The epithelial to-mesenchymal transition (EMT) in cancer-metastasis
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This slide is about role of EMT in cancer metastasis, how EMT plays a critical role in metastatic tumor development and in the last part of the slide we discuss about the role of EMT in embryonic development purpose. Slide no 1 : Describes about epithelial to mesenchymal transition. Slide no 2: Describes about molecular markers of epithelial cell and mesenchymal cell. Slide no 3 : Describes about transcription factors that induce EMT Slide no 4 : Describes about how different transcription factors will function Slide no 5 : Describes about roll of micro- RNAs in EMT Slide no 6 and 7 : Describes about signaling pathways involve in EMT Slide no 8 : Describes about roll of EMT in tumor metastasis Slide no 9 : Describes about roll of EMT in tumor microenvironment Slide no 10 and 11 : Describes about roll of EMT in embryonic development
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The tumour microenvironment consists of cells, molecules and blood vessels that surround and support tumour cells. It includes cancer-associated fibroblasts, myeloid suppressor cells, tumour infiltrating lymphocytes, and the extracellular matrix. Hypoxic conditions in the tumour microenvironment activate HIF signalling pathways and cause changes that promote cancer progression in both tumour and stromal cells. Immune cells in the microenvironment like regulatory T cells and myeloid suppressor cells suppress antitumour immune responses and help tumours escape immune surveillance. Targeting the microenvironment may be a promising approach for future cancer immunotherapies.
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3) DOT1L promotes breast cancer cell invasion and migration in vitro, and lung metastasis in vivo in orthotopic xenograft mouse models. DOT1L may promote metastasis by facilitating EMT.
Thesis-Final Draft
This document summarizes a study investigating the role of microRNA-302 in regulating retinal epithelial cell fate by targeting the TGF-β type II receptor. The study demonstrates that microRNA-302 promotes pluripotency in ARPE cells in vitro by regulating TGF-β signaling and epigenetic changes. It also shows that small molecules DZNEP and SB431542 can induce pluripotency by attenuating pathways involved in cell differentiation, supporting the potential for microRNAs and small molecules in regenerative medicine and therapeutics for diseases like diabetic retinopathy.
Vlasova_Yulia_V_Hematology_Forum
1) The role of allo-HSCT in treating patients with the T315I mutation causing resistance to tyrosine kinase inhibitors (TKIs) is still debated.
2) A retrospective analysis of 53 CML patients with the T315I mutation found 5-year overall survival was 42% but was significantly worse for those in blast crisis.
3) 16 patients received allo-HSCT with 5-year survival of 37% while pharmacological therapy alone (TKIs or other drugs) resulted in 42% 5-year survival, showing allo-HSCT may be a potential option for select patients in chronic phase.
University of Missouri - Columbia, POSH Inhibitor-Based Cancer Therapy
This document summarizes research into developing a non-toxic cancer treatment by inhibiting POSH and JNK1/JNK2. The treatment shows promise in killing various leukemia and lymphoma cell lines as well as drug-resistant cancer cells in mice. It may also have applications for autoimmune diseases and viral infections by selectively eliminating T-cells and reducing HIV viral release. Next steps include further testing in mice and canines along with developing targeted delivery methods before potential human trials. The researchers are seeking partners for licensing, sponsored research, and collaboration.
So, Who Hopes For A Piece Of Protease ?
This document summarizes several novel mutations that have been discovered in myeloproliferative neoplasms (MPNs) including JAK2, MPL, TET2, ASXL1, CBL, IDH, and IKZF1. The mutations have different frequencies in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The functional consequences of these mutations include deregulated JAK-STAT signaling, epigenetic changes, and abnormal protein accumulation, but how they contribute to disease initiation and progression is still unclear. The document focuses on describing the mutations and their associations with the various MPN diseases.
