This document describes how to mark the surface anatomy of arteries, nerves, and other structures of the upper extremity. It provides landmarks and guidelines for tracing the brachial, radial, and ulnar arteries. Landmarks are also given for marking the median, musculocutaneous, radial, and ulnar nerves in both the arm and forearm. Finally, points are identified for marking the flexor retinaculum of the wrist.
Lateral ventricle of Brain. By Dr.N.Mugunthan.M.Smgmcri1234
Lateral ventricle of brain. Lecture by Dr.N.Mugunthan.
Associate Professor,
Mahatma Gandhi Medical College & Research Institute,
Sri Balaji Vidyapeeth, Pondicherry.
Lateral ventricle of Brain. By Dr.N.Mugunthan.M.Smgmcri1234
Lateral ventricle of brain. Lecture by Dr.N.Mugunthan.
Associate Professor,
Mahatma Gandhi Medical College & Research Institute,
Sri Balaji Vidyapeeth, Pondicherry.
describes the muscles, nerves and vessels of arm region. it gives an overview to understand to basic anatomical aspect of arm region including cubital fossa.
describes the muscles, nerves and vessels of arm region. it gives an overview to understand to basic anatomical aspect of arm region including cubital fossa.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
3. Brachial Artery
Corresponds to a line by joining
the following Points:
1. A Point at the junction of
anterior one-third and
posterior two thirds of the
lateral wall of axilla, where the
pulsation of the artery is felt.
2. A point at the cubital fossa 1cm
below the bend of the
elbow just medial to the
tendon of biceps brachii.
4. Brachial Artery
• A Point at the
junction of anterior
one-third
and posterior two
thirds of the lateral
wall of axilla, where
the pulsation of the
artery is felt.
5. Brachial Artery
• A point at the cubital
fossa 1cm below the
bend
of the elbow just
medial to the tendon
of biceps brachii.
6. Radial Artery
Corresponds to a line by
joining the following Points:
1. A point in front of the elbow at the
level of the neck of the radius
medial to the tendon of the biceps
brachii.
2. The second point at the wrist
between the anterior border of
the radius laterally and the tendon
of the flexor carpi radialis medially,
where the radial pulse is
commonly felt.
7. Radial Artery
1. A point in front of the
elbow at the level of
the neck of the radius
medial to the tendon
of the biceps brachii.
8. Radial Artery
2. The second point at the
wrist between the anterior
border of the radius
laterally and the tendon of
the flexor carpi radialis
medially, where the radial
pulse is commonly felt.
9. Ulnar Artery
Corresponds to a line by joining the
following Points:
1. A point in front of the elbow at the
level of the neck of the radius
medial to the tendon of the biceps
brachii
2. A second point at the junction of
the upper one-third and lower
two-thirds of the medial border of
the forearm (lateral to the ulnar
nerve)
3. The third point lateral to the
pisiform bone
10. Ulnar Artery
1. A point in front
of the elbow at
the level of the
neck of the
radius medial to
the tendon of the
biceps brachii
11. Ulnar Artery
2. A second point
at the junction of
the upper one-
third and lower
two-thirds of the
medial border of
the forearm (lateral
to the ulnar nerve)
13. Superficial Palmer Arch
Corresponds to a line by
joining the following Points:
1. A point just lateral and
distal to the pisiform bone
2. The second point medial
to the hook of the hamate
bone.
3. The third point on the
distal border of the thenar
eminence in line with the
cleft between the index
and middle fingers.
15. Musculocutaneous Nerve
Corresponds to a line by joining the
following Points:
1. A point lateral to the axillary artery
3 cm above its termination
2. A point lateral to the tendon of
the biceps brachii muscle 2 cm
above the bend of the elbow. Here
it pierces the deep fascia and
continues as the lateral cutaneous
nerve of the forearm
16. Median Nerve (In the arm)
1. Mark the brachial artery. The
nerve is then marked lateral to the
artery in the upper half, and
medial to the artery in the lower
half of the arm. The nerve crosses
the artery anteriorly in the middle
of the arm
17. Median Nerve (In the Forearm)
Corresponds to a line by joining the
following Points:
1. A point medial to the brachial
artery at the bend of the elbow
2. A point in front of the wrist, over
the tendon of the palmaris longus
or 1cm medial to the tendon of
the flexor carpi radialis
18. Radial Nerve (In the arm)
Corresponds to a line by joining the
following Points:
1. The first point is at the lateral wall
of the axilla at its lower limit
2. The second point is at the junction
of the upper one third and lower
two-thirds of a line joining the
lateral epicondyle with the
insertion of the deltoid
3. The third point is on the front of
the elbow just below the level of
the lateral epicondyle 1 cm lateral
to the tendon of the biceps brachii
19. Radial Nerve (In the arm)
1. The first point is at the lateral wall
of the axilla at its lower limit
2. The second point is at the junction
of the upper one third and lower
two-thirds of a line joining the
lateral epicondyle with the
insertion of the deltoid
20. Radial Nerve (In the arm)
1. The first point is at the lateral wall
of the axilla at its lower limit
2. The second point is at the junction
of the upper one third and lower
two-thirds of a line joining the
lateral epicondyle with the
insertion of the deltoid
21. Radial Nerve (In the arm)
3. The third point is on the front of
the elbow just below the level of the
lateral epicondyle 1 cm lateral to the
tendon of the biceps brachii
22. Radial Nerve (In the forearm)
Corresponds to a line by joining the
following Points:
1. A point 1 cm lateral to the biceps
tendon just below the level of the
lateral epicondyle
2. The second point at the junction
of the upper two-thirds and lower
one-third of the lateral border of
the forearm just lateral to the
radial artery
3. The third point at the anatomical
snuff box.
23. Radial Nerve (In the forearm)
1. A point 1 cm lateral to the biceps
tendon just below the level of the
lateral epicondyle
2. The second point at the junction
of the upper two-thirds and lower
one-third of the lateral border of
the forearm just lateral to the
radial artery
3. The third point at the anatomical
snuff box.
24. Ulnar Nerve (In the arm)
Corresponds to a line by joining the
following Points:
1. A point on the lateral wall of the
axilla at its lower limit (lower
border of the teres major muscle)
2. The second point at the middle of
the medial border of the arm
3. The third point behind the base of
the medial epicondyle of the
humerus.
25. Ulnar Nerve (In the forearm)
Corresponds to a line by joining the
following Points:
1. A point on the back of the base of
the medial epicondyle of the
humerus
2. The second point lateral to the
pisiform bone.
27. Flexor Retinaculum
Flexor retinaculum is marked by
joining the following four points
1. Pisiform bone
2. Tubercle of the scaphoid bone
3. Hook of the hamate bone
4. Crest of the trapezium.