TCF/LEF talk
•Download as KEY, PDF•
1 like•894 views
The TCF/LEF family of transcription factors are involved in the Wnt signaling pathway and have 4 members that are expressed differently in tissues and developmental stages. Some isoforms of TCF7L2 and LEF1 lack a binding site for beta-catenin, acting as dominant negative regulators of the pathway. The author investigated whether these dominant negative isoforms evolved earlier by examining cDNA data from fish, frog, and lizard, but found no evidence of alternative first exons, suggesting the negative isoforms independently evolved in mammals. More data is needed to better understand the evolution of these isoforms.
Report
Share
Report
Share
Recommended
Present status of FIsheries sector and Potential for sustainable Aquaculture ...
Indian marine and Inland Fisheries resources, and their production potential, fishermen livelihoods, seed production,Inland and marine fish production since 1980' to 2021-22 and State wise per capita consumption, exports, fisheries contribution in GDP, achivements status of PMMSY and potential for mari culture and brackish water fish farming.
Estuarine fisheries n.a.k.
This document discusses estuaries and estuarine fisheries in India. It defines an estuary and notes that India has over 55 estuaries along its eastern and western coasts, totaling approximately 30,000 square kilometers. Several major river systems like the Ganges, Mahanadi, Godavari and Krishna form highly productive estuarine ecosystems. The document examines the fish production and ecology of estuaries like the Hooghly, Krishna, Godavari, Mahanadi, Chilka, Pulicat Lake, and Kerala backwaters. It provides details on fish catches, species diversity, and threats like overfishing in several of India's important estuarine systems.
Inner ear and weberian apparatus
The inner ear of fishes is located in the posterior angles of the cranium and contains receptors for vibrations and balance. It includes three semicircular canals, the utriculus, sacculus, and lagena pockets filled with endolymph. These pockets contain otoliths that help the fish sense vibrations and orientation. Some bony fishes have a Weberian apparatus connecting the swim bladder to the inner ear, which improves hearing by transmitting pressure changes through a chain of four ossicles.
ETHOLOGY-HORMONES & BEHAVIOR
This document discusses several topics related to animal behavior and hormones:
1) It describes homeostasis as the tendency of a system to maintain internal stability in response to stimuli.
2) It discusses the hormone leptin, which is secreted by adipose tissue and plays a key role in regulating food intake and hypothalamic development.
3) It contrasts homeostatic and non-homeostatic systems in regulating food intake, noting that cognitive and executive decisions can override hunger signals.
Pertemuan Keempat | Budidaya Tiram Mutiara| Aspek Budidaya Tiram Mutiara
Dokumen tersebut membahas tentang aspek-aspek budidaya tiram mutiara, mulai dari persiapan, sarana dan prasarana, teknik pembenihan, pembiakan, insersi, pemeliharaan, panen, hingga permasalahan yang sering dihadapi. Budidaya tiram mutiara memerlukan persiapan yang matang dan dilakukan secara hati-hati agar hasil panennya optimal.
Induced breeding of tilapia
Induced breeding is a technique whereby ripe fish breeders are stimulated by pituitary hormone or any other synthetic hormone introduction to breed in captive condition. The stimulation promotes timely release of sperms and eggs.
Teratogenesis
This document discusses teratogens and their effects on fetal development. It defines teratogens as any substance that can alter fetal morphology or function when the fetus is exposed. The main causes of congenital anomalies are discussed, with drugs and chemicals accounting for 5%. Several factors determine the effect of teratogens on the fetus, including developmental stage at exposure and genetic susceptibility. The effects of teratogens can be immediate, at birth, or delayed. Various teratogenic agents are outlined, including maternal medical disorders, infections, ionizing radiation, chemicals, and drugs categorized by the FDA. Specific examples of each category and their risks are provided.
Recommended
Present status of FIsheries sector and Potential for sustainable Aquaculture ...
Indian marine and Inland Fisheries resources, and their production potential, fishermen livelihoods, seed production,Inland and marine fish production since 1980' to 2021-22 and State wise per capita consumption, exports, fisheries contribution in GDP, achivements status of PMMSY and potential for mari culture and brackish water fish farming.
Estuarine fisheries n.a.k.
This document discusses estuaries and estuarine fisheries in India. It defines an estuary and notes that India has over 55 estuaries along its eastern and western coasts, totaling approximately 30,000 square kilometers. Several major river systems like the Ganges, Mahanadi, Godavari and Krishna form highly productive estuarine ecosystems. The document examines the fish production and ecology of estuaries like the Hooghly, Krishna, Godavari, Mahanadi, Chilka, Pulicat Lake, and Kerala backwaters. It provides details on fish catches, species diversity, and threats like overfishing in several of India's important estuarine systems.
Inner ear and weberian apparatus
The inner ear of fishes is located in the posterior angles of the cranium and contains receptors for vibrations and balance. It includes three semicircular canals, the utriculus, sacculus, and lagena pockets filled with endolymph. These pockets contain otoliths that help the fish sense vibrations and orientation. Some bony fishes have a Weberian apparatus connecting the swim bladder to the inner ear, which improves hearing by transmitting pressure changes through a chain of four ossicles.
ETHOLOGY-HORMONES & BEHAVIOR
This document discusses several topics related to animal behavior and hormones:
1) It describes homeostasis as the tendency of a system to maintain internal stability in response to stimuli.
2) It discusses the hormone leptin, which is secreted by adipose tissue and plays a key role in regulating food intake and hypothalamic development.
3) It contrasts homeostatic and non-homeostatic systems in regulating food intake, noting that cognitive and executive decisions can override hunger signals.
Pertemuan Keempat | Budidaya Tiram Mutiara| Aspek Budidaya Tiram Mutiara
Dokumen tersebut membahas tentang aspek-aspek budidaya tiram mutiara, mulai dari persiapan, sarana dan prasarana, teknik pembenihan, pembiakan, insersi, pemeliharaan, panen, hingga permasalahan yang sering dihadapi. Budidaya tiram mutiara memerlukan persiapan yang matang dan dilakukan secara hati-hati agar hasil panennya optimal.
