08.09.19
Invited Lecture to the Green IT Workshop
Canada-California Strategic Innovation Partnership
Title: Toward Greener Cyberinfrastructure
Palo Alto, CA
08.09.19
Invited Lecture to the Green IT Workshop
Canada-California Strategic Innovation Partnership
Title: Toward Greener Cyberinfrastructure
Palo Alto, CA
08.04.14
Invited Talk
National Astrobiology Institute Executive Council Meeting
Astrobiology Science Conference 2008
Santa Clara Convention Center
Title: High Performance Collaboration
Santa Clara, CA
High Performance Cyberinfrastructure is Needed to Enable Data-Intensive Scien...Larry Smarr
11.03.28
Remote Luncheon Presentation from Calit2@UCSD
National Science Board
Expert Panel Discussion on Data Policies
National Science Foundation
Title: High Performance Cyberinfrastructure is Needed to Enable Data-Intensive Science and Engineering
Arlington, Virginia
Toward a Global Interactive Earth Observing CyberinfrastructureLarry Smarr
05.01.12
Invited Talk to the 21st International Conference on Interactive Information Processing Systems (IIPS) for Meteorology, Oceanography, and Hydrology Held at the 85th AMS Annual Meeting
Title: Toward a Global Interactive Earth Observing Cyberinfrastructure
San Diego, CA
The Jump to Light Speed - Data Intensive Earth Sciences are Leading the Way t...Larry Smarr
05.06.14
Keynote to the 15th Federation of Earth Science Information Partners Assembly Meeting: Linking Data and Information to Decision Makers
Title: The Jump to Light Speed - Data Intensive Earth Sciences are Leading the Way to the International LambdaGrid
San Diego, CA
Global Telepresence in Support of Global Public HealthLarry Smarr
08.04.17
Briefing
University of California School of Global Health
All Campuses Planning Committee
Calit2@UCSD
Title: Global Telepresence in Support of Global Public Health
La Jolla, CA
Why Researchers are Using Advanced NetworksLarry Smarr
07.07.03
Remote Talk from Calit2 to:
Building KAREN Communities for Collaboration Forum
KIWI Advanced Research and Education Network
University of Auckland, Auckland City, New Zealand
Title: Why Researchers are Using Advanced Networks
La Jolla, CA
OptIPuter-A High Performance SOA LambdaGrid Enabling Scientific ApplicationsLarry Smarr
07.03.21
IEEE Computer Society Tsutomu Kanai Award Keynote
At the Joint Meeting of the: 8th International Symposium on Autonomous Decentralized Systems
2nd International Workshop on Ad Hoc, Sensor and P2P Networks
11th IEEE International Workshop on Future Trends of Distributed Computing Systems
Title: OptIPuter-A High Performance SOA LambdaGrid Enabling Scientific Applications
Sedona, AZ
The Singularity: Toward a Post-Human RealityLarry Smarr
06.02.13
Talk to UCSD's Sixth College
Honor's Course on Kurzweil's The Singularity is Near
Title: The Singularity: Toward a Post-Human Reality
La Jolla, CA
06.06.20
Remote Telepresence Talk
The 2006 NCSA Private Sector Program Annual Meeting
In Honor of John Stevenson’s Retirement
Title: NCSA and Telepresence Collaboration
La Jolla, CA
Remote Telepresence for Exploring Virtual WorldsLarry Smarr
08.01.26
Foundational Talk
Virtual World and Immersive Environments
NASA Ames
Title: Remote Telepresence for Exploring Virtual Worlds
Mountain View, CA
Using the Pacific Research Platform for Earth Sciences Big DataLarry Smarr
Grand Challenge Lecture
Big Data and the Earth Sciences: Grand Challenges Workshop
Calit2’s Qualcomm Institute
University of California, San Diego
May 31, 2017
The Pacific Research Platform: A Regional-Scale Big Data Analytics Cyberinfra...Larry Smarr
National Ocean Exploration Forum 2017
Ocean Exploration in a Sea of Data
Calit2’s Qualcomm Institute
University of California, San Diego
October 21, 2017
08.04.14
Invited Talk
National Astrobiology Institute Executive Council Meeting
Astrobiology Science Conference 2008
Santa Clara Convention Center
Title: High Performance Collaboration
Santa Clara, CA
High Performance Cyberinfrastructure is Needed to Enable Data-Intensive Scien...Larry Smarr
11.03.28
Remote Luncheon Presentation from Calit2@UCSD
National Science Board
Expert Panel Discussion on Data Policies
National Science Foundation
Title: High Performance Cyberinfrastructure is Needed to Enable Data-Intensive Science and Engineering
