Introduction
Historical Perspectives
Creation of tip-edge
Tip –edge concepts
Bonding and setting up
Treatment stages
Stage I
Stage II
Torque in tip-edge
Stage III
Advantages
Disadvantages
Case reports
Articles
Conclusion
References
Space closure by frictionless mechanics 2 /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Friction mechanics /certified fixed orthodontic courses by Indian dental aca...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Intrusion arches /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Space closure by frictionless mechanics 2 /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Friction mechanics /certified fixed orthodontic courses by Indian dental aca...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Intrusion arches /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
Friction less mechanics in orthodontics /certified fixed orthodontic course...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Comparison of The Roth prescription,Alexander prescription & MBT prescription...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
MBT system in orthodontics /certified fixed orthodontic courses by Indian den...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
in Orthodontics, Torque is a vital ingredient in the achievement of optimal esthetics, function and health of teeth and surrounding tissues, as also in stability of the treatment results
Functional & ceph analysis for functional appliance /certified fixed ortho...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Bioprogressive therapy /certified fixed orthodontic courses by Indian dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
lingual appliance in orthodontics.
a recent advancement in orthodontics.
invisible orthodontics.
invisible braces.
invisible braces for adults.
adult orthodontics.
braces for adults.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Tip edge /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in
continuing dental education , training dentists
in all aspects of dentistry and offering a wide
range of dental certified courses in different
formats.
Indian dental academy provides dental crown &
Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit
www.indiandentalacademy.com ,or call
0091-9248678078
Comparison of The Roth prescription,Alexander prescription & MBT prescription...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
MBT system in orthodontics /certified fixed orthodontic courses by Indian den...Indian dental academy
Welcome to Indian Dental Academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy has a unique training program & curriculum that provides students with exceptional clinical skills and enabling them to return to their office with high level confidence and start treating patients
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
in Orthodontics, Torque is a vital ingredient in the achievement of optimal esthetics, function and health of teeth and surrounding tissues, as also in stability of the treatment results
Functional & ceph analysis for functional appliance /certified fixed ortho...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
00919248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Bioprogressive therapy /certified fixed orthodontic courses by Indian dental ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
lingual appliance in orthodontics.
a recent advancement in orthodontics.
invisible orthodontics.
invisible braces.
invisible braces for adults.
adult orthodontics.
braces for adults.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Tip edge /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in
continuing dental education , training dentists
in all aspects of dentistry and offering a wide
range of dental certified courses in different
formats.
Indian dental academy provides dental crown &
Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit
www.indiandentalacademy.com ,or call
0091-9248678078
The Begg light-wire appliance remains unique in the history of orthodontic innovation. Whereas many current self-ligating bracket appliances purport to be low friction or friction free, it is the Begg appliance that best exemplifies low friction, free sliding mechanics.
By creating only a single point of contact between the bracket and the arch-wire Dr Begg was able to greatly decrease resistance to sliding, both by reducing friction between the bracket and the arch-wire and virtually eliminating the binding of the arch-wire in the bracket slot, as is seen in all horizontal slot brackets.
Begg’s bracket design allowed teeth to freely tip mesially and distally as well as lingually and labially. This often gave teeth the appearance of being over tipped during treatment and required considerable diligence by Begg practitioners to keep tooth movement under control.
This freedom of tooth movement allowed unprecedented correction of large overbites and overjets to an edge-to-edge position and rapid closure of extraction spaces by initially tipping the adjacent teeth into the extraction site and uprighting the teeth afterwards.
Individual tooth root correction was managed by the use of fine springs that were designed, and often individually crafted to upright, torque and rotate teeth into their correct positions once the position of tooth crowns had been established.
One key advantage of the appliance set up was the use of light elastic forces for the correction of anterior overbites and overjets. All anchorage could be established intra-orally without headgear, without the need for ancillary appliances such as trans-palatal arches, or needing to set up molar anchorage prior to treatment, as Dr Tweed advocated.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Bracket systems in orthodontics / online fixed orthodontics courses Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Dr. William Roth
Introduction
The Roth Rx
Reasons For Modification
Treatment Philosophy
Treatment Goals
Roth Rationale
Selection Of Treatment Mechanics
Roth Set-up
Sequencing Of Treatment Objectives
Treatment Mechanics
Anchorage Considerations
Detailing Of Tooth Position
Advantages
Comparisons
Conclusions
Introduction
History
Indications and contraindications
Timing of distalization
Second molar extraction
Mandibular molar distalization
Rickett’s criterion
Classification and various distalization appliances
References
Introduction.
