This document summarizes a study on the sub-chronic toxicity potential of the alcoholic extract of Biophytum reinwardtii, a whole plant used ethnobotanically to treat various ailments. Key findings from the study include:
1) The median acute toxicity value (LD50) of the B. reinwardtii extract in mice was determined to be 588.88 mg/kg body weight when administered intraperitoneally.
2) In a 30-day sub-chronic toxicity study in rats, doses of 50, 75, and 100 mg/kg of the extract did not significantly affect food/fluid intake, body weight, organ weights, or liver/hematological
1) The document describes a study that evaluated the hepatoprotective potential of extracts from in vitro regenerated Boerhaavia diffusa plants compared to extracts from naturally grown plants.
2) Mice of both sexes were intoxicated with carbon tetrachloride to induce hepatic injury, then treated with extracts from in vitro plants or natural plants. Serum levels of liver enzymes (SGOT and SGPT) were measured to assess hepatoprotection.
3) Treatment with both in vitro and natural plant extracts significantly reduced elevated liver enzyme levels compared to untreated intoxicated mice, indicating both were effective at protecting the liver from carbon tetrachloride toxicity. This suggests the in vitro regenerated plants produced bioactive molecules with
Influence of gongronema latifolium leaf extracts treatment on some hepatic...Alexander Decker
This document summarizes a study on the effects of extracts from the leaves of Gongronema latifolium on hepatic enzyme activity in rats. Rats were treated with various doses of ethanolic and water extracts for 7 days. Blood samples were then analyzed for liver enzyme levels. The results showed that the extracts increased the activity of AST and ALT liver enzymes at doses of 25mg/kg, indicating potential liver cell damage. The extracts also increased serum amylase levels in a dose-dependent manner. However, the extracts did not significantly affect blood urea levels. The conclusion is that while G. latifolium extracts may have some medical benefits, chronic high dose use could adversely impact liver function.
This document describes a study that evaluated the anti-diabetic effects of an Ayurvedic herbo-mineral formulation called Trushanadi loha. The formulation contains 14 plant and mineral ingredients. An aqueous extract was tested in rats. Blood glucose levels were measured. The extract produced a 40% reduction in blood glucose levels in normal rats, demonstrating significant anti-diabetic activity. The formulation was also found to be non-toxic in acute oral toxicity tests in rats at doses up to 5,000 mg/kg. Overall, the study provides evidence that Trushanadi loha has anti-diabetic properties and a safe toxicity profile.
This document reports on a study that investigated the aging process in rat liver from 8-12 weeks old to 20 weeks old. It examined age-dependent changes, the effects of the liver toxin carbon tetrachloride (CCl4), and the hepatoprotective effects of the seeds of Vitis vinifera (grapevine). Biochemical markers and histological analysis showed that aging leads to changes in liver structure similar to low doses of CCl4. CCl4 treatment significantly increased liver damage markers and oxidative stress. Treatment with an ethanolic extract of grape seeds significantly reduced liver damage markers, oxidative stress, and improved liver structure compared to CCl4 treatment alone. The results suggest the grape seed extract has hepatoprotect
The use of medicinal plants in the treatment of harmful impacts of xenobiotics in animals is attracting an increasing attention in recent times. The aim of the current study is to assess the preventive potential of Costus afer aqueous leaves extract (CAAE) in treating metabolic aberrations imposed by crude oil contaminated diet in Wistar albino rats. Six groups of rats were treated as follows: A = Normal diet; B= Normal diet + 100 mg/kg body weight of CAAE; C =Normal diet + 200 mg/kg body weight of CAAE; D= Crude oil contaminated diet; E= crude oil contaminated diet + 100 mg/kg body weight of CAAE, F = crude oil contaminated diet + 200 mg/kg body weight of CAAE. After thirty days of exposure to the diet and administration of the corresponding plant extracts, the rats were sacrificed with chloroform and the required organs were excised. The hematological indices, as well as function indicators and levels of drug metabolizing enzymes in the liver and kidney, were investigated with standard protocols. The results indicated that the hematological parameters and kidney and liver function indices were altered in rats fed with crude oil contaminated diet. However, the values came close to those in control rats when Costus afer aqueous extracts were administered. Similarly, the activities of oxidase enzymes (aldehyde oxidase, monoamine oxidase, xanthine oxidase, and sulphite oxidase), following their inhibition by the ingestion of crude oil contaminated diet, equally restored close to control values upon treatment with Costus afer aqueous extract. This study, therefore, was able to establish an aqueous extract of Costus afer leave as an antidote for crude oil intoxication.
Preliminary phytochemical studies and evaluation of Antipyretic property of t...researchplantsciences
Purpose-The root of Ritchiea longipedicellata was claimed to have anti pyretic, analgesic and antimicrobial properties. The people of Idemili area in Anambra State of Nigeria use the decoction of it to treat wounds, running stomach, aches and pains as well as fever. It is to this backdrop that this investigation was carried out to ascertain the veracity of the claim.
Methodology-The root of Ritchiea longipedicellata was collected and dried at ambient temperature. It was pulverized into powder. 500 gm of the powdered drug was placed into a two litre beaker containing one litre of methanol. It was allowed to stand with occasional shaking for 48 h. The content was filtered and the filtrate was concentrated using rotary evaporator. The extract contains the following secondary metabolites-alkaloids, flavonoids, terpenoids, saponins and glycosides. The antipyretic activity was investigated using brewer’s yeast to induce pyrexia.
Result -The root of Ritchiea longipedicellata exhibited significant (p<0.05) antipyretic effect at 600 mg/kg from 1 h to 4 h and at 3 h to 4 h at 300 mg/kg compared with the control.
Conclusion-The claim of Idemili people of Anambra State Nigeria on the use of Ritchiea longipedicellata appears to be obvious in line with the results of the investigation.
Article Citation:
Chinedu Fred Anowi, Ezugwu CO, Ilodigwe EE, Ajaghaku DL.
Preliminary Phytochemical Studies and Evaluation of Antipyretic Property of the Methanol Extract of the Rootbark of Ritchiea longipedicellata Gilg (capparidaceae)
Journal of Research in Plant Sciences (2013) 2(2): 192-195.
Full Text:
http://plantsciences.co.in/documents/PS0048.pdf
The document summarizes a study that analyzed samples collected from diarrhea patients and their mothers in rural Bangladesh to detect coliform bacteria. Several species of coliform bacteria were isolated from the samples, with isolation rates ranging from 38.01-3.51%. Extracts of Moringa oleifera leaves were tested against the isolated bacteria. The leaf extracts showed antibacterial effects and were able to inhibit the growth of all tested bacterial pathogens, including E. coli, Shigella, Salmonella, Enterobacter, Klebsiella, and Serratia species. The extracts had zone of inhibition ranging from 8-23 mm and minimum inhibitory concentration values between 62.5-1000 μg/mL, suggesting M. oleifera extracts could
Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection
against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported
by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2
insult.
Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione)
were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly
(p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in
catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were
significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of
rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of
rats acutely exposed to cadmium and rising lipid peroxidation profile.
Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts
conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target
against its deleterious effects.
1) The document describes a study that evaluated the hepatoprotective potential of extracts from in vitro regenerated Boerhaavia diffusa plants compared to extracts from naturally grown plants.
2) Mice of both sexes were intoxicated with carbon tetrachloride to induce hepatic injury, then treated with extracts from in vitro plants or natural plants. Serum levels of liver enzymes (SGOT and SGPT) were measured to assess hepatoprotection.
3) Treatment with both in vitro and natural plant extracts significantly reduced elevated liver enzyme levels compared to untreated intoxicated mice, indicating both were effective at protecting the liver from carbon tetrachloride toxicity. This suggests the in vitro regenerated plants produced bioactive molecules with
Influence of gongronema latifolium leaf extracts treatment on some hepatic...Alexander Decker
This document summarizes a study on the effects of extracts from the leaves of Gongronema latifolium on hepatic enzyme activity in rats. Rats were treated with various doses of ethanolic and water extracts for 7 days. Blood samples were then analyzed for liver enzyme levels. The results showed that the extracts increased the activity of AST and ALT liver enzymes at doses of 25mg/kg, indicating potential liver cell damage. The extracts also increased serum amylase levels in a dose-dependent manner. However, the extracts did not significantly affect blood urea levels. The conclusion is that while G. latifolium extracts may have some medical benefits, chronic high dose use could adversely impact liver function.
This document describes a study that evaluated the anti-diabetic effects of an Ayurvedic herbo-mineral formulation called Trushanadi loha. The formulation contains 14 plant and mineral ingredients. An aqueous extract was tested in rats. Blood glucose levels were measured. The extract produced a 40% reduction in blood glucose levels in normal rats, demonstrating significant anti-diabetic activity. The formulation was also found to be non-toxic in acute oral toxicity tests in rats at doses up to 5,000 mg/kg. Overall, the study provides evidence that Trushanadi loha has anti-diabetic properties and a safe toxicity profile.
