The changing face of canine pyoderma- new strategies for control
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This document summarizes a webinar on the changing face of canine pyoderma (bacterial skin infections in dogs) and strategies for control. It discusses why dogs are prone to pyoderma due to defective natural defenses. It also covers classification of pyoderma, clinical signs, diagnosis, treatment including antibiotics and alternatives, and problems with antibiotic resistance. The webinar aims to educate veterinarians on pyoderma identification, treatment, and prevention of further resistance issues.
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The changing face of canine pyoderma- new strategies for control
- 1. The Changing Face of Canine Pyoderma- New Strategies for Control Anthony Chadwick BVSc CertVD MRCVS The Webinar Vet
- 3. David Lloyd • Antibiotic stewardship CPD should be obligatory • FECAVA conference Dublin 2012
- 4. Ian Mason “The dog is a pyoderma waiting to happen”
- 5. What we are covering this afternoon • Why is the dog a pyoderma waiting to happen? • Classification of pyoderma • Clinical signs • Diagnosis of pyoderma- ddx • Treatment • Problems with resistance
- 6. Why?
- 7. Normal defence mechanisms defective • Physical • Chemical • Microbial
- 8. A Pathogenic Staphylococcus • S pseudintermedius • Bacteria produces a variety of substances including enterotoxins, toxic shock protein, protein A and haemolysins • Increase adhesion to keratinocytes • Act as superantigens and upregulate the immunological responses • Some strains produce slime which encapsulate the bacteria and inhibit phagocytosis whilst increasing its ability to adhere
- 10. Classification of pyoderma • Surface • Superficial • Deep
- 11. Surface pyodermas • Pyotraumatic dermatitis • Intertrigo(skin fold pyoderma) • Impetigo
- 12. Superficial pyodermas • Superficial bacterial folliculitis • Mucocutaneous pyoderma
- 13. Deep pyodermas • Deep folliculitis/furunculosis • Deep pyotraumatic furunculosis • Nasal folliculitis/furunculosis • Pedal furunculosis • GSD pyoderma • Acral lick dermatitis • Abscesses and granulomas
- 14. Clinical signs
- 15. Clinical signs
- 22. Diagnosis • Cytology • Culture and sensitivity • Biopsy
- 26. What is your most likely diagnosis? • Acute Pyoderma • Demodicosis • Chronic pyoderma • Mycosis fungoides • Pemphigus foliaceous
- 28. Differential Diagnosis Pyoderma is always a secondary disease
- 29. Differentials • Allergy • Ectoparasite • Endocrine
- 30. How long would you treat a pyoderma case? • 7 days • 7-14 days • 15-21 days • 22-30 days • Longer than 1 month
- 31. Treatment • Systemic • Topical
- 32. Systemic Treatments • Antibiotics • Staphage lysate • Autogenous vaccines
- 33. Topical Treatments • Shampoos • Creams • Ointments
- 34. Antibiotics • Potentiated sulphonamides 15-30mg/kg bid • Clindamycin 11mg/kg sid • Potentiated amoxicillin 12.5mg/kg bid • Cephalexin 15-30mg/kg bid • Cefovecin 8mg/kg ev 14 days • Enrofloxacin 5mg/kg sid • Marbofloxacin 2mg/kg sid
- 36. Cefovecin • Can increase compliance • But sub-optimal levels of antibiotic after the 2 weeks • Is a 3rd generation cephalosporin
- 37. Staphage lysate • Stimulates both humoral and cellular immunity • 1 study showed 77% of dogs had significant benefits
- 38. Autogenous vaccines • Prepared individually for each dog from a culture • Given with antibiotics and then weaned off antibiotics • Speak to RVC • Particularly useful in cases of recurrent idiopathic pyoderma
- 46. Shampoos • Ethyl Lactate • Chlorhexidine • Benzoyl peroxide
- 47. Creams • Fusidic acid • Mupirocin
- 48. Problems with Resistance Ollie 3yo
- 49. Ollie 3yo Bulldog • Pyoderma caused by MRSP • Sensitive to doxycycline • Treated with chlorhexidine shampoo
- 50. Lab reports
- 51. MRSA and MRSP How often have you seen a resistant case this year • 0 • 1-2 • 3-5 • 6-10 • More than 10
- 52. Methicillin resistance • First reported in 1960s • Due to a mecA gene encoding an altered PBP • S aureus human pathogen • S pseudintermedius companion animal pathogen • More of a problem in USA and Europe but coming
- 53. How can we prevent • Better hygiene in the practice. • Use less antibiotics where possible. • Higher doses and for longer times. • Use appropriate antibiotic for pyoderma. • Teach compliance. • Don’t use corticosteroids at the same time
- 54. Do you use something milky for your cat speys? • Yes • No
- 55. Thanks • David Lloyd • Tony Liepman at Animalcare • You for listening
- 56. Any Questions?