The document describes the anatomy of the anterior compartment of the arm. It contains the coracobrachialis, biceps brachii, and brachialis muscles. The brachial artery and musculocutaneous, median, ulnar, and radial nerves also pass through this compartment. It provides details on the origin, insertion, nerve supply, and actions of the coracobrachialis and biceps brachii muscles. Additionally, it discusses the course and branches of the musculocutaneous nerve.
brachial plexus, branches of brachial plexus, main nerves of brachial plexus and their innervations, disorders of brachial plexus injury, Erb's palsy, Klumpke's palsy, compression of brachial plexus
anatomy of arm of human beings with its muscles, nerves and action of muscles . origin , insertion,nerve supply and action of different muscles of arm. brachial artery
Anatomy of brachial plexus explained in detail along with nerve supply of all the muscles of upper limb and various paralysis caused by brachial plexus injury
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
2. INTRODUCTION
• The arm extends from
the shoulder joint till
the elbow joint. The
skeleton of the arm is a
solo bone, the
humerus.
3. • The arm or brachium is
enveloped by a sleeve of
deep fascia (brachial
fascia),which projects
into its interior as medial
and lateral inter-
muscular septa and
divides the arm into an
anterior or flexor
compartment and a
posterior or extensor
compartment.
• These septa are well
defined in the lower part
of the arm and provide
additional areas for the
attachments of muscles.
8. BICEPS BRACHII
• It is an elongated
fusiform muscle and
arises by two
tendinous heads, short
and long.
• ORIGIN:
1. SHORT HEAD –tip of
the coracoid process
2. LONG HEAD – arises
from supraglenoid
tubercle of scapula
and from glenoid
labrum.
9. INSERTION:
Short head – posterior
rough part of radial
tuberosity.
Long head – tendon
gives off an
extension called
bicipital
aponeurosis. This
merge with deep
fascia of forearm
10. ACTION:
1. It is strong supinator when
the forearm is flexed, all
screwing movements are
done with it.
2. It is flexor of elbow
3. The short head is flexor of
arm
4. Long head prevents upwards
displacement of head of
humerus
11. BRACHIALIS
ORIGIN:
1. lower half of front of humerus,
including both Antero-medial and
antero-lateral surfaces and
anterior border.
2. Superiorly It embraces the
insertion of deltoid
3. Medial and lateral intermuscular
septa
INSERTION:
1. Ulnar tuberosity
2. Rough anterior surface of
coronoid process of ulna
13. CORACOBRACHIALIS
MORPHOLOGY :
The coracobrachialis represent an
adductor muscle of the arm, but such
action insignificant in man.
• In some animals it is tricipital in origin.
In man upper two heads are fused to
take origin from the coracoid process
and enclose the musculo-cuteneous
nerve between them.
14. The lower head is usually
suppressed in man. sometime
it is represented by a fibrous
band, the ligament of
Struthers, which extend from
trochlear spine to medial
epicondyle of humerus
Median nerve or brachial
artery may pass below the
ligament which compresses
upon them producing
vascular spasm or median
nerve palsy
15. ANATOMICAL EVENTS AT THE LEVEL OF THE INSERTION OF
CORACOBRACHIALIS:
• Bone:
the
circular
shaft
becomes
triangular
below
this level.
16. Fascial septa: the
medial and lateral
inter-muscular
septa become
better defined
from this level
down.
ANATOMICAL EVENTS AT THE LEVEL OF THE INSERTION OF
CORACOBRACHIALIS:
19. • The profunda
brachii artery
runs in the
spiral groove
and divides
into its
anterior
descending(
radial
collateral
artery) and
posterior
descending(
middle
collateral
artery)
branches.
20. • The superior
ulnar collateral
artery originate
from the
brachial artery,
and pierces the
medial inter-
muscular
septum with
the ulnar nerve.
• The nuterient
artery of the
humerus enters
the bone
21. VEINS:
i. The basilic vein pierces the
deep fascia.
ii. Two venae comitants of the
brachial artery may unite to
form one brachial vein.
22. • NERVES:
• The median
nerve crosses the
brachial artery
from the lateral
to the medial
side.
• The ulnar nerve
pierces the
medial inter-
muscular septum
with the superior
ulnar collateral
artery and goes
to the posterior
compartment.
23. • The radial nerve
pierces the lateral
inter-muscular
septum with the
anterior descending
(radial collateral)
branch of the
profunda brachii
artery and passes
from the posterior to
the anterior
compartment.
• The medial cutaneous
nerve of the arm
pierces the deep
fascia.
• The medial cuteneous
nerve of the forearm
pierces the deep
fascia.
24. Applied anatomy
• The tendon of the long head of the
biceps brachii lies within the capsule
of the shoulder joint.
• In osteoarthritis of this joint
abnormal irregular projection
develop from the bones concerned
and friction against them can lead to
inflammation. There is pain in the
shoulder.
• Damage to the tendon can end in
rupture
• The biceps tendon reflex is induced
by a tap on the biceps tendon
a) The examinar places his thumb over
the tendon and gives a tap on his
thumb.
b) There is reflex contraction of biceps
25. MUSCULO-CUTANEOUS
NERVE
• The musculo-
cutaneous nerve is the
main nerve of the front
of the arm, and
continues below as the
lateral cutaneous nerve
of the forearm.
• It is a branch of the
lateral cord of the
brachial plexus, arising
at the lower border of
the pectoralis minor
muscle(c5,c6,c7).
• ROOT VALUE: ventral
rami of c5-c7 segments
of spinal cord.
26. COURSE AND RELATIONS
• In the lower part of the axilla – the nerve initially accompanies the
third part of axillary artery ;leaves the axilla, and enters the front of
the arm by piercing the coracobrachialis.
• It has the following relations :-
Anteriorly: pectoralis major
Posteriorly: subscapularis
Medially: axillary artery and lateral root of the median nerve
Laterally :coracobrachialis
27. COURSE AND
RELATIONS
• In the arm – it runs
downward and
laterally between the
biceps and brachialis to
reach the lateral side
of the tendon of the
biceps.It ends by
piercing the fascia 2cm
above the bend of the
forearm.
28. Branches and Distribution
–
• Muscular: to the
muscles; the biceps
brachii,coracobrachialis
and brachialis.
• Articular branches: the
elbow joint through its
branches to the
brachialis
• to humerus through a
separate branch which
enters the bone along
with its nutrient artery.
29. Cutaneous:
through the lateral
cutaneous nerve of
forearm it supplies
the skin on the
front and lateral
aspect of the
forearm from the
elbow to the wrist
including the ball
of the thumb.
30. Communicating branches:
through the lateral
cutaneous nerve of forearm
communicates with the
neighbouring nerve,namely
the superficial branch of the
radial nerve,the posterior
cutaneous nerve of
forearm,and the palmar
cutaneous branch of the
median nerve.
Variations – instead of piercing
the coraco brachialis it may
pass behind it to reach
interval between biceps and
brachialis
Temporaily, it may either give
fibers to or receive fibres
from median nerve