The document discusses the metabolic response to injury and trauma. It describes how injury causes the release of damage signals that activate the innate immune system and inflammatory response. This leads to a graded response, initially causing hypermetabolism and catabolism (CARS), but can progress to suppressed immunity (CARS) if severe. Nutritional support is important to meet increased caloric and protein demands caused by the metabolic stress response. Enteral nutrition is preferred but parenteral nutrition may be needed if enteral feeding is not possible. Both have risks if not properly administered.
التغذية لمرضي الجراحة
للزملاء المتقدمين لامتحانات اجنبية زي MRCS
و للزملاء اللي منتقلين حديثا للعمل بالمملكة المتحدة او بينوو العمل فيها
تابعونا علي الصفحة الجراح
https://www.facebook.com/algarra7/
عنوان الفيديوعلى اليوتيوب
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التغذية لمرضي الجراحة
للزملاء المتقدمين لامتحانات اجنبية زي MRCS
و للزملاء اللي منتقلين حديثا للعمل بالمملكة المتحدة او بينوو العمل فيها
تابعونا علي الصفحة الجراح
https://www.facebook.com/algarra7/
عنوان الفيديوعلى اليوتيوب
https://youtu.be/PNe2e41pv_w
Enteric nutrition part 1 ( In Maxillofacial, Head and Neck Surgery )Maxfac Center
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Email : maxfacmail@gmail.com
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Appropriate and safe assessment and administration of fuid therapy and nutritional support is of key importance in good surgical practice. It is imperative that the preoperative nutritional state of the patient and the impact of any surgical intervention are taken into account when considering nutritional requirements and the mode of nutrient delivery.
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
1. The metabolic response
injury
Dr Rajeev Kumar Pandit
FCPS 1st Yr Surgery Resident
Manmohan Memorial Medical College
Swoyambhu, Nepal
2. • The inflammatory response to injury or infection occurs as a consequence
of the local or systemic release of “pathogen associated” or “damage-
associated” molecules, which use similar signaling pathways to mobilize
the necessary resources required for the restoration of homeostasis.
3. Traumatic injury
alarmins or damage-associated molecular patterns (DAMPs)
pathogen-associated molecular patterns (PAMPs)
activates the innate immune system
9. • Compensatory anti inflammatory response syndrome (CARS)
characterized by suppressed immunity and diminished resistance to
infection.
• Physiological/metabolic changes but also to immunological
changes/sequelae.
• Systemic inflammatory response syndrome (SIRS), hypermetabolism,
marked catabolism, shock and even multiple organ dysfunction
(MODS).
• https://docs.google.com/forms/d/1KIjYNi7Fq7NFe81xOy1TJ6xn8pbdK
BLInYnVWTB-8JU/edit#responses
10. • The innate immune system (principally macrophages) interacts in a
complex manner with the adaptive immune system (T cells, B cells) in
co-generating the metabolic response to injury (Figure 1.2).
Proinflammatory cytokines including interleukin-1 (IL-1), tumour
necrosis factor alpha (TNFα), IL-6 and IL-8 are produced within the
first 24 hours and act directly on the hypothalamus to cause pyrexia.
20. • A normal healthy adult requires approximately 22 to 25 kcal/kg per
day drawn from carbohydrate, lipid, and protein sources.
21.
22.
23.
24.
25. • Insulin resistance
• CHANGES IN BODY COMPOSITION FOLLOWING
INJURY
• The main labile energy reserve in the body is
fat, and the main labile protein reserve is
skeletal muscle.
• Within lean issue, each 1 g of nitrogen is
contained within 6.25 g of protein, which is
contained in approximately 36 g of wet weight
tissue.
• Protein turnover in the whole body is of the
order of 150–200 g per day. A normal human
ingests about 70–100 g protein per day, which
is metabolised and excreted in urine as
ammonia and urea (i.e. approximately 14 g
N/day)
26. NUTRITION IN THE SURGICAL PATIENT
• Basal energy expenditure (BEE) may also be estimated
using the Harris-Benedict equations:
BEE (men) = 66.47 + 13.75 (W) + 5.0 (H) – 6.76 (A) kcal/d
BEE (women) = 655.1 + 9.56 (W) +1.85 (H) – 4.68 (A) kcal/d
• where W = weight in kilograms; H = height in centimeters; and A = age in years.