Umbrella concept
Principles of Bioprogressive therapy.
Visual treatment objective.
Orthopedics in Bioprogressive therapy.
Forces used in Bioprogressive therapy.
Sectional and utility arches.
Synopsis of extraction and non-extraction treatment mechanics.
Bioprogressive therapy appliances
Conclusion
Introduction
Incidence
Development of canine
Eruption of canine
Etiology of canine impaction
Sequelae of canine impaction
Classification of canine impaction
Diagnosis
Radiographic Prediction
Prognosis
Prevention of maxillary impaction
Extraction of impacted canine
Treatment alternatives
General principles of mechanotherapy
Methods of gaining space
Anchorage considerations
Surgical Methods
Surgical exposure for natural eruption
One step vs two step
Types of flaps
Attachments
Methods of traction
Mandibular canine impaction
Canine impaction and resorption
Canine impaction and periodontium
Retention
Complications of treatment
Complications of untreated impacted canine
Conclusions
References
Airway analysis and its relevance in orthodonticsMiliya Parveen
Introduction
Anatomy
Naso – respiratory function and craniofacial growth
Methods of analysis
Clinical examination
Otorhinolaryngology tests for upper airway
Supplementary examinations
LC
CBCT
Airway and skeletal patterns
Obstructive Sleep Apnoea
Mouth breathing
Effect of orthodontics on airway
Extraction cases
Expansion
Mandibular advancement
Orthognathic surgery
Adenoidectomy or tonsillectomy
Role of orthodontist
Conclusion
Molecular and ultracellular basis of orthodontic tooth movementMiliya Parveen
Contents -
Introduction
Response to normal function
Response to Continuous Pressure
Force for Orthodontic Tooth Movement
Modes of Orthodontic Tooth Movement
Hyalinization
Role of Piezoelectric Current
Theories of orthodontic mechanisms
Phases of tooth movement
Pathways of tooth movement
Signaling molecules and metabolites in orthodontic tooth movement
Role of Cytokines, Growth Factors and Transcription Factors
Role of Prostaglandins
Cellular networking in tooth remodeling
The intracellular second-messenger systems
Role of Vitamin D and diacylglycerol
RANK RANKL/OPG pathway
Sequence of events after force application
Changes in PDL
Changes in Gingiva
Markers For Orthodontic Tooth Movement
Conclusion
Treatment of class 3 malocclusion using MBT bracket prescription/system.
Contents -
Introduction
Accurate Record-taking
Mandibular Prognathism or Maxillary Retrognathism
Timing Of Class III Treatment
Surgical/Non-surgical Decision In Class III Treatment
The Posterior 'Squeezing Out' Effect
Class III Mechanics
Four-stage Treatment Planning Process
Orthognathic treatment of Class III malocclusion
Surgical treatment of Class III malocclusion
Case reports
A quick overview of all components that make up the aesthetic considerations during orthodontic treatment.
Contents -
Introduction
History
Records for studying esthetics
Smile design wheel
Macro-aesthetics
Mini-aesthetics
Deep Overbite correction
Treatment of gummy smiles
Micro-aesthetics
Elements of a balanced smile
Six horizontal lines
Canine to lateral incisor
Premolar to canine
Influence of extractions on smile esthetics
Conclusion
Introduction
Essential Diagnostic Aids
Supplemental Diagnostic Aids
Study Cast Analysis
Dental Arch Width
Pont’s Index
Anterior Dental Arch Length
Korkhaus’ Analysis
Intramaxillary Symmetry
Palatal Height
Analysis Of Supporting Zones
Space Analysis
Nance Analysis
Lundstrom Segmental Analysis
Analysis In The Vertical Plane
Bolton Analysis
Analysis Of The Apical Base
Examination Of Occlusion
Overview of Diagnostic Aids
Case History and Clinical Examination- General examination
Extra-oral examination
Functional examination
Photographic Analysis
Overall description of bone metabolism.
Introduction
Types of bone tissue
Composition of bone
Cells of bone
Regulators of bone metabolism
Calcium and phosphate balance
Calcium and phosphate
Parathyroid hormone
Calcitonin
Vitamin D
Fibroblast growth factor
Growth hormone and IGF-1
Thyroid hormone
Estrogens, progesterone and androgens
Cortisol and related glucocorticoids
Disorders of bone metabolism
Orthodontic considerations
Growth rotations in relation to Orthodontics.
