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Temperature Regulation
Dr Dileep Verma
Associate Professor
Deptt of Physiology
KGMU
Lecture-1 :Topics
 Core and Shell body temp.
 Heat Balance
 Factors promoting -
a) Heat gain
b) Heat loss
 Temp. regulatory mechanisms
Learning Objectives
 Normal Body Temperature
 Ways of measuring Body Temp
 List the mechanisms of heat
production & heat loss
 Regulation of Body Temp.
Body Temperature
 Normal Body Temperature (NBT) –
98.60F(370C)
 Range of NBT ----- (970F to 990F)
 Rectal Temp ----- (0.50F to 10F) above
the Oral
 Rectal Temp reflects the internal body
Temp (Core Body Temp)
 Core Body Temp remain almost constant
 Skin Temp (Shell Temp)-----Variable
Temperature Homeostasis
 Keep the body temp within a very narrow
range
 Range of NBT (970F to 990F)
 Temperatures above this:
denature enzymes and block metabolic
pathways
 Temperatures below this:
slow down metabolism and affect the brain.
Heat Balance
 Heat balance maintains the body temp
 Balance between heat production &
heat loss (Heat Balance)
 Heat Balance
 Heat production= Heat loss
 Heat production is called
thermogenesis
 Heat loss is called as thermolysis
Heat Production (Thermogenesis)
 BMR
 Specific Dynamic Action of food
 Activity of skeletal muscle
Shivering
Exercise
 Chemical Thermogenesis
Epinephrine &Norepinephrine
Thyroxine
 Brown Fat-
Source of considerable heat production
Abundant in infants
Heat Loss (Thermolysis)
 Radiation
 Conduction
 Convection
 Evaporation
 Perspiration
 Respiration
 Loss through urine & feces
Role of Skin
Heat Exchange in the Skin
Vasoconstriction and
Vasodilatation
Thermoregulation
 Temperature is regulated by nervous
feedback mechanisms
 Thermoregulatory center located in the
Hypothalamus
 Thermoregulatory regulatory responses
include
Autonomic
Somatic
Endocrine
Behavioural changes
Feedback system
 1) Receptor
◦ Sensor that responds to changes (stimuli)
 2) Control Center
◦ Sets range of values
◦ Evaluates input and
◦ Sends output
 3) Effector-
◦ Receives output from control centre
◦ Produces a response
Body Temperature Control System
 Hypothalamus
◦ Acts as a thermostat
◦ Receives nerve impulses
from cutaneous
thermoreceptors
◦ Thermoreceptors Cold
&Heat
 Hypothalamus- also has
thermoreceptors called
central thermoreceptors
 These detect changes in
blood temperature
Thermoregulatory regulatory responses
 Activated by Exposure to Cold
1. Shivering
2. Increase voluntary activity
3. Increase TSH secretion
4. Increase Catecholamines
5. Vasoconstriction
6. Horripilation
7. Curling up
Thermoregulatory regulatory responses
 Activated by Exposure to Heat
1. Vasodilatation
2. Sweating
3. Increase in Respiration
4. Anorexia
5. Apathy
6. Decrease TSH secretion
Thermoregulatory regulatory responses
Exposure to Cold
Shivering
Increase voluntary activity
Increase TSH secretion
Increase Catecholamines
Vasoconstriction
Horripilation
Curling up
Exposure to Heat
Vasodilatation
Sweating
Increase in Respiration
Anorexia
Apathy
Decrease TSH secretion
1-A major source of heat
production in infants is
A. Increased muscular activity
B. Brown fat
C. Increased sympathetic activity
D. Specific dynamic action of food
2-At normal room temperature
most body heat loss is by-
A. Convention
B. Conduction
C. Radiation
D. Sweating
3-Constituents of secreted sweat are similar
to plasma except for
A. Proteins
B. Chloride
C. Bicarbonate
D. Potassium
4-The only available mechanism of heat transfer
when the environmental temperature is greater than
the body temperature is
A. Radiation
B. Conduction
C. Convection
D. Evaporation
5-Cause of thermogenesis in the
body is
A. Skeletal muscle relaxation
B. Assimilation of food
C. Decreased cardiac metabolism
D. Hypothyroidism
6-A major factor resulting in increase
in body temperature during exercise
is-
A. Heat dissipating mechanisms
inefficient
B. Enormous thermogenesis
C. Vasoconstriction on non-working
muscles
D. Resetting of thermostat
7-Site which reflects the true
value of core temperature
A. Oesophagus and rectum
B. Tympanic membrane
C. Vagina
D. All of the above
8-BMR is dependent on
A. Body weight
B. Surface area
C. Amount of lean body mass
D. Height
9-One feels hotter on a humid day
because-
A. Rate of sweating increases
B. Surrounding temperature is more
C. Heat loss by the body via process of
radiation decreases
D. Rate of evaporation of water from
body decreases
10-A major factor resulting in increase
in body temperature during exercise
is-
A. Heat dissipating mechanisms
inefficient
B. Enormous thermogenesis
C. Vasoconstriction on non-working
muscles
D. Resetting of thermostat
Temperature Regulation
Dr Dileep Verma
Associate Professor
Deptt of Physiology
KGMU
Lecture-2 :Topics
 Life in Hot environment
-Effect of acute heat
 Thermoregulatory responses
 Heat syndrome
-Heat cramps
-Heat exhaustion
-Heat stroke
Contd…
 Life in cold environment
-effect of acute & long term
cold exposure on body
 Applied
-Hypothermia
-Harmful effects of extreme
cold
Learning Objectives
 Effect of Hot & Cold environment on
the body.
