medical slides

1. Wednesday,
April 12, 2023
1
Teratogenic drugs
DR. HIWA OMER AHMED
PROFESSOR IN GENERAL AND BARIATRIC
SURGERY
UNIVERSITY OF SULAIMANI
COLLEGE OF MEDICINE – SULAIMANI CITY-
KURDISTAN

2. Wednesday,
April 12, 2023
2
 Category A
 No risk in human studies
 Like vb6, folic acid , senna , bisacodyle ,
dextromethorpan, doxylamine. Thyroxine isoniazide,
others

3. Wednesday,
April 12, 2023
3
 Category B
 Animal reproduction studies have failed to demonstrate a risk to the
fetus and there are no adequate and well-controlled studies in
pregnant women.
 Example
drugs: metformin, hydrochlorothiazide, cyclobenzaprine, amoxicillin

4. Wednesday,
April 12, 2023
4
 Category C
 Animal reproduction studies have shown an adverse effect on the fetus
and there are no adequate and well-controlled studies in humans, but
potential benefits may warrant use of the drug in pregnant women despite
potential risks.
 Example drugs: gabapentin, amlodipine, trazodone
 Most medications not listed in other categories

5. Wednesday,
April 12, 2023
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 Category D
 There is positive evidence of human fetal risk based on adverse
reaction data from investigational or marketing experience or studies in
humans, but potential benefits may warrant use of the drug in
pregnant women despite potential risks.
 Example drugs: losartan
1. Antimicrobials
gentamicin, neomycin, amikacin, streptomycin, kanamycin, trimethoprim,
doxycycline , tetracycline, fluconazol, primaquine, chloroquine
2. Others ; cortisone, pencillamine, methiomazole, propylthiouracil, KI,
Bismuth , cyclophosphamide, meloxicam, tamoxifen

6. Wednesday,
April 12, 2023
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 Category X
 Studies in animals or humans have demonstrated fetal abnormalities
and/or there is positive evidence of human fetal risk based on adverse
reaction data from investigational or marketing experience, and the risks
involved in use of the drug in pregnant women clearly outweigh potential
benefits.
 Example drugs: atorvastatin, simvastatin, methotrexate, finasteride,
valproate, methotrexate, emergency contraceptions (nlevonorgestrel),
grisofulvin, oxytocin, isotretinoin

7. Wednesday,
April 12, 2023
7
Antibiotics

8. Wednesday,
April 12, 2023
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9. Wednesday,
April 12, 2023
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Analgesia

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April 12, 2023
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