SlideShare a Scribd company logo
1 of 3
Download to read offline
See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/325949259
Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging
using Density Weighted Concentric Rings k-space Trajectory
Conference Paper · June 2018
CITATIONS
0
READS
64
6 authors, including:
Some of the authors of this publication are also working on these related projects:
Big GABA View project
The impact of reward and punishment on skill learning depends on task demands View project
Uzay Emir
130 PUBLICATIONS   2,091 CITATIONS   
SEE PROFILE
Adam Steel
Dartmouth College
41 PUBLICATIONS   261 CITATIONS   
SEE PROFILE
Ulrike Dydak
Purdue University
119 PUBLICATIONS   3,603 CITATIONS   
SEE PROFILE
Xiaopeng Zhou
Purdue University
11 PUBLICATIONS   148 CITATIONS   
SEE PROFILE
All content following this page was uploaded by Uzay Emir on 01 May 2021.
The user has requested enhancement of the downloaded file.
5/1/2021 https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html
https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html 1/2
3966
Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging using
Density Weighted Concentric Rings k-space Trajectory
Uzay E Emir , Pingyu Xia , Xiaopeng Zhou , Mark Chiew , Adam Steel , M Albert Thomas , and Ulrike Dydak
School of Health Sciences, Purdue University, West Lafayette, IN, United States, Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield
Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, Nuffield Department of Medicine, University of Oxford, Oxford, United
Kingdom, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, Department of Radiological Sciences, University of
California, Los Angeles, CA, United States, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United
States
Synopsis
In this study, we have developed and demonstrated a non-water suppressed GABA editing Magnetic Resonance Spectroscopic Imaging technique
using density-weighted concentric rings k-space trajectory that performs robustly within a clinically feasible acquisition time at 3T. The method has
been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with a high in-plane resolution of 7.5 × 7.5 mm .
Experiments qualitatively demonstrate the advantage of the proposed method in terms of its improved resolution and reduced contamination of
spectra from neighboring voxels.
Introduction
Water-suppressed MRS acquisition techniques have been the standard approach used in research and clinical MRI scanners to date. The acquisition of a non-
water-suppressed spectrum is used for artifact correction, reconstruction of phased-array coil data, and metabolite quantification. A non-water suppressed
metabolite-cycling (1) MRSI acquisition technique has recently been proposed for simultaneous detection of the metabolite and water signals. Potential
improvements of voxel-wise frequency, phase, and eddy current correction have been demonstrated (1). In this study, we propose using a MEGA semi-LASER
sequence with non-water suppressed metabolite-cycling as 2D MRSI data acquisition method at 3T for high-resolution GABA detection throughout a whole
axial slice. To improve the point-spread function of the 2D-MRSI acquisition without any loss of SNR and time efficiency, a density-weighted concentric rings k-
space trajectory (DW-CRT) sampling approach is used for the k-space acquisition trajectory of MRSI (2).
Methods
All scans were acquired using a Siemens Prisma 3-Tesla (Siemens, Erlangen, Germany) whole-body MRI scanner and a 20-channel head array receive coil. B0
shimming was achieved using GRESHIM (3). The non-water-suppressed metabolite-cycling MRSI acquisition was achieved by utilizing two asymmetric narrow-
transition-band adiabatic RF pulses with mirrored inversion profiles applied in alternate scans for the inversion of the upfield and downfield (relative to water)
spectral ranges (4) before the semi-LASER localization with a gap of 9.6 ms. The semi-LASER (5) localization (TR = 1.5 s, TE = 68 ms), was used to excite
whole brain slice with a 125 mm x 105 mm x 20 mm region centrally within the field of view (FOV= 240 mm x 240 mm). The Gaussian editing pulses of 65 Hz
width were placed on the H3’ protons at 1.9 ppm in the “ON” acquisition, and at 9.0 ppm in the “OFF” acquisition. For DW-CRT, 64 points per ring were
collected with an ADC bandwidth of 80 kHz, resulting in 512 temporal samples in an effective spectral bandwidth of 1250 Hz (Figure 1). To cover the 32x32