 Thermo-receptors
 Regulation of Body Temperature
Life in Hot environment
 Hot climates- These are two types
a) Hot-dry
b) Warm-humid
 Hot-dry climate-
Found in deserts
Temp >500 C
Not humid
 Warm-humid climate –
Found in tropical forest
Temp usually<350 C
Humidity >75%
Contd----
Effects of acute heat -
Effects of acute exposure to heat
are divided into-
a) Thermoregulatory responses
b) Other effects
Contd----
 Thermoregulatory regulatory responses
Vasodilatation
Sweating
Increase in Respiration
Anorexia
Apathy
Decrease TSH
secretion
Contd----
 Other effects of acute heat exposure on-
Cellular metabolism
Rate of respiration
Work of breathing
Pulse rate
Dehydration
Urinary volume
Contd----
Heat Syndromes- adverse
reaction to heat exposure
a) Heat Cramps
b) Heat Exhaustion
c) Heat Stoke
Life in cold environment
 Effect of cold exposure on body-
a) Acute cold exposure
b) Long term cold exposure
 Applied
-Hypothermia
-Harmful effects of extreme
cold
Contd----
 Effect of acute cold exposure on body
Shivering
Increase voluntary
activity
Increase TSH secretion
Increase Catecholamines
Vasoconstriction
Horripilation
Curling up
Contd----
 Effect of long term cold
exposure
Metabolic Responses
Insulative Responses
Hypothermic Responses
Contd----
Hypothermia –Body temp below
the normal lower limit (<970F)
 Thermoregulatory responses
Greatly impaired at (<940F)
Lost at body temp(<850F)
Contd----
 Frostbite
Occurs at very low temp
Surface area freezes
Ice crystals formed
 Common sites-
Lobes of the ears
Digits of hands
Digits of feet
 Cold induced vasodilatation-
Final protection against frostbite
Summary of Effector Mechanisms
in Temperature Regulation
1- Thermal sweating differs from non-
thermal sweating in that
A. Eccrine glands are responsible for it
B. Occurs due to activation of sympathetic
cholinergic nerves
C. Found mainly over palm, sole and axilla
D. All of the above
Core temperature of 260C leads to death
due to:
a) Brain damage
b) Respiratory insufficiency
c) Cardiac failure
d) All of the above
2- Which area of hypothalamus
functions as thermostat?
A. Preoptic
B. Paraventricular
C. Dorso medial
D. Lateral
3- Insensible water loss (perspiration) will
be absent if humidity is
A. 50%
B. 70%
C. 90%
D. 100%
4- Pyrogens raises body temperature
by
A. Setting the thermostat to higher level
B. Releasing interleukins
C. Decreasing peripheral heat liberating
mechanism
D. Causing peripheral vasoconstriction
5- Heat loss process of the body not
directly under physiological control is
A. Radiation from body
B. Conduction and convection to
surroundings
C. Vaporization of sweat
D. Warming of inspired air
6- Fever is usually caused by
A. Interleukin-1
B. Substance- p
C. Endorphins
D. Encephalin
7- During exposure to cold, body
temperature is raised by
A. Vasoconstriction in the skin
B. Horripilation
C. Thermogenesis
D. All of the above
8- Profound hypothermic signs include
all except
A. Show breathing
B. Bradycardia
C. Hypotension
D. Hyperactivity
9- Aspirin decreases the body
temperature by
A. Inhibiting interleukin-1
B. Inhibiting pyrogens release
C. Killing fever producing organisms
D. Inhibiting prostaglandin synthesis
10- When the core temperature of the body falls
below the hypothalamic set-point temperature
A. The blood vssels of the skin constrict
B. Heat production increases within
minutes
C. The basal metabolic rate increases
D. All of the above
Temp_regulation_Lect.ppt

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Temp_regulation_Lect.ppt

  • 1. Temperature Regulation Dr Dileep Verma Associate Professor Deptt of Physiology KGMU
  • 2. Lecture-1 :Topics  Core and Shell body temp.  Heat Balance  Factors promoting - a) Heat gain b) Heat loss  Temp. regulatory mechanisms
  • 3. Learning Objectives  Normal Body Temperature  Ways of measuring Body Temp  List the mechanisms of heat production & heat loss  Regulation of Body Temp.
