The document presents a comprehensive overview of pharmaceutical plant layout, detailing essential features, principles, types, and the factors affecting layouts for efficient production. It emphasizes the importance of planning for hygiene, minimizing cross-contamination, and ensuring optimal use of space and equipment to improve production quality and reduce costs. The document also highlights the processes of production planning, risk management, and production control to enhance operational efficiency.

1. M. Pharm Sem-I Presentations
Pharmaceutical Plant Layout
SUBMITTED TO
SAVITRIB AI PHULE, PUNE UNIVERSITY , PUNE
FOR
PARTIAL FULFILMENT OF REQUIREMENTS FOR THE AWARDOF
MASTER OF PHARMACY
IN THE SUBJECT
Pharmaceutical Manufacturing Technology
IN THE FACULTYOF SCIENCE ANDTECHNOLOGY
Bhujbal Knowledge City,
MET’s Institute of Pharmacy,
Adgaon, Nashik, 422003.
Maharashtra, India
AcademicYear: 2021-2022 1
Presented By-
Bairagi Akshata A.
Guided By-
Dr. Sapna Ahirrao

2. Contents
 Introduction
 Features of Good Pharmaceutical Plant Layout
 General Requirements of Pharmaceutical Plant
 Principles of Plant Layout
 Types of Plant Layout
 Factors Affecting Plant Layout
 Special Provisions Of Plant Layout
 Production Planning
 Managing Risks
 Production Control
 Advantages
 Conclusions

3. Introduction
3
Pharmaceutical plant layout describes the distribution of space
and the arrangement of equipment, furniture, and other
significant administration and necessary services within a factory
building to perform the various unit operations involved in the
production of dosage forms in an efficient manner and with the
least amount of handling in processing the product from the
receipt of raw material through the distribution of the finished
goods.

4. Features of Good Pharmaceutical Plant Layout
4
• The following traits a successful pharmaceutical plant layout
should have:
• Ample floor space should be available for machine installation
and use.
• For low-cost processing, the equipment should be properly
organized to allow for the least amount of material handling.
• Effective supervision, coordination, and control of the
production processes should be possible with a proper layout.
• When necessary, there should always be an opportunity for
change and correction.

5. General Requirements For Pharmaceutical
Plant
• Pharmaceutical facilities must be positioned, planned, built, and
maintained to accommodate the procedures to be performed.
• To reduce the possibility of mistakes and enable efficient cleaning,
they must be laid out and designed in a way that prevents cross-
contamination.
• Manufacturing facilities should be built in a way that makes it possible
to maintain hygienic conditions at all times.
• For cleaning, maintenance, disinfection, and sanitization, SOPs and
records should be kept.
• Plants should be kept in order Power supply lighting, temperature,
humidity, and HVAC are all important factors.

6. Principles of Plant Layout
Principle of
minimum
movement
Principle of flow
Principle of
space
Principle of
safety
Principle of
flexibility
Principle of
interdependence
Principle of
overall
integration
Principle of
minimum
investment

7. Types of Plant Layout
7
Three different plant layouts exist:
Process flow
Product design layout
In a fixed place
1. Process layout: Based on their operational features, similar
machines are grouped together to form a process layout, also
known as a functional layout or a batch production layout.
2. Product layout: In product layout, also known as straight-line
layout, equipment is arranged in a single line in accordance with
the order of production processes.
3. Fixed position layout: Products that are too huge, heavy, or fragile
to move to a site for completion are put together in this type of
facility layout.

8. Fig. Pharmaceutical Plant Layout For Aseptic Area

9. Factors Affecting Plant Layout
the proposed company's location
monetary considerations (cost)
building a factory
Product type Production method
Production volume
Equipment and machine types
Machinery and equipment repairs and maintenance
Needs of employees and safety
conditions that affect plants

10. Special Provisions of Plant Layout
Premises should
be suitable for
the purpose of
drug
manufacturing &
should prevent
mixing ups of
materials
Building for the
factory should be
constructed so as
to permit the
production under
hygienic
conditions
They should be
confirm to the
conditions laid
down in the
Factories Act,
1948

11. Production Planning
Production planning is a process of converting a set of inputs
such as men, capital, information, and energy into finished
products.
Steps involved in production planning
Production
budget
Selection of
process
Selection of
materials,
methods and
machinery
Selection of
layout
Setup time &
route sheet
process

12. Production Planning Includes
Routing –
Routing is the
path and
optimum
sequence of
operations to be
performed on
the job
Loading –
It indicates
assignment of
work to men,
machines in
advance without
specifying when
the work is to be
done
Scheduling –
It may defined
as the process of
decision taking
to start the work
for production

13. Managing Risks
Process of risk management - Rather than taking a reactive strategy,
risk management is always proactive.
The major goal of this strategy is to reduce the incidence and its
detrimental effects on project time, cost, and quality.
Clifford Gray and Eric W. Larson have broken down the risk
management procedure into four steps:
1. identification of risks
2. risk evaluation
3. development of risk responses
4. Risk response management

14. Production Control
It consists of two parts, progress reporting and corrective action
It involves four stages :
Observation Analysis
Correctiv
e action
Post
operation
evaluation

15. Advantages of Good Pharmaceutical
Plant Layout
• Maximum utilization of the floor area available for
production activities.
• Decreased risk of cross-contamination leads to higher
product quality.
• Efficient planning for raw materials and completed
goods receipt, transportation, storage, and delivery.
• Low material handling costs.
• Increased output with a lower chance of human error.

16. Conclusions
• Considering that choosing medication is a long-term
commitment, planning the layout is important.
• Additionally, it is a constant process because there is always
room for development.
• It should be planned in such a way that the output, floor area,
and manufacturing process all have the best possible
relationships, making the plant's operation very efficient.
• Although the layout of pharmaceutical plants varies from plant
to plant, the fundamental ideas behind pharmaceutical plant
layouts are often the same.

17. References
 Manohar A. Potdar, Pharmaceutical Facilities, Second
Edition, Pharma Med Press.
 Sheetal V. Patil, Dr. Md. Rageeb, PV, A Text Book of
Pharmaceutical Manufacturing Technology, Vikas &
Company (Medical Publishers), Page No.11-13.
 https://www.pharmapproach.com/pharmaceutical-plant-
layout
 https://www.slideshare.net/anks2017/plant-layout-ppt