This document summarizes Dr. Larry Smarr's vision for an integrated science cyberinfrastructure to support data-intensive research. It discusses the exponential growth of digital data and need for dedicated high-bandwidth networks and data repositories. Specific examples are provided of initiatives at UCSD, regional optical networks connecting research institutions, and national projects like the Open Science Grid and Cancer Genomics Hub that are creating cyberinfrastructure to enable data-intensive scientific discovery.