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The document discusses the immune system and its defenses against pathogens. It covers three groups: 1) the non-specific first line defenses of the skin, mucus, and cilia, 2) the inflammatory response involving cells like macrophages, mast cells, and cytokines, and 3) the specific adaptive immune response involving T cells, B cells, antibodies, and memory cells that provide long-term protection against pathogens.
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Immunosurveillance
The document discusses immunosurveillance, which refers to the immune system's ability to detect and eliminate cancer cells. It describes how innate and adaptive immunity both play roles in immunosurveillance. Innate immune cells like NK cells help provide initial detection of stressed or cancerous cells. Adaptive immune responses generate antigen-specific T cells that can recognize and attack tumor cells. However, cancer cells have developed mechanisms to evade the immune system, such as shedding antigens, producing immunosuppressive cytokines, or proliferating too quickly for immune responses to control. The interplay between the immune system and cancer cells is crucial throughout tumor development and progression.
IMMUNE RESPONSE TO TUMORS
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
Tumourclasss
1. A tumor is abnormal tissue consisting of genetic-altered cells that can arise due to mutations or environmental factors like radiation or infections.
2. The immune system can recognize and destroy early cancer cells but tumors evolve mechanisms to evade the immune response through loss of antigen presentation or secretion of factors that suppress T cells.
3. Immunotherapy aims to enhance anti-tumor immunity through vaccines, adoptive cell therapies, monoclonal antibodies, or cytokines to help the immune system overcome tumor evasion and eliminate cancer cells in a targeted manner with less toxicity than other treatments.
Cancer Immuno editing
1) T cell responses against antigens expressed in autochthonous lung tumors can delay malignant tumor progression. However, these T cell responses are not sustained over time.
2) Vaccination against antigens expressed in autochthonous lung tumors promotes an initial protective T cell response but also drives tumor antigen loss, allowing tumor escape.
3) Transplantation of lung tumor cell lines or vaccination against antigens in transplantable lung tumor models results in rejection of tumor or selection of antigen-loss variants, demonstrating immune editing.
Immune Escape Mechanisms of Cancers and High Grade Glial Tumors
The document discusses immune escape mechanisms of cancers and high grade gliomas. It describes how dendritic cell treatment can be used for glioblastomas, using glioblastoma associated antigens, glioblastoma stem cell antigens, tumor lysates, tumor RNA, or peptides. The optimal dosage of dendritic cells for treatment ranges from 1 million to 10 billion cells. It also discusses how the expression of coinhibitory molecules on tumor cell surfaces limits antitumor responses and the efficacy of dendritic cell vaccination. Finally, it outlines multiple approaches for cancer immunotherapy, including cytokine secreting tumor cells, ex vivo tumor loaded dendritic cells, antibodies targeting costimulatory lymphocyte receptors, and depletion of regulatory T cells and myeloid-derived suppress
Cancer Immunology and Immunotherapy in Treatment of High Grade Glial Tumors
This document discusses various cancer immunotherapy approaches for treating high grade glial tumors, including tumor immunotherapy using exogenously produced and reinfused cytotoxic T cells, depletion of immunosuppressive Treg cells, genetic production and propagation of T cells carrying tumor-antigen specific T cell receptors, vaccination approaches using peptide vaccines, dendritic cell vaccines, and autologous/whole tumor cell vaccines. It also discusses the advantages and disadvantages of different vaccine types as well as ways to augment antitumor immunity, including through adoptive T cell therapy, checkpoint inhibitors, cytokines, and other agents.
Theory of immune surveillance
The document discusses the theory of immune surveillance, which proposes that the immune system patrols the body to recognize and destroy both invading pathogens and abnormal host cells, such as cancer cells. It provides evidence from experiments in mice and clinical observations in humans that support this theory. The key components of immune surveillance systems that eliminate cancer cells are natural killer cells, cytotoxic T-lymphocytes, B-cells and macrophages. The process by which cancer cells can evade immune destruction is called immunoediting, which occurs through three sequential phases - elimination, equilibrium, and escape.
Tumor immunology
Tumor immunology describes the interaction between cancer cells and the immune system. While intrinsic and environmental factors can cause dysregulated cell growth leading to cancer, the immune system provides innate and adaptive responses to identify and eliminate tumor cells. However, cancer cells can evade the immune system through various mechanisms. Cancer immunotherapy seeks to boost the immune response against cancer through cytokines, monoclonal antibodies, and vaccines to help treat certain cancers.
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Immunosurveillance
The document discusses immunosurveillance, which refers to the immune system's ability to detect and eliminate cancer cells. It describes how innate and adaptive immunity both play roles in immunosurveillance. Innate immune cells like NK cells help provide initial detection of stressed or cancerous cells. Adaptive immune responses generate antigen-specific T cells that can recognize and attack tumor cells. However, cancer cells have developed mechanisms to evade the immune system, such as shedding antigens, producing immunosuppressive cytokines, or proliferating too quickly for immune responses to control. The interplay between the immune system and cancer cells is crucial throughout tumor development and progression.
