This article will provide clarity on all below mentioned points,
FDA Audit - The Do and Don't List
How to Prepare for a FDA Inspection
FDA Basics for Industry > What should I expect during an inspection?
What to Expect When Being Inspected - FDA
FDA Inspections: Face the Challenge Through Proactive PreparationTips to Help You Prepare for an FDA Inspection
Inspection Readiness
US food and drug administration Indian site inspections: An experience
Dealing with a "difficult" FDA investigator
Strategies For Managing FDA Inspection Compliance Risks
Dear Readers,
Through PRES we are trying to connect with the Global Pharma community. Where we discussed, share and explore lots of pharmaceutical hot topics. Being a Pharma professional it is very difficult to get time for own to do something different other than routine responsibilities. Hope you all paraprofessionals are agreed with my views.
That’s you, the readers and followers of my blog, who always encouraged me a lot to do something different than my routine schedule. All the information are easily available web media, I am just trying too collate all those information in a single article.
I have collated the information’s broadly from the Pharmacompliancemonitor, FDA and other regulatory website for this article.
Once again I would like to thanks my readers, followers and seniors, who has encourage me a lot.
PRES Mission
To develop scientifically sound, practical, technical information and resources to advance science and regulation for the pharmaceutical industry
PRES Vision
To be the foremost global provider of science, technology, and regulatory information and education for the pharmaceutical community
Computer Systems Servicing National Certificate Level II (NC II).
BASIC COMPETENCIES
Participate in Workplace Communication
Work in Team Environment
Practice Career Professionalism
Practice Occupational Health and Safety Procedures
Note: References/Source not included, forgot to attached po.. Credits to all those original owner of the information.. No intentions of copyright infringement..
Chapman Institute’s WellCert program is the premier, and most established, professional certification program in the U.S. for Worksite Wellness practitioners.
Why it's essential to have wellbeing programmes in the workplaceJustine Clement
Wellbeing programmes must start with what the possibilities could be, not just from the problems that currently exist (e.g. risks, illnesses, absences). Starting with what could be, forces any wellbeing programme to determine how to create a new reality instead of JUST fixing what is wrong. Creating an improved, “idealised” outcome means that not only are the existing problems addressed, but that a programmes serves to exceed expectation. This is the reason why we it's essential to have wellbeing programmes in organisations today.
This article will provide clarity on all below mentioned points,
FDA Audit - The Do and Don't List
How to Prepare for a FDA Inspection
FDA Basics for Industry > What should I expect during an inspection?
What to Expect When Being Inspected - FDA
FDA Inspections: Face the Challenge Through Proactive PreparationTips to Help You Prepare for an FDA Inspection
Inspection Readiness
US food and drug administration Indian site inspections: An experience
Dealing with a "difficult" FDA investigator
Strategies For Managing FDA Inspection Compliance Risks
Dear Readers,
Through PRES we are trying to connect with the Global Pharma community. Where we discussed, share and explore lots of pharmaceutical hot topics. Being a Pharma professional it is very difficult to get time for own to do something different other than routine responsibilities. Hope you all paraprofessionals are agreed with my views.
That’s you, the readers and followers of my blog, who always encouraged me a lot to do something different than my routine schedule. All the information are easily available web media, I am just trying too collate all those information in a single article.
I have collated the information’s broadly from the Pharmacompliancemonitor, FDA and other regulatory website for this article.
Once again I would like to thanks my readers, followers and seniors, who has encourage me a lot.
PRES Mission
To develop scientifically sound, practical, technical information and resources to advance science and regulation for the pharmaceutical industry
PRES Vision
To be the foremost global provider of science, technology, and regulatory information and education for the pharmaceutical community
Computer Systems Servicing National Certificate Level II (NC II).
BASIC COMPETENCIES
Participate in Workplace Communication
Work in Team Environment
Practice Career Professionalism
Practice Occupational Health and Safety Procedures
Note: References/Source not included, forgot to attached po.. Credits to all those original owner of the information.. No intentions of copyright infringement..
