Therapeutic Effects of Albendazole on Disposition Kinetics of Florfenicol in Goats

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7th International Scientific Conference on Applied Sciences and Engineering 27-28 February, 2016 Flora Grand Hotel, Dubai

Abstract of Applied Sciences and Engineering, 2016, Vol.7
DOI: 10.18488/journal.1001/2016.7/1001.7
7th
International Scientific Conference on Applied
Sciences and Engineering
27-28 February, 2016
Flora Grand Hotel, Dubai
Conference Website: www.scihost.org
8
Paper ID: 24/16/ 7
th
ISCASE
Therapeutic Effects of Albendazole on Disposition Kinetics
of Florfenicol in Goats
Muhammad Ahsan Naeem1
--- Bilal Aslam2
--- Muhammad Mudassar Ashraf3
--- Ijaz Javed4
1,2,3,4
Institute of Pharmacy, Physiology and Pharmacology, Faculty of Veterinary Science,
University of Agriculture, Faisalabad.
Abstract
Effect of albendazole on the pharmacokinetics of florfenicol was investigated in ten
healthy adult goats. In each experiment, after restraining the animal, a single dose of
florfenicol was administered intramuscularly. After wash out period of 7 days, florfenicol
along with albendazole suspension was administered orally. Blood samples were
collected in plastic centrifuge tubes. Prior to drug administration, a control blood sample
was collected in each experiment. Following drug administration, blood samples were
drawn at half hourly interval up to 4 hours followed by hourly interval up to 8 hours and
thereafter, at 10 and 12 hours. Blood samples were centrifuged and serum was
separated and stored at -20°C until analysis. The concentration of florfenicol in serum
samples was determined by using high performance liquid chromatography HPLC
technique. The results of present study indicated that albendazole significantly
(P<0.05) increased or decreased the pharmacokinetic parameters of florfenicol after
their concurrent administration i.e. decreased peak serum concentration Cmax (4.22 ±
0.32 to 3.3 ± 0.21 µg mL-1
), extrapolated zero time drug concentration B (5.29 ± 0.46 to
4.85 ±0.51 µg mL-1
), elimination half-life t1/2 β (6.56 ± 0.94 to 5.06 ± 0.77 hours) and
increased volume of distribution Vd (4.05 ± 0.35 to 4.49 ± 0.4 L kg-1
) and total body
clearance CLB (0.47 ± 0.04 to 0.69 ± 0.06 mL min-1
kg-1
). As florfenicol is metabolized
by the same cytochrome P450 isoenzymes (CYP1A1 and CYP1A2) which are induced
by albendazole, the change in pharmacokinetics parameters of florfenicol may be
attributed to its drug action with albendazole. Thus it may be conceived that the
change in pharmacokinetic parameters is due to rapid elimination of florfenicol when
given concurrently with albendazole to healthy adult goats which in turn may be due to
induction of CYP3A4 isoenzyme by albendazole.
Keywords: Florfenicol, Albendazole, Cytochrome, Disposition kinetics, Clearance and volume of
distribution

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HPLC is a chromatographic technique employed in active compound chemistry and biochemistry to separate a mixture and substances with the goal of identifying, measuring, and purifying the different components of the mixture. Its a much better variety of column and traditional chromatography. The objective of the research work is to develop and validate a simple and accurate reverse phase chromatographic method to estimate amount of drug in dosage form. The developed method successfully can be applied to estimate the amount of Dapagliflozin in tablet dosage form. After oral administration of dapagliflozin, the maximum plasma concentration Concentration max under two hours. High performance liquid chromatographic system was alleviated according to the chromatographic settings. After attaining the steady base line, to verify the system suitability, a single 40 Âµg ml of standard solution proportional to 100 test concentration of dapagliflozin was injected into the HPLC system. The gradient mobile phase flow rate programming assisted in optimising the lengthy run duration and resolution of sample analysis, making the approach more cost effective and quick. Validation of the developed and optimized HPLC method was carried out according to ICH guidelines with respect to parameters such as linearity, specificity, precision and accuracy. Junaid Ahmed | Himanchal Sharma | Shiva Teotia "Method Development and Validation for Estimation of Oral Hypoglycaemic Drug Dapagliflozinina Tablet Dosage form by the Employment of Rp-HPLC" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, URL: https://www.ijtsrd.com/papers/ijtsrd46395.pdf Paper URL : https://www.ijtsrd.com/pharmacy/analytical-chemistry/46395/method-development-and-validation-for-estimation-of-oral-hypoglycaemic-drug-dapagliflozinina-tablet-dosage-form-by-the-employment-of-rphplc/junaid-ahmed