This document reports on a study that investigated the aging process in rat liver from 8-12 weeks old to 20 weeks old. It examined age-dependent changes, the effects of the liver toxin carbon tetrachloride (CCl4), and the hepatoprotective effects of the seeds of Vitis vinifera (grapevine). Biochemical markers and histological analysis showed that aging leads to changes in liver structure similar to low doses of CCl4. CCl4 treatment significantly increased liver damage markers and oxidative stress. Treatment with an ethanolic extract of grape seeds significantly reduced liver damage markers, oxidative stress, and improved liver structure compared to CCl4 treatment alone. The results suggest the grape seed extract has hepatoprotect
The use of medicinal plants in the treatment of harmful impacts of xenobiotics in animals is attracting an increasing attention in recent times. The aim of the current study is to assess the preventive potential of Costus afer aqueous leaves extract (CAAE) in treating metabolic aberrations imposed by crude oil contaminated diet in Wistar albino rats. Six groups of rats were treated as follows: A = Normal diet; B= Normal diet + 100 mg/kg body weight of CAAE; C =Normal diet + 200 mg/kg body weight of CAAE; D= Crude oil contaminated diet; E= crude oil contaminated diet + 100 mg/kg body weight of CAAE, F = crude oil contaminated diet + 200 mg/kg body weight of CAAE. After thirty days of exposure to the diet and administration of the corresponding plant extracts, the rats were sacrificed with chloroform and the required organs were excised. The hematological indices, as well as function indicators and levels of drug metabolizing enzymes in the liver and kidney, were investigated with standard protocols. The results indicated that the hematological parameters and kidney and liver function indices were altered in rats fed with crude oil contaminated diet. However, the values came close to those in control rats when Costus afer aqueous extracts were administered. Similarly, the activities of oxidase enzymes (aldehyde oxidase, monoamine oxidase, xanthine oxidase, and sulphite oxidase), following their inhibition by the ingestion of crude oil contaminated diet, equally restored close to control values upon treatment with Costus afer aqueous extract. This study, therefore, was able to establish an aqueous extract of Costus afer leave as an antidote for crude oil intoxication.
Preliminary phytochemical studies and evaluation of Antipyretic property of t...researchplantsciences
Purpose-The root of Ritchiea longipedicellata was claimed to have anti pyretic, analgesic and antimicrobial properties. The people of Idemili area in Anambra State of Nigeria use the decoction of it to treat wounds, running stomach, aches and pains as well as fever. It is to this backdrop that this investigation was carried out to ascertain the veracity of the claim.
Methodology-The root of Ritchiea longipedicellata was collected and dried at ambient temperature. It was pulverized into powder. 500 gm of the powdered drug was placed into a two litre beaker containing one litre of methanol. It was allowed to stand with occasional shaking for 48 h. The content was filtered and the filtrate was concentrated using rotary evaporator. The extract contains the following secondary metabolites-alkaloids, flavonoids, terpenoids, saponins and glycosides. The antipyretic activity was investigated using brewer’s yeast to induce pyrexia.
Result -The root of Ritchiea longipedicellata exhibited significant (p<0.05) antipyretic effect at 600 mg/kg from 1 h to 4 h and at 3 h to 4 h at 300 mg/kg compared with the control.
Conclusion-The claim of Idemili people of Anambra State Nigeria on the use of Ritchiea longipedicellata appears to be obvious in line with the results of the investigation.
Article Citation:
Chinedu Fred Anowi, Ezugwu CO, Ilodigwe EE, Ajaghaku DL.
Preliminary Phytochemical Studies and Evaluation of Antipyretic Property of the Methanol Extract of the Rootbark of Ritchiea longipedicellata Gilg (capparidaceae)
Journal of Research in Plant Sciences (2013) 2(2): 192-195.
Full Text:
http://plantsciences.co.in/documents/PS0048.pdf
The document summarizes a study that analyzed samples collected from diarrhea patients and their mothers in rural Bangladesh to detect coliform bacteria. Several species of coliform bacteria were isolated from the samples, with isolation rates ranging from 38.01-3.51%. Extracts of Moringa oleifera leaves were tested against the isolated bacteria. The leaf extracts showed antibacterial effects and were able to inhibit the growth of all tested bacterial pathogens, including E. coli, Shigella, Salmonella, Enterobacter, Klebsiella, and Serratia species. The extracts had zone of inhibition ranging from 8-23 mm and minimum inhibitory concentration values between 62.5-1000 μg/mL, suggesting M. oleifera extracts could
Background: The probable mechanism of an earlier reported capacity of palm oil extracts to confer protection
against high dose cadmium poisoning in rats was reported in this study. Similar experimental design earlier reported
by us was retained. Rats therefore were sacrificed at intervals of twelve; twenty four and forty eight hours post CdCl2
insult.
Results: Oxidative stress and antioxidant status (malondialdehyde, superoxide dismutase, catalase and glutathione)
were assessed in tissues (liver, kidney, heart, brain, muscle) and serum. Oxidative stress indicators showed a significantly
(p < 0.05) increased lipid peroxidation and alterations in antioxidant defence systems occasioned by drop in
catalase and superoxide dismutase enzymes (serum, liver, heart, brain and kidneys) of the rats. Also observed were
significant (p < 0.05) reduction in the non-enzymatic antioxidant reduced glutathione over time. Pre-administration of
rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of
rats acutely exposed to cadmium and rising lipid peroxidation profile.
Conclusions: Regulation of stress and antioxidant response was the underlying mechanism by which the extracts
conferred protection against high dose cadmium insult thus suggesting its potential as a viable therapeutic target
against its deleterious effects.
This research paper evaluated the hepatoprotective activity of Tephrosia purpurea Linn stem. The stem was extracted with methanol and subjected to phytochemical screening which revealed the presence of flavonoids, phytosterols, alkaloids and proteins. An acute toxicity study found the extract was safe up to a dose of 2000 mg/kg. Hepatoprotective activity was evaluated against CCl4-induced hepatotoxicity in rats. Biochemical parameters (SGPT, SGOT, ALP, bilirubin) were assessed. The methanol extract reduced these serum levels and exhibited dose-dependent hepatoprotective activity comparable to the standard drug silymarin. Phytoc
This research article evaluated the potential aphrodisiac effects of Moringa oleifera seed extracts in male albino rats. Researchers administered aqueous, alcohol, and chloroform extracts of M. oleifera seeds to male rats for 21 days. They observed several parameters of sexual behavior and found that the extracts significantly increased mounting frequency, intromission frequency, and ejaculation latency, while decreasing mounting latency, intromission latency, and post-ejaculatory interval. The extracts also increased libido without any adverse effects. The results suggest that M. oleifera seed extracts can enhance sexual behavior in male rats, supporting its traditional use as an aphrodisiac.
This research article studied the anti-obesity effects of Moringa oleifera leaf extract (MEMOL) in rats with high fat diet-induced obesity. Rats were fed a high fat diet to induce obesity over 49 days. Treatment with MEMOL for 49 days significantly reduced body weight, total cholesterol, triglycerides, and LDL levels in obese rats, and increased body temperature, compared to untreated obese rats. MEMOL treated rats also showed decreased levels of liver enzymes and blood glucose. The results indicate that MEMOL attenuated body weight gain in obese rats without affecting food intake, and demonstrated hypoglycemic and hypolipidemic effects, suggesting it may help treat obesity and related disorders.
Phytochemical Profile and in vitro and in vivo Anticonvulsant and Antioxidant...Self-employed researcher
This study presents the phytochemical profile and in vitro and in
vivo anticonvulsant and antioxidant activities of Epilobium hirsutum, which
has been traditionally used in the treatment of epilepsy by local people of
Turkey. In vitro studies revealed that the extract contained a pronounced
amount of phenolics (206.3±0.9 mg Gallic acid Eq/g extract) and exhibited
significant levels of antioxidant (FRAP; 6226 µmol Fe2+/g extract, ORAC;
6593 µmol Trolox Eq/g extract, DPPH; IC50:33.8 ug/mL and metal chelation;
IC50:114 ug/mL) and anticonvulsant (AChE; IC50:71.2 ug/mL, BChE; IC50:92.5
ug/mL, GABA-T; IC50:94.7 ug/mL) activities. In vivo studies shown that the
the extract exhibited high anticonvulsant activities. In addition, the extracts
regulated the behavior, locomotion, and mental activities of the mice tested.
Biochemical evaluation of the brain tissue revealed that the extract inhibited
the production of MDA and stimulated the increase of antioxidant enzyme
levels, which suggest the possible antioxidative role of the extract that worked
as neuroprotective agents by scarfing the free radicals produced through PTZ
seizure inducer and attenuate convulsions. Moreover the extract regulated
serum biochemical parameters, total antioxidants, total oxidant, and ischemia modified albumin levels. Chromatographic studies were revealed that gallic
acid principally might be the major contributor of anticonvulsant and
antioxidant activities with the additive contributions of fatty acids and mineral
compounds. Findings obtained from this study partially justified the traditional
use of Epilobium hirsutum in the treatment of epilepsy and suggest potential
use of the extract as an industrial or pharmaceutical agent.
Hypoglycemic effect of gongronema latifolia extracts in ratsAlexander Decker
This study investigated the hypoglycemic effects of water and ethanolic extracts of Gongronema latifolia leaves in rats. Phytochemical analysis found both extracts contained alkaloids, saponins, tannins, cardiac glycosides, flavonoids and high levels of polyphenols. Rats treated with various doses of both extracts for 21 days had significantly reduced blood glucose levels compared to controls, in a dose-dependent manner. The polyphenol content may cause insulin-like effects by binding insulin receptors or stimulating insulin release, reducing blood glucose similarly to insulin and justifying G. latifolia's traditional use for treating diabetes.
1) The aqueous extract of Sida rhombifolia ssp. retusa roots showed hepatoprotective effects against liver damage induced by thioacetamide and allyl alcohol in rats.