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
This document presents a case report of a rare occurrence of simultaneous diffuse large B-cell lymphoma (DLBCL) and multiple myeloma in a 70-year-old man. Positron emission tomography/computed tomography (PET/CT) scanning revealed discrepancies in fluorodeoxyglucose (FDG) uptake between myelomatous bone lesions and an inguinal lymph node. Biopsy of the lymph node confirmed DLBCL. The case highlights the important role of PET/CT scanning in determining the optimal biopsy site when evaluating patients for potential dual hematological malignancies. PET/CT scanning can help guide diagnosis and treatment planning in these complex cases.
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Simultaneous presentation of two lymphatic haematological malignancies is extremely rare. Adequate and optimal diagnostic steps including various imaging techniques and histopathological biopsies are required unpin the exact diagnoses to be able to deliver the best management strategies...
Critical_Role_of_PET_Scan_in_Unravelling.pdf
The simultaneous occurrence of two lymphatic malignancies in
one patient is extremely rare with an incidence rate of 1.4–6.5
cases/1,000,000 individuals [8]. Co-existence of MM and other
lymphoid malignancies like Chronic Lymphocytic Leukemia (CLL)
[9], MM and Hodgkin’s Disease (HD) [10], MM and Lympho
Plasmacytic Lymphoma (LPL) [11] has been reported. However,
there are less than 5 reported cases in PubMed of simultaneous
presentation of DLBCL and MM
Similar to The epithelial to-mesenchymal transition (EMT) in cancer-metastasis (20)
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
A 43-Year-Old Male with PCM1-JAK2 Gene Fusion Experienced T-Lymphoblastic Lym...
Comprehensive assessment of chamber-specific and transmural heterogeneity in ...
Comprehensive assessment of chamber-specific and transmural heterogeneity in ...
University of Missouri - Columbia, POSH Inhibitor-Based Cancer Therapy
University of Missouri - Columbia, POSH Inhibitor-Based Cancer Therapy
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
Critical Role of PET-Scan in Unravelling the Dual Pathology- Review of Litera...
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一比一原版美国佩斯大学毕业证如何办理
原版一模一样【微信：741003700 】【美国佩斯大学毕业证成绩单】【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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办理美国佩斯大学毕业证【微信：741003700 】外观非常简单，由纸质材料制成，上面印有校徽、校名、毕业生姓名、专业等信息。
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Anti-Universe And Emergent Gravity and the Dark Universe
Recent theoretical progress indicates that spacetime and gravity emerge together from the entanglement structure of an underlying microscopic theory. These ideas are best understood in Anti-de Sitter space, where they rely on the area law for entanglement entropy. The extension to de Sitter space requires taking into account the entropy and temperature associated with the cosmological horizon. Using insights from string theory, black hole physics and quantum information theory we argue that the positive dark energy leads to a thermal volume law contribution to the entropy that overtakes the area law precisely at the cosmological horizon. Due to the competition between area and volume law entanglement the microscopic de Sitter states do not thermalise at sub-Hubble scales: they exhibit memory effects in the form of an entropy displacement caused by matter. The emergent laws of gravity contain an additional ‘dark’ gravitational force describing the ‘elastic’ response due to the entropy displacement. We derive an estimate of the strength of this extra force in terms of the baryonic mass, Newton’s constant and the Hubble acceleration scale a0 = cH0, and provide evidence for the fact that this additional ‘dark gravity force’ explains the observed phenomena in galaxies and clusters currently attributed to dark matter.
Mites,Slug,Snail_Infesting agricultural crops.pdf
Order : Trombidiformes (Acarina) Class : Arachnida
Mites normally feed on the undersurface of the leaves but the symptoms are more easily seen on the uppersurface.
Tetranychids produce blotching (Spots) on the leaf-surface.
Tarsonemids and Eriophyids produce distortion (twist), puckering (Folds) or stunting (Short) of leaves.