Determining rotational growth changes
Mandibular rotations
Clinical significance of Rotation :
Relationship between Condylar growth and Rotations
Relationship between Dentition and Rotations
Relationship between Chin position and Rotations
Prediction of Rotation
Prediction by the structural method
Reliability of prediction
Maxillary rotations
Maxillary Rotational Patterns:
Cranial base rotations
Interrelationship between rotation of skeletal components
Orthodontics and Rotation
Treatment protocol
Embryology is necessary to understand the growth of various anatomical structures pertinent to orthodontics and will help understand the anomalies associated with its maldevelopment.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
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Hot Selling Organic intermediates
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. CONTENTS:
• Introduction
• Historical Perspectives
• Creation of tip-edge
• Tip –edge concepts
• Bonding and setting up
• Treatment stages
• Stage I
• Stage II
• Torque in tip-edge
• Stage III
• Advantages
• Disadvantages
• Case reports
• Articles
• Conclusion
• References
3. INTRODUCTION:
• The Tip-Edge bracket was invented by Dr.Peter Kesling
to introduce differential tooth movement within an
edgewise based bracket system.
• Tip-Edge technique was first introduced at the Kesling-
Rocke Orthodontic Center, Westville, Indiana, USA, in
1986.
• As its name suggests, Tip-Edge combines an initial
degree of tooth tipping, which greatly facilitates tooth
movement, prior to 'edgewise' precision finishing.
4. HISTORICAL PERSPECTIVES:
• Dr. Edward Angle, the father of fixed appliance orthodontics
created the ‘Edgewise’ Bracket in 1925.
• It provides the neatest way of achieving three-dimensional root
control in its day.
• Angle himself appreciated that tooth movement was facilitated
by allowing a tooth to tip.
¤ Unfortunately, he had no means of subsequent root uprighting.
• His well known non-extraction treatment doctrine was best
suited for his edgewise bracket.
5. • Dr. Raymond Begg evolved a different bracket system that
was a modification of Angle’s earlier ‘ribbon arch’ bracket.
• It was designed to overcome one of the prime disadvantages
inherent in all edgewise systems.
• This is - every tooth is subject to mesio-distal bodily control
from the moment of archwire engagement, thus increasing
resistance to retraction.
• Begg introduced a new sequence of tooth movement -
tipping the crowns into their corrected positions before
uprighting the roots as a later procedure.
¤ Root recovery, sometimes from extreme angles, could be less
than reliable
¤ Molar control and buccal segment torque were denied by the
inability to use rectangular archwires.
6. • The ‘straight-wire’ bracket system, pioneered by
Dr. Lawrence Andrews in the late 1970s.
• By incorporating in–out adjustments and finishing
angulations of tip and torque into the bracket itself,
individualized finishing prescriptions for each tooth became
available.
• Such new technology set higher standards for case finishing,
as defined by Andrews’ six keys to normal occlusion.
• Subsequent alternative prescriptions appeared, notably the
Roth ‘modified edgewise’.
7. • Dr. Peter Kesling, a student of Dr. Raymond Begg,
evolved the design of tip edge bracket system.
• Because of its initial tipping followed by edgewise
finishing functions, he nicknamed the slot as “tip edge”.
• It is officially and more formally known as the “differential
straight arch technique”.
• Initial crown tipping followed by controlled root
uprighting with straight arch wires (differential tooth
movement with straight arch wires).
• It converges the divergent philosophies of Begg and PEA
into one bracket system with no additional use of extra-
oral anchorage.
8. CREATION OF THE TIP-EDGE:
• Kesling modified a single straight-wire bracket to create the Tip-
Edge - the Rx-1 bracket.
• Removed two diagonally opposite corners from the rectangular
archwire slot which allowed the bracket to tip up to 25° either
mesially or distally.
• Each bracket requires an auxiliary in the final stage in order to
deliver root correction and coming of the latest Ni-Ti wires – TE
Plus brackets
• These had a horizontal ‘deep tunnel’ in the bracket base allows
torquing and tipping powered by a light Ni-Ti auxiliary archwire
9. 1. BRACKET FACE -
• Conventional tie-wings for elastomeric ligature.