2) Pretreatment with the extract significantly reduced elevated liver enzymes and normalized liver weight and volume caused by thioacetamide toxicity. The extract also prevented decreases in body weight and reduced necrosis caused by allyl alcohol.
3) The study demonstrates that the roots of Sida rhombifolia ssp. retusa have potent hepatoprotective properties against chemically-induced liver damage in rats.
The document reports on a study that evaluated the hepatoprotective activity of Stephania abyssinica, a plant used traditionally in Ethiopia to treat liver diseases. Rats were treated with carbon tetrachloride to induce liver damage. Administration of the methanolic extracts of S. abyssinica roots and rhizomes reduced serum markers of liver damage. Fractionation led to the identification of a new alkaloid, 6-(3’-hydroxy-4’-methoxycinnamoyl)stephine, which displayed moderate hepatoprotective activity. The results provide evidence supporting the traditional use of S. abyssinica for liver diseases.
Background: Dennentia tripetalla (Pepper Fruit) belongs to the Annonaceae family and is abundant in Nigeria. Its
fruit in folklore medicine is used for treatment of varying ailments. While ample research evidence exists on the
plants fruit and seed, no current study exists on the toxicological profile of the plant leaves.
Methods: qualitative and quantitative phytochemicals and In vitro antioxidant assays were carried out using
standard methods. The acute toxicity study indicates that the LD50 was higher than 2000 mg/Kg body weight. Subchronic
toxicity studies was carried out using five groups of rats. Group 1 served as control, 2–5 received 100 mg/
Kg, 200 mg/Kg, 500 mg/Kg and 1000 mg/Kg body weight orally for 28 days.
Results: Post-administration biochemical analysis indicates there was increased weight in rats administered 100
mg/kg and 200 mg/kg while it reduced in the 500 mg/kg group. Significant elevations of liver function markers
were reported for 200 mg/kg and 500 mg/kg respectively. Serum and hepatic protein profiles remained unaltered.
Renal function analysis revealed elevated serum urea and creatinine for 200 and 500 mg/kg groups, elevated serum
Na+ and Ca+ and reduced serum Cl− for the 500 mg/Kg group. Elevated Kidney K+ and Ca+ levels, reduced Cl−
were significantly observed in 500 mg/Kg group. Significant rise in hepatic and renal lipid peroxidation was
observed in 200 and 500 mg/Kg groups. There were observed disarmament of the antioxidant defense systems
occasioned by rise and drop in tissue (hepatic, renal, testes, heart) Superoxide dismutase (SOD), Catalase (Cat),
Glutathione-s-transferase (GST), Glutathione peroxidase (GPx) activities in the test groups relative to control.
Histopathological examination indicated architectural aberrations at 500 and 1000 mg/kg.
Conclusions: It concluded that the plant had significant phytochemical and antioxidant properties of medical
interest and possessed toxic properties in rats when administered at a dose above 200 mg/Kg over a prolonged
period of time.
Hepatoprotective Activity of Cinnamon Zeylanicum Leaves against Alcohol Induc...IJERA Editor
Plants play an important role in the life of human, as the major source of food, as well as for the maintenance and improvement of health and for the elimination of the enemies since ages. Plants are the basic source of knowledge of modern medicine. The present study was conducted to evaluate the hepatoprotective activity of aqueos extract of aerial parts of Cinnamon zeylanicum are evaluated in alcohol induced hepatotoxicity in albino rats. Silymarin (100mg/kg) was given as reference standard. The aqueos extract of aerial parts of Cinnamon zeylanicum have shown very significant hepatoprotection against alcohol induced hepatotoxicity in albino rats in reducing SGOT, SGPT, Alkaline phosphatase (ALP) and GGT and levels of total bilirubin and total protein were investigated and showed an increase in alcohol induced rats when compared to control. The extracts of the test plant exhibited significant (p < 0.05) hepatoprotective activity against the alcohol induced liver models by improving liver function which was indicated by reduction in the levels of SGOT, SGPT, ALP, GGT, total bilirubin and total protein.
Hepatotoxicity and Nephrotoxicity Studies of Ethanol Extracts of Annona Muric...Premier Publishers
The study determined the effects of administration of ethanol extracts of Annona muricata leaves (AML) and Fagara zanthoxyloide roots (FZR) on liver and kidney indices in zidovudine (ZDV)-induced Wistar rats. Animals were grouped into five (5); group 1 served as normal control, groups 2-5 were induced with 100g/mlZDV/Kgbw and group 3 treated with 35IU/Kgbw of erythropoietin, group 4 with 4.5g/mlAML/Kgbw and group 5 with 3.8g/mlFZR/Kgbw for six weeks. Serum liver enzymes, other biochemicals (total protein, albumin, globulin, bilirubin, urea and creatinine), organ weights and histological examination were used to assess the impact on the liver and kidney using standard methods. A significant elevation (p≤0.05) in the activities of serum liver enzymes and bilirubin accompanied by a significant decrease (p≤0.05) in the other biochemicals were observed in group 2. Treatment with extracts resulted in a modulation of the induced effects of ZDV causing a significant decrease in the serum liver enzymes, bilirubin and increase in the total protein, albumin and globulin concentrations. Histology of the liver showed altered architecture, blood vessel congestion and necrosis; while the kidneys were hypoplastic with signs of swelling (group 2) which was gradually reverted on treatment with extracts. The study suggests that extracts of AML and FZR may confer some degree of protection to the liver and kidney.
Analgesic and antipyretic activity of methanolic extract of Acacia leucophloe...pharmaindexing
The document studies the antipyretic (fever-reducing) activity of Scaevola taccada leaf extracts in rats. Preliminary screening found the leaves contain alkaloids, flavonoids, lipids, terpenoids, glycosides and saponins. Ethanolic and aqueous leaf extracts were tested on yeast-induced fever in rats. Both extracts significantly reduced fever, comparable to the standard drug paracetamol. The antipyretic effects may be due to inhibition of prostaglandin synthesis.
Evaluation of Analgesic Activity of Some Polyherbal Extracts against Acetic A...Jing Zang
Aloe vera contains salicylic acid which is an aspirin like compound with anti-inflammatory, analgesic and anti bacterial properties. Cannabis sativa is an annual herbaceous plant in the cannabaceae family. The aim of present study was to evaluate analgesic activity of that combination extract against acetic acid induced writhing in mice. All animals were divided into four groups of six mice each. Group I was treated as toxicant control to observe writhing and group II was pretreated with diclofenac sodium (100 mg/kg, i.p.) Group III and IV were pretreated with polyherbal leaves extract of Aloe vera and Cannabis sativa at two doses 100mg/kg and 200mg/kg p.o. respectively. Polyherbal extract and Diclofenac sodium were given before 60 minute of acetic acid administration. The results showed that polyherbal extract significantly reduced number of writhing when compared with group I (Toxicant control) mice and the results were dose dependent. The toxicity study also revealed its safeness, thus the combination of plant extract can be hypothesized it is nontoxic. It is concluded that polyherbal extract can offer protection against acetic acid induced writhing in mice.
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
This study evaluated the antiasthmatic potential of a polyherbal formulation containing extracts of four plants - Solanum xanthocarpum, Aegle marmelos, Caesalpinia bonduc, and Murraya koenigii. Experimental models in rats and guinea pigs were used to assess mast cell stabilization, antihistaminic, and anticholinergic effects. The results demonstrated that the polyherbal formulation dose-dependently inhibited mast cell degranulation and protected against histamine- and acetylcholine-induced bronchospasm in guinea pigs, suggesting antiasthmatic effects through mast cell membrane stabilization, antihistaminic, and anticholinergic mechanisms of action. This
Blood glucose and lipid reducing activities of the oral administration of aqu...Alexander Decker
1. The study investigated the effects of repeated oral administration of an aqueous extract of Moringa oleifera leaves on blood glucose and lipid levels in male Wistar rats over 56 days.
2. The extract significantly reduced blood glucose and serum lipid levels like total cholesterol and triglycerides in a dose-dependent manner. It also significantly increased HDL cholesterol.
3. The extract maintained or slightly reduced body weight in the rats. It significantly reduced food intake, which may be due to effects on appetite or metabolism in the gastrointestinal tract.
1) The study evaluated the antiulcer activity of an aqueous extract of Brassica oleraceae (cabbage) leaves in laboratory rat models of gastric and duodenal ulcers.
2) Cabbage extract showed dose-dependent protection against ethanol/HCl-induced gastric ulcers and indomethacin-induced gastric ulcers compared to control groups. The highest dose of 750 mg/kg provided over 90% protection against indomethacin-induced ulcers.
3) In a cysteamine-induced duodenal ulcer model, the lowest dose of 100 mg/kg cabbage extract gave 85% protection, higher than the standard drug omeprazole.
Hepatoprotective Effect of Cestrum parqui L. aerial parts and Phytochemical ...Jing Zang
This study deals with the investigation of hepatoprotective effect of 70% methanolic extract from Cestrum parqui aerial parts and determination of the bioactive components of the plant. The hepatoprotective effect of Cestrum parqui methanol extract (100, 500, 1000 mg/kg) was analysed on carbon tetrachloride (CCl4)-induced acute liver injury. The administration of a single dose of 40% CCl4 (1ml/kg b.w.) causes an increase in the activities of serum alanine aminotransferase (ALT) and aspirate aminotransferase (AST) enzymes and so pretreated orally of a dose from Cestrum parqui methanol extract (100, 500, 1000 mg/kg) and silymarin (200 mg/kg) for three consecutive days prior to The administration of a single dose of CCl4 significantly prevented the increase in the activities of these enzymes. Histological analysis showed that Cestrum parqui methanol extract at doses of 500 and 1000 mg/kg and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl4. The extract cause a negative result on the antioxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl4-treated group and this suggests that the hepatoprotective activity of the extract is due to the antioxidant effect of the extract. Phytochemical analysis of the methanol extract from Cestrum parqui aerial parts showed that it contained different phytoconstituents, flavonoids, tannins, saponins, alkaloids, terpenes and carbohydrates.
