Speed up pharmaceutical compounds synthesis
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Chemical synthesis is commonly employed in compound preparation, especially for pharmaceutical applications. The appearance of synthesis chemistry helps to save cost both for researchers and practical usages. Take pharmaceutical field alone for example, medicine prices are greatly decreased since synthesis chemistry is widely applied. A recent advance in the field will furtherly boost the efficiency of synthesis while make it cheaper.
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his article focus mainly on click chemistry mechanisms and its applications, click chemistry is an easy way to generate substances quickly and reliably by joining small units together, with this ease of use mechanism, click chemistry as found its applications in various technologies especially in drug discovery ,medicinal chemistry, enzyme activity, chemistry natural products, material science, polymers, nanotechnology and bioconjugation
Pharmaceutical organic chemistry research
Combinatorial chemistry allows for the rapid synthesis of large compound libraries that can be efficiently screened. It works by applying the same reactions to produce many analogs at once, rather than synthesizing compounds one by one. This increases the likelihood of identifying compounds with therapeutic value. Applications include generating structurally diverse HIV protease inhibitors on solid supports. Combinatorial chemistry reduces drug development time and costs while also improving chances of success. Challenges include the complex interplay of techniques needed and managing the large amounts of scientific information generated.
Pharmaceutical organic chemistry research
Combinatorial chemistry allows for the rapid synthesis of large compound libraries that can be efficiently screened. It works by creating many analogs using the same reaction conditions. This increases the likelihood of finding novel therapeutic compounds. Applications include generating diverse HIV protease inhibitor libraries containing hundreds of compounds for screening. Challenges include managing the complex information generated from large compound collections.
Basic Principles of Green Chemistry
This document discusses the basic principles of green chemistry. It summarizes that green chemistry aims to make chemical processes and products more environmentally friendly and sustainable. A combination of factors is making green chemistry increasingly important in both the short and long term. These factors include rising costs of energy and waste processing, limited petroleum resources, and new legislation regulating chemicals. The document provides examples of green chemistry principles and technologies that can be applied throughout a chemical product's lifecycle from raw materials to end of life. It also discusses metrics for quantifying the environmental impact of chemical processes and comparing the greenness of alternative routes.
J comb chem
This document describes the development of standardized protocols and optimized precursor sets for applying automated parallel synthesis to lead optimization using the Mitsunobu reaction. Sets of aliphatic alcohols and phenols were designed as precursors for the reaction. The alcohols were selected to probe hydrophobic interactions while the phenols aimed for diversity. An automated protocol using resin-supported triphenylphosphine and di-tert-butylazodicarboxylate achieved yields comparable to manual reactions. 48 reactions identified several unreactive precursors that were replaced to better suit the Mitsunobu conditions.
JBEI Science Highlights - February 2023
February 2023 - Summary slides of Joint BioEnergy Institute (JBEI) research on biofuels and bioproducts.
Mark a nagy_cv_12_29_15
Mark Nagy has over 19 years of experience in medicinal chemistry, organic synthesis, and analytical chemistry. He is currently a Scientist II at Celgene Corporation, where he designs and synthesizes small molecule compounds for drug discovery projects in fibrosis, inflammation, immunology, autophagy, and oncology. Prior to Celgene, he held roles of increasing responsibility at Pfizer, Pharmacia, and Sigma Chemical Company, gaining expertise in medicinal chemistry, peptide chemistry, and chemical production.
Application and scope of atom economy green chemistry
This document discusses principles of atom economy and green chemistry, including maximizing incorporation of materials into products, designing chemical products and processes to be less toxic and minimize waste. It provides examples of applying these principles in organic synthesis reactions and developing renewable biomass and biocatalysts as more sustainable alternatives to petroleum feedstocks. Transition metal catalyzed reactions are highlighted as being both selective and having high atom economy for forming compounds of biological interest.
Green Chemistry in Pharmaceutical Industry
Green chemistry techniques can help reduce waste and minimize environmental impact in the pharmaceutical industry. Some key principles of green chemistry include designing safer chemicals and solvents, using renewable feedstocks, and developing biocatalytic processes. Several companies have implemented greener synthetic routes for drugs like sertraline, paclitaxel, and sitagliptin by eliminating toxic solvents and developing more efficient single-step processes. Continuous flow microreactor technology has also allowed for greener synthesis of ibuprofen with shorter reaction times and improved yields. Widespread adoption of green chemistry approaches could help the pharmaceutical industry develop more sustainable and environmentally friendly methods for drug production.
