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The Effect of Physical Activity on
Alzheimer’s Disease
Belinda Brown
Benefits of Physical Activity
• Benefits of regular physical activity;
 Prevents cardiovascular disease
 Increases independence
 Reduces body weight
 Alleviation of depression
Physical Activity Levels in Australia
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Delay AD
Physical Activity and Memory
Source: Fabre et al, 2002
• French Study
• Physical and Mental
Activity improved
cognition
• Eight people per
group
• Only outcome was
cognition
Physical Exercise and Cognitive Stimulation (PEACS)
• 200 participants; 50 allocated to each trial group
▫ Control Group
▫ Physical Activity
▫ Cognitive Stimulation (2 programmes from POSIT Science)
▫ Combined PA+CS
• Each individual undertakes;
▫ Memory tests
▫ Blood testing
▫ Activity Monitor Assessment
• Sub-groups;
▫ PET brain imaging
▫ CSF collection (Lumbar Puncture)
▫ DEXA Scanning (Body Composition)
▫ Physical Fitness Assessments
Lowest intensity activity = Lowest
memory score
Highest intensity activity =
Highest memory score
Our Research....
0
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Prevent AD
0 20 40 60 80
Genetic Risk
Factors
Risk Factors
Protective Factors
High
Education
Socio-Economic
Status Factors
Life Habits (eg smoking), hypertension,
occupation, depression, head trauma
Physical Activity Diet
Rich social networks
Mental ActivitiesDiet
Protective factor at mid-life and late-life
Physical Activity and Onset Delay of AD
Source: Larson et al 2006
Those exercising
more than three
times a week, are
more likely to be
dementia free as
they age
DementiaRisk
More Exercise = Less Dementia Risk
Our Research....
• Collecting longitudinal data every 18 months to
find out;
▫ Do individuals that exercise, have a less chance of
developing Alzheimer’s in the future?
▫ Do individuals that go from being sedentary to
physically active, still receive the benefit of reduce
AD risk?
Physical Activity and Cognition/Memory
Physical Activity and Dementia/Alzheimer’s Disease
How Physical Activity May Prevent AD
Decrease in Amyloid – Mouse Model
Source: Adlard, P. A. et al
The effect of exercise on Amyloid-β load in three different brain
regions of transgenic mice
Decrease in Amyloid – Our Research...
0
Lowest activity = highest Aβ
Highest activity = lowest Aβ
Some other ideas....
• Increase in brain-derived neurotrophic factor
(BDNF)
▫ Stimulates growth of new brain cells
▫ Improves learning and mental performance
• Increase in synaptic plasticity (ability of brain
to learn and remember)
• Reduces risk of Cardiovascular Disease
and Type II Diabetes
• You don’t have to be an elite
athlete
• Benefits can be gained from 30
minutes exercise daily
• More pronounced benefit when
intensity is higher
No matter what age you are, your life-style
choices may contribute to the risk of AD
Beyond increases to cognition, physical activity
can aid in many aspects of health and increase
function and independence

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The Effect of Physical Activity on Alzheimer's Disease

  • 1. The Effect of Physical Activity on Alzheimer’s Disease Belinda Brown
  • 2. Benefits of Physical Activity • Benefits of regular physical activity;  Prevents cardiovascular disease  Increases independence  Reduces body weight  Alleviation of depression
  • 4.
  • 5. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Delay AD
  • 6. Physical Activity and Memory Source: Fabre et al, 2002 • French Study • Physical and Mental Activity improved cognition • Eight people per group • Only outcome was cognition
  • 7. Physical Exercise and Cognitive Stimulation (PEACS) • 200 participants; 50 allocated to each trial group ▫ Control Group ▫ Physical Activity ▫ Cognitive Stimulation (2 programmes from POSIT Science) ▫ Combined PA+CS • Each individual undertakes; ▫ Memory tests ▫ Blood testing ▫ Activity Monitor Assessment • Sub-groups; ▫ PET brain imaging ▫ CSF collection (Lumbar Puncture) ▫ DEXA Scanning (Body Composition) ▫ Physical Fitness Assessments
  • 8. Lowest intensity activity = Lowest memory score Highest intensity activity = Highest memory score Our Research.... 0
  • 9. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Prevent AD
  • 10. 0 20 40 60 80 Genetic Risk Factors Risk Factors Protective Factors High Education Socio-Economic Status Factors Life Habits (eg smoking), hypertension, occupation, depression, head trauma Physical Activity Diet Rich social networks Mental ActivitiesDiet Protective factor at mid-life and late-life
  • 11. Physical Activity and Onset Delay of AD Source: Larson et al 2006 Those exercising more than three times a week, are more likely to be dementia free as they age DementiaRisk More Exercise = Less Dementia Risk
  • 12. Our Research.... • Collecting longitudinal data every 18 months to find out; ▫ Do individuals that exercise, have a less chance of developing Alzheimer’s in the future? ▫ Do individuals that go from being sedentary to physically active, still receive the benefit of reduce AD risk?
  • 13. Physical Activity and Cognition/Memory Physical Activity and Dementia/Alzheimer’s Disease How Physical Activity May Prevent AD
  • 14. Decrease in Amyloid – Mouse Model Source: Adlard, P. A. et al The effect of exercise on Amyloid-β load in three different brain regions of transgenic mice
  • 15. Decrease in Amyloid – Our Research... 0 Lowest activity = highest Aβ Highest activity = lowest Aβ
  • 16. Some other ideas.... • Increase in brain-derived neurotrophic factor (BDNF) ▫ Stimulates growth of new brain cells ▫ Improves learning and mental performance • Increase in synaptic plasticity (ability of brain to learn and remember) • Reduces risk of Cardiovascular Disease and Type II Diabetes
  • 17. • You don’t have to be an elite athlete • Benefits can be gained from 30 minutes exercise daily • More pronounced benefit when intensity is higher
  • 18. No matter what age you are, your life-style choices may contribute to the risk of AD Beyond increases to cognition, physical activity can aid in many aspects of health and increase function and independence

Editor's Notes

  1. 14