Toxicity Studies of Aqueous-Methanol Extract of Dennettia tripetala (Pepper f...Scientific Review SR
1) The study evaluated the toxicity of an aqueous-methanol extract of Dennettia tripetala fresh ripe fruits in rats over 14 days.
2) The extract showed no significant effects on liver and kidney function at 100 mg/kg body weight but caused toxicity at higher doses based on changes in biochemical parameters and antioxidant levels.
3) The extract significantly decreased levels of antioxidant enzymes like SOD, GSH, GPx and GST at doses of 200 and 400 mg/kg, indicating potential oxidative stress, while MDA and CAT were not significantly affected.
The aim of the present work is to carry out acute toxicity study for root bark powder of Argemone mexicana. It is one of the potent liver tonics used for liver disorders. The exposure of this powder in the form of aqueous slurry on Swiss mice was carried out and the exposure route was oral single administration with water. The observations of changes in body weight, food and water intake as well as cage side observations were reported. The observations prove that the plant material is found to be nontoxic.
Biochemical and histopathological changes in wistar rats following chronic ad...Alexander Decker
The document summarizes a study that investigated the effects of chronic administration of three oral doses (50, 100, and 150 mg/kg body weight) of an ethanol extract of a diherbal mixture of Zanthoxylum leprieurii and Piper guineense on biochemical parameters, liver histology, and testicular histology in male Wistar rats. The study found significant increases in liver enzymes (AST, ALT, ALP) in test groups compared to the control in a dose-dependent manner. Histopathological examination revealed distortion of seminiferous tubules and delayed germ cell maturation in testes, as well as micro- to macrovesicular steatosis (fatty change) in livers,
DIURETIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF LEPIDIUM SATIVUMpharmaindexing
The document summarizes a study that evaluated the diuretic activity of the methanolic extract of leaves of Lepidium sativum in rats. The extract was administered orally at doses of 200 and 400 mg/kg. It was found to significantly increase urine volume as well as the urinary concentration of sodium, potassium, and chloride ions compared to the control group in a dose-dependent manner. This suggests that the extract has potent diuretic properties, possibly through inhibition of sodium-potassium-chloride co-transporter in the kidney, similar to the diuretic drug frusemide. The results provide support for the traditional use of L. sativum as a diuretic.
This research paper evaluated the hepatoprotective activity of Tephrosia purpurea Linn stem. The stem was extracted with methanol and subjected to phytochemical screening which revealed the presence of flavonoids, phytosterols, alkaloids and proteins. An acute toxicity study found the extract was safe up to a dose of 2000 mg/kg. Hepatoprotective activity was evaluated against CCl4-induced hepatotoxicity in rats. Biochemical parameters (SGPT, SGOT, ALP, bilirubin) were assessed. The methanol extract reduced these serum levels and exhibited dose-dependent hepatoprotective activity comparable to the standard drug silymarin. Phytoc
This research article evaluated the potential aphrodisiac effects of Moringa oleifera seed extracts in male albino rats. Researchers administered aqueous, alcohol, and chloroform extracts of M. oleifera seeds to male rats for 21 days. They observed several parameters of sexual behavior and found that the extracts significantly increased mounting frequency, intromission frequency, and ejaculation latency, while decreasing mounting latency, intromission latency, and post-ejaculatory interval. The extracts also increased libido without any adverse effects. The results suggest that M. oleifera seed extracts can enhance sexual behavior in male rats, supporting its traditional use as an aphrodisiac.
This research article studied the anti-obesity effects of Moringa oleifera leaf extract (MEMOL) in rats with high fat diet-induced obesity. Rats were fed a high fat diet to induce obesity over 49 days. Treatment with MEMOL for 49 days significantly reduced body weight, total cholesterol, triglycerides, and LDL levels in obese rats, and increased body temperature, compared to untreated obese rats. MEMOL treated rats also showed decreased levels of liver enzymes and blood glucose. The results indicate that MEMOL attenuated body weight gain in obese rats without affecting food intake, and demonstrated hypoglycemic and hypolipidemic effects, suggesting it may help treat obesity and related disorders.
Phytochemical Profile and in vitro and in vivo Anticonvulsant and Antioxidant...Self-employed researcher
This study presents the phytochemical profile and in vitro and in
vivo anticonvulsant and antioxidant activities of Epilobium hirsutum, which
has been traditionally used in the treatment of epilepsy by local people of
Turkey. In vitro studies revealed that the extract contained a pronounced
amount of phenolics (206.3±0.9 mg Gallic acid Eq/g extract) and exhibited
significant levels of antioxidant (FRAP; 6226 µmol Fe2+/g extract, ORAC;
6593 µmol Trolox Eq/g extract, DPPH; IC50:33.8 ug/mL and metal chelation;
IC50:114 ug/mL) and anticonvulsant (AChE; IC50:71.2 ug/mL, BChE; IC50:92.5
ug/mL, GABA-T; IC50:94.7 ug/mL) activities. In vivo studies shown that the
the extract exhibited high anticonvulsant activities. In addition, the extracts
regulated the behavior, locomotion, and mental activities of the mice tested.
Biochemical evaluation of the brain tissue revealed that the extract inhibited
the production of MDA and stimulated the increase of antioxidant enzyme
levels, which suggest the possible antioxidative role of the extract that worked
as neuroprotective agents by scarfing the free radicals produced through PTZ
seizure inducer and attenuate convulsions. Moreover the extract regulated
serum biochemical parameters, total antioxidants, total oxidant, and ischemia modified albumin levels. Chromatographic studies were revealed that gallic
acid principally might be the major contributor of anticonvulsant and
antioxidant activities with the additive contributions of fatty acids and mineral
compounds. Findings obtained from this study partially justified the traditional
use of Epilobium hirsutum in the treatment of epilepsy and suggest potential
use of the extract as an industrial or pharmaceutical agent.
Hypoglycemic effect of gongronema latifolia extracts in ratsAlexander Decker
This study investigated the hypoglycemic effects of water and ethanolic extracts of Gongronema latifolia leaves in rats. Phytochemical analysis found both extracts contained alkaloids, saponins, tannins, cardiac glycosides, flavonoids and high levels of polyphenols. Rats treated with various doses of both extracts for 21 days had significantly reduced blood glucose levels compared to controls, in a dose-dependent manner. The polyphenol content may cause insulin-like effects by binding insulin receptors or stimulating insulin release, reducing blood glucose similarly to insulin and justifying G. latifolia's traditional use for treating diabetes.
1) The aqueous extract of Sida rhombifolia ssp. retusa roots showed hepatoprotective effects against liver damage induced by thioacetamide and allyl alcohol in rats.
2) Pretreatment with the extract significantly reduced elevated liver enzymes and normalized liver weight and volume caused by thioacetamide toxicity. The extract also prevented decreases in body weight and reduced necrosis caused by allyl alcohol.
3) The study demonstrates that the roots of Sida rhombifolia ssp. retusa have potent hepatoprotective properties against chemically-induced liver damage in rats.
The document reports on a study that evaluated the hepatoprotective activity of Stephania abyssinica, a plant used traditionally in Ethiopia to treat liver diseases. Rats were treated with carbon tetrachloride to induce liver damage. Administration of the methanolic extracts of S. abyssinica roots and rhizomes reduced serum markers of liver damage. Fractionation led to the identification of a new alkaloid, 6-(3’-hydroxy-4’-methoxycinnamoyl)stephine, which displayed moderate hepatoprotective activity. The results provide evidence supporting the traditional use of S. abyssinica for liver diseases.
Background: Dennentia tripetalla (Pepper Fruit) belongs to the Annonaceae family and is abundant in Nigeria. Its
fruit in folklore medicine is used for treatment of varying ailments. While ample research evidence exists on the
plants fruit and seed, no current study exists on the toxicological profile of the plant leaves.
Methods: qualitative and quantitative phytochemicals and In vitro antioxidant assays were carried out using
standard methods. The acute toxicity study indicates that the LD50 was higher than 2000 mg/Kg body weight. Subchronic
toxicity studies was carried out using five groups of rats. Group 1 served as control, 2–5 received 100 mg/
Kg, 200 mg/Kg, 500 mg/Kg and 1000 mg/Kg body weight orally for 28 days.
Results: Post-administration biochemical analysis indicates there was increased weight in rats administered 100
mg/kg and 200 mg/kg while it reduced in the 500 mg/kg group. Significant elevations of liver function markers
were reported for 200 mg/kg and 500 mg/kg respectively. Serum and hepatic protein profiles remained unaltered.
Renal function analysis revealed elevated serum urea and creatinine for 200 and 500 mg/kg groups, elevated serum
Na+ and Ca+ and reduced serum Cl− for the 500 mg/Kg group. Elevated Kidney K+ and Ca+ levels, reduced Cl−
were significantly observed in 500 mg/Kg group. Significant rise in hepatic and renal lipid peroxidation was
observed in 200 and 500 mg/Kg groups. There were observed disarmament of the antioxidant defense systems
occasioned by rise and drop in tissue (hepatic, renal, testes, heart) Superoxide dismutase (SOD), Catalase (Cat),
Glutathione-s-transferase (GST), Glutathione peroxidase (GPx) activities in the test groups relative to control.
