Presented at the Fall ACS 2015 #CINF session "The Growing Impact of Openness in Chemistry: A Symposium in Honor of JC Bradley"

1. The
context
of
crowdsourcing:
A
driver
of
organiza7onal
openness?
David
C.
Thompson
Jörg
Bentzien

3. Weak
• A
loosely
connected
network
of
individuals
who,
through
internet
enabled
services
and
community,
can
be
engaged
in
a
full
spectrum
of
ac7vi7es
ranging
from
micro-­‐
task
through
to
mul7-­‐hour
research
project.
• Such
actors
may
associate
with
skills-­‐based
communi7es
that
have
no
connec7on
with
the
pharmaceu7cal
industry,
or
healthcare.

4. Jörg
Bentzien,
Ingo
Muegge,
Ben
Hamner,
and
David
C.
Thompson,
“Crowd
compu7ng:
Using
compe77ve
dynamics
to
develop
and
refine
highly
predic7ve
models”
Drug
Discov.
Today.
18
472
(2013)

5. “What is described is a process for
organizational Exploration in the face of the
need to determine objective solutions. The
process uses the dynamics of ‘Exploit’, to
enable Exploration in an open and
transparent fashion. What is described will
not replace the scientific method, or robust
hypothesis generation and evaluation. In
our experience this process generated a
host of solutions that are statistically
equivalent, and of a variety of different
complexities of implementation.”
“We
don’t
know
it
all:
Crowd
compu7ng
to
develop
and
refine
predic7ve
in
silico
models”,
Jörg
Bentzien,
David
C.
Thompson,
and
Ingo
Muegge,
The
Gordon
Research
Conference
on
Computer-­‐Aided
Drug
Design,
West
Dover,
VT
(2013)

8. Open
Science
• Scien7sts
need
to
be
more
open
among
themselves
and
with
the
public
and
media
• Greater
recogni7on
needs
to
be
given
to
the
value
of
data
gathering,
analysis
and
communica7on
• Common
standards
for
sharing
informa7on
are
required
to
make
it
widely
usable
• Publishing
data
in
a
reusable
form
to
support
findings
must
be
mandatory
• More
experts
in
managing
and
suppor7ng
the
use
of
digital
data
are
required
• New
sobware
tools
need
to
be
developed
to
analyze
the
growing
amount
of
data
being
gathered.
Royal
Society
(Great
Britain).,
and
Policy
Studies
Unit.
2012.
Science
as
an
Open
Enterprise.

10. Consor7um
Fa7gue
“We
need
an
evidence-­‐based
approach
-­‐
a
science
of
collabora7on
-­‐
to
evaluate
and
inform
the
evolving
mul7-­‐stakeholder
collabora7on
environment
in
biomedical
innova7on.”
Papadaki,
M.
and
Hirsch,
G.
(2013)
Curing
Consor7um
Fa7gue,
Sci.
Transl.
Med.
5,
200fs35.

11. hfps://xkcd.com/244/

12. hfp://www.ny7mes.com/2015/04/14/health/the-­‐tangle-­‐of-­‐coordinated-­‐health-­‐care.html

13. [RITTEL]

14. “In
a
pluralis7c
society
there
is
nothing
like
the
undisputable
public
good”
[RITTEL,
p156]

15. [RITTEL,
p156]
“There
is
no
objec7ve
defini7on
of
equity”

16. Gelng
the
fit
right
Weak
Par5al
Strong
Abstract
coupling
constant
Drug
Discov.
Today.
2015
Jan
27.
pii:
S1359-­‐6446(15)00033-­‐1.
doi:
10.1016/j.drudis.2015.01.011

17. Stuff
to
think
about
• The
act
of
scien7fic
innova7on
is
technically
complex,
and
…
• embedded
in
a
sociological
system
that
is
itself
a
wicked
problem
• Sustainable
progress
will
require
thinking
how
work
can
be
structured
around
these
observa7ons
• There
are
strategies
to
cope
with
wickedness
that
depend
on
how
power
is
distributed
throughout
a
system
…
which
also
impacts
the
openness
of
the
system
Roberts,
N.
(2000)
Wicked
problems
and
network
approaches
to
resolu7on,
Interna7onal
Public
Management
Review,
1
(1-­‐19)