• It has been demonstrated that the provision of 30 kcal/kg per day will adequately meet
energy requirements in most postsurgical patients
• These additional nonprotein calories provided after injury are usually 1.2 to 2.0 times
greater than calculated resting energy expenditure, depending on the type of injury
• The second objective of nutritional support is to meet the substrate requirements for
protein synthesis. An appropriate nonprotein-calorie:nitrogen ratio of 150:1 (e.g., 1 g N =
6.25 g protein) should be maintained, which is the basal calorie requirement provided to
limit the use of protein as an energy source.
27.
28.
29.
30.
31. • Overfeeding
• Overestimation of caloric needs
• Critically ill with significant fluid overload and the obese
• Overfeeding may contribute to clinical deterioration via increased oxygen
consumption, increased carbon dioxide production and prolonged need for
ventilatory support, fatty liver, suppression of leukocyte function, hyperglycemia,
and increased risk of infection
32. ENTERAL NUTRITION
• There is no evidence to support withholding enteric feedings for
patients after bowel resection or for those with low-output
enterocutaneous fistulas of 500ml.
33. • The principal indications for parenteral nutrition are malnutrition,
sepsis, or surgical or traumatic injury in seriously ill patients for whom
use of the gastrointestinal tract for feedings is not possible.
34. • The following are patient groups for whom parenteral nutrition has been used in an
effort to achieve these goals:
• 1. Newborn infants with catastrophic gastrointestinal anomalies, such as tracheoesophageal fistula,
gastroschisis, omphalocele, or massive intestinal atresia
• 2. Infants who fail to thrive due to gastrointestinal insufficiency associated with short-bowel
syndrome, malabsorption, enzyme deficiency, meconium ileus, or idiopathic diarrhea
• 3. Adult patients with short-bowel syndrome secondary to massive small-bowel resection (500 mL/d)
• 5. Surgical patients with prolonged paralytic ileus after major operations (>7 to 10 days), multiple
injuries, or blunt or open abdominal trauma, or patients with reflex ileus complicating various medical
diseases
• 6. Patients with normal bowel length but with malabsorption secondary to sprue, hypoproteinemia,
enzyme or pancreatic insufficiency, regional enteritis, or ulcerative colitis
• 7. Adult patients with functional gastrointestinal disorders such as esophageal dyskinesia after
cerebrovascular accident, idiopathic diarrhea, psychogenic vomiting, or anorexia nervosa
• 8. Patients with granulomatous colitis, ulcerative colitis, or tuberculous enteritis in whom major
portions of the absorptive mucosa are diseased
• 9. Patients with malignancy, with or without cachexia, in whom malnutrition might jeopardize
successful use of a therapeutic option
• 10. Patients in whom attempts to provide adequate calories by enteral tube feedings or high residuals
have failed
• 11. Critically ill patients who are hypermetabolic for >5 days or for whom enteral nutrition is not
feasible
35. • Patients in whom hyperalimentation is contraindicated include the
following:
• 1. Patients for whom a specific goal for patient management is lacking or for whom,
instead of extending a meaningful life, inevitable dying would be delayed
• 2. Patients experiencing hemodynamic instability or severe metabolic derangement
(e.g., severe hyperglycemia, azotemia, encephalopathy, hyperosmolality, and fluid-
electrolyte disturbances) requiring control or correction before hypertonic
intravenous feeding is attempted
• 3. Patients for whom gastrointestinal tract feeding is feasible; in the vast majority of
instances, this is the best route by which to provide nutrition
• 4. Patients with good nutritional status
• 5. Infants with <8cm of small bowel because virtually all have been unable to adapt
sufficiently despite prolonged periods of parenteral nutrition
• 6. Patients who are irreversibly decerebrate or otherwise dehumanized
36.
37. • Total Parenteral Nutrition
• Also referred to as central parenteral nutrition, requires access to a large-
diameter vein to deliver the entire nutritional requirements of the individual.
• Dextrose content of the solution is high (15% to 25%), and all other
macronutrients and micronutrients are deliverable by this route.
• Peripheral Parenteral Nutrition
• The lower osmolarity of the solution used for peripheral parenteral nutrition
(PPN), secondary to reduced levels of dextrose (5% to 10%) and protein (3%),
allows its administration via peripheral veins
• Typically, PPN is used for short periods.
38. • Technical Complications
• Central line–associated bloodstream infections (CLABSI) occur as a
consequence of hematogenous seeding of the 59Systemic Response
to Inju ry and Metabolic Suppo r t CHAPTER 2 catheter with bacteria.