Histopathological examination indicated architectural aberrations at 500 and 1000 mg/kg.
Conclusions: It concluded that the plant had significant phytochemical and antioxidant properties of medical
interest and possessed toxic properties in rats when administered at a dose above 200 mg/Kg over a prolonged
period of time.
Hepatoprotective Activity of Cinnamon Zeylanicum Leaves against Alcohol Induc...IJERA Editor
Plants play an important role in the life of human, as the major source of food, as well as for the maintenance and improvement of health and for the elimination of the enemies since ages. Plants are the basic source of knowledge of modern medicine. The present study was conducted to evaluate the hepatoprotective activity of aqueos extract of aerial parts of Cinnamon zeylanicum are evaluated in alcohol induced hepatotoxicity in albino rats. Silymarin (100mg/kg) was given as reference standard. The aqueos extract of aerial parts of Cinnamon zeylanicum have shown very significant hepatoprotection against alcohol induced hepatotoxicity in albino rats in reducing SGOT, SGPT, Alkaline phosphatase (ALP) and GGT and levels of total bilirubin and total protein were investigated and showed an increase in alcohol induced rats when compared to control. The extracts of the test plant exhibited significant (p < 0.05) hepatoprotective activity against the alcohol induced liver models by improving liver function which was indicated by reduction in the levels of SGOT, SGPT, ALP, GGT, total bilirubin and total protein.
Hepatotoxicity and Nephrotoxicity Studies of Ethanol Extracts of Annona Muric...Premier Publishers
The study determined the effects of administration of ethanol extracts of Annona muricata leaves (AML) and Fagara zanthoxyloide roots (FZR) on liver and kidney indices in zidovudine (ZDV)-induced Wistar rats. Animals were grouped into five (5); group 1 served as normal control, groups 2-5 were induced with 100g/mlZDV/Kgbw and group 3 treated with 35IU/Kgbw of erythropoietin, group 4 with 4.5g/mlAML/Kgbw and group 5 with 3.8g/mlFZR/Kgbw for six weeks. Serum liver enzymes, other biochemicals (total protein, albumin, globulin, bilirubin, urea and creatinine), organ weights and histological examination were used to assess the impact on the liver and kidney using standard methods. A significant elevation (p≤0.05) in the activities of serum liver enzymes and bilirubin accompanied by a significant decrease (p≤0.05) in the other biochemicals were observed in group 2. Treatment with extracts resulted in a modulation of the induced effects of ZDV causing a significant decrease in the serum liver enzymes, bilirubin and increase in the total protein, albumin and globulin concentrations. Histology of the liver showed altered architecture, blood vessel congestion and necrosis; while the kidneys were hypoplastic with signs of swelling (group 2) which was gradually reverted on treatment with extracts. The study suggests that extracts of AML and FZR may confer some degree of protection to the liver and kidney.
Analgesic and antipyretic activity of methanolic extract of Acacia leucophloe...pharmaindexing
The document studies the antipyretic (fever-reducing) activity of Scaevola taccada leaf extracts in rats. Preliminary screening found the leaves contain alkaloids, flavonoids, lipids, terpenoids, glycosides and saponins. Ethanolic and aqueous leaf extracts were tested on yeast-induced fever in rats. Both extracts significantly reduced fever, comparable to the standard drug paracetamol. The antipyretic effects may be due to inhibition of prostaglandin synthesis.
Evaluation of Analgesic Activity of Some Polyherbal Extracts against Acetic A...Jing Zang
Aloe vera contains salicylic acid which is an aspirin like compound with anti-inflammatory, analgesic and anti bacterial properties. Cannabis sativa is an annual herbaceous plant in the cannabaceae family. The aim of present study was to evaluate analgesic activity of that combination extract against acetic acid induced writhing in mice. All animals were divided into four groups of six mice each. Group I was treated as toxicant control to observe writhing and group II was pretreated with diclofenac sodium (100 mg/kg, i.p.) Group III and IV were pretreated with polyherbal leaves extract of Aloe vera and Cannabis sativa at two doses 100mg/kg and 200mg/kg p.o. respectively. Polyherbal extract and Diclofenac sodium were given before 60 minute of acetic acid administration. The results showed that polyherbal extract significantly reduced number of writhing when compared with group I (Toxicant control) mice and the results were dose dependent. The toxicity study also revealed its safeness, thus the combination of plant extract can be hypothesized it is nontoxic. It is concluded that polyherbal extract can offer protection against acetic acid induced writhing in mice.
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
This study evaluated the antiasthmatic potential of a polyherbal formulation containing extracts of four plants - Solanum xanthocarpum, Aegle marmelos, Caesalpinia bonduc, and Murraya koenigii. Experimental models in rats and guinea pigs were used to assess mast cell stabilization, antihistaminic, and anticholinergic effects. The results demonstrated that the polyherbal formulation dose-dependently inhibited mast cell degranulation and protected against histamine- and acetylcholine-induced bronchospasm in guinea pigs, suggesting antiasthmatic effects through mast cell membrane stabilization, antihistaminic, and anticholinergic mechanisms of action. This
Blood glucose and lipid reducing activities of the oral administration of aqu...Alexander Decker
1. The study investigated the effects of repeated oral administration of an aqueous extract of Moringa oleifera leaves on blood glucose and lipid levels in male Wistar rats over 56 days.
2. The extract significantly reduced blood glucose and serum lipid levels like total cholesterol and triglycerides in a dose-dependent manner. It also significantly increased HDL cholesterol.
3. The extract maintained or slightly reduced body weight in the rats. It significantly reduced food intake, which may be due to effects on appetite or metabolism in the gastrointestinal tract.
1) The study evaluated the antiulcer activity of an aqueous extract of Brassica oleraceae (cabbage) leaves in laboratory rat models of gastric and duodenal ulcers.
2) Cabbage extract showed dose-dependent protection against ethanol/HCl-induced gastric ulcers and indomethacin-induced gastric ulcers compared to control groups. The highest dose of 750 mg/kg provided over 90% protection against indomethacin-induced ulcers.
3) In a cysteamine-induced duodenal ulcer model, the lowest dose of 100 mg/kg cabbage extract gave 85% protection, higher than the standard drug omeprazole.
Hepatoprotective Effect of Cestrum parqui L. aerial parts and Phytochemical ...Jing Zang
This study deals with the investigation of hepatoprotective effect of 70% methanolic extract from Cestrum parqui aerial parts and determination of the bioactive components of the plant. The hepatoprotective effect of Cestrum parqui methanol extract (100, 500, 1000 mg/kg) was analysed on carbon tetrachloride (CCl4)-induced acute liver injury. The administration of a single dose of 40% CCl4 (1ml/kg b.w.) causes an increase in the activities of serum alanine aminotransferase (ALT) and aspirate aminotransferase (AST) enzymes and so pretreated orally of a dose from Cestrum parqui methanol extract (100, 500, 1000 mg/kg) and silymarin (200 mg/kg) for three consecutive days prior to The administration of a single dose of CCl4 significantly prevented the increase in the activities of these enzymes. Histological analysis showed that Cestrum parqui methanol extract at doses of 500 and 1000 mg/kg and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl4. The extract cause a negative result on the antioxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl4-treated group and this suggests that the hepatoprotective activity of the extract is due to the antioxidant effect of the extract. Phytochemical analysis of the methanol extract from Cestrum parqui aerial parts showed that it contained different phytoconstituents, flavonoids, tannins, saponins, alkaloids, terpenes and carbohydrates.
Toxicity Studies of Aqueous-Methanol Extract of Dennettia tripetala (Pepper f...Scientific Review SR
1) The study evaluated the toxicity of an aqueous-methanol extract of Dennettia tripetala fresh ripe fruits in rats over 14 days.
2) The extract showed no significant effects on liver and kidney function at 100 mg/kg body weight but caused toxicity at higher doses based on changes in biochemical parameters and antioxidant levels.
3) The extract significantly decreased levels of antioxidant enzymes like SOD, GSH, GPx and GST at doses of 200 and 400 mg/kg, indicating potential oxidative stress, while MDA and CAT were not significantly affected.
The aim of the present work is to carry out acute toxicity study for root bark powder of Argemone mexicana. It is one of the potent liver tonics used for liver disorders. The exposure of this powder in the form of aqueous slurry on Swiss mice was carried out and the exposure route was oral single administration with water. The observations of changes in body weight, food and water intake as well as cage side observations were reported. The observations prove that the plant material is found to be nontoxic.
Biochemical and histopathological changes in wistar rats following chronic ad...Alexander Decker
The document summarizes a study that investigated the effects of chronic administration of three oral doses (50, 100, and 150 mg/kg body weight) of an ethanol extract of a diherbal mixture of Zanthoxylum leprieurii and Piper guineense on biochemical parameters, liver histology, and testicular histology in male Wistar rats. The study found significant increases in liver enzymes (AST, ALT, ALP) in test groups compared to the control in a dose-dependent manner. Histopathological examination revealed distortion of seminiferous tubules and delayed germ cell maturation in testes, as well as micro- to macrovesicular steatosis (fatty change) in livers,
DIURETIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF LEPIDIUM SATIVUMpharmaindexing
The document summarizes a study that evaluated the diuretic activity of the methanolic extract of leaves of Lepidium sativum in rats. The extract was administered orally at doses of 200 and 400 mg/kg. It was found to significantly increase urine volume as well as the urinary concentration of sodium, potassium, and chloride ions compared to the control group in a dose-dependent manner. This suggests that the extract has potent diuretic properties, possibly through inhibition of sodium-potassium-chloride co-transporter in the kidney, similar to the diuretic drug frusemide. The results provide support for the traditional use of L. sativum as a diuretic.