Stable Isotope labeled organic molecules publication
Stable isotope labeled organic molecules have various applications in the pharmaceutical industry. Deuterium was discovered in 1932 and is used to study reaction mechanisms through kinetic isotope effects. Replacing hydrogen with deuterium in drug molecules can alter their metabolism and pharmacokinetics, potentially improving properties. Stable isotopes are also used as reference standards in mass spectrometry to improve quantification of drugs and metabolites. The global market for stable isotope labeled compounds was estimated at $220 million in 2013, with the pharmaceutical industry as the largest segment due to increasing clinical trials and quantification techniques. Challenges include high costs, but availability of resources in countries like India may allow for lower costs.
Pharmaceutical Process Chemistry Presentation.pdf
The document discusses key aspects of process chemistry for developing an active pharmaceutical ingredient (API). It covers three main stages: chemical development, which involves selecting a synthetic route and optimizing reaction conditions; process development, which focuses on further optimization, scale-up, and technology transfer; and process support, which provides ongoing improvements. Critical factors for a successful scale-up include thorough planning, understanding differences between lab and production equipment, applying criteria like safety and throughput, and ensuring analytical, production and safety systems are in place. The overall goal is to establish a practical, efficient and compliant manufacturing process for an API.
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New Green Synthesis Approaches of Pharmacologically Active Heterocyclic Compo...
New Green Synthesis Approaches of Pharmacologically Active Heterocyclic Compo...
Green Approaches For The Industrial Production Of Active Pharmaceutical Ingre...
Green Approaches For The Industrial Production Of Active Pharmaceutical Ingre...
A Focus amp Review on the Advancement of Green Chemistry.pdf
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Ecofriendly green biosynthesized of metallic nanoparticles: Bio-reduction mec...
Ecofriendly green biosynthesized of metallic nanoparticles: Bio-reduction mec...
BP Dalian Energy Innovation Laboratory 2013 brochure
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Recently uploaded
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
Randomised Optimisation Algorithms in DAPHNE
Slides from talk:
Aleš Zamuda: Randomised Optimisation Algorithms in DAPHNE .
Austrian-Slovenian HPC Meeting 2024 – ASHPC24, Seeblickhotel Grundlsee in Austria, 10–13 June 2024
https://ashpc.eu/
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
bordetella pertussis.................................ppt
Bordettela is a gram negative cocobacilli spread by air born drop let
SAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
The pygmy halfbeak Dermogenys colletei, is known for its viviparous nature, this presents an intriguing case of relatively low fecundity, raising questions about potential compensatory reproductive strategies employed by this species. Our study delves into the examination of fecundity and the Gonadosomatic Index (GSI) in the Pygmy Halfbeak, D. colletei (Meisner, 2001), an intriguing viviparous fish indigenous to Sarawak, Borneo. We hypothesize that the Pygmy halfbeak, D. colletei, may exhibit unique reproductive adaptations to offset its low fecundity, thus enhancing its survival and fitness. To address this, we conducted a comprehensive study utilizing 28 mature female specimens of D. colletei, carefully measuring fecundity and GSI to shed light on the reproductive adaptations of this species. Our findings reveal that D. colletei indeed exhibits low fecundity, with a mean of 16.76 ± 2.01, and a mean GSI of 12.83 ± 1.27, providing crucial insights into the reproductive mechanisms at play in this species. These results underscore the existence of unique reproductive strategies in D. colletei, enabling its adaptation and persistence in Borneo's diverse aquatic ecosystems, and call for further ecological research to elucidate these mechanisms. This study lends to a better understanding of viviparous fish in Borneo and contributes to the broader field of aquatic ecology, enhancing our knowledge of species adaptations to unique ecological challenges.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...
THEMATIC APPERCEPTION TEST(TAT) cognitive abilities, creativity, and critic...Abdul Wali Khan University Mardan,kP,Pakistan
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skillsBob Reedy - Nitrate in Texas Groundwater.pdf
Presented at June 6-7 Texas Alliance of Groundwater Districts Business Meeting
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学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
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◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
waterlessdyeingtechnolgyusing carbon dioxide chemicalspdf
The technology uses reclaimed CO₂ as the dyeing medium in a closed loop process. When pressurized, CO₂ becomes supercritical (SC-CO₂). In this state CO₂ has a very high solvent power, allowing the dye to dissolve easily.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Cytokines and their role in immune regulation.pptx
This presentation covers the content and information on "Cytokines " and their role in immune regulation .