grid, 16 rings resulting in an individual voxel size of 1.125 mL (7.5 mm x 7.5 mm x 20 mm) were acquired for DW-CRT. The Hanning filter weighting function with
an alpha value of 1 was used to compute radial sampling locations for the DW-CRT (2). For DW-CRT, four spatial interleaves (64 unique rings) were used to
ensure that minimum field of view requirement was met, resulting in an acquisition duration of 384 s with metabolite cycling and mega editing. The number of
averages was 2, corresponding to a total acquisition duration of 12.8 minutes. The feasibility of the whole brain slice with the proposed methods was tested on
a healthy volunteer (male; 31 years old) after giving informed consent under an institutionally approved technical development protocol. All reconstructions
were implemented in MATLAB using the non-uniform FFT (NUFFT) toolbox (6). Lipid contamination was removed during post‐processing using a lipid‐basis
penalty algorithm (7).
Results
Figure 2 shows the non-water suppressed image of a whole brain slice as well as in-vivo edited spectra from the same slice of a healthy volunteer using
metabolite cycling. After subtraction of the even MR spectra from the odd MR spectra, the edited in vivo MR spectra from 1.125 mL voxels showed well-
defined GABA peaks at 3.0 ppm both in a central brain region (Figure 2) and a cortical brain region close to the lipid layer (Figure 3).
Conclusion
We have developed and demonstrated a non-water suppressed MEGA semi-LASER MRSI sequence with DW-CRT that performs robustly at 3 Tesla, within a
clinically feasible acquisition time of 13 min. The feasibility of the detection of GABA with the proposed method was shown in a healthy volunteer with a high in-
plane resolution of 7.5 × 7.5 mm2. Experiments qualitatively demonstrate the advantage of DW-CRT in terms of its improved resolution and reduced
contamination of spectra from neighboring voxels. Future work will focus on implementing the method for whole brain coverage with a reduced TR.
Acknowledgements
This work was supported by NIH R01 ES020529
References
1. Emir UE, Burns B, Chiew M, Jezzard P, Thomas MA. Non-water-suppressed short-echo-time magnetic resonance spectroscopic imaging using a concentric
ring k-space trajectory. NMR Biomed 2017;30(7).
1 1 1 2 3,4 5 1,6
1 2
3
4 5
6
2
5/1/2021 https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html
https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html 2/2
2. Chiew M, Jiang W, Burns B, Larson P, Steel A, Jezzard P, Albert Thomas M, Emir UE. Density-weighted concentric rings k-space trajectory for 1H magnetic
resonance spectroscopic imaging at 7 T. NMR in Biomedicine:e3838-n/a.
3. Shah S, Kellman P, Greiser A, Weale P, Zuehlsdorff S, Jerecic R. Rapid Fieldmap Estimation for Cardiac Shimming. Proceedings 17th Scientific Meeting,
International Society for Magnetic Resonance in Medicine. Honolulu 2009. p 565.
4. Dreher W, Leibfritz D. New method for the simultaneous detection of metabolites and water in localized in vivo 1H nuclear magnetic resonance spectroscopy.
Magn Reson Med 2005;54(1):190-195.
5. Scheenen TW, Heerschap A, Klomp DW. Towards 1H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses. MAGMA 2008;21(1-
2):95-101.
6. Fessler JA, Sutton BP. Nonuniform fast Fourier transforms using min-max interpolation. IEEE Transactions on Signal Processing 2003;51(2):560-574.
7. Bilgic B, Chatnuntawech I, Fan AP, Setsompop K, Cauley SF, Wald LL, Adalsteinsson E. Fast image reconstruction with L2-regularization. J Magn Reson
Imaging 2014;40(1):181-191.
Figures
Figure 1 Pulse sequence diagram of the proposed MEGA semi-LASER method without water suppression, allowing simultaneous detection of GABA and water
signals. Prior to a MEGA semi-LASER editing sequence, two asymmetric narrow-transition-band adiabatic RF pulses invert the spectral range where metabolite
signals are expected either upfield or downfield with respect to water.
Figure 2 Edit “OFF”, EDIT “ON” and difference spectra from 3 x 3 voxels in the center of the whole brain slice semi-LASER localization acquired using non-
water suppressed metabolite cycling with MEGA editing for GABA detection.
Edit “OFF”, EDIT “ON” and difference spectra from 3 x 3 voxels close to the lipid layer of the whole brain slice semi-LASER localization acquired using non-
water suppressed metabolite cycling with MEGA editing for GABA detection.
Proc. Intl. Soc. Mag. Reson. Med. 26 (2018)
3966
View publication stats
View publication stats