• Bracket identification - small circular markers on
disto-gingival tie wing for maxillary anteriors &
triangular for mandibular.
• The ‘cut out surfaces’ of the archwire slot form the
‘tip limiting surfaces’ - restrict the degree of
tipping permitted during tooth translation.
• The intact surfaces - the ‘finishing surfaces’, containing the individualized finishing
prescription for each tooth.
• The point at which the tip-limiting and finishing surfaces meet constitutes the central
ridge; the opposing central ridges provide vertical control until final finishing.
• The laterally extended surface lingual to the main archwire preserves rotational control
throughout the range of tip permitted by the bracket.
10. 2. BRACKET SLOT -
• Slot size: 0.022”X0.028” is called the propeller slot.
• It is a ‘dynamic’ slot because:
i. Unique feature that the slot increases its vertical archwire
space from 0.022 to 0.028 inches as the tooth tips
ii. When the vertical slot is closed down by the auxiliary
against a rectangular archwire, it produces a three-
dimensional precision finish.
iii. It reduces friction during the first stage of treatment.
• Vertical slot is 0.020 inches square, lingual to main.
• Has a rounded ‘funnel shaped’ entry to facilitate insertion
of auxillaries.
11. 3. THE FIRST MOLAR TUBES -
• Tip-Edge employs double buccal tubes –
i. a normally sited preadjusted straight-wire rectangular tube of
.022 × .028”
ii. a gingivally placed round tube of .036” diameter.
• The first comes with a convertible rectangular buccal tube and
tie-wings so that the tube can become a bracket when the
buccal welded insert is peeled away - facilitates alignment of
second molars.
• Non-convertible molar tube has been introduced - carries no
tie-wings, helps patient comfort and reduces the chance of
occlusal interferences.
• All rectangular tubes are of Easy-Out® design, with the
posterior inner lumen slightly flared towards the occlusal -
facilitate archwire removal when a cinch back has been used
12. 4. AUXILIARIES -
A. The Side-Winder
• Used to be the everyday ‘workhorse’ among auxiliaries.
• Primarily in Plus, it generates mesio-distal root movement.
• For the Rx-1 bracket - produces torque correction as well, when used with rectangular
archwires.
• Made in .014 inch high tensile stainless steel wire.
• So called because it carries its coils along the archwire, over the bracket face.
• Side-Winders - only be used with SS arches, others are insufficiently stiff to resist the
vertical deflections arising from the active arms of the springs.
13. B. Invisible side-winder springs
• Wire of spring lies on archwire & brackets.
• Advantages
i. Aesthetic
ii. Retained in position by the elastomeric
module, in addition to its own spring pressure
- reduces the risk of detachment
iii. Enables modules to be changed if necessary during the root uprighting process
without removing springs.
iv. Because the bulbous hook has been reduced, the spring arm has a wider range of
activation
• Steel ligature ties avoided – insufficiently elastic to allow the bracket to rotate relative to
the archwire, as is necessary for the correction of tip (and torque) - therefore restricts the
action of the spring.
14. • Side-Winder springs should always be inserted from the
occlusal and never gingivally.
• The action of the spring will be the same either way but the
forces of mastication coming from the occlusal will be
deflected harmlessly off and if gingivally inserted, it will be
distorted.
• The direction of action of each spring can easily be ‘read’ in
the mouth by the clinician, according to the direction of the
spring arm. Since each spring is inserted occlusally, the
spring arm points in the direction towards which the
occlusal tip will rotate.
• Out of the mouth, hold the spring in a plier, hook facing the
operator - starting from its free end, if the hook curves away
in a clockwise direction, it is a clockwise spring, and vice-
versa
15. C. Power Pin
• This is a traction hook that can be fitted in the vertical slot
• Made of soft stainless steel, inserted from the gingival, and is
retained in the slot by bending the occlusally projecting tail 90
degrees.
• Strictly, this bend should be made in the opposite direction to the
elastic pull, since this avoids the possibility of a slackly turned pin
doing a ‘U-turn’ and being pulled out of the slot by the elastic.
• Most commonly used as hooks for seating elastics in the final
treatment visits.
• Also useful when an individual tooth requires retraction. Using an
elastomeric to a Power Pin, instead of directly to the bracket,
reduces the risk of distal rotation, since the bracket is secured by its
own elastomeric module (instead of by the end link of elastomeric
chain, which will inevitably be stretched open by the traction)
16. D. Rotating Spring
• Seldom required for correcting initial rotations – because
rotations of anterior teeth are dealt with by full bracket
engagement with light Ni-Ti wires.