Chapman Institute’s WellCert program is the premier, and most established, professional certification program in the U.S. for Worksite Wellness practitioners.
Why it's essential to have wellbeing programmes in the workplaceJustine Clement
Wellbeing programmes must start with what the possibilities could be, not just from the problems that currently exist (e.g. risks, illnesses, absences). Starting with what could be, forces any wellbeing programme to determine how to create a new reality instead of JUST fixing what is wrong. Creating an improved, “idealised” outcome means that not only are the existing problems addressed, but that a programmes serves to exceed expectation. This is the reason why we it's essential to have wellbeing programmes in organisations today.
CSO crisis accommodation program The Interview Process For New AspirantsBluecare
Volunteer Support Worker Interview In order for a CSO to function properly it needs to determine the roles and responsibilities of its employee's by providing them with a clear definition and understanding of this in their workplace. This will help to avoid disputes and misunderstandings over authority. [Job Description - Ensures the well-being of clients in the day program and/or group home and promotes their development. A key component of this job is to assist clients in their physical, social, emotional and daily life skills development. This increases their independence and allows them to function appropriately in the community. Provides support to adults in care. Services provided include crisis intervention, behaviour management, and life skills training, whether on a one-to-one basis or in a group environment.
A talk by Rob Catalano
Chief Engagement Officer, WorkTango
As uncertainty spreads through organizations, executives, HR professionals, and every single employee, it gets challenging to operate in a ‘new normal.’
But in unprecedented times, your employees matter now, more than ever. This session will discuss:
· The impact uncertain times have on employees and why it’s important for companies to respond
· Specific recommendations on how to engage employees given the uncertainty in the workplace
· The mindset and approach that you need to start with
· Examples of companies that are doing it well to inspire action in your organization
Watch REPLAY here:
https://leading-in-crisis.turnkeycoachingsolutions.com/talks/how-to-engage-employees-in-uncertain-times/
**Leading in a Crisis Free Virtual Summit 40+ Speakers:**
https://leading-in-crisis.turnkeycoachingsolutions.com/
The Terrorist, He WatchesThe bomb will explode in the bar at twe.docxssusera34210
The Terrorist, He Watches
The bomb will explode in the bar at twenty past one.
Now it’s only sixteen minutes past.
Some will still have time to enter,
some to leave.
The terrorist’s already on the other side.
That distance protects him from all harm
and well it’s like the pictures:
A woman in a yellow jacket, she enteres.
A man in dark glasses, he leaves.
Boys in jeans, they’re talking.
Sixteen minutes past and four seconds.
The smaller one he’s lucky, mounts his scooter,
but that taller chap he walks in.
Seventeen minutes and forty seconds.
A girl, she walks by, a green ribbon in her hair.
But that bus suddenly hides her.
Eighteen minutes past.
The girl’s disappeared.
Was she stupid enough to go in, or wasn’t she.
We shall see when they bring out the bodies.
Nineteen minutes past.
No one else appears to be going in.
On the other hand, a fat bald man leaves.
But seems to search his pockets and
at ten seconds to twenty past one
he returns to look for his wretched gloves.
It’s twenty past one.
Time, how it drags.
Surely, it’s now.
No, not quite.
Yes, now.
The bomb, it explodes.
–Wislawa Szymborska
Please reword these paragraphs in your own words DO NOT USE the same words as in the paragraphs. Thanks.
· 1-According to Chapter 14, the competing values framework (CVF) provides a practical way for managers to understand, measure, and change organizational culture. There are four types or organizational culture; clan culture, adhocracy culture, market culture, and hierarchy culture. Clan culture describes companies that have an internal, family-type, focus that encourages collaboration, trust, and support to achieve effectiveness. Adhocracy culture describes companies that have an external focus on creating new products and services by being creative and adapting quickly to changes. Market culture describes companies that value stability and control. Competition drives these organizations with a high focus on customers and profits. Hierarchy culture describes companies that have an internal focus valuing stability and control over flexibility.