Induced breeding of tilapia
Induced breeding is a technique whereby ripe fish breeders are stimulated by pituitary hormone or any other synthetic hormone introduction to breed in captive condition. The stimulation promotes timely release of sperms and eggs.
Teratogenesis
This document discusses teratogens and their effects on fetal development. It defines teratogens as any substance that can alter fetal morphology or function when the fetus is exposed. The main causes of congenital anomalies are discussed, with drugs and chemicals accounting for 5%. Several factors determine the effect of teratogens on the fetus, including developmental stage at exposure and genetic susceptibility. The effects of teratogens can be immediate, at birth, or delayed. Various teratogenic agents are outlined, including maternal medical disorders, infections, ionizing radiation, chemicals, and drugs categorized by the FDA. Specific examples of each category and their risks are provided.
Assessing damage and loss in fisheries and aquaculture
This presentation discusses the impacts of disasters on fisheries and aquaculture (F&A). It explores the specific characteristics of F&A, sources of baseline data, and how different types of disasters can affect F&A differently. Some methodologies for assessing disasters capture F&A better than others. Stressors like climate change also impact F&A through changes in oceans, fish distribution and abundance. The presentation concludes that an information system on disasters and losses needs minimum core variables and engagement to improve F&A data, as methodologies are still being developed to fully assess impacts on F&A.
Inland fishing craft and gears
Coracles are dominant fishing craft in South Indian reservoirs. They are made of a large, circular basket with low sides and a hide covering. Fishermen use gill nets, shore seines and longlines from coracles. Catamarans, made of 3-5 logs tied together, are used in pairs for boat seines and individually for longlines and cast nets. Common inland fishing gears include cast nets, gill nets, seines, lift nets, drag nets, hooks and lines, and traps. Trawlers have been tried experimentally in some Indian reservoirs.
Prawn culture
Prawn cultureBangabandhu Sheikh Mujibur Rahman Agricultural University, Salna , Gazipur-1706, Bangladesh
Macrobrachium rosenbergii, also known as the giant river prawn or giant freshwater prawn, is a commercially important species of palaemonid freshwater prawn. It is found throughout the tropical and subtropical areas of the Indo-Pacific region, from India to Southeast Asia and Northern Australia.Natural fish seed collection
Transport of hatchlings, fry, and fingerlings is common in aquaculture. Proper techniques involve understanding fish physiology and mortality causes during transport. Seed can be collected from wild or hatcheries. Major carps are collected from flooded rivers during monsoon season. Seed from estuaries and coastal waters include milkfish, mullets, pearlspot, and seabass. Bundhs are seasonal flooded areas that stimulate breeding. Induced spawning techniques breed species that don't spawn in captivity using hormones. Transport uses open or closed oxygenated systems. Factors causing mortality are oxygen depletion, waste accumulation, temperature fluctuations, and stress. Anaesthetics and antibiotics are used to reduce stress and prevent disease.
Pokkali ppt
The document discusses Pokkali, an indigenous rice cultivation practice in Kerala, India. Some key points:
Pokkali is a traditional integrated farming system practiced in coastal Kerala wetlands. It utilizes saline-tolerant rice varieties and integrates rice cultivation with shrimp/prawn farming. This system is sustainable with the rice and prawns providing mutual benefits.
However, the area under Pokkali farming has declined significantly due to issues like land conversion, pollution, and unscientific shrimp monoculture. There are also challenges from climate change impacts like rising sea levels and increased salinity.
Despite the limitations, Pokkali farming remains an ecologically sound practice that supports livelihoods and
TCFLEFTalk
The TCF/LEF family of transcription factors are involved in the Wnt signaling pathway and have 4 family members that are expressed differently in tissues and developmental stages. Some isoforms of TCF7L2 and LEF1 lack a binding site for beta-catenin and serve as dominant negative regulators of the pathway. The researcher investigated whether these dominant negative isoforms evolved early in vertebrate evolution by examining data from fish, frog, and lizard, but found no evidence that they existed prior to mammals, suggesting they independently evolved in mammals. More data is needed to further understand the evolution of these negative isoforms.
Getting undergrads excited about evolution and science
This document summarizes research on the evolution of animal body plans and insights from genomics studies of marine invertebrates. It finds that basal metazoans like Placozoa, Cnidaria, Porifera, and Ctenophora exhibit a wide variety of body plans and life histories. The genome of Pleurobrachia bachei, a ctenophore, was sequenced which provides insights into the evolution of nervous systems. Analysis of Wnt signaling pathway genes in P. bachei found conservation with other animals and potential roles in development and neurotransmission. The study of P. bachei's genome involved undergraduate students and provided hands-on research experience in genomics.
PCDDFpresentation
This research aimed to discover more bacterial species capable of degrading polychlorinated dioxins/dibenzofurans (PCDD/Fs) through bioinformatics analysis. The researcher identified 31 additional species with genes for PCDD/F degradation, significantly expanding knowledge of gene families involved. Phylogenetic analysis provided insights into relationships between newly discovered and known species. While several findings require further study, this research substantially increased understanding of bacteria that can potentially aid bioremediation of these toxic compounds.
Expanding the Genetic Code
presentation on how to expand the genetic code; it's pre-requisites; xenobiology and xeno-nucleic acids; planet's first Semi-Synthetic Organism ( with 6 nucleotides) and Hachimoji DNA (8 Nucleotide DNA)
BIO420 Chapter 25
This document discusses evolutionary developmental biology and how changes in development can lead to evolutionary changes. It provides examples of modularity and molecular parsimony which help explain this. Modularity means parts of the body and DNA can develop differently. Molecular parsimony means organisms share developmental toolkit genes. The document then discusses specific examples like stickleback fish pelvic spines being due to different Pitx1 expression, and Darwin's finches having beak shape variations due to differing Bmp4 and Calmodulin expression levels. Mechanisms of evolutionary change include changes in location, timing, amount, or kind of gene expression.