• Very useful for recapturing a rotation that has recurred in
treatment, particularly if the patient is in a heavy archwire.
• E.g if a ligature or a bracket has detached from a previously
rotated tooth - convenient to be able to realign the
rotation with the flexibility of an auxiliary spring, than
stepping down to a lighter archwire.
• Comes in clockwise and counter-clockwise versions
• Made in .014 inch high tensile stainless steel.
17. • By using elastic ligatures in the normal way, there is a risk that
ligature failure or stretch may allow the spring arm to displace
the crown lingually.
• The difference between wire or elastic ligatures is that a wire
tie will limit the action to a perfect alignment, while an elastic
ligature will allow some degree of over-rotation.
• The ligature should be placed first, before inserting the spring.
• A wire tie should only secure the archwire on the side of the
bracket which is contacting the archwire and the ligature
should run around the backplate, rather than across it.
• To avoid occlusal interference, Rotating Springs should always
be inserted gingivally
18. E. Tip edge rings
• Elastomeric rings designed to function with tip-
edge brackets.
• Provide both arch wire attachment and mesial or
distal tip control in Stage III by filling the
chamfered wedge area.
• It parallels the archwire with the gingival and
occlusal edges of the tie wing tips. This is called
“hammock effect”.
• These rings are normally used only in the final
stage of treatment to maintain the crown
uprighting achieved with springs.
19. F. Straight Shooter
• A ligature gun, invented by Dr. Peter Kesling, is
ideally suited to Tip-Edge.
• Made from autoclavable plastic.
• Secure in position and press the trigger - the ring
is released.
• Advantages,
i. Less time consuming
ii. Places less pressure on the tooth ,more
comfortable for the patient
iii. Needs less concentration from the operator
iv. Safer
20. G. E-links
• Space closure is carried out using elastomeric
E-Links.
• Preferred to elastomeric chain, the force of
which can only be crudely adjusted
according to the number of links chosen.
• E-Links come in graded lengths with a
working life of up to 3 months in the mouth.
• Runs from the buccal hook on the first molar
to the cuspid circle.
• A long strand of elastomeric running parallel
to the archwire can be routed beneath the
retaining module on the premolar.
21. H. Outrigger appliance –
• Automatically reminds non-compliant
patients to replace the elastics by flicking out
sideways whenever the elastics are not
attached.
• Consists of a pair of hooks, coiled on the end
of an interconnecting span made in .016 inch.
• Seated in the occlusal tie-wings of the upper
central and laterals using ‘bilevel pins’.
23. DIFFERENTIAL TOOTH MOVEMENT -
• The very design of the edgewise derived brackets exerts
mesiodistal second order root forces from the time of first
engagement with an archwire.
• Yet it is recognized that positioning a root apex toward the
direction of pull will generate resistance to tooth movement
in response to that force.
• Dr. Charles Tweed developed the concept of ‘anchorage
preparation’, moving his apices mesially in the mandibular
buccal segments so as to increase anchorage resistance to
Class II elastic traction. (Tent- peg analogy)
24. • A bracket designed for differential tooth movement will not
impart root-angulating forces when an archwire is engaged.
• Instead, the crown will be able to tip in the direction of
desired tooth movement, essentially leaving the root apex to
trail behind.
• Such simple free tipping requires far less force and
anchorage than moving the same tooth bodily, although this
would in itself amount to incomplete treatment - makes
initial decrowding and reduction of big overjets dramatically
easy and rapid.
• This lends stability to the subsequent root uprighting
process - by establishing a strong interdigitation and
bringing the labial segments within the safety of normal lip
control.
25. VARIABLE ANCHORAGE -
• With differential tooth movement,
root control of the bracketed teeth
can be prescribed by the operator,
rather than occurring automatically
from first archwire engagement.
• This can be simply done by the
addition of an auxiliary (Side-Winder)
spring or springs, as was the case with
the Rx-1 bracket.
• The orthodontist now has the choice of which roots to control and when, perpetuates
the concept of variable anchorage control.
• This was not possible with conventional brackets, without resorting to more
complicated add-ons such as lingual arches, headgears or other anchorage
reinforcement.
26. LIGHT FORCES -
• It is fundamental to differential tooth movement that all forces should be light.
