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PETALUTE
Preclinical Applications Novel Rosette for FAST-Flexible Contrast MR(S)I
OVERVIEW
We have demonstrated a sequence, PETALUTE, for clinical and preclinical high (3T) and ultra-high
fields (>7T) scanners.
The modified Rosette kspace dual-echo Acquisition/ PETALUTE strategy could further enhance
integrated and translational research studies to understand human and non-human complex
structures and physiologies better.
Preclinical Scanners
Stephen Sawiak1, Xin Shen2, Uzay Emir3, Alex Lipka3, Joseph Rispoli3, Gregory Tamer Jr3, Deng-Yuan Chang3, Jessica Leigh Veenstra3, Thejas Vishnu Ramesh3,
Matthew Scarpelli3
1University of Cambridge, Cambridge, United Kingdom, 2University of California San Francisco, CA, USA, 3Purdue University, West Lafayette, IN, United States,
Clinical Scanners
Shen et al. 2023 demonstrated the addition of modified
rosette trajectory measurements in MRI and MRSI at
ultra-high and high-field clinical scanners (1-3).
q Offers greater efficiency, allowing a center-out (1st
echo) and center-in (2nd echo) sampling pattern
that provides more outer and center k-space per
petal samples than radial spokes.
q Samples center k-space in a more incoherent
pattern, offering the potential for further
acceleration using higher under-sampling factors
and the compressed sensing technique for
reconstruction.
23NA
3T
PETALUTE
MRI
1H
3T
PETALUTE
MRI
1H
7T
PETALUTE
MT MRI
31P
3T
PETALUTE
MRSI
Motivation: Implementing the dual-echo novel rosette k-space trajectory for preclinical applications of 3D VFA
PETALUTE, 3D PETALUTE MRSI, MEGA-SLASER PETAL MRSI
3D VFA PETALUTE
Abdominal Variable Flip Angle (VFA) T1 Mapping with accelerated
PETALUTE
• Outcome: VFA measurement with an
isotropic 240µm3 resolution in ~ 2 minutes
7T horizontal-bore small animal MRI system (BioSpec 70/30) and a
volume Tx/Rx 1H RF coil(40mm). VFA-PETALUTE T1 Mapping, FA: 4°,20°,
DUAL-TEs = 16 µs and 2 ms, TR = 7 ms, # petals =18,192, Resolution 240
µm3, Acceleration Factor = 4
31P 3D PETALUTE MRSI
Abdominal 31P 3D PETALUTE MRSI
• Outcome: Metabolite maps with an isotropic
1mm3 resolution in 48 minutes
7T horizontal-bore small animal MRI system (BioSpec 70/30) and a dual-tune
transceive coil for 31P/1H. PETALUTE 1H, FA: 4°, Dual TEs = 0.016, 2 ms, TR = 7
ms, # petals =18,192, Resolution 175 µm3, Acceleration Factor = 1 Total
acquisition duration =2.15 minutes. 3D PETALUTE 31P MRSI, TE=16 µs TR = 500
ms, # petals =1444, Spectral bandwidth =6.5kHz, Resolution 1 mm3,
Acceleration Factor = 1, Number of averages = 4, Total Acquisition duration=
48 minutes.
MEGA-SLASER PETAL MRSI
Neurotransmitter imaging with MEGA-SLASER PETAL
MRSI
• Outcome: Neurotransmitter maps
with 1mm2 resolution in 8.5
minutes
9.4 T horizontal-bore small animal MRI system(BioSpec
94/20) and a 2 × 2 phased array surface coil. MEGA-
SLASER PETAL MRSI: GABA Editing, TE=68 m, TR =1000ms,
#petals=256, in-plane Resolution 1 mm3, SLASER
Localization
Reference: Shen X., Özen A. C., Sunjar A., Ilbey S., Sawiak S., Shi R., Chiew M., Emir U., Ultra-short T2 components imaging of the whole brain using 3D dual-echo UTE MRI with
rosette k-space pattern. Magn. Reson. Med. 89, 508–521 (2023).