The more the merrier: the genomics of single, double and polysymbioses
This document discusses endosymbiotic relationships through analysis of genomic data from various symbiotic systems. It summarizes genomic studies of Wolbachia pipientis and the glassy-winged sharpshooter's symbionts. These studies found trends in endosymbiont genomes like smaller size and higher evolutionary rates compared to free-living relatives. The document also discusses future directions like analyzing more diverse symbiotic systems and obligate symbionts through metagenomic approaches.
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...Charles Malcolm Roberson
This study aimed to generate induced pluripotent stem cells (iPSCs) from urine cells of patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder. Urine samples were collected from three patients, cultured, and characterized. The cells were then to be reprogrammed into iPSCs via electroporation of plasmids containing reprogramming factors. While initial culturing of control urine cells was unsuccessful, culturing of cells from a second FOP patient showed promise. Future work includes characterizing the urine cells and reprogramming them to produce patient-specific iPSCs for studying FOP.Geneticschapter7dnastructureandreplication 140305210513-phpapp01
DNA replication is semiconservative and bidirectional. It involves unwinding the parental DNA strands at an origin of replication followed by synthesis of new complementary strands. Each parental strand serves as a template for a new daughter strand. DNA polymerase adds nucleotides to the 3' end of the growing strand based on complementary base pairing. The leading strand is synthesized continuously while the lagging strand is synthesized discontinuously in short segments called Okazaki fragments. RNA primers are required for initiation and DNA polymerase proofreads and corrects errors to ensure high fidelity. Telomeres and the telomerase enzyme allow complete replication of linear chromosomes.
gnomAD at AGBT
This document summarizes the key findings from the gnomAD 2.1.1 database, which contains genetic variation data from over 125,000 exomes and 15,000 whole genomes. The database identifies over 400,000 loss-of-function variants after filtering. Analysis of these variants reveals the spectrum of intolerance to loss-of-function variation across the human genome. Genes are classified into deciles based on observed vs expected loss-of-function variants, correlating with phenotypes like disease association and essentiality. Constraint metrics also vary between populations and can improve diagnosis of developmental disorders.
Genetics chapter 7 dna structure and replication
The document summarizes key discoveries related to DNA as the genetic material. It describes early evidence that DNA is the molecule responsible for heredity, including Griffith's experiments showing transformation of bacteria with heat-killed DNA and Avery, MacLeod, and McCarty's experiments showing DNA is the transforming principle. It also summarizes Hershey and Chase's experiments demonstrating that DNA enters the host bacterial cell during viral infection. The document then covers Watson and Crick's discovery of the double helix structure of DNA and key features like base pairing and the sugar-phosphate backbone. It also summarizes semiconservative replication of DNA and key molecules involved like DNA polymerase, primers, and proofreading. Finally, it discusses telomer
2014 bangkok-talk
This document discusses opportunities and challenges presented by next-generation DNA sequencing technologies. It begins by introducing the speaker, C. Titus Brown, and their commitment to open science. It then describes the dramatic decreases in cost and increases in scale of DNA sequencing. While this enables sequencing entire genomes and environmental samples, it presents challenges for analysis due to lack of reference genomes and limited computational tools. The document outlines goals for shotgun sequencing analysis and challenges for non-model organisms. It concludes by emphasizing the need for training in data analysis to take advantage of the vast amounts of sequencing data being generated.
Transfer of genetic information-Bijesh
Genetic information can be transferred between prokaryotes through several mechanisms, including conjugation, transformation, and transduction. Conjugation involves the direct transfer of DNA via cell-to-cell contact, mediated by plasmids or sex pili. It can result in the transfer of entire plasmids or portions of chromosomal DNA. The key steps in conjugation include formation of mating pairs between donor and recipient cells, nicking and unwinding of the donor DNA at the origin of transfer site by relaxase and helicase enzymes, and transfer of the single-stranded DNA through a channel into the recipient cell where it is resealed by relaxase. This allows for both plasmid and chromosomal genes to
Lecture4 psych125 bunge
This document discusses genetic and environmental influences on early brain development. It begins by defining key terms like morphogens, transcription factors, and transcription/translation. It then discusses how protein gradients form in embryos through diffusion of maternal mRNA and proteins. Specific morphogens like Bicoid and Sonic hedgehog are discussed. The role of Hox genes and developmental regulatory genes in patterning embryos is covered. The document emphasizes that both genes and the environment through epigenetics influence phenotypes. Prenatal factors like nutrients can impact brain development through epigenetic modifications.
Hertweck Evolution 2014
Presented at Evolution 2014 in Raleigh, NC (http://evolution2014.org)
Jumping genes and life history: De novo transposable element insertions respond to selection for accelerated and delayed development times
Kate L Hertweck, NESCent, k8hertweck@gmail.com
Mira Han, UNLV, mira.han@unlv.edu
Lee F Greer, University of California, Irvine, lgreer@uci.edu
Mark A Phillips, UC Irvine, mphillips6789@gmail.com
Michael R Rose, University of California, Irvine, mrrose@uci.edu
Joseph L Graves, JSNN, North Carolina A&T State University, gravesjl@ncat.edu
A wealth of scientific literature has speculated on the response of both the genome and organism to proliferation of transposable elements (TEs, or jumping genes). In particular, the relationship between TEs and aging has been addressed by both theory and empirical studies. Theory suggests TEs may contribute to life history features such as aging, by introducing detrimental somatic mutation. However, a comparison TEs between organisms indicate the number of copies may increase, decrease, or have no effect on lifespan, depending on the model system and type of TE investigated. Long-term studies in experimental evolution allow explicit testing of such hypothesis using replicated populations. Our data represent pooled population genome-wide resequencing from Drosophila selected for both delayed and accelerated reproduction times and development. Our previous results indicate that insertion frequencies of ancestral TEs (i.e., annotated in the fully sequenced reference genome) respond fairly consistently to selection. For the present study, we use two independent approaches (PoPoolation TE and RelocaTE) to identify de novo TE insertions. We find that the magnitude of TE proliferation varies among multiple families of LTRs, LINEs, and DNA transposons. We present methodological considerations for interpreting such results.