Arlington, Virginia
Toward a Global Interactive Earth Observing CyberinfrastructureLarry Smarr
05.01.12
Invited Talk to the 21st International Conference on Interactive Information Processing Systems (IIPS) for Meteorology, Oceanography, and Hydrology Held at the 85th AMS Annual Meeting
Title: Toward a Global Interactive Earth Observing Cyberinfrastructure
San Diego, CA
The Jump to Light Speed - Data Intensive Earth Sciences are Leading the Way t...Larry Smarr
05.06.14
Keynote to the 15th Federation of Earth Science Information Partners Assembly Meeting: Linking Data and Information to Decision Makers
Title: The Jump to Light Speed - Data Intensive Earth Sciences are Leading the Way to the International LambdaGrid
San Diego, CA
Global Telepresence in Support of Global Public HealthLarry Smarr
08.04.17
Briefing
University of California School of Global Health
All Campuses Planning Committee
Calit2@UCSD
Title: Global Telepresence in Support of Global Public Health
La Jolla, CA
Why Researchers are Using Advanced NetworksLarry Smarr
07.07.03
Remote Talk from Calit2 to:
Building KAREN Communities for Collaboration Forum
KIWI Advanced Research and Education Network
University of Auckland, Auckland City, New Zealand
Title: Why Researchers are Using Advanced Networks
La Jolla, CA
OptIPuter-A High Performance SOA LambdaGrid Enabling Scientific ApplicationsLarry Smarr
07.03.21
IEEE Computer Society Tsutomu Kanai Award Keynote
At the Joint Meeting of the: 8th International Symposium on Autonomous Decentralized Systems
2nd International Workshop on Ad Hoc, Sensor and P2P Networks
11th IEEE International Workshop on Future Trends of Distributed Computing Systems
Title: OptIPuter-A High Performance SOA LambdaGrid Enabling Scientific Applications
Sedona, AZ
The Singularity: Toward a Post-Human RealityLarry Smarr
06.02.13
Talk to UCSD's Sixth College
Honor's Course on Kurzweil's The Singularity is Near
Title: The Singularity: Toward a Post-Human Reality
La Jolla, CA
06.06.20
Remote Telepresence Talk
The 2006 NCSA Private Sector Program Annual Meeting
In Honor of John Stevenson’s Retirement
Title: NCSA and Telepresence Collaboration
La Jolla, CA
Remote Telepresence for Exploring Virtual WorldsLarry Smarr
08.01.26
Foundational Talk
Virtual World and Immersive Environments
NASA Ames
Title: Remote Telepresence for Exploring Virtual Worlds
Mountain View, CA
Using the Pacific Research Platform for Earth Sciences Big DataLarry Smarr
Grand Challenge Lecture
Big Data and the Earth Sciences: Grand Challenges Workshop
Calit2’s Qualcomm Institute
University of California, San Diego
May 31, 2017
The Pacific Research Platform: A Regional-Scale Big Data Analytics Cyberinfra...Larry Smarr
National Ocean Exploration Forum 2017
Ocean Exploration in a Sea of Data
Calit2’s Qualcomm Institute
University of California, San Diego
October 21, 2017
2014.02.06
Calit2 Director Larry Smarr invited short talk to a workshop on "Enriching Human Life and Society," one of the planned themes for the UCSD Strategic Plan to be adopted in 2014.
Coupling Australia’s Researchers to the Global Innovation EconomyLarry Smarr
08.10.08
Third Lecture in the
Australian American Leadership Dialogue Scholar Tour
Monash University
Title: Coupling Australia’s Researchers to the Global Innovation Economy
Clayton, Australia
Creating a Big Data Machine Learning Platform in CaliforniaLarry Smarr
Big Data Tech Forum: Big Data Enabling Technologies and Applications
San Diego Chinese American Science and Engineering Association (SDCASEA)
Sanford Consortium
La Jolla, CA
December 2, 2017
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
The Transformational Nature of NSF Long-Term Fundingon Santa Ana Wildfires in Southern California
1. “The Transformational Nature of NSF Long-Term Funding
on Santa Ana Wildfires in Southern California”
Invited Presentation with Ilkay Altintas
To the Council on Competitiveness
SDSC, UC San Diego
March 8, 2019
Dr. Larry Smarr
Director, California Institute for Telecommunications and Information Technology
Harry E. Gruber Professor,
Dept. of Computer Science and Engineering
Jacobs School of Engineering, UCSD
http://lsmarr.calit2.net
1
2. The Digital Transformation of
