This document discusses the layout, facilities, environmental requirements, and equipment of a pharmaceutical manufacturing facility. It describes the facility as being designed according to GMP practices to prevent cross contamination with proper air handling, cleaning, lighting, and plumbing. The layout is organized with three types: circular flow, parallel flow, and crossover traffic. Environmental controls are needed for product and employee protection including temperature, humidity, and air pressure controls. The equipment listed includes mixing, granulation, drying, compression, coating, and packaging machinery.

1. By ,
Mr. Nitin B.Londhe
JSPM’S Charak College of
Pharmacy& Research ,Wagholi,
Pune.

2. BUILDING & FACILITIES
 Designed according to GMP practices which
ensures ;
 Prevention of cross contamination
 Proper air handling systems.
 Proper cleaning & sanitary facilities.
 Proper Lighting
 Proper Plumbing
 Proper washing .etc.

3. LAYOUT
 It is the organized properly planned Interdepartment and
Intradepartment arrangements.
 Proper layout
 Increases productivity
 Helps in proper utilization of
 MAN
 MATERIAL
 MONEY
 MACHINES

4. TYPES OF LAYOUT
 Three Types of layout With
1) Circular Flow
2) Parallel Flow
3) Crossover Traffic

5. layout with Central warehouse
(crossover traffic)

6. Circular flow

7. Parallel flow

8. Environmental Requirements
 Proper maintenance is required for
 Product Protection
 Employee Comfort
 Controlled Process
Parameters

9. Some Important Aspects
 low Humidity for Effervescent tablets & moisture sensitive drugs.
 Pressure within areas like mixing & tableting area should remain on
negative side than central corridor
 All areas should be free from dust & floating particles , if possible air
conditioned.
 In coating section suitable exhaust systems
 There should be properly organized & working air handling system to supply
purified air.

10.  Temp control & Air control should be such that there
should be comfortable working environment.
 And no impact on characteristics of in-process
materials such as granulations, raw materials.
 All areas should be properly ventilated.

11. LIST OF EQUIPMENTS
 MIXING, GRANULATION & DRYING AREA
 Powder mixer
 Mass mixer / Planetary mixer / Rapid mixer granulator
 Sifter
 Granulators (High shear granulator, chilsonator, )
 Tray dryer / FBD
 Weighing Machines

12.  COMPRESSION AREA
 Tablet compression machine
 Single punch / Multipunch / Rotary
 Punch & Die storage cabinet
 Tablet deduster
 Tablet inspection unit or belt.
 Dissolution testing apparatus
 IPQC instruments

13.  COATING AREA
 Jacketed kettle (steam, gas, Electrically heated)
 Coating pans
 Polishing pans
 Exhaust system
 Air conditioning & Dehumidification equipment
 Weighing balance.

14.  PACKAGING AREA
 Strip or Blister packaging Machine.
 Tablet counter
 Leak tester
Air conditioning & Dehumidification equipment

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