More Related Content

What's hot

Sigma xi nerve viability presentation
Sigma xi nerve viability presentationSigma xi nerve viability presentation
Sigma xi nerve viability presentation
jffried
 
Kimpo et al_JNsci 2003
Kimpo et al_JNsci 2003Kimpo et al_JNsci 2003
Kimpo et al_JNsci 2003
Rhea Kimpo
 
ARTICLE_RNROY_Neuroergo
ARTICLE_RNROY_NeuroergoARTICLE_RNROY_Neuroergo
ARTICLE_RNROY_Neuroergo
Alexandre Moly
 
Vignal-mottin-2008, phys medbiol-highlights 2008
Vignal-mottin-2008, phys medbiol-highlights 2008Vignal-mottin-2008, phys medbiol-highlights 2008
Vignal-mottin-2008, phys medbiol-highlights 2008
Stéphane MOTTIN
 
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
IJARIIT
 
A multimodal brain imaging study of repetition suppression in the
A multimodal brain imaging study of repetition suppression in theA multimodal brain imaging study of repetition suppression in the
A multimodal brain imaging study of repetition suppression in the
fizyoloji12345
 
Annotated bibliography final 13 n.r.e
Annotated bibliography final 13 n.r.eAnnotated bibliography final 13 n.r.e
Annotated bibliography final 13 n.r.e
Nicole Rivera
 
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
rachelsalk
 

What's hot (20)

Sigma xi nerve viability presentation
Sigma xi nerve viability presentationSigma xi nerve viability presentation
Sigma xi nerve viability presentation
 
Kimpo et al_JNsci 2003
Kimpo et al_JNsci 2003Kimpo et al_JNsci 2003
Kimpo et al_JNsci 2003
 
ARTICLE_RNROY_Neuroergo
ARTICLE_RNROY_NeuroergoARTICLE_RNROY_Neuroergo
ARTICLE_RNROY_Neuroergo
 
Vignal-mottin-2008, phys medbiol-highlights 2008
Vignal-mottin-2008, phys medbiol-highlights 2008Vignal-mottin-2008, phys medbiol-highlights 2008
Vignal-mottin-2008, phys medbiol-highlights 2008
 
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
Effect of naringenin on 3 np induced huntington’s disease like symptoms by es...
 
A multimodal brain imaging study of repetition suppression in the
A multimodal brain imaging study of repetition suppression in theA multimodal brain imaging study of repetition suppression in the
A multimodal brain imaging study of repetition suppression in the
 
Gourov and Curran 2014
Gourov and Curran 2014Gourov and Curran 2014
Gourov and Curran 2014
 
Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...Improved target recognition response using collaborative brain-computer inter...
Improved target recognition response using collaborative brain-computer inter...
 
Exploring Neural Circuitry of Predatory Pursuit, Capture and Kill in Mice
Exploring Neural Circuitry of Predatory Pursuit, Capture and Kill in MiceExploring Neural Circuitry of Predatory Pursuit, Capture and Kill in Mice
Exploring Neural Circuitry of Predatory Pursuit, Capture and Kill in Mice
 
Annotated bibliography final 13 n.r.e
Annotated bibliography final 13 n.r.eAnnotated bibliography final 13 n.r.e
Annotated bibliography final 13 n.r.e
 
Bio-field Treatment: An Effective Strategy to Improve the Quality of Beef Ext...
Bio-field Treatment: An Effective Strategy to Improve the Quality of Beef Ext...Bio-field Treatment: An Effective Strategy to Improve the Quality of Beef Ext...
Bio-field Treatment: An Effective Strategy to Improve the Quality of Beef Ext...
 
Peer reviewed research of low level laser therapy
Peer reviewed research of low level laser therapyPeer reviewed research of low level laser therapy
Peer reviewed research of low level laser therapy
 
IMSC 2016 Final
IMSC 2016 FinalIMSC 2016 Final
IMSC 2016 Final
 
2018 BDSRA Roine CLN3
2018 BDSRA Roine CLN32018 BDSRA Roine CLN3
2018 BDSRA Roine CLN3
 
neu%2E2015%2E4008
neu%2E2015%2E4008neu%2E2015%2E4008
neu%2E2015%2E4008
 
Mechanisms of LLLT/Anti-Aging_Hamblin_A4M_Orlando_2011
Mechanisms of LLLT/Anti-Aging_Hamblin_A4M_Orlando_2011Mechanisms of LLLT/Anti-Aging_Hamblin_A4M_Orlando_2011
Mechanisms of LLLT/Anti-Aging_Hamblin_A4M_Orlando_2011
 
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
An Effective Strategy to Improve the Quality of Beef Extract and Meat Infusio...
 
SR_bmes_2006_FINAL_061009
SR_bmes_2006_FINAL_061009SR_bmes_2006_FINAL_061009
SR_bmes_2006_FINAL_061009
 
Publications
PublicationsPublications
Publications
 
nihms-277379
nihms-277379nihms-277379
nihms-277379
 

Similar to Metabolite Cycled GABA Edited Magnetic Resonance Spectroscopic Imaging MRSI MEGA-PRESS MEGA-SLSER

Multisite UTE 31P Rosette MRSI(PETALUTE)
Multisite UTE 31P Rosette MRSI(PETALUTE)Multisite UTE 31P Rosette MRSI(PETALUTE)
Multisite UTE 31P Rosette MRSI(PETALUTE)
Uzay Emir
 
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
Applied Research and Photonics, Inc.
 