Seminar LN

LN Neupane

The document summarizes a student's seminar presentation on the comparative pharmacokinetics study of Ginseng fruit, Ginkgo biloba plant extract, and the drug Isoniazid using a proliposome delivery system. The presentation introduces the materials and methods used in the study, including the preparation of proliposome formulations for each component and analytical techniques. Results are discussed relating to pharmacokinetic properties, particle size, solid state characterization, and aerosol performance of the formulations. The conclusion states that the proliposome formulations improved absorption and bioavailability compared to ordinary tablets.

Hepatoprotective Effect of Cestrum parqui L. aerial parts and Phytochemical ...

Jing Zang

This study deals with the investigation of hepatoprotective effect of 70% methanolic extract from Cestrum parqui aerial parts and determination of the bioactive components of the plant. The hepatoprotective effect of Cestrum parqui methanol extract (100, 500, 1000 mg/kg) was analysed on carbon tetrachloride (CCl4)-induced acute liver injury. The administration of a single dose of 40% CCl4 (1ml/kg b.w.) causes an increase in the activities of serum alanine aminotransferase (ALT) and aspirate aminotransferase (AST) enzymes and so pretreated orally of a dose from Cestrum parqui methanol extract (100, 500, 1000 mg/kg) and silymarin (200 mg/kg) for three consecutive days prior to The administration of a single dose of CCl4 significantly prevented the increase in the activities of these enzymes. Histological analysis showed that Cestrum parqui methanol extract at doses of 500 and 1000 mg/kg and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl4. The extract cause a negative result on the antioxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl4-treated group and this suggests that the hepatoprotective activity of the extract is due to the antioxidant effect of the extract. Phytochemical analysis of the methanol extract from Cestrum parqui aerial parts showed that it contained different phytoconstituents, flavonoids, tannins, saponins, alkaloids, terpenes and carbohydrates.

Glucose lowering potential of hydromethanolic extract of Rauwolfia

Jing Zang

The objective of the present study was to evaluate the phytochemistry, acute toxicity and glucose lowering potential of hydromethanolic roots extract (HMREt) of Rauwolfia serpentina. The qualitative analysis of HMREt showed the presence of many important phyto-constituents except anthraquinones, carbohydrates and saponins whereas quantitatively it found rich in total phenols. In acute toxicity study, orally administrated HMREt from 5-250 mg/ kg was observed safe and non-sedative while its doses from 500-2500 mg/kg were found sedative and induced mortalities (17-100%) within 4 hours of administration. The median lethal dose (LD50) of same extract was calculated as 1412.54 mg / kg (log LD50 = 3.15 mg/ kg) from log doses verses probit graph. The HMREt in doses of 50, 100 and 150 mg/kg induced significant percent decrease in blood glucose level at 30, 60 and 120 minutes in normo-hyperglycemic test mice as compared to control and negative control groups (p<0.05). The results concluded that HMREt has glucose lowering potential either by developing glucose tolerance or by pancreatic action in normo-hyperglycemic mice.

ausama PP.PDF

ausama jaccob

The study evaluated the long-term effects of administering silibinin, epigallocatechin, quercetin, or rutin on the absorption and tissue distribution of zinc, copper, and iron in rats. The results showed that all flavonoids increased serum and tissue levels of the trace elements compared to controls. Specifically, the flavonoids increased absorption of all three elements and their availability in brain, kidney, and liver tissues. However, the effects varied between flavonoids, with epigallocatechin generally having the greatest effect on iron absorption and tissue levels. The study suggests long-term intake of high-dose flavonoid supplements could increase absorption and tissue accumulation of some trace elements.

DEVELOPMENT AND OPTIMIZATION OF CIPROFLOXACIN HCL HOLLOW MICROSPHERES (MICRO ...

