Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
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This document summarizes a study that developed a novel dual-echo Rosette fMRI sequence to capture submillimeter functional MRI (fMRI) signals at 3T. The sequence uses a Rosette k-space trajectory with two echo times of 1 ms and 9 ms. In vivo testing on human subjects during a visual stimulation task found that the dual-echo Rosette sequence was able to detect comparable activation maps in the motor cortex as a multiband echo-planar imaging sequence, while also recovering submillimeter resolution fMRI signal. This novel sequence demonstrates the feasibility of acquiring submillimeter resolution fMRI data using widely available 3T scanners.
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Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
- 1. SubmillimeterfMRIAcquisition UsingaDual-echoRosette-kspace Trajectoryat3T Gianna Nossa Humberto Monsivais, Seokkyoon Hong, Taewoong Park, Fethi Sila Erdil, Xin Shen, Ali Calgar Özen, Serhat Ilbey, Mark Chiew, Cecilia Steinwurzel, Zoe Kourtzi, Yen-Yu Ian Shih, Uzay Emir 1
- 2. fMRIprovides functionalconnectivityinformationinthebrain Novel approaches have improved millimeter and submillimeter functional mapping of cortical areas 2 However, there are still limitations such as the timescale difference between neuronal activation and blood oxygenation levels. ADVANCES Ø Laminar fMRI Ø Multiband Accelerated Ø VASO NEURONAL ACTIVATION Ø DIANA
- 3. RosetteTrajectory EPI schemes are subject to trade-offs between spatial and temporal resolutions § Requires short TR and short TE § Efficient k-space sampling with a very short TE is needed § Rosette trajectory has been found to be superior • It is fast without sacrificing resolution 3 Shen X, et al. (2022) We developed a novel Very Short TE (VSE) dual-echo Rosette fMRI sequence to capture submillimeter fMRI signal GOAL: To test feasibility in vivo and compare against multiband EPI
- 4. Methods 30s ON, 15s OFF visual stimulus 4 2D Rosette sequence § TR = 2.4s § Dual- TEs = 1 and 9 ms § Slice thickness = 2mm § Flip Angle = 7 degrees § Number of slices = 1 § Number of petals with an acceleration factor 4 = 189 § Nominal in-plane resolution = 0.468mm 2D CMRR Multiband-EPI § TR = 1.05s § TE = 46 ms § Slice thickness = 2mm § Flip Angle = 52 degrees § Number of slices = 72 § acceleration factor = 8 § Nominal in-plane resolution = 1.468mm Data Analysis § ESPIRiT-based parallel imaging and compressed sensing reconstruction: • 11-wavelets in space and total variation time using BART tool • Resolutions defined: 0.468 and 0.936mm with a 512x512 matrix § fMRI data processed using the FEAT tool of FSL
- 5. Resolution 5 1st echo acquisition: 95 petals; 11ms/petal 2nd echo acquisition: 95 petals; 11ms/petal Reduced Field of View
- 8. SubmillimeterfMRIDataisAcquiredViaDual-echoRosetteTrajectory § This methods has also already been tested at 7T § Acquisition can be tailored easily for DIANA-type approaches § For future updates, check out GITHUB! § We are always looking for collaborators! 8 This novel sequence can detect functional signals from a submillimeter resolution (~ 0.5 mm in-plane resolution) using clinically and widely available 3T scanners
- 9. THANKYOU! 9