Brighton Astro - Neutron Star PresentationGareth Jenkins
Presentation from 28th March 2017 to Brighton Astro group. Slideshare removes embedded videos, so two in here are the following:
https://www.youtube.com/watch?v=e-P5IFTqB98&t=18s
https://www.youtube.com/watch?v=NhOVDDiSvMM
Brighton Astro - Neutron Star PresentationGareth Jenkins
Presentation from 28th March 2017 to Brighton Astro group. Slideshare removes embedded videos, so two in here are the following:
https://www.youtube.com/watch?v=e-P5IFTqB98&t=18s
https://www.youtube.com/watch?v=NhOVDDiSvMM
The Effects of Space Weather - March 2019ChadCogan
Some forms of space weather have the ability to impair or damage electical grids, communications satellites and weather satellites, GPS, and a variety of radio signal dependent technology. Proper education, engineering, and operational awareness can all assist in mitigating systems’ vulnerabilities space weather.
How a Solar Storm Two Years Ago Nearly Caused a Catastrophe on EarthHope Small
“I have come away from our recent studies more convinced than ever that Earth and its inhabitants were incredibly fortunate that the 2012 eruption happened when it did,” Baker tells NASA. “If the eruption had occurred only one week earlier, Earth would have been in the line of fire.”
Solar storms are known as called solar flares. The solar magnetic field causes solar activities. It is an intense burst of radiation that is generated due to the release of magnetic energy from the sunspots. These are the biggest explosive events in our solar system. The solar storm looks like a bright spot in the sun, lasting from a few minutes to a few hours.
This article aims to present possible strategies to save humanity from the consequences related to the cosmic rays that reach the planet Earth, especially the gamma rays emitted by supernovae, and those that threaten human beings in space travel.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
2. Contents
1. INTRODUCTION OF SOLAR FLARE
2. HOW SOLAR FLARE OCCURS ?
3. STAGES OF SOLAR FLARE
4. ITS EFFECT ON EARTH & HUMAN LIFE
5. PREDICTION OF SOLAR FLARE
6. PRECAUTIONARY PREPARATIONS BEFORE
ITS IMPACT
7. CONCLUSION
3. INTRODUCTION
A SOLAR FLARE IS A SUDDEN BRIGHT ERUPTION OF
A LARGE AMOUNT OF ENERGY FROM THE SUN’S
SURFACE. THE AMOUNT OF ENERGY RELEASED
MAYBE UPTO 6*10^25 JOULES. THE SOLAR FLARE
MAINLY CONSISTS OF ELECTRONS,IONS AND
ATOMS. DUE TO INTENSE HEAT IN THE SUN’S
ATMOSPHERE,THEY PRODUCE RADIATION ACROSS
THE ELECTROMAGNETIC SPECTRUM AT ALL
WAVELENGHTS..FROM ‘RADIOWAVES TO GAMMA
RAYS’. THIS PHENOMENON CANNOT BE OBSERVED
WITH NAKED EYE ,BUT ONLY WITH SPECIAL
INSTRUMENTS.
4. How does it occur…
SOLAR FLARES OCCUR WHEN ACCELERATED CHARGED
PARTICLES INTERACT WITH PLASMA MEDIUM OF THE SUN.
SCIENTIFIC STUDIES INDICATE THAT MAGNETIC
RECONNECTION IS RESPONSIBLE FOR THE ACCELERATION OF
THE CHARGED PARTICLES. AS PER SUN IS CONCERNED,
MAGNETIC RECONNECTION CAN OCCUR ON SOLAR ARCADES,
WHICH IS A SERIES OF CLOSELY OCCURING LOOPS OF
MAGNETIC LINES OF FORCE. THESE LINES OF FORCE QUICKLY
RECONNECT INTO A LOW ARCADE OF LOOPS HAVING A HELIX
OF MAGNETIC FIELD UNCONNECTED TO THE REST OF
ARCADE.THESE RESULTS IN THE SUDDEN RELEASE OF ENERGY
LEADING TO PARTICLE ACCELERATION. THIS ENORMOUS
AMOUNT OF ENERGY RELEASED TRAVELS THROUGH THE SPACE
AND REACHES EARTH CAUSING TREMENDOUS DAMAGE TO
SATELLITES AND ALL KINDS OF ELECTRICAL EQUIPMENTS.