At my company, the elements that have the greatest influence on organizational culture are create and collaborate. Without the create element, we would remain the same and end up losing out on business because our competitors would keep moving forward while we remained the same. To remain competitive in the business we must keep up with the technological advances. Collaboration is key to keeping employees involved and motivated. The morale of the workers and the company's investment in developing them, keeps employees and their knowledge in the company and hopefully not leaving to go work for a competitor.
· 2-According to Chapter 14, organizational culture is defined as the set of shared, taken-for-granted implicit assumptions that a group holds and that determines how it perceives, thinks about, and reacts to its various environments. The four characteristics of organizational culture are shared concept ...
Week 1· Organizational Theory read all sections from Why Study .docxcelenarouzie
Week 1
· Organizational Theory: read all sections from Why Study Organizational Theory, Classical Perspectives, Behavioral Perspectives, Modern Thinking, and Evolving Organizations
· Organizational Theory Timeline (This timeline is an outline of the Schools of Thought and the theorists who proposed their philosophies of management since the early 1900's to current day. This timeline is important in completing Assignment #1 due in week 3). Note: This document provides snippets of brief information and is not meant to be the only source document used to complete Assignment 1.
· Accelerate! The Evolution of the 21st Century Organization
· Introduction to Management: Current Challenges in Management - read all sections
· Organizational Structure: Trends in Organization: read all sections
· Diversity in a Global Business World: Diversity in Organizations - read section Trends in Organizational Diversity
· History of Management Thought
Week 2
· Organizational Culture and Innovation: read all sections from Adapting and Innovating, Technology and Innovation, Managing Change for Organizations, and Managing Change for Employees
· Strategic Management: Internal Analysis Inputs to Strategy - read section Porter's Competitive Strategies
· Organizational Capability - Creating Competitive Advantage
· Adaptability: The New Competitive Advantage
· Building a Learning Organization
· Navigating in the new competitive landscape: Building strategic flexibility and competitive advantage in the 21st century
· Competitive Advantage in the Enterprise Performance
Week 3
https://courses.lumenlearning.com/boundless-management/chapter/internal-analysis-inputs-to-strategy/
https://courses.lumenlearning.com/boundless-management/chapter/strategic-management/
https://courses.lumenlearning.com/boundless-management/chapter/defining-leadership/
https://www.diffen.com/difference/Mission_Statement_vs_Vision_Statement
http://smallbusiness.chron.com/purpose-mission-vision-statements-strategic-planning-13161.html
http://smallbusiness.chron.com/develop-strategic-planning-vision-statements-4501.html
http://smallbusiness.chron.com/vision-mission-statement-30844.html
Week 4
Strategic Management: Internal Analysis Inputs to Strategy - read section SWOT Analysis
SWOT Analysis
· Strategic Management: Planning Tools - read sections Goal Setting, Management by Objectives, and SMART Goals
· Strategic Management: Strategic Management - read sections The Importance of Strategy, and Making Strategy Effective
Project 2 Group Project Due Week 5
In this group project your team will begin to learn about the elements of strategic planning. Specifically, students will
complete an external environmental analysis and an internal environmental analysis. For an organization to do a
comprehensive analysis both the external and internal analysis must be completed. The external environment consists of
variables that an organization cannot control whereas the internal environment consi.
The guidance – led by CIPR Health - is designed to help employers build a working environment that supports positive mental health and advises practitioners on how to take care of their mental wellbeing.
In this word document, I describe my interpersonal communication strategy in which you can find how I see myself as a leader and how I want to improve my communication skills.
Sterilization mathematics (F0. Fphy, Fbio, Sterility Assurance (SAL) calculat...Palash Das
Sterile means free from viable microorganisms and sterilization is any physical or chemical process which destroys all life forms, with special regard to microorganisms (including bacteria and sporogenous forms) and inactivates viruses.