IMMUNE RESPONSE TO TUMORS
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
Tumourclasss
1. A tumor is abnormal tissue consisting of genetic-altered cells that can arise due to mutations or environmental factors like radiation or infections.
2. The immune system can recognize and destroy early cancer cells but tumors evolve mechanisms to evade the immune response through loss of antigen presentation or secretion of factors that suppress T cells.
3. Immunotherapy aims to enhance anti-tumor immunity through vaccines, adoptive cell therapies, monoclonal antibodies, or cytokines to help the immune system overcome tumor evasion and eliminate cancer cells in a targeted manner with less toxicity than other treatments.
Cancer Immuno editing
1) T cell responses against antigens expressed in autochthonous lung tumors can delay malignant tumor progression. However, these T cell responses are not sustained over time.
2) Vaccination against antigens expressed in autochthonous lung tumors promotes an initial protective T cell response but also drives tumor antigen loss, allowing tumor escape.
3) Transplantation of lung tumor cell lines or vaccination against antigens in transplantable lung tumor models results in rejection of tumor or selection of antigen-loss variants, demonstrating immune editing.
Immune Escape Mechanisms of Cancers and High Grade Glial Tumors
The document discusses immune escape mechanisms of cancers and high grade gliomas. It describes how dendritic cell treatment can be used for glioblastomas, using glioblastoma associated antigens, glioblastoma stem cell antigens, tumor lysates, tumor RNA, or peptides. The optimal dosage of dendritic cells for treatment ranges from 1 million to 10 billion cells. It also discusses how the expression of coinhibitory molecules on tumor cell surfaces limits antitumor responses and the efficacy of dendritic cell vaccination. Finally, it outlines multiple approaches for cancer immunotherapy, including cytokine secreting tumor cells, ex vivo tumor loaded dendritic cells, antibodies targeting costimulatory lymphocyte receptors, and depletion of regulatory T cells and myeloid-derived suppress
Cancer Immunology and Immunotherapy in Treatment of High Grade Glial Tumors
This document discusses various cancer immunotherapy approaches for treating high grade glial tumors, including tumor immunotherapy using exogenously produced and reinfused cytotoxic T cells, depletion of immunosuppressive Treg cells, genetic production and propagation of T cells carrying tumor-antigen specific T cell receptors, vaccination approaches using peptide vaccines, dendritic cell vaccines, and autologous/whole tumor cell vaccines. It also discusses the advantages and disadvantages of different vaccine types as well as ways to augment antitumor immunity, including through adoptive T cell therapy, checkpoint inhibitors, cytokines, and other agents.
Theory of immune surveillance
The document discusses the theory of immune surveillance, which proposes that the immune system patrols the body to recognize and destroy both invading pathogens and abnormal host cells, such as cancer cells. It provides evidence from experiments in mice and clinical observations in humans that support this theory. The key components of immune surveillance systems that eliminate cancer cells are natural killer cells, cytotoxic T-lymphocytes, B-cells and macrophages. The process by which cancer cells can evade immune destruction is called immunoediting, which occurs through three sequential phases - elimination, equilibrium, and escape.
Tumor immunology
Tumor immunology describes the interaction between cancer cells and the immune system. While intrinsic and environmental factors can cause dysregulated cell growth leading to cancer, the immune system provides innate and adaptive responses to identify and eliminate tumor cells. However, cancer cells can evade the immune system through various mechanisms. Cancer immunotherapy seeks to boost the immune response against cancer through cytokines, monoclonal antibodies, and vaccines to help treat certain cancers.
Immune
This document contains a list of over 70 key terms related to the immune system and immunity, including different types of cells like B cells, T cells, and macrophages that participate in immune responses. It also includes the mechanisms of both innate, nonspecific defenses as well as adaptive, antigen-specific defenses against pathogens. Terms cover concepts like antibodies, antigens, cytokines, the complement system, antigen presentation, cell-mediated and humoral immunity, and the development of immunological memory.
Dendritic Vaccines Glioma 2016
Dendritic cell vaccines show potential for treating high grade glial tumors. Dendritic cells can present tumor antigens to activate CD8 and CD4 T cells. They undergo a maturation process where they migrate to lymph nodes, interact with T cells and release cytokines to stimulate an immune response. Dendritic cells can be obtained from patients and loaded with tumor antigens ex vivo before being reinfused to induce anti-tumor immunity. Multiple methods are being studied to enhance dendritic cell vaccines including combination with other immunotherapies.