Genomics,proteomics and comparative genomics
This document provides an introduction to genomics, proteomics, and comparative genomics. It discusses the central dogma of molecular biology involving DNA replication, transcription, and translation. It describes DNA and RNA structure and explains how genetic information flows from DNA to protein. The document also discusses genome sequencing, gene mapping, and how comparative analysis of genomes from different species can provide insights into evolutionary relationships and biological functions.
Final shweta protein kinase cascade
This document provides an overview of protein kinase cascades. It begins with an introduction to protein kinases and their function in phosphorylating proteins and playing roles in cellular processes. It then discusses the classification of protein kinases based on the amino acid they phosphorylate. Next, it explains the basic mechanism of phosphorylation by protein kinases using ATP. It proceeds to describe protein kinase cascades where one kinase phosphorylates and activates the next in a series. Examples of double phosphorylation and multi-layer perceptrons in cascades are illustrated. Finally, some biological examples of different types of protein kinases are mentioned before concluding with references.
More Related Content
What's hot
Assessing damage and loss in fisheries and aquaculture
This presentation discusses the impacts of disasters on fisheries and aquaculture (F&A). It explores the specific characteristics of F&A, sources of baseline data, and how different types of disasters can affect F&A differently. Some methodologies for assessing disasters capture F&A better than others. Stressors like climate change also impact F&A through changes in oceans, fish distribution and abundance. The presentation concludes that an information system on disasters and losses needs minimum core variables and engagement to improve F&A data, as methodologies are still being developed to fully assess impacts on F&A.
Inland fishing craft and gears
Coracles are dominant fishing craft in South Indian reservoirs. They are made of a large, circular basket with low sides and a hide covering. Fishermen use gill nets, shore seines and longlines from coracles. Catamarans, made of 3-5 logs tied together, are used in pairs for boat seines and individually for longlines and cast nets. Common inland fishing gears include cast nets, gill nets, seines, lift nets, drag nets, hooks and lines, and traps. Trawlers have been tried experimentally in some Indian reservoirs.
Prawn culture
Prawn cultureBangabandhu Sheikh Mujibur Rahman Agricultural University, Salna , Gazipur-1706, Bangladesh
Macrobrachium rosenbergii, also known as the giant river prawn or giant freshwater prawn, is a commercially important species of palaemonid freshwater prawn. It is found throughout the tropical and subtropical areas of the Indo-Pacific region, from India to Southeast Asia and Northern Australia.Natural fish seed collection
Transport of hatchlings, fry, and fingerlings is common in aquaculture. Proper techniques involve understanding fish physiology and mortality causes during transport. Seed can be collected from wild or hatcheries. Major carps are collected from flooded rivers during monsoon season. Seed from estuaries and coastal waters include milkfish, mullets, pearlspot, and seabass. Bundhs are seasonal flooded areas that stimulate breeding. Induced spawning techniques breed species that don't spawn in captivity using hormones. Transport uses open or closed oxygenated systems. Factors causing mortality are oxygen depletion, waste accumulation, temperature fluctuations, and stress. Anaesthetics and antibiotics are used to reduce stress and prevent disease.
Pokkali ppt
The document discusses Pokkali, an indigenous rice cultivation practice in Kerala, India. Some key points:
Pokkali is a traditional integrated farming system practiced in coastal Kerala wetlands. It utilizes saline-tolerant rice varieties and integrates rice cultivation with shrimp/prawn farming. This system is sustainable with the rice and prawns providing mutual benefits.
However, the area under Pokkali farming has declined significantly due to issues like land conversion, pollution, and unscientific shrimp monoculture. There are also challenges from climate change impacts like rising sea levels and increased salinity.
Despite the limitations, Pokkali farming remains an ecologically sound practice that supports livelihoods and
What's hot (6)
Assessing damage and loss in fisheries and aquaculture
Assessing damage and loss in fisheries and aquaculture
Similar to TCF/LEF talk
TCFLEFTalk
The TCF/LEF family of transcription factors are involved in the Wnt signaling pathway and have 4 family members that are expressed differently in tissues and developmental stages. Some isoforms of TCF7L2 and LEF1 lack a binding site for beta-catenin and serve as dominant negative regulators of the pathway. The researcher investigated whether these dominant negative isoforms evolved early in vertebrate evolution by examining data from fish, frog, and lizard, but found no evidence that they existed prior to mammals, suggesting they independently evolved in mammals. More data is needed to further understand the evolution of these negative isoforms.
Getting undergrads excited about evolution and science
This document summarizes research on the evolution of animal body plans and insights from genomics studies of marine invertebrates. It finds that basal metazoans like Placozoa, Cnidaria, Porifera, and Ctenophora exhibit a wide variety of body plans and life histories. The genome of Pleurobrachia bachei, a ctenophore, was sequenced which provides insights into the evolution of nervous systems. Analysis of Wnt signaling pathway genes in P. bachei found conservation with other animals and potential roles in development and neurotransmission. The study of P. bachei's genome involved undergraduate students and provided hands-on research experience in genomics.
PCDDFpresentation
This research aimed to discover more bacterial species capable of degrading polychlorinated dioxins/dibenzofurans (PCDD/Fs) through bioinformatics analysis. The researcher identified 31 additional species with genes for PCDD/F degradation, significantly expanding knowledge of gene families involved. Phylogenetic analysis provided insights into relationships between newly discovered and known species. While several findings require further study, this research substantially increased understanding of bacteria that can potentially aid bioremediation of these toxic compounds.
Expanding the Genetic Code
presentation on how to expand the genetic code; it's pre-requisites; xenobiology and xeno-nucleic acids; planet's first Semi-Synthetic Organism ( with 6 nucleotides) and Hachimoji DNA (8 Nucleotide DNA)
BIO420 Chapter 25
This document discusses evolutionary developmental biology and how changes in development can lead to evolutionary changes. It provides examples of modularity and molecular parsimony which help explain this. Modularity means parts of the body and DNA can develop differently. Molecular parsimony means organisms share developmental toolkit genes. The document then discusses specific examples like stickleback fish pelvic spines being due to different Pitx1 expression, and Darwin's finches having beak shape variations due to differing Bmp4 and Calmodulin expression levels. Mechanisms of evolutionary change include changes in location, timing, amount, or kind of gene expression.