Verification of a treatment planning system using an in-house designedtrunk p...
Verification of a treatment planning system using an in-house designedtrunk p...Verification of a treatment planning system using an in-house designedtrunk p...
Verification of a treatment planning system using an in-house designedtrunk p...
IOSR Journals
 

Similar to Metabolite Cycled GABA Edited Magnetic Resonance Spectroscopic Imaging MRSI MEGA-PRESS MEGA-SLSER (20)

Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppress...
Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppress...Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppress...
Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppress...
 
ISMRM_2006-2015_compressed
ISMRM_2006-2015_compressedISMRM_2006-2015_compressed
ISMRM_2006-2015_compressed
 
Mutli vendor mrsi_2020
Mutli vendor mrsi_2020Mutli vendor mrsi_2020
Mutli vendor mrsi_2020
 
Multisite UTE 31P Rosette MRSI(PETALUTE)
Multisite UTE 31P Rosette MRSI(PETALUTE)Multisite UTE 31P Rosette MRSI(PETALUTE)
Multisite UTE 31P Rosette MRSI(PETALUTE)
 
Making effective use of graphics processing units (GPUs) in computations
Making effective use of graphics processing units (GPUs) in computationsMaking effective use of graphics processing units (GPUs) in computations
Making effective use of graphics processing units (GPUs) in computations
 
08039246
0803924608039246
08039246
 
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
 
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
AUTOMATED SEGMENTATION OF FLUORESCENT AND FUNDS IMAGES BASED ON RETINAL BLOOD...
 
Example
ExampleExample
Example
 
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
 
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
AN EFFICIENT WAVELET BASED FEATURE REDUCTION AND CLASSIFICATION TECHNIQUE FOR...
 
Qualitative analysis of Fruits and Vegetables using Earth’s Field Nuclear Mag...
Qualitative analysis of Fruits and Vegetables using Earth’s Field Nuclear Mag...Qualitative analysis of Fruits and Vegetables using Earth’s Field Nuclear Mag...
Qualitative analysis of Fruits and Vegetables using Earth’s Field Nuclear Mag...
 
IEEE Sensor journal 2016 Title and Abstract
IEEE Sensor journal 2016 Title and AbstractIEEE Sensor journal 2016 Title and Abstract
IEEE Sensor journal 2016 Title and Abstract
 
Ultra-Short Echo Time 31P 3D MRSI at 3T/7T with Novel Rosette k-space Trajectory
Ultra-Short Echo Time 31P 3D MRSI at 3T/7T with Novel Rosette k-space TrajectoryUltra-Short Echo Time 31P 3D MRSI at 3T/7T with Novel Rosette k-space Trajectory
Ultra-Short Echo Time 31P 3D MRSI at 3T/7T with Novel Rosette k-space Trajectory
 
An Ultrasound Image Despeckling Approach Based on Principle Component Analysis
An Ultrasound Image Despeckling Approach Based on Principle Component AnalysisAn Ultrasound Image Despeckling Approach Based on Principle Component Analysis
An Ultrasound Image Despeckling Approach Based on Principle Component Analysis
 
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
Terahertz Spectroscopic Analysis and Multispectral Imaging of Epitaxially Gro...
 
3D-UTE Rosette MRI and MRSI at UHF human (7T) and animal scanners (9.4T) usin...
3D-UTE Rosette MRI and MRSI at UHF human (7T) and animal scanners (9.4T) usin...3D-UTE Rosette MRI and MRSI at UHF human (7T) and animal scanners (9.4T) usin...
3D-UTE Rosette MRI and MRSI at UHF human (7T) and animal scanners (9.4T) usin...
 
IEEE Bio medical engineering 2016 Title and Abstract
IEEE Bio medical engineering  2016 Title and Abstract IEEE Bio medical engineering  2016 Title and Abstract
IEEE Bio medical engineering 2016 Title and Abstract
 
28 15017 estimation of turbidity in water(edit)
28 15017 estimation of turbidity in water(edit)28 15017 estimation of turbidity in water(edit)
28 15017 estimation of turbidity in water(edit)
 
Verification of a treatment planning system using an in-house designedtrunk p...
Verification of a treatment planning system using an in-house designedtrunk p...Verification of a treatment planning system using an in-house designedtrunk p...
Verification of a treatment planning system using an in-house designedtrunk p...
 

More from Uzay Emir

More from Uzay Emir (20)

PETALUTE modified rosette for Sodium MRI
PETALUTE modified rosette for Sodium MRIPETALUTE modified rosette for Sodium MRI
PETALUTE modified rosette for Sodium MRI
 
PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible ...
PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible ...PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible ...
PETALUTE: Preclinical Applications of the Modified Rosette for FAST-Flexible ...
 