EVALUATION OF ANTI HYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF AMARANTHUS...gynomark
The document describes a study that evaluated the anti-hyperlipidemic activity of the ethanolic extract of Amaranthus roxbhurgianus in albino rats. Preliminary phytochemical screening of the extract showed the presence of carbohydrates, glycosides, flavonoids, and sterols. Acute toxicity studies in rats found no deaths up to a dose of 2g/kg. Rats fed a high-cholesterol diet and treated with the Amaranthus roxbhurgianus extract at doses of 100mg/kg and 200mg/kg showed a significant reduction in serum cholesterol, triglycerides, LDL, and atherogenic index, and an increase in HDL levels compared to the
Hepatoprotective Activity of Methanolic Extract of Whole Plant of Pulicaria W...IOSRJPBS
Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of Pulicaria wightiana in wistar rats. The studies were conducted using the two popular inducing agents Paracetamol (2 g/kg, p.o.) in 1% NaCMC and Carbon tetrachloride (1 ml/kg). Silymarin (100 mg/kg, p.o.) was used as reference drug in the respective models. The effect was estimated by measuring the enzymatic levels and histo- pathological studies. The methanolic extract of whole plant of Pulicaria wightiana has shown very significant hepatoprotection against both Paracetamol and CCl4 - induced hepatotoxicity study models in wistar rats. This was evidenced by marked reduction in marker enzymes in serum. Histopathological studies also confirmed the hepatoprotective nature of the extract
Acute Oral Toxicity Study of Aqueous Leaf Extract of Celosia Argentea in Fema...YogeshIJTSRD
Celosia argentea is a plant of family Amaranthaceae used as traditional medicine for various diseases. The aim of the study is to evaluate the acute toxicity effect of Celosia argentea leaf extract for 14 days in female albino rats. The aqueous extract of Celosia argentea showed no evidence of single dose toxicity 2000 mg kg when studying acute toxicity on biochemical, hematological or histological parameters. The results showed that .C. argentea does not cause toxicity at the doses studied. M. Sridevi | B. Senthilkumar | K. Devi "Acute Oral Toxicity Study of Aqueous Leaf Extract of Celosia Argentea in Female Albino Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, URL: https://www.ijtsrd.com/papers/ijtsrd39811.pdf Paper URL: https://www.ijtsrd.com/biological-science/zoology/39811/acute-oral-toxicity-study-of-aqueous-leaf-extract-of-celosia-argentea-in-female-albino-rats/m-sridevi
This document summarizes a study that evaluated the antifertility effects of an aqueous leaf extract of Prosopis cineraria in male albino rats. Rats were divided into three groups: a control group and two treatment groups that received either 150 mg/kg or 250 mg/kg of the P. cineraria extract daily for 35 days. Treatment resulted in decreased testis, epididymis and seminal vesicle weights as well as reduced sperm motility, viability and counts. Serum testosterone levels also declined in the treatment groups. However, after a 65 day recovery period without treatment, the fertility parameters increased toward normal levels, indicating the antifertility effects were reversible. The study suggests the P. c
Effects of Metformin, Pioglitazone and Aqueous Extract of Delonix Regia on Bl...iosrjce
The effects of Delonix regia extract (d200mg, d300mg, and d400mg), metformin (m8.3mg, m12.5mg
and m16.5mg), pioglitazone (p0.5mg, p0.7mg and p0.9mg) and combined formulation of metformin and extract
(m6.25d150mg) on glycated hemoglobin status in streptozotocin-induced diabetic Albino wistar rats. Diabetic
status of these rats was assessed by estimating fasting blood glucose levels. A total of 150 albino rats were used
for the investigation and were grouped into twelve groups of twelve rats each as follows; Group I: normal
control rats (NCR). Group II: Diabetic control rats (DCR). Group III: Diabetic rats treated with d200mg.
Group IV: Diabetic rats treated with d300mg. Group V: Diabetic rats treated with d400mg. Group VI: Diabetic
rats treated with m8.3mg. Group VII: Diabetic rats treated with m12.5mg. Group VIII: Diabetic rats treated
with m16.5mg. Group IX: Diabetic rats treated with p0.5mg. Group X: Diabetic rats treated with p0.75mg.
Group XI: Diabetic rats treated with p1.0mg. Group XII: Diabetic rats treated with m125d300mg each for male
and female respectively, for a total of 56 days. After every two weeks interval of treatment for eight weeks three
rats from each group were sacrificed and blood sample were collected and analyzed for various parameters.
The result obtained showed an elevated level of glycated hemoglobin in diabetic-induced wistar albino rats
compared with normal control rats. However, there was reversal of the effects when treated with the
drug/extract. Also there was reduction in the blood glucose level of the diabetic rats treated with metformin
(from 6.37±0.69 to 5.20±0.62mmol/l), pioglitazone (from 7.30±0.21mmol/l to 4.70±0.46), aqueous extract of
Delonixregia (from 8.20±0.81mmol/l to 6.10±0.60) and combined formulation of metformin and extract (from
7.81±0.34 to 4.80±0.17), at p<0.05 confidence level when compared with diabetic control rats in the various
weeks of treatment respectively
Antifertility Effect of Aqueous Leaf Extract of Prosopis cineraria in Male Al...BRNSSPublicationHubI
This study evaluated the antifertility effects of an aqueous leaf extract of Prosopis cineraria in male albino rats. Rats were divided into three groups: a control group and two treatment groups that received either 150 mg/kg or 250 mg/kg of the leaf extract daily for 35 days. The extract decreased testis and epididymis weight and sperm motility, viability, and count in a dose-dependent manner. It also reduced testosterone levels and caused abnormal sperm morphology. After 65 days without further treatment, fertility markers increased in the treated groups but did not return to control levels. The study suggests the leaf extract has antifertility properties in male rats.
Effect of Administration Ethanol Leaf Extract of Terminalia Chebula on Liver ...oyepata
Effect of Administration Ethanol Leaf Extract of
Terminalia Chebula on Liver of Wister Rat
Joseph Oyepata Simeon1*, Modupe Builders2, Wazis Chama Haruna3, Joseph Opeyemi Tosin4, Sabastine Aliyu
Zubairu5, Musa Tabitha Lubo6, Moh’d A. Sadiq
This study investigated the antioxidant activity of Cee'Rich Vitamin C supplement in rats with chemically-induced liver toxicity. Rats were given carbon tetrachloride to cause liver damage and were treated with Cee'Rich Vitamin C supplement at doses of 200 and 400 mg/kg for 10 days. Biomarkers of liver damage (serum SGPT, SGOT, LDH) were decreased and antioxidant enzyme levels (SOD) were increased in rats treated with Cee'Rich compared to those that received only carbon tetrachloride, indicating a protective effect on the liver. The presence of flavonoids in Cee'Rich were found to exhibit significant antioxidant and hepatoprotective properties, protecting
This study evaluated the prophylactic (preventive) and curative effects of a hydro-alcoholic extract of Moringa oleifera pods on carbon tetrachloride (CCl4)-induced liver damage in rats. Rats were pre-treated or post-treated with three different doses of the extract (100, 250, 500 mg/kg) for 14 days before or after being administered CCl4 to induce liver injury. Biochemical markers, glutathione, malondialdehyde, and histopathological examination of the liver were used to assess the degree of liver damage and the protective effects of the extract. The extract was found to significantly reduce liver damage markers and bilirubin levels in a dose-dependent
This document outlines a research proposal to study the effect of crude beetroot peel extract on blood sugar levels, body mass index, and organ weights in albino rats. The study aims to determine how different doses of the extract impact these measures in treated rats compared to untreated controls. Twenty-five rats will be divided into five groups receiving varying daily doses of the extract for 28 days. Blood glucose and body weight will be measured regularly, and organ weights will be analyzed after sacrifice. The results could provide insights into the safety and effects of beetroot peel consumption.
