The nasal cavity consists of bones, tissues, blood vessels, and nerves that make up the interior of the nose. It has three main functions: warming and humidifying inhaled air, acting as a barrier for the immune system, and providing the sense of smell. The nasal cavity contains three regions - the vestibule, respiratory region, and olfactory region. It is made up of 12 bones and has complex blood supply from various arteries in the head and face.
pharynx, wall of pharynx, boundaries of pharynx, parts of pharynx, blood supply lympahtic drainage, nerve supply of pharynx, potential weak ares of pharynx, muscles of pharynx, potential weak ares of pharyngeal wall
The framework of the nose consists of bone and cartilage. Two small nasal bones and extensions of the maxillae form the bridge of the nose, which is the bony portion. The remainder of the framework is cartilage and is the flexible portion. Connective tissue and skin cover the framework.
Air enters the nasal cavity from the outside through two openings: the nostrils or external nares. The openings from the nasal cavity into the pharynx are the internal nares. Nose hairs at the entrance to the nose trap large inhaled particles.
Paranasal sinuses are air-filled cavities in the frontal, maxilae, ethmoid, and sphenoid bones. These sinuses, which have the same names as the bones in which they are located, surround the nasal cavity and open into it. They function to reduce the weight of the skull, to produce mucus, and to influence voice quality by acting as resonating chambers.
pharynx, wall of pharynx, boundaries of pharynx, parts of pharynx, blood supply lympahtic drainage, nerve supply of pharynx, potential weak ares of pharynx, muscles of pharynx, potential weak ares of pharyngeal wall
The framework of the nose consists of bone and cartilage. Two small nasal bones and extensions of the maxillae form the bridge of the nose, which is the bony portion. The remainder of the framework is cartilage and is the flexible portion. Connective tissue and skin cover the framework.
Air enters the nasal cavity from the outside through two openings: the nostrils or external nares. The openings from the nasal cavity into the pharynx are the internal nares. Nose hairs at the entrance to the nose trap large inhaled particles.
Paranasal sinuses are air-filled cavities in the frontal, maxilae, ethmoid, and sphenoid bones. These sinuses, which have the same names as the bones in which they are located, surround the nasal cavity and open into it. They function to reduce the weight of the skull, to produce mucus, and to influence voice quality by acting as resonating chambers.
The pharynx is a hollow tube that starts behind the nose, goes down the neck, and ends at the top of the trachea and esophagus. The three parts of the pharynx are the nasopharynx, oropharynx, and hypopharynx.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
This presentation explains the working of the ear... It is best for medical students.. It includes all the key points necessary for an exam too... So this presentation can also be used as a notes for your exams...
The pharynx is a hollow tube that starts behind the nose, goes down the neck, and ends at the top of the trachea and esophagus. The three parts of the pharynx are the nasopharynx, oropharynx, and hypopharynx.
I have tried my level best to complete this one. Basics & subjective details as much possible, are included here with understandable diagrams, CT-scans & charts. Clinical associations with possible anatomical structures are also touched . Frequent questions based on the topic discussed, will be there at the middle & end of presentation.
If you find it helpful then please like it & if any query regarding this ppt or upcoming ppts then mail me
drsuraj1997@gmail.com
Development of the middle ear is not covered in this presentation. If you are interested then please mail me. I will try to upload it as a separate one.
This presentation explains the working of the ear... It is best for medical students.. It includes all the key points necessary for an exam too... So this presentation can also be used as a notes for your exams...
a biological system consisting of specific organs and structures used for the process of respiration in an organism, intake and exchange of oxygen and carbon dioxide between an organism and the environment, explore anatomy of the upper and lower respiratory tracts, from nasal passages to the lungs
Anatomy of respiratory system with special reference to anatomy of lungs,
mechanism of respiration, regulation of respiration
Lung Volumes and capacities transport of respiratory gases, artificial respiration,
and resuscitation methods.
The respiratory system is a biological system consisting of specific organs and structures used for the respiration process in an organism. It is involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment.
The branch of medicine that deals with the diagnosis and treatment of diseases of the ears, nose, and throat is called Otorhinolaryngology.