• A mere 50gms of intermaxillary elastic force bilaterally is quite sufficient for the
reduction of even large overjets.
• Heavier forces - unnecessary and harmful - posterior anchorage will be strained and
periodontal ligament put at risk.
• Differential tooth movement naturally implies a differential periodontal response -
tipping a tooth will induce most root movement at the gingival, diminishing towards
the apex - forces are therefore less evenly dissipated along the root.
• With light forces, this will not present any hazard.
27. ROOT UPRIGHTING -
• Edgewise & straight wire brackets offer very poor recovery from tipped angulations.
• Correction of mesio-distal crown tip by engaging the brackets with an active archwire
provokes major vertical consequences with extrusion of adjacent teeth.
• Use of power arms may facilitate the uprighting process but the vertical archwire
deflections remain.
• In tip edge recovery is by the light and progressive action of auxiliary springs.
• The vertical arch stability is maintained by relatively heavy but passive archwire
28. BONDING AND SETTING UP :
• The Tip-Edge appliance should be set up just like any other straight-wire
appliance.
• Some noted features will be explained under –
i. Bracket placement
ii. Premolar brackets
iii. Molar banding
29. 1. BRACKET PLACEMENT -
• Each bracket should be aligned with its vertical axis parallel with the long axis of
the tooth, and at the mid-point of the crown mesio-distally.
• The height of the bracket should be at the vertical mid-point of the fully erupted
clinical crown.
• Being a smaller bracket has aesthetic advantages, but also makes the accurate
placement more difficult - supplied with the option of plastic jigs.
• These provide ready ‘sight lines’ for the correct angulation and make the brackets
much easier to handle with conventional bonding tweezers.
30. • The jigs were produced only in ‘L-shaped’
form, which prescribes a fixed bonding
height for each bracket from the incisal
edge or tip, as denoted by the colour
coding.
• Jigs can be modified by cutting off the
horizontal section leaving only straight
vertical markers
• Universal jigs are more recent and can
easily be aligned up the long axis of the
tooth, while the mid-crown height can be
gauged by eye.
31. 2. PREMOLAR BRACKETS -
• Anterior tip-Edge brackets are designed to allow distal
crown tipping but premolars may require to tip either
mesially or distally, according to the extraction pattern.
• E.g: In a first molar extraction case, a second premolar
will require to tip distally.
If first premolars have been extracted, the same second
premolar will need to tip mesially into the extraction
space.
• Simplified bracket selection by using identical torque
and tip values in upper 1st and 2nd premolars – only
need to check whether the bracket is an upper or lower,
and if it is required to tip clockwise or counter-
clockwise.
32. • Upper premolar brackets are identified by circular
markings on the tie wings, lowers by triangular markings.
• These are offset towards the direction of tip.
• On the occlusal tie wings, an arrow is an additional
indicator of the direction of rotation.
• In various possible extraction patterns, the arrows usually
point towards the extraction site and in a non-extraction
case, towards the distal.
• As a rule of thumb, all the arrows point distally, except
second premolars in first premolar extraction cases
33. 3. MOLAR BANDS -
• Use of bonded first molar tubes is contraindicated - the withdrawal of the rectangular
archwires at the end of Stage III is likely to cause bond failure.
• The rectangular buccal tubes should be aligned to the brackets, at mid-crown height,
just as with a straight-wire appliance.
• The round tube will sit towards the gingival margin.
• In the mandibular arch, the tubes should be parallel to the occlusal cusps; in the
maxillary arch, seating the band fractionally higher toward the distal may be helpful in
obtaining final seating of the disto-buccal cusp.
34. TREATMENT STAGES :
STAGE 1
Anterior alignment
and incisor space
closure
STAGE 2
Closure of extraction
spaces
STAGE 3
Root uprighting
35. STAGE I :
• Objectives:
1. Initial alignment of upper/lower anterior segments
2. Closure of anterior spaces
3. Correction of increased overjet or reverse overjet
4. Correction of increased overbite or AOB
5. Work towards arch coordination
36. • Mechanics:
1. Place upper and lower 0.016 SS base archwires with cuspid circles just mesial to
the canine brackets and gently engage all possible teeth into round molar tube.
2. Severely displaced teeth can be engaged with elastic thread passed through the
vertical slot.