Therefore, the terms “sterile” and “sterilization”, in a strictly biological sense, describe the absence and, respectively, the destruction of all viable microorganisms. In other words, they are absolute terms: an object or system is either “sterile” or “non-sterile”.
The destruction of a microbial population subjected to a sterilization process follows a logarithmic progression: only a treatment of infinite duration can provide the absolute certainty that the entire microbial population has been destroyed, and that the system is sterile.
Hosting remote inspection at pharmaceutical facilities Palash Das
COVID-19 pandemic has put manufacturers, affiliates and inspectors in a new and challenging situation where it is in the public interest to continue to supply medicines while ensuring demonstrated compliance. Regulatory agencies coming with the idea for conducting remote inspection across foreign manufacturing site
CSO crisis accommodation program The Interview Process For New AspirantsBluecare
Volunteer Support Worker Interview In order for a CSO to function properly it needs to determine the roles and responsibilities of its employee's by providing them with a clear definition and understanding of this in their workplace. This will help to avoid disputes and misunderstandings over authority. [Job Description - Ensures the well-being of clients in the day program and/or group home and promotes their development. A key component of this job is to assist clients in their physical, social, emotional and daily life skills development. This increases their independence and allows them to function appropriately in the community. Provides support to adults in care. Services provided include crisis intervention, behaviour management, and life skills training, whether on a one-to-one basis or in a group environment.
A talk by Rob Catalano
Chief Engagement Officer, WorkTango
As uncertainty spreads through organizations, executives, HR professionals, and every single employee, it gets challenging to operate in a ‘new normal.’
But in unprecedented times, your employees matter now, more than ever. This session will discuss:
· The impact uncertain times have on employees and why it’s important for companies to respond
· Specific recommendations on how to engage employees given the uncertainty in the workplace
· The mindset and approach that you need to start with
· Examples of companies that are doing it well to inspire action in your organization
Watch REPLAY here:
https://leading-in-crisis.turnkeycoachingsolutions.com/talks/how-to-engage-employees-in-uncertain-times/
**Leading in a Crisis Free Virtual Summit 40+ Speakers:**
https://leading-in-crisis.turnkeycoachingsolutions.com/
The Terrorist, He WatchesThe bomb will explode in the bar at twe.docxssusera34210
The Terrorist, He Watches
The bomb will explode in the bar at twenty past one.
Now it’s only sixteen minutes past.
Some will still have time to enter,
some to leave.
The terrorist’s already on the other side.
That distance protects him from all harm
and well it’s like the pictures:
A woman in a yellow jacket, she enteres.
A man in dark glasses, he leaves.
Boys in jeans, they’re talking.
Sixteen minutes past and four seconds.
The smaller one he’s lucky, mounts his scooter,
but that taller chap he walks in.
Seventeen minutes and forty seconds.
A girl, she walks by, a green ribbon in her hair.
But that bus suddenly hides her.
Eighteen minutes past.
The girl’s disappeared.
Was she stupid enough to go in, or wasn’t she.
We shall see when they bring out the bodies.
Nineteen minutes past.
No one else appears to be going in.
On the other hand, a fat bald man leaves.
But seems to search his pockets and
at ten seconds to twenty past one
he returns to look for his wretched gloves.
It’s twenty past one.
Time, how it drags.
Surely, it’s now.
No, not quite.
Yes, now.
The bomb, it explodes.
–Wislawa Szymborska
Please reword these paragraphs in your own words DO NOT USE the same words as in the paragraphs. Thanks.
· 1-According to Chapter 14, the competing values framework (CVF) provides a practical way for managers to understand, measure, and change organizational culture. There are four types or organizational culture; clan culture, adhocracy culture, market culture, and hierarchy culture. Clan culture describes companies that have an internal, family-type, focus that encourages collaboration, trust, and support to achieve effectiveness. Adhocracy culture describes companies that have an external focus on creating new products and services by being creative and adapting quickly to changes. Market culture describes companies that value stability and control. Competition drives these organizations with a high focus on customers and profits. Hierarchy culture describes companies that have an internal focus valuing stability and control over flexibility.