  • 4. Body Temperature  Normal Body Temperature (NBT) – 98.60F(370C)  Range of NBT ----- (970F to 990F)  Rectal Temp ----- (0.50F to 10F) above the Oral  Rectal Temp reflects the internal body Temp (Core Body Temp)  Core Body Temp remain almost constant  Skin Temp (Shell Temp)-----Variable
  • 5. Temperature Homeostasis  Keep the body temp within a very narrow range  Range of NBT (970F to 990F)  Temperatures above this: denature enzymes and block metabolic pathways  Temperatures below this: slow down metabolism and affect the brain.
  • 6. Heat Balance  Heat balance maintains the body temp  Balance between heat production & heat loss (Heat Balance)  Heat Balance  Heat production= Heat loss  Heat production is called thermogenesis  Heat loss is called as thermolysis
  • 7.
  • 8. Heat Production (Thermogenesis)  BMR  Specific Dynamic Action of food  Activity of skeletal muscle Shivering Exercise  Chemical Thermogenesis Epinephrine &Norepinephrine Thyroxine  Brown Fat- Source of considerable heat production Abundant in infants
  • 9. Heat Loss (Thermolysis)  Radiation  Conduction  Convection  Evaporation  Perspiration  Respiration  Loss through urine & feces
  • 10.
  • 12. Heat Exchange in the Skin
  • 14. Thermoregulation  Temperature is regulated by nervous feedback mechanisms  Thermoregulatory center located in the Hypothalamus  Thermoregulatory regulatory responses include Autonomic Somatic Endocrine Behavioural changes
  • 15. Feedback system  1) Receptor ◦ Sensor that responds to changes (stimuli)  2) Control Center ◦ Sets range of values ◦ Evaluates input and ◦ Sends output  3) Effector- ◦ Receives output from control centre ◦ Produces a response
  • 16. Body Temperature Control System  Hypothalamus ◦ Acts as a thermostat ◦ Receives nerve impulses from cutaneous thermoreceptors ◦ Thermoreceptors Cold &Heat  Hypothalamus- also has thermoreceptors called central thermoreceptors  These detect changes in blood temperature
  • 17.
  • 18. Thermoregulatory regulatory responses  Activated by Exposure to Cold 1. Shivering 2. Increase voluntary activity 3. Increase TSH secretion 4. Increase Catecholamines 5. Vasoconstriction 6. Horripilation 7. Curling up
  • 19. Thermoregulatory regulatory responses  Activated by Exposure to Heat 1. Vasodilatation 2. Sweating 3. Increase in Respiration 4. Anorexia 5. Apathy 6. Decrease TSH secretion
  • 20. Thermoregulatory regulatory responses Exposure to Cold Shivering Increase voluntary activity Increase TSH secretion Increase Catecholamines Vasoconstriction Horripilation Curling up Exposure to Heat Vasodilatation Sweating Increase in Respiration Anorexia Apathy Decrease TSH secretion
  • 21. 1-A major source of heat production in infants is A. Increased muscular activity B. Brown fat C. Increased sympathetic activity D. Specific dynamic action of food
  • 22. 2-At normal room temperature most body heat loss is by- A. Convention B. Conduction C. Radiation D. Sweating
  • 23. 3-Constituents of secreted sweat are similar to plasma except for A. Proteins B. Chloride C. Bicarbonate D. Potassium
  • 24. 4-The only available mechanism of heat transfer when the environmental temperature is greater than the body temperature is A. Radiation B. Conduction C. Convection D. Evaporation
  • 25. 5-Cause of thermogenesis in the body is A. Skeletal muscle relaxation B. Assimilation of food C. Decreased cardiac metabolism D. Hypothyroidism
  • 26. 6-A major factor resulting in increase in body temperature during exercise is- A. Heat dissipating mechanisms inefficient B. Enormous thermogenesis C. Vasoconstriction on non-working muscles D. Resetting of thermostat
  • 27. 7-Site which reflects the true value of core temperature A. Oesophagus and rectum B. Tympanic membrane C. Vagina D. All of the above
  • 28. 8-BMR is dependent on A. Body weight B. Surface area C. Amount of lean body mass D. Height
  • 29. 9-One feels hotter on a humid day because- A. Rate of sweating increases B. Surrounding temperature is more C. Heat loss by the body via process of radiation decreases D. Rate of evaporation of water from body decreases
  • 30. 10-A major factor resulting in increase in body temperature during exercise is- A. Heat dissipating mechanisms inefficient B. Enormous thermogenesis C. Vasoconstriction on non-working muscles D. Resetting of thermostat
  • 31.