RESPIRATION- The oxidative process occurring within living cells by which the chemical energy of organic molecules is released in a series of metabolic steps involving the consumption of oxygen and the liberation of carbon dioxide and water is called as respiration.
In the human body, a complex network of fluids and vessels works tirelessly to transport essential substances, ensuring the proper functioning of every cell and organ. This system, known as the circulatory system, plays a vital role in distributing oxygen, nutrients, hormones, and other crucial molecules while removing waste products.
In our journey through this topic, we will explore the composition of blood, the functions of various blood components, the mechanisms of circulation, and the importance of maintaining a healthy circulatory system. Understanding body fluids and circulation is not only essential for grasping the basics of human physiology but also for appreciating the intricate balance required to sustain life.
For more information, visit-www.vavaclasses.com
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
3. The nasal cavity consists of all the bones, tissues, blood vessels
and nerves that make up the interior portion of the nose. The
most important functions of the nasal cavity include warming and
humidifying the air as you breathe and acting as a barrier for the
immune system to keep harmful microbes from entering the
body.
4. Anatomy
The inside of the nose, including the bones, cartilage and
other tissue, blood vessels and nerves, all the way back
posteriorly to the nasopharynx, is called the nasal cavity.
It is considered part of the upper respiratory tract due to
its involvement in both inspiration and exhalation.
5.
6. The Vestibule
The most anterior portion of the nasal cavity is called the
vestibule. The exterior nares, or nostrils lead into this
portion of the nasal cavity which is essentially just a
short passageway lined with hair that leads into the
respiratory region of the nasal cavity.
7. The Respiratory Region
The respiratory region makes up the largest portion of the
nasal cavity. The specialized tissue in this area functions
to aid in the respiratory process. This part of the nasal
cavity is lined with ciliated pseudo-stratified epithelium
and mucus-secreting goblet cells.
Ciliated pseudo-stratified epithelium is a type of tissue
that has tiny hairs (cilia) that project out of it and move
back and forth to sweep mucus out of the respiratory tract.
The goblet cells secrete the mucus
8.
9. The Olfactory Region
The apex (uppermost pyramidal area) of the nasal cavity
contains all of the receptors and cells necessary for
olfaction, or your sense of smell.
The Nasal Septum
The nasal septum is the wall in the middle of the nasal
respiratory cavity. It is made up of the septal cartilage,
the vomer bone, and the perpendicular plate of the ethmoid
bone. The septal cartilage sits on top of the vomer bone and
in front of the ethmoid bone, which it joins further back.
10. Bones
There are 12 bones that contribute to the structure of the nasal cavity. They
are the nasal bone, maxilla, sphenoid, vomer, palatine, lacrimal, and ethmoid
bones. The first four bones listed are paired (two on each side) The ethmoid
bone makes up the largest portion of the nasal cavity.
The Turbinates
Inside the nasal cavity are three curved shelves of bone called turbinates or
nasal conchae. They project from the lateral walls of the cavity and are called
the superior, middle and inferior turbinates. The space between the turbinates
is called the meatus. The superior turbinate projects from the ethmoid bone and
is somewhat separate from the other two turbinates.
Nerves
There are many nerves that are involved in the function of the nasal cavity.
Some of the most notable include the olfactory nerve, nasopalatine nerve,
trigeminal nerve, and nasociliary nerve.
11. Blood Vessels
The nasal cavity has a vast and complicated blood supply. Most of the vessels
that supply the nasal cavity branch off from the carotid artery and include the
anterior ethmoidal artery, posterior ethmoidal artery, sphenopalatine artery,
tgreater palatine artery, superior labial artery, and lateral nasal arteries.
These arteries form connections with each other called anastomoses. The
blood vessels in the nasal cavity are essential to the function of warming and
humidification of the air you breathe. Blood is carried away from the nasal
cavity via a network of veins that drain into the pterygoid plexus, facial vein, or
cavernous sinus. Anatomical differences may be found in the blood vessels that
supply and drain the nasal cavities. For example, some individuals may be born
with nasal veins that join with the sagittal sinus