3D UTE 31P-MRSI with modified rosette k-space (PETALUTE): Comparison with con...
3D UTE 31P-MRSI with modified rosette k-space (PETALUTE): Comparison with con...3D UTE 31P-MRSI with modified rosette k-space (PETALUTE): Comparison with con...
3D UTE 31P-MRSI with modified rosette k-space (PETALUTE): Comparison with con...
 
Modified Rosette PETALUTE for preclinical imaging
Modified Rosette PETALUTE for preclinical imagingModified Rosette PETALUTE for preclinical imaging
Modified Rosette PETALUTE for preclinical imaging
 
Lung imaging Using 3D Dual-Echo FID Ultra-short Echo Time MRI with novel Rose...
Lung imaging Using 3D Dual-Echo FID Ultra-short Echo Time MRI with novel Rose...Lung imaging Using 3D Dual-Echo FID Ultra-short Echo Time MRI with novel Rose...
Lung imaging Using 3D Dual-Echo FID Ultra-short Echo Time MRI with novel Rose...
 
Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9....
Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9....Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9....
Rosette Applications (MRI and MRSI) at UHF human (7T) and animal scanners (9....
 
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3TSubmillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
 
Fast 3D-P31-MRSI Using Custom Rosette Petal Trajectory at 3T with 4x Accelera...
Fast 3D-P31-MRSI Using Custom Rosette Petal Trajectory at 3T with 4x Accelera...Fast 3D-P31-MRSI Using Custom Rosette Petal Trajectory at 3T with 4x Accelera...
Fast 3D-P31-MRSI Using Custom Rosette Petal Trajectory at 3T with 4x Accelera...
 
Rosette Trajectory/kspace MRI
Rosette Trajectory/kspace MRI Rosette Trajectory/kspace MRI
Rosette Trajectory/kspace MRI
 
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectorySubmillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory
 
Ultra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space Trajectory
Ultra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space TrajectoryUltra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space Trajectory
Ultra-Short Echo Time 31P 3D MRSI at 3T with Novel Rosette k-space Trajectory
 
UTE 31P 3D Rosette MRSI reproducibility
UTE 31P 3D Rosette MRSI reproducibilityUTE 31P 3D Rosette MRSI reproducibility
UTE 31P 3D Rosette MRSI reproducibility
 
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3TSubmillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
Submillimeter fMRI Acquisition using a dual-echo Rosette kspace trajectory at 3T
 
3D dual-echo UTE Rosette fMRI
3D dual-echo UTE Rosette fMRI 3D dual-echo UTE Rosette fMRI
3D dual-echo UTE Rosette fMRI
 
rosette fmri very high resolution at 3T
rosette fmri very high resolution at 3T rosette fmri very high resolution at 3T
rosette fmri very high resolution at 3T
 
Laminar fMRI at 3T using Dual-echo Rosette with a TE= 15 us
Laminar fMRI at 3T using Dual-echo Rosette  with a TE= 15 usLaminar fMRI at 3T using Dual-echo Rosette  with a TE= 15 us
Laminar fMRI at 3T using Dual-echo Rosette with a TE= 15 us
 
Laminar fMRI with Rosette space trajectory
Laminar fMRI with Rosette space trajectoryLaminar fMRI with Rosette space trajectory
Laminar fMRI with Rosette space trajectory
 
Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short E...
Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short E...Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short E...
Quantitative Susceptibility Mapping (QSM) Using High-resolution Ultra-Short E...
 
High Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for...
High Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for...High Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for...
High Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for...
 
1H/31P 3D MRSI at 3T with Novel Rosette k-space Trajectory with compressed se...
1H/31P 3D MRSI at 3T with Novel Rosette k-space Trajectory with compressed se...1H/31P 3D MRSI at 3T with Novel Rosette k-space Trajectory with compressed se...
1H/31P 3D MRSI at 3T with Novel Rosette k-space Trajectory with compressed se...
 