- Round nickel–titanium underarch, usually of .014 inch diameter can be used to
align instanding anterior teeth,
3. Leave out the premolars.
37. 4. Place gentle anchor bends in front of the molars, placing the base archwire in the
gingival slot. These bends reciprocally intrude incisors by the idea of ‘’dig in heels’ of
lower molars to resist the light mesial pull of the elastics.
38. 5. Once anterior alignment has been achieved, each canine bracket should be
ligatured to its respective cuspid circle with an elastomeric.
- Purposes:
i. the canines are prevented from unwanted further distal migration, so that the
anterior segment will not become spaced
ii. the archwire is stabilized laterally, and cannot swing from side to side.
6. Use Class II elastics (60g only) from circles on the upper archwire to the lower 6’s.
39. 7. Power tipping: If unwanted proclination of lower incisors during overbite
reduction, utilize ‘reverse Side-Winder springs’ – induce distal crown torque to
the lower canines, and hence distal retraction, which in turn uprights the lower
anterior segment lingually
40. 8. The Protraction Arch: In non-extraction cases with mildly crowded lower incisors, a
small amount of proclination of the incisors is deemed permissible.
- Fabricated from the same wire, .016 inch high tensile stainless, cuspid circles are
placed at least 3 mm distal to the canine bracket
- Protraction is activated by means of an elastomeric module stretched between each
canine bracket and the circle behind it
- As the elastomeric contracts, the archwire will be drawn forwards through the molar
tubes, making more wire available at the front, allowing the incisors to align onto a
bigger curvature.
41. STAGE II:
• Objectives:
1. Closure of residual spacing - by retraction of labial segments or by protraction of
buccal segments.
2. Correction of centrelines.
3. Derotation of first molars.
4. Levelling of first molars.
5. Continuing crossbite correction.
6. Maintenance of Stage I corrections.
42. • Mechanics:
1. Premolars should be included prior to the start of Stage II and use the same archwires
after removing the anchorage bends and replacing them with vertical bite
sweeps,(reverse curve of spee) to retain the overbite reduction. The wire is inserted into
the rectangular molar tubes.
2. Correction of premolar displacements and rotations can be corrected with elastomeric
E-Links, elastic threads or an .014 inch nickel–titanium underarch.
43. 3. The archwire size is then increased to 0.020” round SS.
4. When closing buccal segment spacing, by class one elastic by using E-links
between the circles on the archwire to the hooks on the 6’s, it is possible to choose
between retraction of the labial segment or protraction of the posterior segment
by adding adding Side-Winder ‘brakes’.
44. 5. In view of a centreline discrepancy, consider using unilateral sidewinders.
- The centreline is to the patient’s right,
where the extraction space closed.
Closure of remaining space will
automatically correct the centreline
without the need for a brake.
- With a correct centreline, a defensive
brake is now required to the left canine,
so that space is closed by protraction.
45. - The centreline needs correcting into the patient’s left quadrant space, by retraction,
whereas the space remaining in the right quadrant must be closed by protraction. The
lower right canine is therefore braked and an additional side-winder is placed on the
right central incisor, for distal root movement.
46. 6. A limited amount of first molar rotation can be expected as a result of space
closure with free-sliding mechanics.
- Requires a simple adjustment to the archwire, placing a 1 mm buccal offset and
10 degrees of lingual toe-in opposite the interspace between the fi rst molar
and premolar
- To prevent space recurring, the distal archwire ends should be annealed and
turned gingivally.
47. 7. Leveling of molar should done to allow the placement of rectangular archwires
- Anti-tip bend of 10° opposite to premolar-molar contact point.
- Ensures seating of the distal cusp of tipped molars
8. Maintain Class II elastics as required to keep the upper and lower incisors in
gentle contact.
48. TORQUE IN TIP-EDGE :
• A conventional edgewise or straight-wire bracket has flaws,
i. Rectangular wire required to provide active torquing and offering three-
dimensional stability to the remainder – physical impossibility
ii. active torque imparted to a single unit, or quadrant - unwanted secondary
torque reactions in adjacent units
iii. flexibility of a nickel–titanium archwire preferable for torquing with light forces
but stainless steel preferable for maintaining stability.
iv. nearly 10 degrees of ‘torque slop’ between .019 × .025 inch archwire and .022 ×
.028 inch bracket slot
49. • A Tip-Edge bracket cannot be torqued by an
active archwire in the conventional manner as
intact upper and
• lower finishing surfaces in each bracket are
offset from one another, and are therefore never
directly opposed.