The more the merrier: the genomics of single, double and polysymbioses
This document discusses endosymbiotic relationships through analysis of genomic data from various symbiotic systems. It summarizes genomic studies of Wolbachia pipientis and the glassy-winged sharpshooter's symbionts. These studies found trends in endosymbiont genomes like smaller size and higher evolutionary rates compared to free-living relatives. The document also discusses future directions like analyzing more diverse symbiotic systems and obligate symbionts through metagenomic approaches.
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...Charles Malcolm Roberson
This study aimed to generate induced pluripotent stem cells (iPSCs) from urine cells of patients with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder. Urine samples were collected from three patients, cultured, and characterized. The cells were then to be reprogrammed into iPSCs via electroporation of plasmids containing reprogramming factors. While initial culturing of control urine cells was unsuccessful, culturing of cells from a second FOP patient showed promise. Future work includes characterizing the urine cells and reprogramming them to produce patient-specific iPSCs for studying FOP.Geneticschapter7dnastructureandreplication 140305210513-phpapp01
DNA replication is semiconservative and bidirectional. It involves unwinding the parental DNA strands at an origin of replication followed by synthesis of new complementary strands. Each parental strand serves as a template for a new daughter strand. DNA polymerase adds nucleotides to the 3' end of the growing strand based on complementary base pairing. The leading strand is synthesized continuously while the lagging strand is synthesized discontinuously in short segments called Okazaki fragments. RNA primers are required for initiation and DNA polymerase proofreads and corrects errors to ensure high fidelity. Telomeres and the telomerase enzyme allow complete replication of linear chromosomes.
gnomAD at AGBT
This document summarizes the key findings from the gnomAD 2.1.1 database, which contains genetic variation data from over 125,000 exomes and 15,000 whole genomes. The database identifies over 400,000 loss-of-function variants after filtering. Analysis of these variants reveals the spectrum of intolerance to loss-of-function variation across the human genome. Genes are classified into deciles based on observed vs expected loss-of-function variants, correlating with phenotypes like disease association and essentiality. Constraint metrics also vary between populations and can improve diagnosis of developmental disorders.
Genetics chapter 7 dna structure and replication
The document summarizes key discoveries related to DNA as the genetic material. It describes early evidence that DNA is the molecule responsible for heredity, including Griffith's experiments showing transformation of bacteria with heat-killed DNA and Avery, MacLeod, and McCarty's experiments showing DNA is the transforming principle. It also summarizes Hershey and Chase's experiments demonstrating that DNA enters the host bacterial cell during viral infection. The document then covers Watson and Crick's discovery of the double helix structure of DNA and key features like base pairing and the sugar-phosphate backbone. It also summarizes semiconservative replication of DNA and key molecules involved like DNA polymerase, primers, and proofreading. Finally, it discusses telomer
2014 bangkok-talk
This document discusses opportunities and challenges presented by next-generation DNA sequencing technologies. It begins by introducing the speaker, C. Titus Brown, and their commitment to open science. It then describes the dramatic decreases in cost and increases in scale of DNA sequencing. While this enables sequencing entire genomes and environmental samples, it presents challenges for analysis due to lack of reference genomes and limited computational tools. The document outlines goals for shotgun sequencing analysis and challenges for non-model organisms. It concludes by emphasizing the need for training in data analysis to take advantage of the vast amounts of sequencing data being generated.
Transfer of genetic information-Bijesh
Genetic information can be transferred between prokaryotes through several mechanisms, including conjugation, transformation, and transduction. Conjugation involves the direct transfer of DNA via cell-to-cell contact, mediated by plasmids or sex pili. It can result in the transfer of entire plasmids or portions of chromosomal DNA. The key steps in conjugation include formation of mating pairs between donor and recipient cells, nicking and unwinding of the donor DNA at the origin of transfer site by relaxase and helicase enzymes, and transfer of the single-stranded DNA through a channel into the recipient cell where it is resealed by relaxase. This allows for both plasmid and chromosomal genes to
Lecture4 psych125 bunge
This document discusses genetic and environmental influences on early brain development. It begins by defining key terms like morphogens, transcription factors, and transcription/translation. It then discusses how protein gradients form in embryos through diffusion of maternal mRNA and proteins. Specific morphogens like Bicoid and Sonic hedgehog are discussed. The role of Hox genes and developmental regulatory genes in patterning embryos is covered. The document emphasizes that both genes and the environment through epigenetics influence phenotypes. Prenatal factors like nutrients can impact brain development through epigenetic modifications.
Hertweck Evolution 2014
Presented at Evolution 2014 in Raleigh, NC (http://evolution2014.org)
Jumping genes and life history: De novo transposable element insertions respond to selection for accelerated and delayed development times
Kate L Hertweck, NESCent, k8hertweck@gmail.com
Mira Han, UNLV, mira.han@unlv.edu
Lee F Greer, University of California, Irvine, lgreer@uci.edu
Mark A Phillips, UC Irvine, mphillips6789@gmail.com
Michael R Rose, University of California, Irvine, mrrose@uci.edu
Joseph L Graves, JSNN, North Carolina A&T State University, gravesjl@ncat.edu
A wealth of scientific literature has speculated on the response of both the genome and organism to proliferation of transposable elements (TEs, or jumping genes). In particular, the relationship between TEs and aging has been addressed by both theory and empirical studies. Theory suggests TEs may contribute to life history features such as aging, by introducing detrimental somatic mutation. However, a comparison TEs between organisms indicate the number of copies may increase, decrease, or have no effect on lifespan, depending on the model system and type of TE investigated. Long-term studies in experimental evolution allow explicit testing of such hypothesis using replicated populations. Our data represent pooled population genome-wide resequencing from Drosophila selected for both delayed and accelerated reproduction times and development. Our previous results indicate that insertion frequencies of ancestral TEs (i.e., annotated in the fully sequenced reference genome) respond fairly consistently to selection. For the present study, we use two independent approaches (PoPoolation TE and RelocaTE) to identify de novo TE insertions. We find that the magnitude of TE proliferation varies among multiple families of LTRs, LINEs, and DNA transposons. We present methodological considerations for interpreting such results.