Recently uploaded

LUNULARIA -features, morphology, anatomy ,reproduction etc.
LUNULARIA -features, morphology, anatomy ,reproduction etc.LUNULARIA -features, morphology, anatomy ,reproduction etc.
LUNULARIA -features, morphology, anatomy ,reproduction etc.
Cherry
 
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
US Environmental Protection Agency (EPA), Center for Computational Toxicology and Exposure
 
Porella : features, morphology, anatomy, reproduction etc.
Porella : features, morphology, anatomy, reproduction etc.Porella : features, morphology, anatomy, reproduction etc.
Porella : features, morphology, anatomy, reproduction etc.
Cherry
 
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.pptGENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
SyedArifMalki
 
CYTOGENETIC MAP................ ppt.pptx
CYTOGENETIC MAP................ ppt.pptxCYTOGENETIC MAP................ ppt.pptx
CYTOGENETIC MAP................ ppt.pptx
Cherry
 
COMPOSTING : types of compost, merits and demerits
COMPOSTING : types of compost, merits and demeritsCOMPOSTING : types of compost, merits and demerits
COMPOSTING : types of compost, merits and demerits
Cherry
 
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
Cherry
 
Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.
Cherry
 

Recently uploaded (20)

LUNULARIA -features, morphology, anatomy ,reproduction etc.
LUNULARIA -features, morphology, anatomy ,reproduction etc.LUNULARIA -features, morphology, anatomy ,reproduction etc.
LUNULARIA -features, morphology, anatomy ,reproduction etc.
 
Energy is the beat of life irrespective of the domains. ATP- the energy curre...
Energy is the beat of life irrespective of the domains. ATP- the energy curre...Energy is the beat of life irrespective of the domains. ATP- the energy curre...
Energy is the beat of life irrespective of the domains. ATP- the energy curre...
 
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
Chemistry Data Delivery from the US-EPA Center for Computational Toxicology a...
 
Porella : features, morphology, anatomy, reproduction etc.
Porella : features, morphology, anatomy, reproduction etc.Porella : features, morphology, anatomy, reproduction etc.
Porella : features, morphology, anatomy, reproduction etc.
 
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.pptGENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
GENETICALLY MODIFIED ORGANISM'S PRESENTATION.ppt
 
Sequence submission tools ............pptx
Sequence submission tools ............pptxSequence submission tools ............pptx
Sequence submission tools ............pptx
 
Adaptive Restore algorithm & importance Monte Carlo
Adaptive Restore algorithm & importance Monte CarloAdaptive Restore algorithm & importance Monte Carlo
Adaptive Restore algorithm & importance Monte Carlo
 
Genome organization in virus,bacteria and eukaryotes.pptx
Genome organization in virus,bacteria and eukaryotes.pptxGenome organization in virus,bacteria and eukaryotes.pptx
Genome organization in virus,bacteria and eukaryotes.pptx
 
CYTOGENETIC MAP................ ppt.pptx
CYTOGENETIC MAP................ ppt.pptxCYTOGENETIC MAP................ ppt.pptx
CYTOGENETIC MAP................ ppt.pptx
 
GBSN - Microbiology (Unit 4) Concept of Asepsis
GBSN - Microbiology (Unit 4) Concept of AsepsisGBSN - Microbiology (Unit 4) Concept of Asepsis
GBSN - Microbiology (Unit 4) Concept of Asepsis
 
ABHISHEK ANTIBIOTICS PPT MICROBIOLOGY // USES OF ANTIOBIOTICS TYPES OF ANTIB...
ABHISHEK ANTIBIOTICS PPT MICROBIOLOGY  // USES OF ANTIOBIOTICS TYPES OF ANTIB...ABHISHEK ANTIBIOTICS PPT MICROBIOLOGY  // USES OF ANTIOBIOTICS TYPES OF ANTIB...
ABHISHEK ANTIBIOTICS PPT MICROBIOLOGY // USES OF ANTIOBIOTICS TYPES OF ANTIB...
 
Molecular phylogeny, molecular clock hypothesis, molecular evolution, kimuras...
Molecular phylogeny, molecular clock hypothesis, molecular evolution, kimuras...Molecular phylogeny, molecular clock hypothesis, molecular evolution, kimuras...
Molecular phylogeny, molecular clock hypothesis, molecular evolution, kimuras...
 
COMPOSTING : types of compost, merits and demerits
COMPOSTING : types of compost, merits and demeritsCOMPOSTING : types of compost, merits and demerits
COMPOSTING : types of compost, merits and demerits
 
GBSN - Microbiology (Unit 5) Concept of isolation
GBSN - Microbiology (Unit 5) Concept of isolationGBSN - Microbiology (Unit 5) Concept of isolation
GBSN - Microbiology (Unit 5) Concept of isolation
 
EU START PROJECT. START-Newsletter_Issue_4.pdf
EU START PROJECT. START-Newsletter_Issue_4.pdfEU START PROJECT. START-Newsletter_Issue_4.pdf
EU START PROJECT. START-Newsletter_Issue_4.pdf
 
Terpineol and it's characterization pptx
Terpineol and it's characterization pptxTerpineol and it's characterization pptx
Terpineol and it's characterization pptx
 
Efficient spin-up of Earth System Models usingsequence acceleration
Efficient spin-up of Earth System Models usingsequence accelerationEfficient spin-up of Earth System Models usingsequence acceleration
Efficient spin-up of Earth System Models usingsequence acceleration
 
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
Major groups of bacteria: Spirochetes, Chlamydia, Rickettsia, nanobes, mycopl...
 
Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.Phenolics: types, biosynthesis and functions.
Phenolics: types, biosynthesis and functions.
 
SaffronCrocusGenomicsThessalonikiOnlineMay2024TalkOnline.pptx
SaffronCrocusGenomicsThessalonikiOnlineMay2024TalkOnline.pptxSaffronCrocusGenomicsThessalonikiOnlineMay2024TalkOnline.pptx
SaffronCrocusGenomicsThessalonikiOnlineMay2024TalkOnline.pptx
 

Metabolite Cycled GABA Edited Magnetic Resonance Spectroscopic Imaging MRSI MEGA-PRESS MEGA-SLSER

  • 1. See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/325949259 Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging using Density Weighted Concentric Rings k-space Trajectory Conference Paper · June 2018 CITATIONS 0 READS 64 6 authors, including: Some of the authors of this publication are also working on these related projects: Big GABA View project The impact of reward and punishment on skill learning depends on task demands View project Uzay Emir 130 PUBLICATIONS   2,091 CITATIONS    SEE PROFILE Adam Steel Dartmouth College 41 PUBLICATIONS   261 CITATIONS    SEE PROFILE Ulrike Dydak Purdue University 119 PUBLICATIONS   3,603 CITATIONS    SEE PROFILE Xiaopeng Zhou Purdue University 11 PUBLICATIONS   148 CITATIONS    SEE PROFILE All content following this page was uploaded by Uzay Emir on 01 May 2021. The user has requested enhancement of the downloaded file.
  • 2. 5/1/2021 https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html 1/2 3966 Non-water Suppressed GABA Edited Magnetic Resonance Spectroscopic Imaging using Density Weighted Concentric Rings k-space Trajectory Uzay E Emir , Pingyu Xia , Xiaopeng Zhou , Mark Chiew , Adam Steel , M Albert Thomas , and Ulrike Dydak School of Health Sciences, Purdue University, West Lafayette, IN, United States, Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States, Department of Radiological Sciences, University of California, Los Angeles, CA, United States, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States Synopsis In this study, we have developed and demonstrated a non-water suppressed GABA editing Magnetic Resonance Spectroscopic Imaging technique using density-weighted concentric rings k-space trajectory that performs robustly within a clinically feasible acquisition time at 3T. The method has been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with a high in-plane resolution of 7.5 × 7.5 mm . Experiments qualitatively demonstrate the advantage of the proposed method in terms of its improved resolution and reduced contamination of spectra from neighboring voxels. Introduction Water-suppressed MRS acquisition techniques have been the standard approach used in research and clinical MRI scanners to date. The acquisition of a non- water-suppressed spectrum is used for artifact correction, reconstruction of phased-array coil data, and metabolite quantification. A non-water suppressed metabolite-cycling (1) MRSI acquisition technique has recently been proposed for simultaneous detection of the metabolite and water signals. Potential improvements of voxel-wise frequency, phase, and eddy current correction have been demonstrated (1). In this study, we propose using a MEGA semi-LASER sequence with non-water suppressed metabolite-cycling as 2D MRSI data acquisition method at 3T for high-resolution GABA detection throughout a whole axial slice. To improve the point-spread function of the 2D-MRSI acquisition without any loss of SNR and time efficiency, a density-weighted concentric rings k- space trajectory (DW-CRT) sampling approach is used for the k-space acquisition trajectory of MRSI (2). Methods All scans were acquired using a Siemens Prisma 3-Tesla (Siemens, Erlangen, Germany) whole-body MRI scanner and a 20-channel head array receive coil. B0 shimming was achieved using GRESHIM (3). The non-water-suppressed metabolite-cycling MRSI acquisition was achieved by utilizing two asymmetric narrow- transition-band adiabatic RF pulses with mirrored inversion profiles applied in alternate scans for the inversion of the upfield and downfield (relative to water) spectral ranges (4) before the semi-LASER localization with a gap of 9.6 ms. The semi-LASER (5) localization (TR = 1.5 s, TE = 68 ms), was used to excite whole brain slice with a 125 mm x 105 mm x 20 mm region centrally within the field of view (FOV= 240 mm x 240 mm). The Gaussian editing pulses of 65 Hz width were placed on the H3’ protons at 1.9 ppm in the “ON” acquisition, and at 9.0 ppm in the “OFF” acquisition. For DW-CRT, 64 points per ring were collected with an ADC bandwidth of 80 kHz, resulting