This document discusses two important questions for climate research in 2014 regarding uncertainties in climate models and natural explanations for modern climate change. It notes that scientists should approach new information with an open mind without bias. It questions whether modern climate change is unusual, whether CO2 is responsible, whether humans are responsible for increased CO2, and whether the focus should be on CO2 reduction. The document argues that climate is influenced by natural variations like the Pacific Decadal Oscillation and Atlantic Multidecadal Oscillation and that climate models do not fully reproduce natural variations. It calls for reconsidering natural variations, CO2 sensitivity, temperature-CO2 dynamics, and modeling based on natural variations.