Tumour immunology leture notes
This document provides an overview of tumor immunology, including definitions of cancer and carcinogenesis, tumor antigens, the immune response to cancer, and mechanisms by which tumors escape the immune system. It discusses how tumors stimulate an immune response through antigens but also ways they can evade immunity, such as through low immunogenicity, antigen modulation, and immune suppression. It describes experimental evidence for tumor antigens and the immune response against tumors.
Tumor immunology by nidhi
What is immunology?
What is Tumor?
Types of tumor
Classification of Malignant tumors
Malignant transformation of cells
General features of Tumor immunity
Tumor antigens
Tumor specific antigen
Tumor associated antigens
Immune response to tumor
Evasion of immune response by tumor
Cancer Immunosurveillance versus Immunoediting
Immunotechniques
RIA
ELISA
Immunosurveillance
The document discusses immunosurveillance, which is the concept that the immune system prevents tumour development by detecting and eliminating abnormal cells. It provides a history of the theory and describes the mechanisms by which the immune system responds to tumour antigens through cellular and humoral responses. However, tumours can evade the immune system through mechanisms like antigen loss or suppression of immune cells. While the immune system plays a role in controlling cancer, its theory is imperfect as tumours still develop, requiring updated concepts like cancer immunoediting.
Tumor immunology mahlet
The immune system plays a dual role in cancer by both suppressing tumor growth through destroying cancer cells and inhibiting outgrowth, but also promoting tumor progression by selecting for tumor cells that can survive and establishing conditions to facilitate tumor outgrowth. The cancer immunoediting hypothesis proposes that the immune system shapes tumor immunogenicity through three sequential phases - elimination, equilibrium, and escape. In the elimination phase, the innate and adaptive immune responses work to destroy cancer cells. Some tumors enter equilibrium where the immune system controls but does not eliminate the tumor. Tumors can eventually escape immune control by losing antigens and inducing immunosuppression.
Immunosurveillance,
This document discusses immunosurveillance and immunotherapy for cancer treatment. It explains that the immune system normally surveils and destroys mutated cells to prevent tumor development, but tumors can evade this response through various mechanisms such as antigen shedding or fast proliferation. Immunotherapy aims to boost the immune system's ability to fight cancer, for example through monoclonal antibodies, non-specific stimulants, cancer vaccines, or T-cell therapies.
Tumour immunology
The document discusses cancer immunosurveillance and immunoediting. It describes how the immune system plays an important role in controlling cancer development through 3 phases - elimination, equilibrium, and escape. In the elimination phase, innate and adaptive immunity work to eliminate cancer cells. Some cancer cells may survive this phase if they acquire properties to evade the immune system, entering the equilibrium phase. Eventually, in the escape phase, cancer cells are able to avoid immune destruction through various mechanisms and form clinically detectable tumors. Immunotherapy aims to enhance the immune response against cancer cells.
Immune response against tumors
Types of tumor antigens recognized by T cells
Immune mechanisms of tumor rejection
How tumors evade immune responses?
Novel therapeutic approaches (immunotherapies)
Iimmunity to tumors
1. Cancer is caused by uncontrolled cell growth that can spread and kill the host. Tumors can be benign or malignant.
2. The immune system plays an important role in tumor rejection through spontaneous regression, lymphocyte infiltration of tumors, and increased cancer risk with immunosuppression.
3. Tumors elicit specific adaptive immune responses through antigens, but the immune system often fails to prevent tumor growth due to weak immunogenicity, rapid tumor growth, and immune evasion mechanisms.
Immunology and cancer
Cytokine-tumor interactions within its microenvironment play a critical role in pathogenesis and management of any neoplasm. Here, I summarize points from a 2004 Nature paper that are still pertinent today.
Slide Template: www.presentationmagazine.com
Tumor Immunology presentation by Sharmista
Tumor, Tumor immunology, cancer, hallmarks of cancer, carcinoma, lymphoma, metastasis, malignant, benign, angiogenesis, oncogenes and cancer induction, kuby detailed study quick revision, proto-oncogenes, tumor antigens, antibody, experiments for tumor antigens, methods for characterization of TSTA, Immunoediting, Current research n new approaches, monoclonal antibody
cancer de mama
This document discusses cancer immunology and the immune system's response to cancer. It covers topics like tumor antigens, cells of the immune system like T cells, B cells, and antigen-presenting cells. It also summarizes theories of cancer immunoediting where the immune system eliminates, edits, or reaches an equilibrium with tumors. The document outlines mechanisms tumors use to escape immune destruction like expressing inhibitory molecules. It concludes by discussing immunotherapies to modulate the immune response and target cancers.
Cancer immunology
The document summarizes key concepts in cancer immunology. It defines cancer and how the immune system views cancer cells. It describes how the innate and adaptive immune systems recognize and attack tumors through mechanisms like complement activation, NK cell activation, and T cell responses. It also discusses how cancers can evade the immune system through antigen loss, immunosuppressive microenvironments, and immune checkpoint proteins. The document concludes by outlining several immunotherapy approaches like non-specific immune stimulation, T cell therapy, immune checkpoint inhibitors, cancer vaccines, and monoclonal antibodies.