Eriophyids produce distinct galls or blisters (fluid-filled sac in the outer layer)
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
I am the PhD scholar of FND department, Assam down town University
SDSS1335+0728: The awakening of a ∼ 106M⊙ black hole⋆
Context. The early-type galaxy SDSS J133519.91+072807.4 (hereafter SDSS1335+0728), which had exhibited no prior optical variations during the preceding two decades, began showing significant nuclear variability in the Zwicky Transient Facility (ZTF) alert stream from December 2019 (as ZTF19acnskyy). This variability behaviour, coupled with the host-galaxy properties, suggests that SDSS1335+0728 hosts a ∼ 106M⊙ black hole (BH) that is currently in the process of ‘turning on’. Aims. We present a multi-wavelength photometric analysis and spectroscopic follow-up performed with the aim of better understanding the origin of the nuclear variations detected in SDSS1335+0728. Methods. We used archival photometry (from WISE, 2MASS, SDSS, GALEX, eROSITA) and spectroscopic data (from SDSS and LAMOST) to study the state of SDSS1335+0728 prior to December 2019, and new observations from Swift, SOAR/Goodman, VLT/X-shooter, and Keck/LRIS taken after its turn-on to characterise its current state. We analysed the variability of SDSS1335+0728 in the X-ray/UV/optical/mid-infrared range, modelled its spectral energy distribution prior to and after December 2019, and studied the evolution of its UV/optical spectra. Results. From our multi-wavelength photometric analysis, we find that: (a) since 2021, the UV flux (from Swift/UVOT observations) is four times brighter than the flux reported by GALEX in 2004; (b) since June 2022, the mid-infrared flux has risen more than two times, and the W1−W2 WISE colour has become redder; and (c) since February 2024, the source has begun showing X-ray emission. From our spectroscopic follow-up, we see that (i) the narrow emission line ratios are now consistent with a more energetic ionising continuum; (ii) broad emission lines are not detected; and (iii) the [OIII] line increased its flux ∼ 3.6 years after the first ZTF alert, which implies a relatively compact narrow-line-emitting region. Conclusions. We conclude that the variations observed in SDSS1335+0728 could be either explained by a ∼ 106M⊙ AGN that is just turning on or by an exotic tidal disruption event (TDE). If the former is true, SDSS1335+0728 is one of the strongest cases of an AGNobserved in the process of activating. If the latter were found to be the case, it would correspond to the longest and faintest TDE ever observed (or another class of still unknown nuclear transient). Future observations of SDSS1335+0728 are crucial to further understand its behaviour. Key words. galaxies: active– accretion, accretion discs– galaxies: individual: SDSS J133519.91+072807.4
Embracing Deep Variability For Reproducibility and Replicability
Embracing Deep Variability For Reproducibility and ReplicabilityUniversity of Rennes, INSA Rennes, Inria/IRISA, CNRS
Embracing Deep Variability For Reproducibility and Replicability
Abstract: Reproducibility (aka determinism in some cases) constitutes a fundamental aspect in various fields of computer science, such as floating-point computations in numerical analysis and simulation, concurrency models in parallelism, reproducible builds for third parties integration and packaging, and containerization for execution environments. These concepts, while pervasive across diverse concerns, often exhibit intricate inter-dependencies, making it challenging to achieve a comprehensive understanding. In this short and vision paper we delve into the application of software engineering techniques, specifically variability management, to systematically identify and explicit points of variability that may give rise to reproducibility issues (eg language, libraries, compiler, virtual machine, OS, environment variables, etc). The primary objectives are: i) gaining insights into the variability layers and their possible interactions, ii) capturing and documenting configurations for the sake of reproducibility, and iii) exploring diverse configurations to replicate, and hence validate and ensure the robustness of results. By adopting these methodologies, we aim to address the complexities associated with reproducibility and replicability in modern software systems and environments, facilitating a more comprehensive and nuanced perspective on these critical aspects.
https://hal.science/hal-04582287
seed production, Nursery & Gardening.pdf
This presentation offers a general idea of the structure of seed, seed production, management of seeds and its allied technologies. It also offers the concept of gene erosion and the practices used to control it. Nursery and gardening have been widely explored along with their importance in the related domain.