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Modified Rosette PETALUTE for preclinical imaging

  • 1. PETALUTE Preclinical Applications Novel Rosette for FAST-Flexible Contrast MR(S)I OVERVIEW We have demonstrated a sequence, PETALUTE, for clinical and preclinical high (3T) and ultra-high fields (>7T) scanners. The modified Rosette kspace dual-echo Acquisition/ PETALUTE strategy could further enhance integrated and translational research studies to understand human and non-human complex structures and physiologies better. Preclinical Scanners Stephen Sawiak1, Xin Shen2, Uzay Emir3, Alex Lipka3, Joseph Rispoli3, Gregory Tamer Jr3, Deng-Yuan Chang3, Jessica Leigh Veenstra3, Thejas Vishnu Ramesh3, Matthew Scarpelli3 1University of Cambridge, Cambridge, United Kingdom, 2University of California San Francisco, CA, USA, 3Purdue University, West Lafayette, IN, United States, Clinical Scanners Shen et al. 2023 demonstrated the addition of modified rosette trajectory measurements in MRI and MRSI at ultra-high and high-field clinical scanners (1-3). q Offers greater efficiency, allowing a center-out (1st echo) and center-in (2nd echo) sampling pattern that provides more outer and center k-space per petal samples than radial spokes. q Samples center k-space in a more incoherent pattern, offering the potential for further acceleration using higher under-sampling factors and the compressed sensing technique for reconstruction. 23NA 3T PETALUTE MRI 1H 3T PETALUTE MRI 1H 7T PETALUTE MT MRI 31P 3T PETALUTE MRSI Motivation: Implementing the dual-echo novel rosette k-space trajectory for preclinical applications of 3D VFA PETALUTE, 3D PETALUTE MRSI, MEGA-SLASER PETAL MRSI 3D VFA PETALUTE Abdominal Variable Flip Angle (VFA) T1 Mapping with accelerated PETALUTE • Outcome: VFA measurement with an isotropic 240µm3 resolution in ~ 2 minutes 7T horizontal-bore small animal MRI system (BioSpec 70/30) and a volume Tx/Rx 1H RF coil(40mm). VFA-PETALUTE T1 Mapping, FA: 4°,20°, DUAL-TEs = 16 µs and 2 ms, TR = 7 ms, # petals =18,192, Resolution 240 µm3, Acceleration Factor = 4 31P 3D PETALUTE MRSI Abdominal 31P 3D PETALUTE MRSI • Outcome: Metabolite maps with an isotropic 1mm3 resolution in 48 minutes 7T horizontal-bore small animal MRI system (BioSpec 70/30) and a dual-tune transceive coil for 31P/1H. PETALUTE 1H, FA: 4°, Dual TEs = 0.016, 2 ms, TR = 7 ms, # petals =18,192, Resolution 175 µm3, Acceleration Factor = 1 Total acquisition duration =2.15 minutes. 3D PETALUTE 31P MRSI, TE=16 µs TR = 500 ms, # petals =1444, Spectral bandwidth =6.5kHz, Resolution 1 mm3, Acceleration Factor = 1, Number of averages = 4, Total Acquisition duration= 48 minutes. MEGA-SLASER PETAL MRSI Neurotransmitter imaging with MEGA-SLASER PETAL MRSI • Outcome: Neurotransmitter maps with 1mm2 resolution in 8.5 minutes 9.4 T horizontal-bore small animal MRI system(BioSpec 94/20) and a 2 × 2 phased array surface coil. MEGA- SLASER PETAL MRSI: GABA Editing, TE=68 m, TR =1000ms, #petals=256, in-plane Resolution 1 mm3, SLASER Localization Reference: Shen X., Özen A. C., Sunjar A., Ilbey S., Sawiak S., Shi R., Chiew M., Emir U., Ultra-short T2 components imaging of the whole brain using 3D dual-echo UTE MRI with rosette k-space pattern. Magn. Reson. Med. 89, 508–521 (2023).