ANURAG GROUP OF INSTITUTIONS

In the present study, a gastro retentive micro particulate system was formulated with different Polymers by using solvent evaporation technique. A series of 8 formulations was prepared based on 23 Design of experiments. The formulated microspheres were evaluated flow characteristics, Practical yield (up to 80 %) and Encapsulation efficiency (up to 94%). Scanning electron Microscopy confirmed their porous and spherical structure and the particles were of the Size range of (65-525 μm). The release of drug at 1 hour and 8 hours’ time points were taken as the measurable parameters for running the DOE experiments. According to design space Hollow Microspheres formulated with Drug in the range of 50 to 70 mg/unit, Ethyl cellulose 7 cps in the range of 145 to 150 mg/unit and HPMC 5 cps in the range of 0.4 to 2 mg/unit were observed to have the best floating characteristics and in vitro dissolution profile as per the preset target product profile. Stability studies showed no significant change in the drug content in the formulations at 3 months accelerated condition. In this study concluded that a micro particulate floating dosage form of an anti-infective drug can be successfully designed to give controlled release and improved oral bioavailability. KEYWORDS Gastro retentive system, Ciprofloxacin Hcl, Ethyl Cellulose 7 cps, HPMC 5cps, Hollow microspheres.

Formulation and Evaluation of Pantoprazole Sodium Enteric Coated Tablets

SriramNagarajan18

The document summarizes the formulation and evaluation of pantoprazole sodium enteric coated tablets. Pantoprazole is an acid-labile drug that requires enteric coating to protect it from degradation in the stomach. Various enteric coated tablet formulations were prepared using different concentrations of superdisintegrants and enteric coating polymers. Tablets were evaluated for hardness, thickness, weight variation, friability, drug content and in vitro drug release. Formulation EC8, coated with 6% Eudragit RS100, showed the best results with a thickness of 2.2mm, hardness of 3.52kg/cm2, drug release of 100.16% within 2 hours and 45 minutes, and acid resistance

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Therapeutic Effects of Albendazole on Disposition Kinetics of Florfenicol in Goats

1. Abstract of Applied Sciences and Engineering, 2016, Vol.7 DOI: 10.18488/journal.1001/2016.7/1001.7 7th International Scientific Conference on Applied Sciences and Engineering 27-28 February, 2016 Flora Grand Hotel, Dubai Conference Website: www.scihost.org 8 Paper ID: 24/16/ 7 th ISCASE Therapeutic Effects of Albendazole on Disposition Kinetics of Florfenicol in Goats Muhammad Ahsan Naeem1 --- Bilal Aslam2 --- Muhammad Mudassar Ashraf3 --- Ijaz Javed4 1,2,3,4 Institute of Pharmacy, Physiology and Pharmacology, Faculty of Veterinary Science, University of Agriculture, Faisalabad. Abstract Effect of albendazole on the pharmacokinetics of florfenicol was investigated in ten healthy adult goats. In each experiment, after restraining the animal, a single dose of florfenicol was administered intramuscularly. After wash out period of 7 days, florfenicol along with albendazole suspension was administered orally. Blood samples were collected in plastic centrifuge tubes. Prior to drug administration, a control blood sample was collected in each experiment. Following drug administration, blood samples were drawn at half hourly interval up to 4 hours followed by hourly interval up to 8 hours and thereafter, at 10 and 12 hours. Blood samples were centrifuged and serum was separated and stored at -20°C until analysis. The concentration of florfenicol in serum samples was determined by using high performance liquid chromatography HPLC technique. The results of present study indicated that albendazole significantly (P<0.05) increased or decreased the pharmacokinetic parameters of florfenicol after their concurrent administration i.e. decreased peak serum concentration Cmax (4.22 ± 0.32 to 3.3 ± 0.21 µg mL-1 ), extrapolated zero time drug concentration B (5.29 ± 0.46 to 4.85 ±0.51 µg mL-1 ), elimination half-life t1/2 β (6.56 ± 0.94 to 5.06 ± 0.77 hours) and increased volume of distribution Vd (4.05 ± 0.35 to 4.49 ± 0.4 L kg-1 ) and total body clearance CLB (0.47 ± 0.04 to 0.69 ± 0.06 mL min-1 kg-1 ). As florfenicol is metabolized by the same cytochrome P450 isoenzymes (CYP1A1 and CYP1A2) which are induced by albendazole, the change in pharmacokinetics parameters of florfenicol may be attributed to its drug action with albendazole. Thus it may be conceived that the change in pharmacokinetic parameters is due to rapid elimination of florfenicol when given concurrently with albendazole to healthy adult goats which in turn may be due to induction of CYP3A4 isoenzyme by albendazole. Keywords: Florfenicol, Albendazole, Cytochrome, Disposition kinetics, Clearance and volume of distribution

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