Genomics,proteomics and comparative genomics
This document provides an introduction to genomics, proteomics, and comparative genomics. It discusses the central dogma of molecular biology involving DNA replication, transcription, and translation. It describes DNA and RNA structure and explains how genetic information flows from DNA to protein. The document also discusses genome sequencing, gene mapping, and how comparative analysis of genomes from different species can provide insights into evolutionary relationships and biological functions.
Final shweta protein kinase cascade
This document provides an overview of protein kinase cascades. It begins with an introduction to protein kinases and their function in phosphorylating proteins and playing roles in cellular processes. It then discusses the classification of protein kinases based on the amino acid they phosphorylate. Next, it explains the basic mechanism of phosphorylation by protein kinases using ATP. It proceeds to describe protein kinase cascades where one kinase phosphorylates and activates the next in a series. Examples of double phosphorylation and multi-layer perceptrons in cascades are illustrated. Finally, some biological examples of different types of protein kinases are mentioned before concluding with references.
protein kinase cascade
This document provides an overview of protein kinase cascades. It begins with an introduction to protein kinases and their function in phosphorylating proteins and playing roles in cellular processes. It then discusses the classification of protein kinases based on the amino acid they phosphorylate. Next, it explains the basic mechanism of phosphorylation by protein kinases using ATP. It proceeds to describe protein kinase cascades where one kinase phosphorylates and activates the next in a chain. Examples of double phosphorylation and multi-layer perceptrons in cascades are illustrated. Finally, some biological examples of different types of protein kinases are mentioned before concluding with references.
Molecular Biology Fifth Edition Chapter 1 A Brief Hi.docx
Molecular Biology
Fifth Edition
Chapter 1
A Brief History
Lecture PowerPoint to accompany
Robert F. Weaver
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
1-2
A Brief History
• What is molecular biology?
– The attempt to understand biological
phenomena in molecular terms
– The study of gene structure and function at
the molecular level
• Molecular biology is a melding of aspects
of genetics and biochemistry
1-3
1.1 Transmission Genetics
• Transmission genetics deals with the
transmission of traits from parental
organisms to their offspring
• The chemical composition of genes was
not known until 1944
– Gene - genetic units
– Phenotype - observable characteristics
1-4
Mendel’s Laws of Inheritance
• A gene can exist in different forms called
alleles
• One allele can be dominant over the other,
recessive, allele
• The first filial generation (F1) contains
offspring of the original parents
• If each parent carries two copies of a
gene, the parents are diploid for that gene
1-5
Mendel’s Laws of Inheritance
• Homoozygotes have two copies of the same allele
• Heterozygotes have one copy of each allele
• Parents in 1st mating are homozygotes, having 2
copies of one allele
• Sex cells, or gametes, are haploid, containing only
1 copy of each gene
• Heterozygotes produce gametes having either
allele
• Homozygotes produce gametes having only one
allele
1-6
Summary
• Genes can exist in several different forms or alleles
• One allele can be dominant over the other, so
heterozygotes having two different alleles of one
gene will generally exhibit the characteristic
dictated by the dominant allele
• The recessive allele is not lost; it can still exert its
influence when paired with another recessive allele
in a homozygote
1-7
The Chromosome Theory of Inheritance
• Chromosomes are discrete physical entities
that carry genes
• Thomas Hunt Morgan used the fruit fly,
Drosophila melanogaster, to study genetics
• Autosomes occur in pairs in a given
individual (not the X or the Y chromosome)
• Sex chromosomes are identified as X and Y
– Females have two X chromosomes
– Males have one X and one Y chromosome
1-8
Location of Genes on a Chromosome
• Every gene has its place, or locus, on a
chromosome
• Genotype is the combination of alleles
found in an organism
• Phenotype is the visible expression of the
genotype
– Wild-type phenotype is the most common or
generally accepted standard
– Mutant alleles are usually recessive
1-9
Genetic Recombination and Mapping
• In early experiments genes on separate
chromosomes behaved independently
• Genes on the same chromosome behaved
as if they were linked
• This genetic linkage is not absolute
• Offspring show new combinations of
alleles not seen in the parents when
recombination occurs
1-10
Recombination
• During meiosi ...
Subtle animated2
transposable genetic mateial are also known as jumping genes and they play very important role in the evolution of species.
281 lec4 identity_location
A lecture covers the concepts and experiments related to the location and the identity of the genetic material
Similar to TCF/LEF talk (20)
Getting undergrads excited about evolution and science
Getting undergrads excited about evolution and science
The more the merrier: the genomics of single, double and polysymbioses
The more the merrier: the genomics of single, double and polysymbioses
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...
Generation of Induced Pluripotent Stem Cells from Urine Cell Derived from Pat...
Geneticschapter7dnastructureandreplication 140305210513-phpapp01
Geneticschapter7dnastructureandreplication 140305210513-phpapp01
Molecular Biology Fifth Edition Chapter 1 A Brief Hi.docx
Molecular Biology Fifth Edition Chapter 1 A Brief Hi.docx
Recently uploaded
Communications Mining Series - Zero to Hero - Session 1
This session provides introduction to UiPath Communication Mining, importance and platform overview. You will acquire a good understand of the phases in Communication Mining as we go over the platform with you. Topics covered:
• Communication Mining Overview
• Why is it important?
• How can it help today’s business and the benefits
• Phases in Communication Mining
• Demo on Platform overview
• Q/A
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
Maruthi Prithivirajan, Head of ASEAN & IN Solution Architecture, Neo4j
Get an inside look at the latest Neo4j innovations that enable relationship-driven intelligence at scale. Learn more about the newest cloud integrations and product enhancements that make Neo4j an essential choice for developers building apps with interconnected data and generative AI.
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
In this session I delve into the encryption technology used in Microsoft 365 and Microsoft Purview. Including the concepts of Customer Key and Double Key Encryption.
