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Structure of
Skeletal Muscle
Presentation by: Angela Holloman
Introduction
• All activities that involve movement depend on muscles
• 650 muscles in the human body
• Various purposes for muscles for:
– Locomotion
– Upright posture
– Balancing on two legs
– Support of internal organs
– Controlling valves and body openings
– Production of heat
– Movement of materials along internal tubes
• Three types of muscles in the human body
– Skeletal
– Cardiac
– Smooth
Skeletal Muscle
• Skeletal muscles are
muscles which are
attached to the skeleton.
• 40% of human body mass
• Skeletal muscles are
mainly responsible for
locomotion, and voluntary
contraction and relaxation.
Structure of Skeletal muscles
• Skeletal muscles are composed of clusters of muscle
cells.
– Muscle fibers
– Myofibers
– Myocytes
• A muscle consists of packages of muscle cells called
fascicles
• A muscle cell is long and spindle shaped
Structure of Skeletal muscles
• Cell structure
– Muscles cells contain many nuclei
– The plasma membrane→ sarcolemma
– The cytoplasm→ sarcoplasm
– Length
– ranges from 0.1cm to more the 30cm in length
– Diameter
– ranges from 0.001cm to 0.01cm in diameter
• Myofibrils→
– elongated protein molecules
– aligned in parallel arrangements
– extend the full length of the cell.
Structure of Skeletal muscles
• The myofibril consists of protein
chains called myofilaments
– Myofilaments have a symmetrical,
alternating pattern of thick and thin
elements.
Skeletal Muscle Myosin
• Thick myofilament
• consists of a large number of bundled myosin molecules aligned
in overlapping arrays.
• hexameric proteins with two identical heavy chains and two pairs of
different light chains.
– regulatory light chain (RLC)
– essential light chain (ELC)
Skeletal Muscle Actin
• The thin myofilament (F-actin, filamentous actin)
– made up of two helically intertwined chains of G-actin (globular
actin) units.
• Other proteins that bind to the actin molecules:
• Tropomyosin
• The Troponin complex→ made up of three members
Contraction of Skeletal Muscle
• The thick and thin filaments, along with their associated myofibril
proteins, are responsible for muscle contraction.
• How does muscle contraction work?
– Influx of calcium ions in the cell
• as a result of nerve impulses
– troponin complex pulls tropomyosin molecules away from the G-actin
subunits
– Exposure of the myosin binding sites.
– The heads of the myosin molecules can bind to the actin subunits,
forming cross bridges.
• active site in each myosin head disrupts the high-energy bond of
ATP molecules
• release of energy moves the myosin head towards the F- actin,
• when contact is made with the actin subunits, the F-actin is pulled
along, causing the myofilament to contract.
• The coordinated contraction of all the myofilaments of all the
muscle cells of a muscle, causes the entire muscle to contract.
Relaxation of Skeletal Muscle
– Calcium ions are carried
away from the myofilaments
– Myosin- actin linkages
loosen
– The troponin complex and
tropomyosin bind to the
myosin binding sites on the
F-actin subunits,
• Myosin and F- actin
myofilaments return to
their original positions
References:
• Pasternak, Jack J. Human Molecular Genetics: Mechanisms of
Inherited Diseases. Hoboken, New Jersey: John Wilkey &
Sons Inc., 2005.
• http://www.lau-verlag.de/anatom/muscleb.jpg. March, 20, 2006

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StructureofSkeletalMuscle for presentation.ppt

  • 2. Introduction • All activities that involve movement depend on muscles • 650 muscles in the human body • Various purposes for muscles for: – Locomotion – Upright posture – Balancing on two legs – Support of internal organs – Controlling valves and body openings – Production of heat – Movement of materials along internal tubes • Three types of muscles in the human body – Skeletal – Cardiac – Smooth
  • 3. Skeletal Muscle • Skeletal muscles are muscles which are attached to the skeleton. • 40% of human body mass • Skeletal muscles are mainly responsible for locomotion, and voluntary contraction and relaxation.
  • 4. Structure of Skeletal muscles • Skeletal muscles are composed of clusters of muscle cells. – Muscle fibers – Myofibers – Myocytes • A muscle consists of packages of muscle cells called fascicles • A muscle cell is long and spindle shaped
  • 5. Structure of Skeletal muscles • Cell structure – Muscles cells contain many nuclei – The plasma membrane→ sarcolemma – The cytoplasm→ sarcoplasm – Length – ranges from 0.1cm to more the 30cm in length – Diameter – ranges from 0.001cm to 0.01cm in diameter • Myofibrils→ – elongated protein molecules – aligned in parallel arrangements – extend the full length of the cell.
  • 6.
  • 7.
  • 8. Structure of Skeletal muscles • The myofibril consists of protein chains called myofilaments – Myofilaments have a symmetrical, alternating pattern of thick and thin elements.
  • 9. Skeletal Muscle Myosin • Thick myofilament • consists of a large number of bundled myosin molecules aligned in overlapping arrays. • hexameric proteins with two identical heavy chains and two pairs of different light chains. – regulatory light chain (RLC) – essential light chain (ELC)
  • 10. Skeletal Muscle Actin • The thin myofilament (F-actin, filamentous actin) – made up of two helically intertwined chains of G-actin (globular actin) units. • Other proteins that bind to the actin molecules: • Tropomyosin • The Troponin complex→ made up of three members
  • 11.
  • 12. Contraction of Skeletal Muscle • The thick and thin filaments, along with their associated myofibril proteins, are responsible for muscle contraction. • How does muscle contraction work? – Influx of calcium ions in the cell • as a result of nerve impulses – troponin complex pulls tropomyosin molecules away from the G-actin subunits – Exposure of the myosin binding sites. – The heads of the myosin molecules can bind to the actin subunits, forming cross bridges. • active site in each myosin head disrupts the high-energy bond of ATP molecules • release of energy moves the myosin head towards the F- actin, • when contact is made with the actin subunits, the F-actin is pulled along, causing the myofilament to contract. • The coordinated contraction of all the myofilaments of all the muscle cells of a muscle, causes the entire muscle to contract.
  • 13.
  • 14. Relaxation of Skeletal Muscle – Calcium ions are carried away from the myofilaments – Myosin- actin linkages loosen – The troponin complex and tropomyosin bind to the myosin binding sites on the F-actin subunits, • Myosin and F- actin myofilaments return to their original positions
  • 15. References: • Pasternak, Jack J. Human Molecular Genetics: Mechanisms of Inherited Diseases. Hoboken, New Jersey: John Wilkey & Sons Inc., 2005. • http://www.lau-verlag.de/anatom/muscleb.jpg. March, 20, 2006