Fats are classified as either saturated or unsaturated. Saturated fats are generally solid at room temperature and are found in animal products, while unsaturated fats are liquid and found in plants. There are three types of unsaturated fatty acids: monounsaturated, polyunsaturated, and trans fats. Monounsaturated and polyunsaturated fats are considered healthy, but trans and saturated fats should be limited. Omega-3 and omega-6 fatty acids are also polyunsaturated and important for health, with omega-3s having anti-inflammatory benefits.
Role of Essential Fatty Acids by Sayali ParabSayali Parab
Role of Essential Fatty Acids. “Essential Fatty Acid" refers to fatty acids required for biological processes but does not include the fats that only act as fuel.
Fat usually means any ester of fatty acids or mixture of such compounds most commonly those that occur in living beings or in food. Fat is used as the fatty components of foods and diet. Fats are best known members of a chemical group called the lipids.
Content
Classification
Functions
Sources
Digestion
Absorption
Deficiency and disorders of lipids
Essential fatty acid
Role of omega-3 & omega 6 fatty acids in physiological disorders
References
Role of Essential Fatty Acids by Sayali ParabSayali Parab
Role of Essential Fatty Acids. “Essential Fatty Acid" refers to fatty acids required for biological processes but does not include the fats that only act as fuel.
Fat usually means any ester of fatty acids or mixture of such compounds most commonly those that occur in living beings or in food. Fat is used as the fatty components of foods and diet. Fats are best known members of a chemical group called the lipids.
Content
Classification
Functions
Sources
Digestion
Absorption
Deficiency and disorders of lipids
Essential fatty acid
Role of omega-3 & omega 6 fatty acids in physiological disorders
References
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
2. Fats, are known as triglycerides, are esters of
three fatty acid chains and the alcohol glycerol.
The terms "lipid", "oil" and "fat" are often
confused. "Lipid" is the general term, though a
lipid is not necessarily a triglyceride. "Oil"
normally refers to a lipid with short
or unsaturated fatty acid chains that is liquid
at room temperature
An oil is any non polar chemical substance that is
a viscous liquid at ambient temperatures and is
both hydrophobic and lipophilic . Oils have a high
carbon and hydrogen content and are usually
flammable and surface active.
3. Fats are classified into saturated and
unsaturated fats. The classification is
important to enable you to advise your
community about which fats can be
consumed with less risk to people’s health.
Saturated fats are not good for a person’s
health.
As a general rule, plant sources of fats are
better for a person’s health than the animal
sources, because animal fats contain more
saturated fats.
4.
5. Saturated fats are usually solid at cool
temperatures. Eating too much saturated fat
is not good for a person’s health, as it can
cause heart and blood vessel problems.
Unsaturated fats are usually liquid at room
temperature. These types of fats are healthy
fats. Examples include fats from fish, oil
seeds (sesame and sunflower), maize oil and
ground nut oil and breastmilk
6. There are three types of unsaturated fatty
acids:-
Monounsaturated Fatty Acids (MUFA) Fatty
acids in this category have what is known as
one double bond in their chemical make-up.
They are relatively stable to oxidation and the
development of rancidity and are now
considered, in nutritional terms, as being the
best type of fat to eat.
The most common source of monounsaturates
are Olive Oil and Rapeseed oils.
7. Polyunsaturated Fatty Acids (PUFA)
Polyunsaturated fatty acids contain two
or more double bonds in their chemical
make-up.
They are least stable fatty acids to
oxidation and as such are best used in
cold applications.
The most common source of
polyunsaturates is Sunflowerseed oil
8. Trans Fatty Acids (TFA) Trans fatty acids
typically come from two sources,
hydrogenated vegetable oils and animal
fats.
Recent scientific research suggests trans
fats, although consumed in relatively
small proportions, should be avoided due
to their negative affect on blood
cholesterol levels
9.
10.
11. Certain fatty acids are already 'naturally
saturated' in that they cannot be made
'harder' than they are in nature.
As previously noted, the levels of saturates
is generally higher in those fats which are
solid at ambient temperatures.
Saturated fatty acids are extremely stable
i.e. they do not easily become rancid,
meaning they have good keeping properties
(shelf life).
12. However, Government recommendations
advise consumers to limit their intake of
saturated fats as they can increase blood
cholesterol levels, one of the major factors
in heart disease
13. With some exceptions, and in contrast to
animal fats, vegetable oils contain
predominantly unsaturated (light, liquid)
fatty acids of two kinds: monounsaturated
(oleic acid - mainly in extra virgin olive oil)
and polyunsaturated (linoleic acid and
linolenic acid - in oils extracted from
oilseeds).
Industrial and non-food uses of vegetable
oils include the production of soaps,
detergents, fatty acids, paint, varnish,
resin, plastic and lubricants
14. Crude vegetable oils are obtained without
further processing other than degumming or
filtering.
To make them suitable for human consumption,
most edible vegetable oils are refined to remove
impurities and toxic substances, a process which
involves bleaching, deodorization and cooling (to
make the oils stable in cold temperatures).
The FAO concept includes raw, refined and
fractioned oils, but not chemically modified
oils.
15. animal fats that are obtained in the course of
dressing the carcasses of slaughtered animals
(slaughter fats), or at a later stage in the
butchering process when meat is being prepared for
final consumption (butcher fats). Butter and similar
products obtained from milk.
Most animal fats such as meat, butter, cheese and
cream contain relatively high levels of saturated fat
and as such should be eaten in moderation.
Many baked goods such as cakes, biscuits and
pastries can also be high in saturated fat.
16. Omega-3 fatty acids are found in foods, such
as fish and flaxseed, and in dietary
supplements, such as fish oil. The three main
omega-3 fatty acids are alpha-linolenic acid
(ALA), eicosapentaenoic acid (EPA),
and docosahexaenoic acid(DHA). ALA is
found mainly in plant oils such as flaxseed,
soybean, and canola oils
Omega-3 fatty acids are essential nutrients
that are important in preventing and
managing heart disease. Findings show
omega-3 fatty acids may help to: Lower
blood pressure.
17.
18. Omega-6 fatty acids are a family
of polyunsaturated fatty acids that have in
common a final carbon-carbon double bond in
the n-6 position, that is, the sixth bond, counting
from the methyl end.
Members of the family can have pro-inflammatory
or anti-inflammatory effects.
Basically, the omega-3s have anti-inflammatory
benefits and help prevent heart disease,
whereas omega-6s lower blood cholesterol and
support the skin. Like all fats, EFAs provide
energy.