Cancer and immune system
Cancer can both weaken the immune system and be fought by the immune system. It can weaken immunity by spreading to bone marrow and reducing blood cell production, or through side effects of treatments like chemotherapy and radiation. However, parts of the immune system also recognize cancer cells as abnormal and try to kill them. New immunotherapies aim to boost this response by using antibodies, cytokines, vaccines, and other methods to help the immune system better eliminate cancer cells. A balanced relationship exists between cancer and immunity.
Chapter 17 immunotherapy
Cancer immunotherapy utilizes the immune system to recognize and destroy cancer cells. There are several types of immunotherapy including cancer vaccines, adoptive cell transfer, checkpoint inhibitors, and oncolytic viruses. Cancer vaccines educate the immune system to recognize tumor antigens while adoptive cell transfer involves extracting immune cells from patients and expanding tumor-specific T cells ex vivo for reinfusion. Checkpoint inhibitors like anti-CTLA4 and anti-PD1 antibodies block inhibitory pathways and unleash existing anti-tumor immune responses. Oncolytic viruses selectively infect and lyse tumor cells and stimulate antitumor immunity through antigen release.
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Immune
This document contains a list of over 70 key terms related to the immune system and immunity, including different types of cells like B cells, T cells, and macrophages that participate in immune responses. It also includes the mechanisms of both innate, nonspecific defenses as well as adaptive, antigen-specific defenses against pathogens. Terms cover concepts like antibodies, antigens, cytokines, the complement system, antigen presentation, cell-mediated and humoral immunity, and the development of immunological memory.
Dendritic Vaccines Glioma 2016
Dendritic cell vaccines show potential for treating high grade glial tumors. Dendritic cells can present tumor antigens to activate CD8 and CD4 T cells. They undergo a maturation process where they migrate to lymph nodes, interact with T cells and release cytokines to stimulate an immune response. Dendritic cells can be obtained from patients and loaded with tumor antigens ex vivo before being reinfused to induce anti-tumor immunity. Multiple methods are being studied to enhance dendritic cell vaccines including combination with other immunotherapies.
Tumour immunology leture notes
This document provides an overview of tumor immunology, including definitions of cancer and carcinogenesis, tumor antigens, the immune response to cancer, and mechanisms by which tumors escape the immune system. It discusses how tumors stimulate an immune response through antigens but also ways they can evade immunity, such as through low immunogenicity, antigen modulation, and immune suppression. It describes experimental evidence for tumor antigens and the immune response against tumors.
Tumor immunology by nidhi
What is immunology?
What is Tumor?
Types of tumor
Classification of Malignant tumors
Malignant transformation of cells
General features of Tumor immunity
Tumor antigens
Tumor specific antigen
Tumor associated antigens
Immune response to tumor
Evasion of immune response by tumor
Cancer Immunosurveillance versus Immunoediting
Immunotechniques
RIA
ELISA
Immunosurveillance
The document discusses immunosurveillance, which is the concept that the immune system prevents tumour development by detecting and eliminating abnormal cells. It provides a history of the theory and describes the mechanisms by which the immune system responds to tumour antigens through cellular and humoral responses. However, tumours can evade the immune system through mechanisms like antigen loss or suppression of immune cells. While the immune system plays a role in controlling cancer, its theory is imperfect as tumours still develop, requiring updated concepts like cancer immunoediting.
Tumor immunology mahlet
The immune system plays a dual role in cancer by both suppressing tumor growth through destroying cancer cells and inhibiting outgrowth, but also promoting tumor progression by selecting for tumor cells that can survive and establishing conditions to facilitate tumor outgrowth. The cancer immunoediting hypothesis proposes that the immune system shapes tumor immunogenicity through three sequential phases - elimination, equilibrium, and escape. In the elimination phase, the innate and adaptive immune responses work to destroy cancer cells. Some tumors enter equilibrium where the immune system controls but does not eliminate the tumor. Tumors can eventually escape immune control by losing antigens and inducing immunosuppression.
Immunosurveillance,
This document discusses immunosurveillance and immunotherapy for cancer treatment. It explains that the immune system normally surveils and destroys mutated cells to prevent tumor development, but tumors can evade this response through various mechanisms such as antigen shedding or fast proliferation. Immunotherapy aims to boost the immune system's ability to fight cancer, for example through monoclonal antibodies, non-specific stimulants, cancer vaccines, or T-cell therapies.
Tumour immunology
The document discusses cancer immunosurveillance and immunoediting. It describes how the immune system plays an important role in controlling cancer development through 3 phases - elimination, equilibrium, and escape. In the elimination phase, innate and adaptive immunity work to eliminate cancer cells. Some cancer cells may survive this phase if they acquire properties to evade the immune system, entering the equilibrium phase. Eventually, in the escape phase, cancer cells are able to avoid immune destruction through various mechanisms and form clinically detectable tumors. Immunotherapy aims to enhance the immune response against cancer cells.