in 512 temporal samples in an effective spectral bandwidth of 1250 Hz (Figure 1). To cover the 32x32 grid, 16 rings resulting in an individual voxel size of 1.125 mL (7.5 mm x 7.5 mm x 20 mm) were acquired for DW-CRT. The Hanning filter weighting function with an alpha value of 1 was used to compute radial sampling locations for the DW-CRT (2). For DW-CRT, four spatial interleaves (64 unique rings) were used to ensure that minimum field of view requirement was met, resulting in an acquisition duration of 384 s with metabolite cycling and mega editing. The number of averages was 2, corresponding to a total acquisition duration of 12.8 minutes. The feasibility of the whole brain slice with the proposed methods was tested on a healthy volunteer (male; 31 years old) after giving informed consent under an institutionally approved technical development protocol. All reconstructions were implemented in MATLAB using the non-uniform FFT (NUFFT) toolbox (6). Lipid contamination was removed during post‐processing using a lipid‐basis penalty algorithm (7). Results Figure 2 shows the non-water suppressed image of a whole brain slice as well as in-vivo edited spectra from the same slice of a healthy volunteer using metabolite cycling. After subtraction of the even MR spectra from the odd MR spectra, the edited in vivo MR spectra from 1.125 mL voxels showed well- defined GABA peaks at 3.0 ppm both in a central brain region (Figure 2) and a cortical brain region close to the lipid layer (Figure 3). Conclusion We have developed and demonstrated a non-water suppressed MEGA semi-LASER MRSI sequence with DW-CRT that performs robustly at 3 Tesla, within a clinically feasible acquisition time of 13 min. The feasibility of the detection of GABA with the proposed method was shown in a healthy volunteer with a high in- plane resolution of 7.5 × 7.5 mm2. Experiments qualitatively demonstrate the advantage of DW-CRT in terms of its improved resolution and reduced contamination of spectra from neighboring voxels. Future work will focus on implementing the method for whole brain coverage with a reduced TR. Acknowledgements This work was supported by NIH R01 ES020529 References 1. Emir UE, Burns B, Chiew M, Jezzard P, Thomas MA. Non-water-suppressed short-echo-time magnetic resonance spectroscopic imaging using a concentric ring k-space trajectory. NMR Biomed 2017;30(7). 1 1 1 2 3,4 5 1,6 1 2 3 4 5 6 2
  • 3. 5/1/2021 https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html https://cds.ismrm.org/protected/18MProceedings/PDFfiles/3966.html 2/2 2. Chiew M, Jiang W, Burns B, Larson P, Steel A, Jezzard P, Albert Thomas M, Emir UE. Density-weighted concentric rings k-space trajectory for 1H magnetic resonance spectroscopic imaging at 7 T. NMR in Biomedicine:e3838-n/a. 3. Shah S, Kellman P, Greiser A, Weale P, Zuehlsdorff S, Jerecic R. Rapid Fieldmap Estimation for Cardiac Shimming. Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine. Honolulu 2009. p 565. 4. Dreher W, Leibfritz D. New method for the simultaneous detection of metabolites and water in localized in vivo 1H nuclear magnetic resonance spectroscopy. Magn Reson Med 2005;54(1):190-195. 5. Scheenen TW, Heerschap A, Klomp DW. Towards 1H-MRSI of the human brain at 7T with slice-selective adiabatic refocusing pulses. MAGMA 2008;21(1- 2):95-101. 6. Fessler JA, Sutton BP. Nonuniform fast Fourier transforms using min-max interpolation. IEEE Transactions on Signal Processing 2003;51(2):560-574. 7. Bilgic B, Chatnuntawech I, Fan AP, Setsompop K, Cauley SF, Wald LL, Adalsteinsson E. Fast image reconstruction with L2-regularization. J Magn Reson Imaging 2014;40(1):181-191. Figures Figure 1 Pulse sequence diagram of the proposed MEGA semi-LASER method without water suppression, allowing simultaneous detection of GABA and water signals. Prior to a MEGA semi-LASER editing sequence, two asymmetric narrow-transition-band adiabatic RF pulses invert the spectral range where metabolite signals are expected either upfield or downfield with respect to water. Figure 2 Edit “OFF”, EDIT “ON” and difference spectra from 3 x 3 voxels in the center of the whole brain slice semi-LASER localization acquired using non- water suppressed metabolite cycling with MEGA editing for GABA detection. Edit “OFF”, EDIT “ON” and difference spectra from 3 x 3 voxels close to the lipid layer of the whole brain slice semi-LASER localization acquired using non- water suppressed metabolite cycling with MEGA editing for GABA detection. Proc. Intl. Soc. Mag. Reson. Med. 26 (2018) 3966 View publication stats View publication stats