Before Alexander the Great, the Greek city-states (poleis) were in decline due to shifting trade routes, civil wars, and being blocked from the West by Carthage. Philip of Macedon unified Greece and Macedonia through military victories over northern barbarians and Greeks, combining infantry and cavalry, and rallying Greeks against Persia. In 336 BC, Philip was assassinated and his son Alexander launched a war of conquest against Persia, expanding Greek control throughout Central Asia and India before his death at age 33, leaving a Hellenistic world that was a mixture of Greek and Asian influences.