At my company, the elements that have the greatest influence on organizational culture are create and collaborate. Without the create element, we would remain the same and end up losing out on business because our competitors would keep moving forward while we remained the same. To remain competitive in the business we must keep up with the technological advances. Collaboration is key to keeping employees involved and motivated. The morale of the workers and the company's investment in developing them, keeps employees and their knowledge in the company and hopefully not leaving to go work for a competitor.
· 2-According to Chapter 14, organizational culture is defined as the set of shared, taken-for-granted implicit assumptions that a group holds and that determines how it perceives, thinks about, and reacts to its various environments. The four characteristics of organizational culture are shared concept ...
Week 1· Organizational Theory read all sections from Why Study .docxcelenarouzie
Week 1
· Organizational Theory: read all sections from Why Study Organizational Theory, Classical Perspectives, Behavioral Perspectives, Modern Thinking, and Evolving Organizations
· Organizational Theory Timeline (This timeline is an outline of the Schools of Thought and the theorists who proposed their philosophies of management since the early 1900's to current day. This timeline is important in completing Assignment #1 due in week 3). Note: This document provides snippets of brief information and is not meant to be the only source document used to complete Assignment 1.
· Accelerate! The Evolution of the 21st Century Organization
· Introduction to Management: Current Challenges in Management - read all sections
· Organizational Structure: Trends in Organization: read all sections
· Diversity in a Global Business World: Diversity in Organizations - read section Trends in Organizational Diversity
· History of Management Thought
Week 2
· Organizational Culture and Innovation: read all sections from Adapting and Innovating, Technology and Innovation, Managing Change for Organizations, and Managing Change for Employees
· Strategic Management: Internal Analysis Inputs to Strategy - read section Porter's Competitive Strategies
· Organizational Capability - Creating Competitive Advantage
· Adaptability: The New Competitive Advantage
· Building a Learning Organization
· Navigating in the new competitive landscape: Building strategic flexibility and competitive advantage in the 21st century
· Competitive Advantage in the Enterprise Performance
Week 3
https://courses.lumenlearning.com/boundless-management/chapter/internal-analysis-inputs-to-strategy/
https://courses.lumenlearning.com/boundless-management/chapter/strategic-management/
https://courses.lumenlearning.com/boundless-management/chapter/defining-leadership/
https://www.diffen.com/difference/Mission_Statement_vs_Vision_Statement
http://smallbusiness.chron.com/purpose-mission-vision-statements-strategic-planning-13161.html
http://smallbusiness.chron.com/develop-strategic-planning-vision-statements-4501.html
http://smallbusiness.chron.com/vision-mission-statement-30844.html
Week 4
Strategic Management: Internal Analysis Inputs to Strategy - read section SWOT Analysis
SWOT Analysis
· Strategic Management: Planning Tools - read sections Goal Setting, Management by Objectives, and SMART Goals
· Strategic Management: Strategic Management - read sections The Importance of Strategy, and Making Strategy Effective
Project 2 Group Project Due Week 5
In this group project your team will begin to learn about the elements of strategic planning. Specifically, students will
complete an external environmental analysis and an internal environmental analysis. For an organization to do a
comprehensive analysis both the external and internal analysis must be completed. The external environment consists of
variables that an organization cannot control whereas the internal environment consi.
The guidance – led by CIPR Health - is designed to help employers build a working environment that supports positive mental health and advises practitioners on how to take care of their mental wellbeing.
In this word document, I describe my interpersonal communication strategy in which you can find how I see myself as a leader and how I want to improve my communication skills.
