorax CT protocol. Consequently, when
considering the calculated dose reductions one must
take into account the DLP values in Table 5. The result
should be interpreted as an indication of potential for
reducing radiation exposure to the patient.
Large variations in the mAs values are evident at
the beginning and the end of some of the scans (Figs.
3 and 4). One possible explanation for this is that the
particular AEC system has a time delay before correct
adaptation of the tube current.
The different AEC systems were designed for dif-
ferent purposes. The makers of the GE and Toshiba sys-
tems claim that their systems were designed to increase
the uniformity of image quality between different ana-
tomic regions in the same patient. These claims were
verified in this study, as shown by the coefficient of
variation estimates (Table 5). For instance, the esti-
mated standard deviation of the measured SD values
increased when SureExposure 3D was activated but the
coefficient of variation was smaller. This means that
there are greater differences in the image noise, but rel-
ative to the mean value, the image noise is more stable
when SureExposure 3D is activated. The estimation
assumes that the measured SD values follow a normal
distribution throughout the chest phantom. We are
aware that this assumption was not completely fulfilled
in this study.The approach for the SiemensAEC system
is that different sized patients require different levels
of noise in order to obtain adequate image quality. The
Fig. 6. Measured SD (image noise) in the spine region throughout the chest phantom for the respective manufacturer on their 64-slice CT scanner: (A)
GE, (B) Philips, (C) Siemens, (D) Toshiba, when the AEC system was activated and inactivated.
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9. Evaluation of automatic exposure control in CT systems 633
Acta Radiol 2010 (6)
user can also control the extent of tube current adjust-
ment for slim and obese patient sections by selecting
weak, average or strong adaptation strengths (21). The
Philips AEC system, ACS, has the same approach as
Siemens; more noise is accepted for obese patients and
less noise is required for small patients (27).
It is difficult to make direct comparisons between
the different systems. Each system has a different solu-
tion for defining the image quality level. The different
scanner models may also differ in the type of X-ray
tube used, software, detector configuration, scanning
geometry, and beam filtration.
There are many studies on AEC systems in which the
AEC performance and image quality were evaluated
using homogeneous phantoms (9–12, 15). Some studies
have also performed clinical evaluations in which radi-
ologists assessed the image quality (13, 14, 16, 17). In
this study, an anthropomorphic phantom was used to
assess the capabilities and limitations of an AEC system
in a clinical situation. The performances of the AEC
systems might have differed if a uniform phantom had
been used. Likewise, performing noise measurements in
a homogeneous phantom is not analogous to noise anal-
ysis in a human body. The Toshiba images were evalu-
ated on a different workstation and to find out whether
this was a source of bias, images from Siemens were
evaluated on both workstations. The results showed no
difference between the evaluations.
It is difficult to determine the optimal image quality
for a clinical diagnosis, since both quantitative mea-
surements and the observer’s perception are involved.
In this study, the quantum noise was used to assess
the image quality. Image noise is the parameter that
is directly influenced by tube current modulation. An
increase in image noise can potentially impair low con-
trast resolution and affect the diagnostic information.
Image noise is affected by differences in phantom posi-
tion and various scanning parameters (4); therefore, the
position of the phantom was held constant and as many
as possible of the scanning parameters were set equal
for each system. Furthermore, the image noise depends
on the reconstruction process, e.g. reconstruction filter.
These parameters differ between the systems, but they
were standardized as much as possible for a routine
thorax examination.
It is essential that radiologists and medical physi-
cists are aware of the performance of their AEC system
and how image quality is affected. It is necessary to
find the acceptable threshold of image quality with the
minimum possible radiation exposure to the patient,
in agreement with the ALARA principle. This study
did not evaluate whether the diagnostic accuracy was
influenced by the AEC-induced increases in image
noise. A clinical subjective image quality analysis
performed by RIZZO et al. (13) showed that the image
noise was significantly higher in examinations per-
formed with combined modulation (CARE Dose 4D)
as compared with a fixed tube current. However, the
study also concluded that the diagnostic utility of the
images was acceptable.
In conclusion, this study established that the use of
AEC systems could significantly reduce the radiation
exposure to the patient. For the anthropomorphic chest
phantom, the magnitude of the dose savings was con-
siderable, ranging from approximately 35% to 60%.
The dynamics of tube current modulation for each of
the AEC systems were similar, especially between GE
and Toshiba and between Philips and Siemens AEC
systems. We also found that use of the AEC systems
increased image noise. However, the variation in image
noise among images obtained along the scanning direc-
tion was lower when using the AEC systems compared
with the scans with fixed mAs.
Acknowledgments
This project was supported by the Swedish Radiation
Safety Authority (SSI P 1579.07).
Declaration of interest: The authors report no conflicts
of interest. The authors alone are responsible for the
content and writing of the paper.
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