  • 32. Temperature Regulation Dr Dileep Verma Associate Professor Deptt of Physiology KGMU
  • 33. Lecture-2 :Topics  Life in Hot environment -Effect of acute heat  Thermoregulatory responses  Heat syndrome -Heat cramps -Heat exhaustion -Heat stroke
  • 34. Contd…  Life in cold environment -effect of acute & long term cold exposure on body  Applied -Hypothermia -Harmful effects of extreme cold
  • 35. Learning Objectives  Effect of Hot & Cold environment on the body.  Thermo-receptors  Regulation of Body Temperature
  • 36. Life in Hot environment  Hot climates- These are two types a) Hot-dry b) Warm-humid  Hot-dry climate- Found in deserts Temp >500 C Not humid  Warm-humid climate – Found in tropical forest Temp usually<350 C Humidity >75%
  • 37. Contd---- Effects of acute heat - Effects of acute exposure to heat are divided into- a) Thermoregulatory responses b) Other effects
  • 38. Contd----  Thermoregulatory regulatory responses Vasodilatation Sweating Increase in Respiration Anorexia Apathy Decrease TSH secretion
  • 39. Contd----  Other effects of acute heat exposure on- Cellular metabolism Rate of respiration Work of breathing Pulse rate Dehydration Urinary volume
  • 40. Contd---- Heat Syndromes- adverse reaction to heat exposure a) Heat Cramps b) Heat Exhaustion c) Heat Stoke
  • 41. Life in cold environment  Effect of cold exposure on body- a) Acute cold exposure b) Long term cold exposure  Applied -Hypothermia -Harmful effects of extreme cold
  • 42. Contd----  Effect of acute cold exposure on body Shivering Increase voluntary activity Increase TSH secretion Increase Catecholamines Vasoconstriction Horripilation Curling up
  • 43. Contd----  Effect of long term cold exposure Metabolic Responses Insulative Responses Hypothermic Responses
  • 44. Contd---- Hypothermia –Body temp below the normal lower limit (<970F)  Thermoregulatory responses Greatly impaired at (<940F) Lost at body temp(<850F)
  • 45. Contd----  Frostbite Occurs at very low temp Surface area freezes Ice crystals formed  Common sites- Lobes of the ears Digits of hands Digits of feet  Cold induced vasodilatation- Final protection against frostbite
  • 46. Summary of Effector Mechanisms in Temperature Regulation
  • 47. 1- Thermal sweating differs from non- thermal sweating in that A. Eccrine glands are responsible for it B. Occurs due to activation of sympathetic cholinergic nerves C. Found mainly over palm, sole and axilla D. All of the above
  • 48. Core temperature of 260C leads to death due to: a) Brain damage b) Respiratory insufficiency c) Cardiac failure d) All of the above
  • 49. 2- Which area of hypothalamus functions as thermostat? A. Preoptic B. Paraventricular C. Dorso medial D. Lateral
  • 50. 3- Insensible water loss (perspiration) will be absent if humidity is A. 50% B. 70% C. 90% D. 100%
  • 51. 4- Pyrogens raises body temperature by A. Setting the thermostat to higher level B. Releasing interleukins C. Decreasing peripheral heat liberating mechanism D. Causing peripheral vasoconstriction
  • 52. 5- Heat loss process of the body not directly under physiological control is A. Radiation from body B. Conduction and convection to surroundings C. Vaporization of sweat D. Warming of inspired air
  • 53. 6- Fever is usually caused by A. Interleukin-1 B. Substance- p C. Endorphins D. Encephalin
  • 54. 7- During exposure to cold, body temperature is raised by A. Vasoconstriction in the skin B. Horripilation C. Thermogenesis D. All of the above
  • 55. 8- Profound hypothermic signs include all except A. Show breathing B. Bradycardia C. Hypotension D. Hyperactivity
  • 56. 9- Aspirin decreases the body temperature by A. Inhibiting interleukin-1 B. Inhibiting pyrogens release C. Killing fever producing organisms D. Inhibiting prostaglandin synthesis
  • 57. 10- When the core temperature of the body falls below the hypothalamic set-point temperature A. The blood vssels of the skin constrict B. Heat production increases within minutes C. The basal metabolic rate increases D. All of the above