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Applied Science: Thermodynamics, Laws & Methodology.pdf
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Phenomics assisted breeding in crop improvement
As the population is increasing and will reach about 9 billion upto 2050. Also due to climate change, it is difficult to meet the food requirement of such a large population. Facing the challenges presented by resource shortages, climate
change, and increasing global population, crop yield and quality need to be improved in a sustainable way over the coming decades. Genetic improvement by breeding is the best way to increase crop productivity. With the rapid progression of functional
genomics, an increasing number of crop genomes have been sequenced and dozens of genes influencing key agronomic traits have been identified. However, current genome sequence information has not been adequately exploited for understanding
the complex characteristics of multiple gene, owing to a lack of crop phenotypic data. Efficient, automatic, and accurate technologies and platforms that can capture phenotypic data that can
be linked to genomics information for crop improvement at all growth stages have become as important as genotyping. Thus,
high-throughput phenotyping has become the major bottleneck restricting crop breeding. Plant phenomics has been defined as the high-throughput, accurate acquisition and analysis of multi-dimensional phenotypes
during crop growing stages at the organism level, including the cell, tissue, organ, individual plant, plot, and field levels. With the rapid development of novel sensors, imaging technology,
and analysis methods, numerous infrastructure platforms have been developed for phenotyping.
Recently uploaded (20)
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
bordetella pertussis.................................ppt
bordetella pertussis.................................ppt
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
Unlocking the mysteries of reproduction: Exploring fecundity and gonadosomati...
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Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Cytokines and their role in immune regulation.pptx
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Applied Science: Thermodynamics, Laws & Methodology.pdf
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Speed up pharmaceutical compounds synthesis
- 1. Speed up Pharmaceutical Compounds Synthesis Chemical synthesis is commonly employed in compound preparation, especially for pharmaceutical applications. The appearance of synthesis chemistry helps to save cost both for researchers and practical usages. Take pharmaceutical field alone for example, medicine prices are greatly decreased since synthesis chemistry is widely applied. A recent advance in the field will furtherly boost the efficiency of synthesis while make it cheaper. Two young researchers from Indiana University-Purdue University Indianapolis (IUPUI) developed a new synthesis method for nitrogen-based compound to shorten the general time involved in the related projects. Meanwhile, the budget for such synthesis is decreased with the optimization in involved ingredients, which is a perfect example of-one stone with two birds. They published the paper on Nature Chemistry in the title of Site-selective C–H arylation of primary aliphatic amines enabled by a catalytic transient directing group. The new synthesis tech is a hydrocarbon transformation and molecule binding method under the assistance of transition-metal-catalyze. It’s of note that C-H bond changes in compounds directly lead to huge difference in their fictionalizations thus the new synthesis technology is of great potential in pharmaceutical applications and may also bring more possibilities for new types of energy source. What makes the approach more significant is that it’s highly site-selective and the involved transition-metal-catalyze-glyoxylic acid is cheap and with easy access. Besides, with no special requirements on the protective conditions, a wide array of γ-arylated primary alkylamines were produced, fewer special reaction conditions meaning less cost. With the background, the tech can lead to direct preparation of some designed compounds. The team has successfully synthesized fingolimod, which proved the feasibility of the new method. Site-selective carbohydrate transformation has been studied for over a century but no effective and economic ways were found until this year by the two young researchers- Haibo Ge and Yongbing Liu. The tech will facilitate drug discovery process in providing more possibilities while being cost-effective. Also it will boost the drug price goes to a cheaper level as about 75% of pharmaceuticals are synthesized and can benefit from this progress. Organic synthesis (http://www.bocsci.com/custom-synthesis.html) will undoubtedly be leveled up to a brand new state. AuthorBio BOC Sciences is a leading supplier of chemicals and professional services regarding pharmaceutical, biotechnological and agricultural research and development. Chemical synthesis is one of the featured services the company provides, covering carbohydrate synthesis service, enzyme synthesis (http://www.bocsci.com/biosynthesis-of-chemicals.html) service. With the advancement of synthesis, the whole industry will be improved, as well as other industries like green energy.