Immune response against tumors
Types of tumor antigens recognized by T cells
Immune mechanisms of tumor rejection
How tumors evade immune responses?
Novel therapeutic approaches (immunotherapies)
Iimmunity to tumors
1. Cancer is caused by uncontrolled cell growth that can spread and kill the host. Tumors can be benign or malignant.
2. The immune system plays an important role in tumor rejection through spontaneous regression, lymphocyte infiltration of tumors, and increased cancer risk with immunosuppression.
3. Tumors elicit specific adaptive immune responses through antigens, but the immune system often fails to prevent tumor growth due to weak immunogenicity, rapid tumor growth, and immune evasion mechanisms.
Immunology and cancer
Cytokine-tumor interactions within its microenvironment play a critical role in pathogenesis and management of any neoplasm. Here, I summarize points from a 2004 Nature paper that are still pertinent today.
Slide Template: www.presentationmagazine.com
Tumor Immunology presentation by Sharmista
Tumor, Tumor immunology, cancer, hallmarks of cancer, carcinoma, lymphoma, metastasis, malignant, benign, angiogenesis, oncogenes and cancer induction, kuby detailed study quick revision, proto-oncogenes, tumor antigens, antibody, experiments for tumor antigens, methods for characterization of TSTA, Immunoediting, Current research n new approaches, monoclonal antibody
cancer de mama
This document discusses cancer immunology and the immune system's response to cancer. It covers topics like tumor antigens, cells of the immune system like T cells, B cells, and antigen-presenting cells. It also summarizes theories of cancer immunoediting where the immune system eliminates, edits, or reaches an equilibrium with tumors. The document outlines mechanisms tumors use to escape immune destruction like expressing inhibitory molecules. It concludes by discussing immunotherapies to modulate the immune response and target cancers.
Cancer immunology
The document summarizes key concepts in cancer immunology. It defines cancer and how the immune system views cancer cells. It describes how the innate and adaptive immune systems recognize and attack tumors through mechanisms like complement activation, NK cell activation, and T cell responses. It also discusses how cancers can evade the immune system through antigen loss, immunosuppressive microenvironments, and immune checkpoint proteins. The document concludes by outlining several immunotherapy approaches like non-specific immune stimulation, T cell therapy, immune checkpoint inhibitors, cancer vaccines, and monoclonal antibodies.
Cancer and immune system
Cancer can both weaken the immune system and be fought by the immune system. It can weaken immunity by spreading to bone marrow and reducing blood cell production, or through side effects of treatments like chemotherapy and radiation. However, parts of the immune system also recognize cancer cells as abnormal and try to kill them. New immunotherapies aim to boost this response by using antibodies, cytokines, vaccines, and other methods to help the immune system better eliminate cancer cells. A balanced relationship exists between cancer and immunity.
Chapter 17 immunotherapy
Cancer immunotherapy utilizes the immune system to recognize and destroy cancer cells. There are several types of immunotherapy including cancer vaccines, adoptive cell transfer, checkpoint inhibitors, and oncolytic viruses. Cancer vaccines educate the immune system to recognize tumor antigens while adoptive cell transfer involves extracting immune cells from patients and expanding tumor-specific T cells ex vivo for reinfusion. Checkpoint inhibitors like anti-CTLA4 and anti-PD1 antibodies block inhibitory pathways and unleash existing anti-tumor immune responses. Oncolytic viruses selectively infect and lyse tumor cells and stimulate antitumor immunity through antigen release.
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Similar to Terms immune
Immunity-Tcell-Bcell-Cytokines
A brief covering basics of immunity understanding and also allowing students to understand with ease the concepts of innate immunity, adaptive immunity, Tcell, Bcell, MHC molecular genetics, and also cytokines and also its role in various disease.
Neuroimmunology
The document provides an overview of the immune system, including its normal functions, divisions, components, cells, molecules, and regulation. The key points are:
- The immune system protects against pathogens and prevents reinfection through immunological memory. Its divisions are the innate and adaptive systems.
- The innate system provides first response via nonspecific defenses like skin, phagocytes, and natural killer cells. The adaptive system responds antigen-specifically via T and B cells.
- T cells recognize antigen via T cell receptors and MHC molecules and mediate cellular immunity. B cells recognize antigen directly and produce antibodies for humoral immunity.
- Cytokines mediate communication between immune cells, directing immune responses. Regulatory
Presentation 11 - Immunity
The document summarizes key concepts of the human immune system. It describes both innate, nonspecific defenses like skin barriers and phagocytes, as well as acquired, specific defenses mediated by lymphocytes and antibodies. The immune system protects against pathogens through both humoral responses involving B cells and antibodies, and cell-mediated responses involving T cells. Memory responses provide faster protection upon reexposure to pathogens.