Methods of grain storage Structures in India.pdf
•Post-harvestlossesaccountforabout10%oftotalfoodgrainsduetounscientificstorage,insects,rodents,micro-organismsetc.,
•Totalfoodgrainproductioninindiais311milliontonnesandstorageis145mt.InIndia,annualstoragelosseshavebeenestimated14mtworthofRs.7,000croreinwhichinsectsaloneaccountfornearlyRs.1,300crores.
•InIndiaoutofthetotalproduction,about30%ismarketablesurplus
•Remaining70%isretainedandstoredbyfarmersforconsumption,seed,feed.Hence,growerneedstoragefacilitytoholdaportionofproducetosellwhenthemarketingpriceisfavourable
•TradersandCo-operativesatmarketcentresneedstoragestructurestoholdgrainswhenthetransportfacilityisinadequate
TOPIC OF DISCUSSION: CENTRIFUGATION SLIDESHARE.pptx
Centrifugation is a powerful technique used in laboratories to separate components of a heterogeneous mixture based on their density. This process utilizes centrifugal force to rapidly spin samples, causing denser particles to migrate outward more quickly than lighter ones. As a result, distinct layers form within the sample tube, allowing for easy isolation and purification of target substances.
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
ABSTRACT
The J'BaFofi, or "Giant Spider," is a mainly legendary arachnid by reportedly inhabiting the dense rain forests of
the Congo. As despite numerous anecdotal accounts and cultural references, the scientific validation remains more elusive.
My study aims to proper evaluate the existence of the J'BaFofi through the analysis of historical reports,indigenous
testimonies and modern exploration efforts.
Explainable Deepfake Image/Video Detection
Presentation of our paper, "Towards Quantitative Evaluation of Explainable AI Methods for Deepfake Detection", by K. Tsigos, E. Apostolidis, S. Baxevanakis, S. Papadopoulos, V. Mezaris. Presented at the ACM Int. Workshop on Multimedia AI against Disinformation (MAD’24) of the ACM Int. Conf. on Multimedia Retrieval (ICMR’24), Thailand, June 2024. https://doi.org/10.1145/3643491.3660292 https://arxiv.org/abs/2404.18649
Software available at https://github.com/IDT-ITI/XAI-Deepfakes
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Magmatic iron-meteorite parent bodies are the earliest planetesimals in the Solar System,and they preserve information about conditions and planet-forming processes in thesolar nebula. In this study, we include comprehensive elemental compositions andfractional-crystallization modeling for iron meteorites from the cores of five differenti-ated asteroids from the inner Solar System. Together with previous results of metalliccores from the outer Solar System, we conclude that asteroidal cores from the outerSolar System have smaller sizes, elevated siderophile-element abundances, and simplercrystallization processes than those from the inner Solar System. These differences arerelated to the formation locations of the parent asteroids because the solar protoplane-tary disk varied in redox conditions, elemental distributions, and dynamics at differentheliocentric distances. Using highly siderophile-element data from iron meteorites, wereconstruct the distribution of calcium-aluminum-rich inclusions (CAIs) across theprotoplanetary disk within the first million years of Solar-System history. CAIs, the firstsolids to condense in the Solar System, formed close to the Sun. They were, however,concentrated within the outer disk and depleted within the inner disk. Future modelsof the structure and evolution of the protoplanetary disk should account for this dis-tribution pattern of CAIs.
Farming systems analysis: what have we learnt?.pptx
Presentation given at the official farewell of Prof Ken Gillet at Wageningen on 13 June 2024
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Anti-Universe And Emergent Gravity and the Dark Universe
Anti-Universe And Emergent Gravity and the Dark Universe
Introduction_Ch_01_Biotech Biotechnology course .pptx
Introduction_Ch_01_Biotech Biotechnology course .pptx
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
SDSS1335+0728: The awakening of a ∼ 106M⊙ black hole⋆
SDSS1335+0728: The awakening of a ∼ 106M⊙ black hole⋆
Embracing Deep Variability For Reproducibility and Replicability
Embracing Deep Variability For Reproducibility and Replicability
TOPIC OF DISCUSSION: CENTRIFUGATION SLIDESHARE.pptx
TOPIC OF DISCUSSION: CENTRIFUGATION SLIDESHARE.pptx
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Nutaceuticsls herbal drug technology CVS, cancer.pptx
Nutaceuticsls herbal drug technology CVS, cancer.pptx
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Compositions of iron-meteorite parent bodies constrainthe structure of the pr...