GraphSummit Singapore | The Future of Agility: Supercharging Digital Transfor...
Leonard Jayamohan, Partner & Generative AI Lead, Deloitte
This keynote will reveal how Deloitte leverages Neo4j’s graph power for groundbreaking digital twin solutions, achieving a staggering 100x performance boost. Discover the essential role knowledge graphs play in successful generative AI implementations. Plus, get an exclusive look at an innovative Neo4j + Generative AI solution Deloitte is developing in-house.
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
Essentials of Automations: The Art of Triggers and Actions in FME
In this second installment of our Essentials of Automations webinar series, we’ll explore the landscape of triggers and actions, guiding you through the nuances of authoring and adapting workspaces for seamless automations. Gain an understanding of the full spectrum of triggers and actions available in FME, empowering you to enhance your workspaces for efficient automation.
We’ll kick things off by showcasing the most commonly used event-based triggers, introducing you to various automation workflows like manual triggers, schedules, directory watchers, and more. Plus, see how these elements play out in real scenarios.
Whether you’re tweaking your current setup or building from the ground up, this session will arm you with the tools and insights needed to transform your FME usage into a powerhouse of productivity. Join us to discover effective strategies that simplify complex processes, enhancing your productivity and transforming your data management practices with FME. Let’s turn complexity into clarity and make your workspaces work wonders!
How to Get CNIC Information System with Paksim Ga.pptx
Pakdata Cf is a groundbreaking system designed to streamline and facilitate access to CNIC information. This innovative platform leverages advanced technology to provide users with efficient and secure access to their CNIC details.
A tale of scale & speed: How the US Navy is enabling software delivery from l...
Rapid and secure feature delivery is a goal across every application team and every branch of the DoD. The Navy’s DevSecOps platform, Party Barge, has achieved:
- Reduction in onboarding time from 5 weeks to 1 day
- Improved developer experience and productivity through actionable findings and reduction of false positives
- Maintenance of superior security standards and inherent policy enforcement with Authorization to Operate (ATO)
Development teams can ship efficiently and ensure applications are cyber ready for Navy Authorizing Officials (AOs). In this webinar, Sigma Defense and Anchore will give attendees a look behind the scenes and demo secure pipeline automation and security artifacts that speed up application ATO and time to production.
We will cover:
- How to remove silos in DevSecOps
- How to build efficient development pipeline roles and component templates
- How to deliver security artifacts that matter for ATO’s (SBOMs, vulnerability reports, and policy evidence)
- How to streamline operations with automated policy checks on container images
Building RAG with self-deployed Milvus vector database and Snowpark Container...
This talk will give hands-on advice on building RAG applications with an open-source Milvus database deployed as a docker container. We will also introduce the integration of Milvus with Snowpark Container Services.
Enchancing adoption of Open Source Libraries. A case study on Albumentations.AI
Enchancing adoption of Open Source Libraries. A case study on Albumentations.AIVladimir Iglovikov, Ph.D.
Presented by Vladimir Iglovikov:
- https://www.linkedin.com/in/iglovikov/
- https://x.com/viglovikov
- https://www.instagram.com/ternaus/
This presentation delves into the journey of Albumentations.ai, a highly successful open-source library for data augmentation.
Created out of a necessity for superior performance in Kaggle competitions, Albumentations has grown to become a widely used tool among data scientists and machine learning practitioners.
This case study covers various aspects, including:
People: The contributors and community that have supported Albumentations.
Metrics: The success indicators such as downloads, daily active users, GitHub stars, and financial contributions.
Challenges: The hurdles in monetizing open-source projects and measuring user engagement.
Development Practices: Best practices for creating, maintaining, and scaling open-source libraries, including code hygiene, CI/CD, and fast iteration.
Community Building: Strategies for making adoption easy, iterating quickly, and fostering a vibrant, engaged community.
Marketing: Both online and offline marketing tactics, focusing on real, impactful interactions and collaborations.
Mental Health: Maintaining balance and not feeling pressured by user demands.
Key insights include the importance of automation, making the adoption process seamless, and leveraging offline interactions for marketing. The presentation also emphasizes the need for continuous small improvements and building a friendly, inclusive community that contributes to the project's growth.
Vladimir Iglovikov brings his extensive experience as a Kaggle Grandmaster, ex-Staff ML Engineer at Lyft, sharing valuable lessons and practical advice for anyone looking to enhance the adoption of their open-source projects.
Explore more about Albumentations and join the community at:
GitHub: https://github.com/albumentations-team/albumentations
Website: https://albumentations.ai/
LinkedIn: https://www.linkedin.com/company/100504475
Twitter: https://x.com/albumentationsLet's Integrate MuleSoft RPA, COMPOSER, APM with AWS IDP along with Slack
Discover the seamless integration of RPA (Robotic Process Automation), COMPOSER, and APM with AWS IDP enhanced with Slack notifications. Explore how these technologies converge to streamline workflows, optimize performance, and ensure secure access, all while leveraging the power of AWS IDP and real-time communication via Slack notifications.
National Security Agency - NSA mobile device best practices
Threats to mobile devices are more prevalent and increasing in scope and complexity. Users of mobile devices desire to take full advantage of the features
available on those devices, but many of the features provide convenience and capability but sacrifice security. This best practices guide outlines steps the users can take to better protect personal devices and information.
GraphSummit Singapore | Graphing Success: Revolutionising Organisational Stru...
Sudheer Mechineni, Head of Application Frameworks, Standard Chartered Bank
Discover how Standard Chartered Bank harnessed the power of Neo4j to transform complex data access challenges into a dynamic, scalable graph database solution. This keynote will cover their journey from initial adoption to deploying a fully automated, enterprise-grade causal cluster, highlighting key strategies for modelling organisational changes and ensuring robust disaster recovery. Learn how these innovations have not only enhanced Standard Chartered Bank’s data infrastructure but also positioned them as pioneers in the banking sector’s adoption of graph technology.
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!