Adoptive cellular immunotherapy CAR-T cells
The subject deals with adoptive immunotherapy, introduction, its mechanism, processing and use of CAR-T cells, clinical trials and its efficacy. useful for oncology and newer advances in immunotherapy. Immunotherapy is treatment that uses a person's own immune system to fight cancer. Immunotherapy can boost or change how the immune system works so it can find and attack cancer cells. Cellular adoptive immunotherapy is a type of immunotherapy. Immune cells such as T-cells are usually isolated from patients for expansion or engineering purposes and reinfused back into patients to fight diseases using their own immune system.
Immune response
Describes the basic properties and mechanisms of T cells and B cells in maintaining Immune Response against foreign antigens or infections and covers the UG and PG portion of immunology.
Pharm immuno14&15 cancer & transplantpor
The document summarizes key concepts in immunology related to cancer and organ transplants. It discusses how the immune system can recognize and respond to tumors, mechanisms by which tumors evade immune detection, and approaches to cancer immunotherapy. It also covers immune mechanisms of graft rejection, types of transplants, and strategies to prevent rejection through immunosuppression.
Immunity
The document discusses immunity, defining it as the body's ability to resist harmful organisms and toxins. It describes two types of immunity: innate immunity, which is inborn, and acquired immunity, also known as adaptive immunity, which develops in response to antigens. The key aspects of how immunity works are that the immune system recognizes foreign antigens, prepares to destroy them, and uses both cell-mediated immunity and humoral immunity for defense.
DISEASE OF IMMUNITY
The document discusses diseases of immunity, including hypersensitivity reactions and autoimmune diseases. It describes the innate and adaptive immune system, cells involved like T cells, B cells, cytokines, and histocompatibility molecules. Hypersensitivity reactions are classified and immediate (Type I) hypersensitivity is explained, where re-exposure to an antigen leads to rapid allergic reactions mediated by IgE and mast cells.
Diseases Of Immunity
The document discusses diseases of immunity, including hypersensitivity reactions and autoimmune diseases. It describes the innate and adaptive immune system, cells involved like T cells, B cells, cytokines, and histocompatibility molecules. Hypersensitivity reactions are classified and immediate (Type I) hypersensitivity is explained, where re-exposure to an antigen leads to rapid allergic reactions mediated by IgE and mast cells.
Basic principles of cancer immunotherapy
describes the molecular basis behind the stage that controls the concept and application of immunotherapy in cancer management
Immune response to hiv infection
This slide contains detailed information of the immunological response happens during the HIV infection in human
Immune response to hiv infection
This slide contain detailed information regarding the immunological responses during the HIV infection
14,15
The document discusses various types of pathological immune responses including hypersensitivity reactions and autoimmune diseases. It covers four types of hypersensitivity reactions (Type I-IV) defined by their pathophysiology and examples. It also discusses immunological deficiency syndromes, transplantation immunity, and the cells and tissues involved in innate and adaptive immunity.
Adaptive immunity
The document summarizes key principles of the adaptive immune response. It describes how adaptive immunity arose due to limitations of innate immunity, including lack of specificity and memory. The adaptive response involves T and B lymphocytes that recognize specific antigens through cell surface receptors. Activation of T and B cells requires recognition of antigen along with costimulatory signals. This leads to clonal expansion and generation of effector cells and immunological memory. Adaptive immunity allows for tailored, amplified responses with self/non-self discrimination and immunological memory.
Immune response by Dr. Rakesh Prasad Sah
The immune system protects the body from infection through two main arms: innate and adaptive immunity. The immune response requires the participation of antigen presenting cells, T cells, and B cells. When exposed to an antigen, B cells produce antibodies and T cells help activate other immune cells. Memory cells are formed and lead to a stronger secondary response upon reexposure to the same antigen. Cytokines help regulate the immune response through communication between immune cells.
Bohomolets Microbiology Lecture #10
The document summarizes key aspects of the immune system. It discusses the central and peripheral organs of the immune system including the thymus, bone marrow, spleen, lymph nodes, and tonsils. It describes the development and maturation of white blood cells and B and T lymphocytes. It also summarizes the differences between humoral and cell-mediated immunity and the roles of B cells, T cells, antibodies, and cytokines in the immune response.
Access to memory cells
This document discusses memory cells in the innate and adaptive immune system. It defines immunological memory as the ability of the adaptive immune response to generate specific memory cells after infection or vaccination, allowing the body to prevent future infections. The document compares myeloid and lymphoid cells as well as innate and adaptive immunity. It also describes the role of cytokines in the immune response and defines memory cells as cells that allow the immune system to respond faster and more strongly upon second exposure to an antigen. Finally, it provides a figure comparing naïve and memory CD4 T cells.
