This literature review examines previous studies on children undergoing treatment for chronic or life-threatening diseases. The studies found that these children often have lower health-related quality of life than their healthy peers. They also found that current quality of life tests may be too brief or generalized to fully assess these children's experiences. The review suggests that an intervention center could help children through difficult medical treatments by utilizing general quality of life tests along with more customized evaluations. This would help the center better understand children's specific needs and improve their health outcomes and social development.