As the digital landscape continually evolves, operating systems play a critical role in shaping user experiences and productivity. The launch of Nitrux Linux 3.5.0 marks a significant milestone, offering a robust alternative to traditional systems such as Windows 11. This article delves into the essence of Nitrux Linux 3.5.0, exploring its unique features, advantages, and how it stands as a compelling choice for both casual users and tech enthusiasts.
Uni Systems Copilot event_05062024_C.Vlachos.pdf
Unlocking Productivity: Leveraging the Potential of Copilot in Microsoft 365, a presentation by Christoforos Vlachos, Senior Solutions Manager – Modern Workplace, Uni Systems
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
ABSTRACT: A prima vista, un mattoncino Lego e la backdoor XZ potrebbero avere in comune il fatto di essere entrambi blocchi di costruzione, o dipendenze di progetti creativi e software. La realtà è che un mattoncino Lego e il caso della backdoor XZ hanno molto di più di tutto ciò in comune.
Partecipate alla presentazione per immergervi in una storia di interoperabilità, standard e formati aperti, per poi discutere del ruolo importante che i contributori hanno in una comunità open source sostenibile.
BIO: Sostenitrice del software libero e dei formati standard e aperti. È stata un membro attivo dei progetti Fedora e openSUSE e ha co-fondato l'Associazione LibreItalia dove è stata coinvolta in diversi eventi, migrazioni e formazione relativi a LibreOffice. In precedenza ha lavorato a migrazioni e corsi di formazione su LibreOffice per diverse amministrazioni pubbliche e privati. Da gennaio 2020 lavora in SUSE come Software Release Engineer per Uyuni e SUSE Manager e quando non segue la sua passione per i computer e per Geeko coltiva la sua curiosità per l'astronomia (da cui deriva il suo nickname deneb_alpha).
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
Recently uploaded (20)
Communications Mining Series - Zero to Hero - Session 1
Communications Mining Series - Zero to Hero - Session 1
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
GraphSummit Singapore | Neo4j Product Vision & Roadmap - Q2 2024
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
Encryption in Microsoft 365 - ExpertsLive Netherlands 2024
GraphSummit Singapore | The Future of Agility: Supercharging Digital Transfor...
GraphSummit Singapore | The Future of Agility: Supercharging Digital Transfor...
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...
Essentials of Automations: The Art of Triggers and Actions in FME
Essentials of Automations: The Art of Triggers and Actions in FME
How to Get CNIC Information System with Paksim Ga.pptx
How to Get CNIC Information System with Paksim Ga.pptx
A tale of scale & speed: How the US Navy is enabling software delivery from l...
A tale of scale & speed: How the US Navy is enabling software delivery from l...
Building RAG with self-deployed Milvus vector database and Snowpark Container...
Building RAG with self-deployed Milvus vector database and Snowpark Container...
Enchancing adoption of Open Source Libraries. A case study on Albumentations.AI
Enchancing adoption of Open Source Libraries. A case study on Albumentations.AI
Let's Integrate MuleSoft RPA, COMPOSER, APM with AWS IDP along with Slack
Let's Integrate MuleSoft RPA, COMPOSER, APM with AWS IDP along with Slack
National Security Agency - NSA mobile device best practices
National Security Agency - NSA mobile device best practices
GraphSummit Singapore | Graphing Success: Revolutionising Organisational Stru...
GraphSummit Singapore | Graphing Success: Revolutionising Organisational Stru...
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!
Monitoring Java Application Security with JDK Tools and JFR Events
Monitoring Java Application Security with JDK Tools and JFR Events
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Generative AI Deep Dive: Advancing from Proof of Concept to Production
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
Cosa hanno in comune un mattoncino Lego e la backdoor XZ?
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdf
TCF/LEF talk
- 1. Alternative Splicing in the TCF/LEF Family of Transcription Factors Elizabeth Kessell - Professor Scott Roy San Francisco State University - NSF REU Program
- 2. The TCF/LEF Family •Transcription factors •Part of Wnt pathway •4 family members - TCF7, TCF7-l1, TCF7-l2, LEF1 •Transcripts expressed differently in different tissues/developmental stages Image Credits: Wikipedia Commons - http://en.wikipedia.org/wiki/File:Protein_TCF7L2_PDB_1jdh.png , my own work
- 3. Dominant Negative Isoforms •Without a B-catenin binding site, the pathway remains off •This serves as a regulatory mechanism •Proteins lacking a binding site are created through alternative splicing
- 4. Introns, Exons, and Alternative Splicing
- 5. An Evolutionary Question How far back do the dominant negative forms go? How did they evolve?
- 6. What we would expect to see
- 7. Methods •Using sequence mapping to match intron sequence to cDNA data •Looking for a mature RNA that contains sequence previously thought to be intron •Data from danio rerio (fish), xenopus tropicalus (frog), anolis carolinensis (lizard)
- 8. Results None of the data tested showed an alternative 1st exon (for any of the species tested)
- 9. Interpretation •Strong negative result •Implies that TCF7l2 and LEF1 independently evolved dominant negative forms in mammals •Inconclusive -- more data?
- 10. Moving Forward •Get more cDNA data •Learn more about the negative isoforms in mammals •Look beyond vertebrates
- 11. Acknowledgements Many thanks to Professor Roy for mentorship and advice, as well as to San Francisco State University and the National Science Foundation for funding and support.
- 12. References •Weise, et al, Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/!-catenin targets, Nucleic Acids Research, 2010 •Huber, et al, Nuclear localization of !-catenin by interaction with transcription factor LEF-1, Mechanisms of Development 1996 •Lin, et al, Expression of the AmphiTcf Gene in Amphioxus: Insights Into the Evolution of the TCF/LEF Gene Family During Vertebrate Evolution, Developmental Dynamics, 2006 •Klingel, et al, Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors, Developmental Biology, 2012 •Hovanes, et al, The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing, Nucleic acids research, 2000 •Vacik and Lemke, Dominant-negative isoforms of Tcf/Lef proteins in development and disease, Cell Cycle, 2011
- 13. Alternative Splicing in the TCF/LEF Family of Transcription Factors Elizabeth Kessell - Professor Scott Roy San Francisco State University - NSF REU Program
Editor's Notes
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n
- \n