Key concept of immunology
The document summarizes key concepts of immunity, including:
1. Innate immunity provides immediate defenses through physical barriers and cells like phagocytes, while adaptive immunity provides specific responses through antibodies and T cells.
2. The immune system is composed of circulating leukocytes and lymphoid organs that bring together antigens and immune cells.
3. Adaptive immunity involves antigen presentation, lymphocyte activation, proliferation into effector and memory cells, and specialized functions of B cells, cytotoxic T cells, and helper T cells.
HLA and antigen presentation
HLA refers to Human Leukocyte Antigens. HLA forms part of the major Histocompatibility complex (MHC)
Autoimmunity.pptx
1. The document discusses mechanisms of immunological tolerance and the pathogenesis of autoimmune diseases. It describes how central and peripheral tolerance lead to the deletion or inactivation of self-reactive lymphocytes.
2. A loss of tolerance can occur through molecular mimicry with infectious agents, exposure of sequestered antigens, hormonal influences, and genetic factors. This can lead to tissue damage through various effector mechanisms like antibody-mediated cytotoxicity.
3. Examples are given of organ-specific autoimmune diseases associated with certain autoantibodies, as well as immune complex-mediated conditions like vasculitis. Therapeutic approaches aim to restore tolerance or suppress effector responses.
Similar to Terms immune (20)
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Excre terms
This document defines key terms related to excretion and osmoregulation in organisms. It discusses the processes of filtration, reabsorption and secretion in the kidney and the roles of specific kidney structures like nephrons and the loop of Henle in urine formation. It also covers osmoregulatory structures in different animals, hormones involved in urine regulation, and adaptive processes like hibernation, estivation and torpor.
Osmothermoreg activity
This document contains questions for a student about osmoregulation - the process by which aquatic organisms regulate their internal salt concentrations. It asks about nitrogenous waste products in different organisms, and the effects of freshwater vs saltwater on fish. It also asks questions about thermoregulation in humans and how water is used to cool engines and nuclear reactors. The conclusion section is blank.
Overview of excretion in mammals
The mammalian kidney filters blood in the glomerulus and regulates water and salt balance through selective reabsorption and secretion in the nephron's tubule segments. In the proximal tubule, most reabsorption occurs, while the thin ascending loop of Henle secretes salt and the thick ascending loop reabsorbs salt actively. The collecting duct determines salt excretion, reabsorbing water passively. Osmoreceptors detect blood osmolarity and volume changes, triggering antidiuretic hormone and the renin-angiotensin-aldosterone system respectively to regulate water and salt balance. Through selective tubule transport, the kidney maintains homeostasis.
Integumentary activity
The document contains a worksheet asking students to identify different methods of heat transfer and label parts of the skin. It asks students to provide everyday examples of conduction, convection, radiation, and changes of state. It also has a diagram of the skin and asks students to match descriptions to the correct layers labeled A-O.
Immune 20132014 (1)
The immune system defends the body against pathogens through layered lines of defense. The innate immune system provides immediate nonspecific responses while the adaptive immune system mounts targeted responses through lymphocytes. B and T lymphocytes recognize pathogens through antigen receptors and mount humoral or cell-mediated responses involving antibody production or cytotoxic killing. Immune memory develops from these responses to provide faster protection upon reexposure. A balanced immune response is needed, as deficiencies or issues with self-tolerance can lead to infection or autoimmunity.
Cell respi photosynthesis activity
This document contains an activity worksheet on cell respiration and photosynthesis. It includes checklists to identify the key components and processes of glycolysis, the Krebs cycle, the electron transport chain, and photosynthesis. It also poses questions about the importance of glycolysis in ATP production, why the Krebs cycle is aerobic, the types of fermentation, the last electron acceptor in the electron transport chain, and the byproducts of the Krebs cycle and electron transport chain. Additional questions address the importance of light in photosynthesis, the role of Rubisco in sugar formation, and adaptations plants use in hot climates like PEPCO cycling in CAM plants.
Lab activity 1 20122013
The document contains questions about osmoregulation and thermoregulation. It asks about different nitrogenous wastes and their importance, what would happen if freshwater and saltwater fish were placed in the opposite environments, the relationship between loop of Henle length and environmental temperature, properties of water that make it a good cooling agent, and ways organisms cool themselves.
2nd quarter notes
This document contains a series of guide questions covering various topics in biology including circulation, the lymphatic system, blood clotting, EKG waveforms, cellular respiration, photosynthesis, gas exchange, bird anatomy, marine animal respiration, immune system defenses, inflammation, humoral response, cell-mediated response, and immunological memory. It concludes with questions for student feedback on their favorite topic, corrected misconceptions, any additional questions, and recommendations for the next quarter.
Immune notes
The three lines of defense in the immune system are:
1) First line is external non-specific defenses like skin and mucus.