• Insertion of an actively torqued rectangular
archwire will elevate one finishing surface and
depress the other - torquing effort in the
archwire dispersed by increasing the vertical
dimension within the Tip-Edge slot.
• The net result - relapse of root uprighting in the
mesiodistal direction - ‘torque escape’.
50. • Originally torqueing required a Side-Winder for each individual bracket but in
the Plus bracket all torquing and tipping can be carried out with a Ni-Ti
auxiliary archwire, threaded through the deep tunnels.
• In Stage III, a stainless .0215 × .028 inch archwire can be fitted without difficulty
due to the excess vertical dimension of slot.
• No torque will therefore be imparted at this point except in first molars.
51. • The vertical deflections of the auxiliary archwire (.014”) in the deep tunnels will
generate tip correction.
• After some initial correction of tip, a point is soon reached when further closing
down of the bracket becomes obstructed by the opposite corners of the
rectangular archwire.
• A two-point contact is thus established within the bracket.
52. • When the bracket becomes fully closed down to
the vertical dimension of the archwire, the upper
and lower flat surfaces of the bracket slot will be
in contact with the flat upper and lower surfaces
of the archwire.
• The rectangular archwire cross section remains
undeflected throughout the entire torquing
process, thereby the wire can torque teeth
individually, without unwanted torque reactions
to neighbouring teeth.
• In short, instead of increasing archwire thickness
to fill the bracket, a Tip-Edge bracket shrinks its
vertical dimension (under pressure from an
auxiliary) to fit a full sized archwire, conforming
to it precisely in all three dimensions.
54. • Mechanics:
1. Archwire: 0.0215” x 0.028” stainless steel base wire- flat or pre-torqued and place
crimpable hooks between canine and lateral incisor.
2. Using Side Winder springs or piggy back 014 or 016 NiTi in TE plus
- Thread the auxiliary wire first using midline or distal aproach.
55. 3. Maintain the space closure using ligatures from crimpable hooks to the hook on
the molars.
4. Use Class II elastics to maintain light contact between the upper and lower
incisors.
5. Final finishing to be done along with second molar alignment and occlusal
seating.
This should be followed by a long-term retention protocol.
56. ADVANTAGES:
1. Increased inter-bracket span because of the reduced bracket size MD
2. Little need for HG
3. Less anchorage demand because,
i. Differential force theory and light force
ii. Less expression of the tip during the first stage of treatment
iii. Round wire with reduced friction during the first stage of treatment
4. Precision in finishing
5. TE bracket can be used with SW in case of proclined or retroclined canines
57. DISADVANTAGES:
1. Expensive
2. Extraction philosophy and possible profile dishing
3. Reliant on elastic wear
4. Poor rotational control
5. High risk of root resorption and risk of PD damages
7. Complex in stage III specially the old TE system because each bracket requires
an auxiliary spring to deliver its final prescription.
8. Increased friction in later stages
58. CASE REPORTS :
Case report 1: A severe Class II division 1 malocclusion with increased overbite on a
very low mandibular angle Class II base treated with the Plus bracket
59.
60.
61.
62. Case Report 2: A severe Class II division 1 malocclusion with a marked unilateral overjet
treated with the Plus bracket
70. CONCLUSION:
• The tip edge bracket provides varying degrees of tooth control not previously
available in an edgewise type bracket.
• It also offers advantages over ribbon-arch (Begg) brackets through ease of
manipulation provided by the horizontally facing slot plus predetermined
limitation of initial crown tipping and control of final root uprighting.
• But further studies need to be conducted to determine the true efficiency of this
bracket system over the currently accepted treatment protocols.
71. REFERNCES :
Tip-Edge Orthodontics and the Plus Bracket - 2nd Edition, Richard Parkhouse
Parkhouse, R. C. (2007). Current products and practice: Tip-Edge Plus. Journal of
Orthodontics, 34(1), 59–68. doi:10.1179/146531207225021933
Kesling PC. Dynamics of the Tip-Edge bracket. American Journal of Orthodontics
and Dentofacial Orthopedics. 1989 Jul 1;96(1):16-25
Kesling PC, Rocke RT, Kesling CK. Treatment with Tip-Edge brackets and
differential tooth movement. American Journal of Orthodontics and
Dentofacial Orthopedics. 1991 May 1;99(5):387-401.