Biochemical effect of Aqueous Carica papaya Seed and Leaf Extracts on Serum B...iosrjce
The cost of administering modern anti diabetic drugs is usually beyond the reach of most people in
the low income group especially those in the developing world where the disease is on the increase. This has led
to the current shift to the use of preparations from various parts of plants because of the current increase in the
knowledge of their toxicity, side effects, active constituents and doses. This study was conducted to compare the
effects of the aqueous Carica papaya seed and leaf extracts on serum biochemistry of alloxan induced diabetic
rats especially glucose level. Male Wister rats weighing 150-200g were induced with single freshly prepared
alloxan monohydrate (150 mg/kg body weight).Diabetes was confirmed after seven days in alloxan-induced rats
showing fasting blood glucose levels ≥ 200mg/dl. The diabetic rats were randomly allocated into three
experimental groups which received Seed extract, leaf extract or normal saline depending on the group. The
extracts were administered orally for twenty-eight days after which the animals were sacrificed and blood
samples were collected for Biochemical analyses. The results showed that both extracts have significant
hypoglycaemic, hepatoprotective and nephroprotective effects although extract of the seed proved to be more
potent than that of the leaf
Standardization of plectranthus amboinicusshveta arya
The document summarizes the standardization of Plectranthus amboinicus, an herbal plant used in traditional medicine. It describes preparing extracts of the leaves and subjecting them to phytochemical and toxicity testing. The acute and sub-acute toxicity studies in mice found the plant extract to be relatively non-toxic, with no mortality observed up to a 2000 mg/kg dose. Phytochemical analysis identified various compounds in the extract including carbohydrates, glycosides, alkaloids, sterols and flavonoids. Gas chromatography-mass spectrometry was used to analyze volatile compounds in the extract. The study supports the standardized use of P. amboinicus extracts as a potentially safe herbal
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...iosrphr_editor
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research paper publishing, where to publish research paper, journal publishing, how to publish research paper, Call for research paper, international journal, publishing a paper, call for paper 2012, journal of pharmacy, how to get a research paper published, publishing a paper, publishing of journal, research and review articles, Pharmacy journal, International Journal of Pharmacy, hard copy of journal, hard copy of certificates, online Submission, where to publish research paper, journal publishing, international journal, publishing a paper
Toxicological profile of Grewia bicolor root extractIOSRJPBS
The document summarizes a study on the toxicological profile of Grewia bicolor root extract. The study found:
1) The tolerated dose of the extract in rats was 800mg/kg while the toxic dose was 1600mg/kg, with behavioral and neurological signs observed at toxic doses.
2) The median lethal dose (LD50) of the extract was calculated to be 2663.92 mg/kg in acute toxicity testing.
3) In a 28-day sub-acute toxicity study, rats administered 800mg/kg of the extract daily showed no changes in body weight, hematological, or biochemical parameters compared to controls.
Evaluation of antioxidant activities of Cyperusrotundus (Ethanolic extract an...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY.pdfgynomark
Amaranthus roxburghianus is one of the traditionally well-known plants with outstanding therapeutic properties, and
is used mostly in treating different diseases in India. Thus, based on these medicinal properties, various investigations
have been undertaken in order to appraise the pharmacological activities and the chemical composition of these
species. Here, we elucidate the analgesic and anti-inflammatory activity of Amaranthus roxburghianus ethanolic
leaves extract. phytochemical screening of Amaranthus roxburghianus extract showed the presence of alkaloids,
Carbohydrates, Glycosides, Flavonoids, Tannins, Proteins, Amino Acids. the ethanolic leaves extract of Amaranthus
roxburghianus, possess peripheral and central analgesic activity in animal model. The Amaranthus roxburghianus
leaves extract shows anti-inflammatory activity in different animal model. Flavonoids and tannins are the major
constituents of Amaranthus roxburghianus leaves, which may be responsible for its Analgesic, Anti-inflammatory
activity.
KEYWORDS: Amaranthus roxburghianus, Phytochemical screening, Analgesic activity, Anti-inflammatory activity
The document describes a study that investigated the effects of ethanolic extract of Garcinia kola seed on reproductive parameters in male Wistar rats. The extract was administered orally at doses of 100 mg/kg and 200 mg/kg for 3 and 6 weeks. Preliminary analysis found the extract contained various phytochemicals and was considered safe up to a dose of 5000 mg/kg. After 3 weeks, testicular weight decreased significantly in treated groups while sperm count and motility increased. After 6 weeks, epididymal weight increased significantly in the high dose group while testicular changes were not significant. The extract appeared to enhance sperm characteristics at both time points without major toxicity.
Effects of Aqueous and Methanolic Leaf Extracts of Vitex doniana on Lipid Pro...IOSR Journals
The effect of aqueous and methanolic extracts of Vitex doniana leaves in serum lipid profile and liver enzymes in normal and alloxan-induced diabetic rats were investigated using standard analytical protocols. A total of 35 albino rats divided into seven groups of five rats each comprising one normal untreated group as animal control, one diabetic untreated group as diabetic control, one normal treated with 750mg/kg body weight as reference group, three diabetic groups treated with 250, 500 and 750mg/kg body weight respectively and one diabetic group treated with 5mg/kg Glibenclamide as standard. The result of acute toxicity test obtained indicated lethal dose (LD50) of greater than 5000mg/kg extract. The results showed that induction of diabetes caused significant (P<0.05)><0.05)><0.05)><0.05) increase in high density lipoprotein in the reference and diabetic groups when compared to normal and diabetic control groups respectively after oral administration of Vitex doniana leaf extracts. It could therefore be concluded that Vitex doniana leaf extract is safe, medicinal and have anti-lipidemia properties and hepato-protective effects.
Similar to Sub chronic toxicity potential of the alcoholic extract of biophytum reinwardtii whole plant (20)
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Sub chronic toxicity potential of the alcoholic extract of biophytum reinwardtii whole plant
1. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.2, No.6, 2012
Sub chronic toxicity potential of the alcoholic extract of
Biophytum reinwardtii whole plant
Awdhesh Oraon1* Barij Nayan Sinha2
1. Government Pharmacy Institute, Bariatu, Ranchi-834009, Jharkhand, India
2. Department of Pharmaceutical Sciences, Birla Institute of Technology, Ranchi-835215, Jharkhand,
India
* E-mail of the corresponding author: awdheshoraon@rediffmail.com
Abstract
Biophytum reinwardtii Edgew is an important and highly valued sensitive medicinal small herb and whole plant
is ethnobotanically used in the treatment of insomnia, convulsion, inflammation, lithiasis, fevers and gonorrhea.
The present study was carried out to evaluate acute and sub-chronic toxicity of alcoholic extract of Biophytum
reinwardtii Edgew (B. reinwardtii) whole herb extract in albino mice and rats. The median acute toxicity value
( LD50 ) of the extract of B. reinwardtii was determined to be 588.88 mg/kg b.w. (i.p.) in mice. In sub-chronic
toxicity studies 50, 75 and 100 mg/kg b.w. of the alcoholic extracts of B. reinwardtii (AEBR) whole plant were
administered orally to the test groups while distilled water was given to the control group. The parameters
measured include food and fluid intake, body weight, absolute and relative weight of various organs,
haematological parameters [total white blood cell (WBC) and packed cell volume (PCV)], and tests for liver
function: Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT),
alkaline phosphatase and total bilirubin. Rats treated with AEBR in the therapeutic dose level had no progressive
increase in body weight or fluid intake. There were no significant changes in both the absolute and relative organ
weights between the control and the test groups after 30 days. The liver enzymes and haematological parameters
were statistically equal in all the groups. The results of the present study therefore indicated that B. reinwardtii
whole herb is safe in adult male albino mice demonstrating no noticeable toxicity.
Keywords: Biophytum reinwardtii, sub-chronic toxicity, liver function, packed cell volume, absolute weight,
relative weight.
1. Introduction
The genus Biophytum is a member of the family geraniaceae and distributed in tropical Asia, Africa, America
and Philippines. In India nine species are found and out of nine species three species viz. Biophytum sensitivum
DC. Syn.Oxalis sensitive Linn., Biophytum reinwardtii Edgew and Biophytum umbraculum Welw. Syn. B.
petersianum Klotzsch are reported to have ethnomedicinal properties. Biophytum reinwardtii , a sensitive herb, is
distributed from Kumaun to Arunachal Pradesh up to an altitude of 1,800 m and extending into peninsular India
(Mitra and Ambasta1988, Kirtikar and Basu 1975). B. reinwardtii is a graceful little herb with its crown of
pinnate leaves always terminating a slender stem 2.5-10 cm high. Leaves 0.2-0.3 cm long with usually 8-12 pairs
of leaflets, which decrease in size very rapidly towards the base, so that the uppermost are 0.4-0.5 cm long and
the lowest are often only 0.1 cm long, rachis usually hairy, often pink. Peduncles shorter or longer than the
leaves, pubscent; crown of chaffy bracts shorter than the pedicles, which again are longer than the 0.1 cm long
sepals. Sepals equal or somewhat longer than the capsule (Haines 1988). Traditionally in Jharkhand (India), the
leaves and roots of B. reinwardtii are given for the treatment of insomnia and other mental disorders. The
decoction of the whole herb is used against fevers (Kirtikar and Basu 1975, Haines 1988). The present study was
undertaken to investigate the acute and sub-chronic toxicity studies of the alcoholic extract of B. reinwardtii
Edgew. in rats.
2. Materials and Methods
2.1 Plant Material
The whole herbs of B.reinwardtii Edgew (Geraneaceae) were collected from Khunti, Torpa, Basia,Palkot , Bolba,
Bishunpur, Netarhat, Gangaghat and Sisai of Ranchi, Gumla, Simdega and Lohardaga District . The parts were
authenticated by Dr. T.K. Ghosh, Taxonomist, Ranchi University, Ranchi, India and Botanical survey of India,
Govt. of India, Kolkata(India). The voucher specimen no. (GPI 81/2005) was deposited in the Pharmacognosy
laboratory, Govt. Pharmacy Institute, Ranchi (India) for future references.
2.2 Preparation of Extract
The whole herb was dried under shade and then powdered with a mechanical grinder and stored in an airtight
94
2. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.2, No.6, 2012
container. The dried and powdered plant material (whole plant) was subjected to hot extraction in a Soxhlet
continuous extraction apparatus with 50% alcohol. The extraction time period was 72 hours. The extract was
then filtered through whatmann filter paper and the filtrate obtained was lyophilized. The yield of 50% alcoholic
extract (AEBR) was 9.28% w/w.