Environment
• Water, Fire, & Changing California Climate
– Global Climate Change Drives Regional Climate Disruption
– Common “Mirror World” of Southern California for Fire and
Water Management
– Advanced IT/Telecom to Accelerate Response to Wildfires
Early on October 23, 2007, Harris Fire San Diego
Photo by Bill Clayton, http://map.sdsu.edu/
3. SoCal’s Santa Anna Wildfires:
View From NASA’s Aqua Satellite’s MODIS Instrument
NASA/MODIS Rapid Response
www.nasa.gov/vision/earth/lookingatearth/socal_wildfires_oct07.html
October 22, 2007
Moderate Resolution Imaging Spectroradiometer (MODIS)
Calit2, SDSU, and NASA Goddard Used NASA Prioritization and OptIPuter Links
to Cut time to Receive Images from 24 to 3 Hours
4. 15 Years of NSF-Funded Real-Time Network Cameras
on San Diego Mountains for Environmental Observations
Source: Hans Werner Braun,
HPWREN PI
5. HPWREN Real-Time Network Cameras on Mountains
for Environmental Observations and Fires
San Diego County Red Mountain Fire Cameras
• Southeast (left) “Highway” Fire
• Southwest (center rear) “Poinsettia” Fire
• West (right) “Tomahawk” Fire
Source: Frank Vernon,
Hans Werner Braun HPWREN
May 14, 2014
6. The Pacific Research Platform Connects Campus “Big Data Freeways”
to Create a Regional End-to-End Science-Driven “Big Data Superhighway” System
NSF CC*DNI Grant
$6M 10/2015-10/2020
PI: Larry Smarr, UC San Diego Calit2
Co-PIs:
• Camille Crittenden, UC Berkeley CITRIS,
• Tom DeFanti, UC San Diego Calit2/QI,
• Philip Papadopoulos, UCSD SDSC, UCI
• Frank Wuerthwein, UCSD Physics and SDSC
Letters of Commitment from:
• 50 Researchers from 15 Campuses
• 32 IT/Network Organization Leaders
Source: John Hess, CENIC
7. NSF-Funded Pacific Research Platform (PRP) Enabled 2018 Expansion
of HPWREN Wireless Connectivity Into Orange County
• PRP Uses CENIC
100G Optical Fiber
to Link UCSD, SDSU
& UCI HPWREN
Servers
– Data Redundancy
– Disaster Recovery
– High Availability
– Kubernetes Handles
Software Containers
and Data
UCI
UCSD
SDSU
Source: Frank Vernon,
Hans Werner Braun HPWREN
UCI Antenna Dedicated
June 27, 2017
9. San Diego Gas & Electric
Has Been a Pioneering Utility in Wildfire Mitigation
USDA Forest Service, the San Diego Gas and
Electric utility (SDG&E), and the University of
California, Los Angeles (UCLA)
10. Creation of Digital Twin:
Interactive Virtual Reality of San Diego County
0.5 meter image resolution.
2meter resolution elevation
11. All HPWREN and SDG&E Meteorological Stations
Are Represented in Realtime: Wind Direction, Velocity, and Temperature
Source: Jessica Block, Calit2
12. Using Calit2’s Qualcomm Institute NexCAVE
for CAL FIRE Research and Planning
Thom Porter, San Diego CAL FIRE Unit Chief
January 9, 2012
Source: Jessica Block, Calit2
Chief Porter
was appointed
Director,
California
Department of
Forestry and Fire
Protection
by Governor
Gavin Newsom on
January 8, 2019
13. Church Fire, San Diego CA
Alert SD&ECameras/HPWREN
October 21, 2017
NSF-Funded WIFIRE:
Coupling Wireless Wildfire Sensors to Wildfire Simulations
Thomas Fire, Ventura, CA
Firemap Tool, WIFIRE
December 10, 2017
CENIC 2018
Innovations in Networking Award
for Experimental Applications
WIFIRE PI Ilkay Altintas, SDSC
14. Once a Wildfire is Spotted, PRP Brings High-Resolution Weather Data
to Fire Modeling Workflows in WIFIRE
Real-Time
Meteorological Sensors
Weather Forecast
Landscape data
WIFIRE Firemap
Fire Perimeter
Work Flow
PRP
Ilkay Altintas, SDSC
18. San Diego Airborne Intelligence Reconnaissance System (SDAIRS) –
San Diego County Lilac Fire (Dec 7-16, 2017)
3. Final Lilac Fire Perimeter in
comparison to the WIFIRE Fire
Progression Model in SCOUT
1. SDAIRS team at work at the SDFD
Emergency Command and Dispatch Center
2. Lilac Fire Perimeter Capture through
the GA Aircraft and Assimilation of
Perimeters into WIFIRE Fire Models
Red is most recent, the colors change over time and become grey after 72 hours.
You can see 3-4 santa ana events over the course of the month just based on fire detections.
Detections are from VIIRS approximately every 12 hours.
COLORS: up to 12 hours = gold, 12-24 = orangered, 24-48 = red, 2-3 days = black, over 3 days = gray
White – final perimeter
Colors – fire progression from wifire in half hour increments