Farming systems analysis: what have we learnt?.pptx
Farming systems analysis: what have we learnt?.pptx
The epithelial to-mesenchymal transition (EMT) in cancer-metastasis
- 1. The Epithelial- to-Mesenchymal Transition (EMT) in Cancer Arka Laha Semester 5th Session 2019-20 B.Sc in Microbiology Registration Number KNU19111001115 Depertment of Microbiology Michael Madhusudan Memorial College
- 2. Epithelial to mesenchymal transition : Reference : Nieto MA, Huang RY, Jackson RA, Thiery JP. EMT: 2016. Cell. 2016 Jun 30;166(1):21-45. doi: 10.1016/j.cell.2016.06.028. PMID: 27368099.
- 3. Molecular markers of Epithelial cells and Mesenchymal cells : ● Cells have front back polarity ● Cells have apico- basal polarity Reference:Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84. doi: 10.1038/s41580-018-0080-4. PMID: 30459476.
- 4. Transcription factors that induce EMT : Signals of EMT EMT inducing transcription factors : Snail1,Snail2,ZEB1,ZEB2,Twist1, Twist2, LEF-1 Inhibit the epithelial gene expression and activate the mesenchymal gene expression GENE Regulatory sequence Activated transcription factor External signals Gene expression modulation m- RNA Protein ● Transcription factors can both activator as well as repressor Reference : Gonzalez DM, Medici D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 2014 Sep 23;7(344):re8. doi: 10.1126/scisignal.2005189. PMID: 25249658; PMCID: PMC4372086.
- 5. How transcription factors will function : SNAIL (Snail1,Snail2) Twist1,Twist2 ZEB (ZEB1 and ZEB2 LEF -1 Repress the transcription of E.cadherin by binding with the promoter region of CDH1 gene Twist1 + BMI 1 polycomb group repressor complex protein acts on E- cadherin and inhibit p16INK4aplha , also repress several mi- RNAs (HOXD1 Inhibition) Repress the CDH1 gene work on E-Box promoter , co-operate with deacetylase sirtuin1 modifying histone H3 and reduce the binding of RNA pol ii at the CDH1 promoter , repress the plakophilin-2 and ZO-3 dis association of adherens junction It directly induce EMT repress the expression of E- cadherin and also active the beta - catenin
- 6. Roll of micro-RNAs in EMT : TWIST1 SNAIL2 ZEB SNAIL1 miRNA-30 miRNA-29 miRNA-203 miRNA-34 miRNA-200 miRNA-205 miRNA-203 miRNA-204
- 7. Signaling Pathways involve in EMT : Gene expression of vimentin ,fibronectin ,SNAILN,SLUG,ZEB,TWI T
- 8. Signaling Pathways involve in EMT :
- 9. EMT in tumor metastisis : Reference: Mittal V. Epithelial Mesenchymal Transition in Tumor Metastasis. Annu Rev Pathol. 2018 Jan 24;13:395-412. doi: 10.1146/annurev-pathol-020117-043854. PMID: 29414248.
- 10. Tumor microenvironment and EMT : ● Inflammation as an inducer of tumor EMT : TAMs produced TNF- alph ,IL-1 ● Role of hypoxia and oxidative stress in EMT :HIF signals the activation of Snail, mitochondria produce ROS in this induce cancer in certain cells Reference :Epithelial-Mesenchymal Transition in tumor microenvironment .Yingying Jing, Zhipeng Han, Shanshan Zhang, Yan Liu and Lixin Wei*
- 11. Reference: Role of the epithelial–mesenchymal transition and its effects on embryonic stem cells Ye-Seul Kim1, Bo-Rim Yi1, Nam-Hyung Kim2 and Kyung-Chul Choi1 EMT and development :
- 13. Thank you