2.3 Phytochemical Screening
The extract was subjected to preliminary phytochemical analysis for major group of phytoconstituents ( Evans
1989, Khandelwal 2005, Williamson et al 1996).In each test 10% (w/v) solution of the alcoholic extract was used
unless otherwise specified for an individual test. Phytochemical screening of the extracts revealed the presence
of terpenoid(s), steroid(s), tannin(s), flavonoid(s) and saponin(s).
2.4 Animals
Studies were carried out using albino rats and albino mice of either sex weighing between 180-200 g & 20 to 25
g respectively. They were obtained from the animal house, Department of Pharmaceutical Sciences, Birla
Institute of Technology, Mesra, Ranchi, India. The animals were grouped and housed in polyacrylic cages with
not more than six animals per cage and maintained under standard laboratory conditions (temperature 25 ± 2 °C)
with dark and light cycle (14/10 h). Animals were allowed free access to standard pellet (Hindustan Lever,
Mumbai, India) food and drinking water ad libitum. The rats were acclimatized to laboratory condition for 10
days before commencement of experiment (Bose et al 2007). All procedures described were reviewed and
approved by the Institute animal ethical committees (Reg.No.-621/02/ac/CPCSEA and Protocol
No.-PH/IAEC/29/2006).
2.5 Acute toxicity studies
The LD50 was determined using the graphical method of Litchfield and Wilcoxon in mice (Litchfield and
Wilcoxon 1949). Briefly, geometric doses of AEBR (100-1000 mg/kg) was administered i.p. to 10 groups of
mice (n=6). Control group received normal saline (10 ml/kg i.p.) and vehicle control received 10% propylene
glycol (PG) (10 ml/kg i.p.). After administration of dose the animals were observed continuously for first 4 h for
behavioral changes and signs of toxicity and mortality within 24-72 h were noted. The values thus obtained were
plotted against the corresponding log dose. The antilog of log dose corresponding to probit 5 gave the value of
LD50.
2.6 Sub-chronic toxicity study
A total of twenty four mature Wister rats were used in this study. They were divided into four groups of six rats
each. Three of the groups received 50, 75 and 100 mg/ kg body weight of the AEBR (p.o.), respectively, while
the control group received distilled water only. Food and water intake were monitored daily. After 30 days of
exposure, blood was collected from the animals, by cardiac puncture, for haematological and biochemical
analysis. Thereafter, the animals were sacrificed and the following organs isolated and weighed: heart, lungs,
kidney, liver, spleen and pancreas. Relative weight of the respective organs was calculated from each organ's wet
weight and the animal's body weight.
2.6.1 Effect of extract on Liver function
About 5 ml of whole blood collected into a plain tube was centrifuged at 3500 rpm for 5 min using table
centrifuge (Remi, India) and the serum separated and analyzed for the liver enzymes. Serum glutamic
oxaloacetic transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT) were assayed using the
methods of Reitman and Frankel, alkaline phosphatase (ALP) was analysed by the method of King and
Armstrong, while total bilirubin level was determined by the method of Malloy and Evelyn. All assay methods
employed were as reported by Varley (Varley et al 1991).
2.6.2 Haematological assay
EDTA-anticoagulated tubes were used to collect whole blood for these investigations. Packed cell volume (PCV)
was determined by the microhaematocrit method, while total WBC was determined by visual method (Dacie and
Lewis 1991).
2.7 Statistical analysis
Data were analyzed using Student's t-test and expressed as mean ± standard error of mean (SEM).
3. Results
3.1 Effect of extract on fluid and food intake
The effect of the extract on weekly consumption of food and fluid intake of experimental animals treated with
AEBR is shown in Table 1 and Table 2. Alcoholic extract of whole herb of Biophytum reinwardtii did not
increase the food or water intake of the experimental animals compared to control throughout the three weeks of
exposure.
3.2 Effect of extract on different organ weight
Rat treated with the various therapeutic doses of alcoholic extract of Biophytum reinwardtii (50, 75 and
95
3. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.2, No.6, 2012
100mg/kg) had no significant change in body weight. No statistically significant differences existed in the
absolute and relative weight of all the isolated organs between the treated and the control rats (Table 3).
3.3 Effect of extract on SGOT, SGPT and ALP
Subchronic administration of ethanolic extract of B. reinwardtii did not exert any significant effect on the level
of SGOT, SGPT and ALP of the extract treated rats. There was no statistical significant difference between the
means of treated groups and that of the control (Table 4).
3.4 Effect of extract on hematological parameters
The results of the effect of subchronic administration of alcoholic whole plant extract of B. reinwardtii on
haematological parameters of rats is shown in Table 5. There was no significant change in haematological
parameters in the extract treated animals compared to the control.
4. Conclusion
The present study was aimed to investigate the possible toxic effects of the alcoholic extract of B. reinwardtii
whole herb in adult swiss albino rats and mice. In results of acute toxicity study revealed that AEBR may be safe
in swiss albino mice. Various physical, chemical and haematological parameters were thoroughly studied in the
sub-chronic toxicity study.
The body weights, food and water intakes were found to be unaltered during the 30 days treatment period
when compared to control group. Similarly there were no significant changes in different organ weights also. No
mortality was observed during this period. Kluwe documented that the absolute organ weight has been observed
to be a relative sensitive indicator of nephrotoxicity for known nephrotoxicants. An increase in kidney weight
(either absolute or relative) indicates nephrotoxicity (Kluwe 1981). AEBR did not induce any toxic effect on the
kidney and the other organs.
Biochemical parameters related to hepatic vital functions viz. SGPT, SGOT, ALP and bilirubin contents
exhibited no significant alteration as compared with the normal control mice. Certain drugs and other substances
are known to affect and influence circulating bilirubin levels and elevation in bilirubin levels suggests increase in
haemolysis (Kelly 1977). AEBR, however, did not alter significantly the bilirubin levels of the exposed rats as
well as other liver enzymes compared to the control. The extract was observed to cause no significant change in
PCV% and WBC count in the extract treated animals compared to the control. According to Onyenyili and
co-workers, anemia following administration of an agent can be as a result of lysis of blood cells and/or
inhibition of blood cells synthesis by the active constituents of the extract, and decrease in haematological
parameters in an experimental animals has been associated with anaemia (Onyeyilli et al 1998). Study indicates
that there is no lysis of blood cells and/or inhibition in blood cells synthesis by the active constituents of AEBR.
From the present investigation it can be concluded that AEBR exhibited an excellent safety profile in acute
and sub-chronic toxicity studies. The present study establishes the reliable safety profile of AEBR in adult swiss
albino mice offering no obvious toxicity.
Acknowledgement
Authors are extremely thankful to Dr. Manik and Prof. A.K.Pattanayk, Department of Pharmaceutical Sciences,
B.I.T. Mesra, Ranchi for their valuable support during the present research work.
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Table 1. Effect of AEBR on weekly Food (g) intake in Rats
Weeks
Treatments
1 2 3
Control 223.66±1.11 228.16±0.94 226.66±0.88
50 mg/kg 281.33±0.66 287.66±1.25 287.66±0.76
75 mg/kg 302.00±0.96 297.33±0.80 291.66±0.49
100 mg/kg 249.83±1.01 252.83±0.94 258.83±0.60
Each value is mean ± S.E.M (n = 6)
Table 2. Effect of AEBR on weekly Fluid (ml) intake in Rats
Weeks
Treatments
1 2 3
Control 806.00±0.85 813.50±0.76 810.83±0.30
50 mg/kg 815.16±1.42 822.16±0.94 822.66±0.42
75 mg/kg 811.33±0.88 805.66±1.05 802.66±0.33
100 mg/kg 812.33±0.75 809.16±0.60 808.00±0.25
Each value is mean ± S.E.M (n = 6)
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6. Journal of Natural Sciences Research www.iiste.org
ISSN 2224-3186 (Paper) ISSN 2225-0921 (Online)
Vol.2, No.6, 2012
Table 4. Dose Effect Relationship of AEBR on the Liver Function of Rats
Analyte
Treatment
SGOT (iu/l) SGPT (iu/l) ALP (iu/l) Total Bilirubin (mg/dl)
Control 53.54 ± 0.56 20.00 ± 0.46 174.55 ± 0.48 0.07 ± 0.0002
50 mg/ kg 52.58 ± 0.75 20.75 ± 0.28 175.06 ± 0.07 0.08 ± 0.0002
75 mg/kg 52.78 ± 0.77 20.54 ± 0.24 175.05 ± 0.02 0.07 ± 0.0004
100 mg/kg 52.35 ± 0.37 20.84 ± 0.27 175.07 ± 0.05 0.08 ± 0.0003
Values are expressed as mean ± S.E.M (n = 6) (SGOT = Serum Glutamic Oxaloacetic Transaminase, SGPT =
Serum Glutamic Pyruvic Transaminase, ALP = Alkaline Phosphatase)
Table 5. Dose Effect Relationship of AEBR on the Haematological Parameters of Rats
Treatment PCV (%) WBC (cells/mm3)
Control 56.51 ± 0.31 7102.09 ± 20.90
50 mg/kg 54.14 ± 0.13 7136.12 ± 14.88
75 mg/kg 56.23 ± 0.24 7036.94 ± 12.19
100 mg/kg 56.04 ± 0.17 7154.87 ± 19.93
Values are expressed as mean ± S.E.M (n = 6)
99
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