2) Second line is internal non-specific defenses like white blood cells and antimicrobial proteins.
3) Third line is internal specific defenses using B cells, T cells, and antibodies for a targeted response.
Transport activity
This document appears to be a worksheet for a lesson on heart contraction and the transport of materials through the cardiovascular system. It includes key terms related to the heart and cardiac cycle. Students are asked to identify parts of the heart, explain what would happen if different parts were destroyed, and determine the effects of various factors on blood pressure. The worksheet also contains a diagram for which students are to explain what occurs in different sections of the cardiovascular system.
Homework clotting and immune
A student homework assignment asks them to:
1) Draw a diagram of the blood clotting process.
2) Determine possible blood types based on parents' types and if they can donate.
3) Complete a table with cell types and actions.
4) Draw diagrams of humoral and cell-mediated immune responses and their step-by-step processes.
Cell respi and photosynthesis activity
This document contains an activity worksheet about cell respiration and photosynthesis. It asks students to define key terms related to these processes, write out the chemical reactions, and draw a diagram showing the steps of photosynthesis and cell respiration. Students are asked to provide their name, date, and section number at the top of the page. The activity is numbered and divided into three parts - defining terms, writing reactions, and making a diagram.
Transport notes
This document contains 10 questions about transport mechanisms and circulatory systems. It asks about the different transport mechanisms in plants, the transpiration-cohesion-tension mechanism in trees, root pressure, cohesive forces in water, diffusion in different organisms, interstitial fluid, open vs closed circulatory systems, double circulation, single ventricles in amphibians, and different blood vessels and their characteristics.
Biology project sy 2012 2013
This document outlines the requirements for a Biology 2 final project on physiology and anatomy. Students will work in groups to research and present on an approved topic related to concepts discussed in the course. They must submit a topic proposal that includes an introduction, background research sources, and presentation outline. The final presentation should be in video format and resemble a TED Talk, exploring topics like improving human structure and function or examining a specific organ system. Deadlines are provided for topic approval, the written proposal, and the final presentation video.
Bio2 course outline 2012 2013
This document outlines the course description, course outline, references, and grading system for Biology 2, a one unit comparative anatomy and physiology course offered to third year students at the Philippine Science High School - Main Campus. The course covers basic concepts of life processes with a focus on structure-function relationships among organisms. It examines evolutionary trends in organ system development. The course aims to demonstrate unity in diversity and value nature. It is divided into four quarters covering topics like biological organization, life processes, homeostasis, support/locomotion, regulation/control, and reproduction. Student work is evaluated based on tests, exams, class activities, and participation.
Pix educ 280
This document outlines the schedule and activities for an education course during the summer of 2011-2012. It includes reports, meetings, demos and simulations for preparation, and culminates with "the big day" at the end of the course.
Pix educ 280
This document outlines the schedule for EDUC 280 in summer 2011-2012, including reports, meetings, demos and simulations leading up to the final project. Meetings and practice sessions will help prepare students for their culminating presentations.
Fb
The last activity of the Field Biology Batch 2012 will take place on March 18-19 at Mt. Gulugod Baboy in Mabini, Batangas. The trip will focus on conservation, mountaineering, and surveying the flora and fauna of the montane region. Five teachers will supervise the trip to ensure safety. Parents are asked to indicate whether they allow their son/daughter to participate.
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Terms immune
- 1. GROUP 1<br />Differentiate:<br />1st vs 2nd vs 3rd line of defenses<br />Skin<br />Mucus<br />Cilia<br />pH <br />immunity<br />membrane attack complex<br />pathogen<br />nonspecific defense<br />opportunistic disease<br />target cell<br />GROUP 2<br />inflammatory response<br />interferon<br />lysozyme<br />macrophages<br />mast cells<br />natural killer cells<br />monocytes<br />neutrophils<br />phagocytosis<br />prostaglandins<br />pyrogens<br />allergy<br />anaphylactic shock<br />apoptosis<br />basophils<br />complement system<br />cytokine<br />eosinophils<br />histamine<br />GROUP 3 <br />interleukin<br />passive immunity<br />primary immune response<br />secondary immune response<br />suppressor T cell<br />T cell<br />T cell receptor<br />Rh factor<br />tumor antigen<br />plasma cell<br />perforin<br />memory cell<br />MHC<br />vaccine<br />class I MHC<br />class II MHC<br />ABO blood groups<br />active immunity<br />agglutination<br />AIDS<br />antibody<br />antigen<br />antigen receptor<br />antigen-presenting cell<br />autoimmune disease<br />B cell<br />CD4<br />CD8<br />cell-mediated immunity<br />chemokines<br />clonal selection<br />complement fixation<br />cytotoxic T cell<br />effector cell<br />helper T cell<br />HIV<br />humoral immunity<br />immunodeficiency disease<br />immunoglobulin<br />