Sterilization mathematics (F0. Fphy, Fbio, Sterility Assurance (SAL) calculat...Palash Das
Sterile means free from viable microorganisms and sterilization is any physical or chemical process which destroys all life forms, with special regard to microorganisms (including bacteria and sporogenous forms) and inactivates viruses.
Therefore, the terms “sterile” and “sterilization”, in a strictly biological sense, describe the absence and, respectively, the destruction of all viable microorganisms. In other words, they are absolute terms: an object or system is either “sterile” or “non-sterile”.
The destruction of a microbial population subjected to a sterilization process follows a logarithmic progression: only a treatment of infinite duration can provide the absolute certainty that the entire microbial population has been destroyed, and that the system is sterile.
Hosting remote inspection at pharmaceutical facilities Palash Das
COVID-19 pandemic has put manufacturers, affiliates and inspectors in a new and challenging situation where it is in the public interest to continue to supply medicines while ensuring demonstrated compliance. Regulatory agencies coming with the idea for conducting remote inspection across foreign manufacturing site
A review article on visual inspection program for sterile injectable product ...Palash Das
Objective of this article is to conduct a thorough review and understanding on the manually
conduct visual inspection process for liquid Injectable products in liquid and lyophilized form
and to explore the complications identified during the routine process. Along with that
troubleshot to overcome from the challenges. Evaluation quality of product during batch
release and consider continuous process improvement opportunities.
Root cause analysis is an important part for identifying failures during investigation. This article will provide you a number of examples of fish bone diagram, which will be useful for all
Pharmaceutical professional.
Version : 00
Equipment risk management - a quality systems approachPalash Das
Refer before performing risk assessment for pharmaceutical equipment. Can be considered before preparation of User Requirement Specification. in case of existing equipment can be prepare as a part of annual risk review.
Guidance on gloves maintenance in Isolator and RABSPalash Das
A faulty glove or sleeve assembly represents a route of contamination and a critical breach of Isolator integrity. Within this article we will discuss about all these aspects.
Pharmaceutical Isolator technology in aseptic processingPalash Das
These articles describe different aspects of aseptic processing Isolator.
Isolators have been around the Pharmaceutical Industry since the early 1980s and in the Nuclear Industry (glovebox technology) since the 1950s. The intent of isolators is to create an airtight barrier or enclosure around a piece of equipment or process which provides absolute separation between the operator and product. The operator can perform tasks through half- suits or glove ports. Isolators provide a specific environment inside the isolator using HEPA filters. The environment can be positive pressure or negative, can have humidity control, oxygen control, use unidirectional airflow, and can either protect the product from the operator as with aseptic processes, or protect the operator from the product as with potent product handling. The earliest uses of aseptic isolators were for sterility testing. Sterility test isolators make up most of the aseptic isolators in use and are available in many different sizes and configurations. Sterility test isolators do not need to be installed in a classified area. No formal requirement exists for a Grade D environment, but the area should be controlled to allow only trained personnel.
Workshop On Risk Assesment by Palash Ch DasPalash Das
Risk management principles are effectively utilized in many areas of business and government including finance, insurance, occupational safety, public health, pharmacovigilance, and by agencies regulating these industries. Although there are some examples of the use of quality risk management in the pharmaceutical industry today, they are limited and do not represent the full contributions that risk management has to offer. In addition, the importance of quality systems has been recognized in the pharmaceutical industry and it is becoming evident that quality risk management is a valuable component of an effective quality system.
Pharmaceutical Company Facility PresentationPalash Das
This presentation is dedicated to all pharmaceutical organization. this can be use as a standard template for presenting your organization during audit. The concept is designed based on the sterile pharmaceutical facility.
Pharmaceutical HVAC (Heating, ventilating, and air conditioning; also heating...Palash Das
This slide is represent the HVAC design,qualification and operational approach. As we know HVAC is important system for maintaining clean room. This presentation is made based on the requirement of Pharmaceutical Industry. All parameter are considered based on the current guidelines aspect.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The POPPY STUDY (Preconception to post-partum cardiovascular function in prim...
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