5. Stages of solar flares:
1. PRECURSOR STAGE:- IN THIS STAGE, RELEASE OF
MAGNETIC ENERGY IS ACCOMPANIED BY X-RAYS.
2. IMPULSIVE STAGE:- IN THIS STAGE, PROTONS
AND ELECTRONS ARE ACCELERATED TO AN ENERGY
EXCEEDING 1MEV.
3. DECAY STAGE:- IN THIS STAGE, GRADUAL BUILT
UP AND DECAY OF X-RAYS IS NOTICED.
6.
7. First recorded solar event
THE FIRST RECORDED SOLAR FLARE WAS OBSERVED
WIDELY ON THE NIGHT OF 2nd SEPTEMBER ,1859,
WHICH WAS SEEN MOSTLY ALL AROUND THE
WORLD. THE GEOMAGNETIC STORM CAUSED BY THE
SOLAR FLARE CREATED AURORA. THE LIGHT WAS
SO BRIGHT THAT PEOPLE WOKE UP THINKING IT
WAS ALREADY MORNING. TELEGRPAH SYSTEMS ALL
AROUND EUROPE AND NORTH AMERICA FAILED.
TELEGRAPH EQUIPMENTS THREW SPARKS AND
PAPERS CAUGHT FIRE CREATING A GREAT DEAL OF
HAVOC. SOME TELEGRAPH SYSTEMS CONTINUED TO
SEND AND RECEIVE MESSAGES DESPITE HAVING
BEEN DISCONNECTED FROM THEIR POWER
SUPPLIES.
8. What can happen when solar
flares hit earth???
1. THEY CAN CAUSE HEAVY ENVIRONMENTAL
DISTURBANCES LIKE GEOMAGNETIC STORM,SOLAR
RADIATION STORMS, RADIO BLACKOUT,
CELLPHONE DISRUPTION, GPS AND SATELLITE
DISRUPTION.
2. LARGE SOLAR FLARES CAN CAUSE AURORAS.
3. EARTHQUAKES CAN BE ATTRIBUTED TO LARGE
SOLAR ACTIVITY.
4. BIRDS AND MARINE LIFE ARE AFFECTED.
9. Effect on electronic systems
BASICALLY A LARGE SOLAR FLARE COULD PRACTICALLY
TAKE OUT WORLD’s ELECTRICITY ON A SEMI-
PERMANENT BASIS.IT WOULD TAKE MANY YEARS TO
REPAIR THE WORLD’s ELECTRICAL SYSTEM, EVEN IF
REPLACEMENTS ARE AVAILABLE. THERE COULD BE
MASSIVE DAMAGE TO POWER
STATIONS,TRANSFORMERS AND POWER
DISTRIBUTION FACILITIES. WHEN HIGH POWER
TRANSFORMERS ARE DAMAGED, THEY MUST BE
REPLACED. IF THE FACTORIES THAT CREATE OR
REPAIR THESE EQUIPMENTS ARE WITHOUT POWER,
THEY WILL BE UNABLE TO REPAIR OR REBUILT THEM.
IN SHORT, IT WILL TOTALLY DISRUPT THE
EARTH’s ELECTRICAL SYSTEM INCLUDING SATELLITES
AND EVERYTHING THAT RUNS ON ELECTRICITY. IT
WILL DIRECTLY AFFECT HUMAN LIVES. WITHOUT
POWER , CIVILISATION WILL SUFFER A LOT.
10. Prediction of Solar flares
PREDICTING THE SOLAR FLARE IS NOT AN EXACT
SCIENCE. THE ABILITY TO FORECAST AN
IMPENDING THREAT OF SOLAR FLARE IS STILL NOT
ACCURATELY AVAILABLE. BUT, SEVERAL SCIENTIFIC
COMMUNITIES ARE TRYING TO STUDY IT AND FIND
WAYS OF PREDICTING IT. OBSERVATORIES ARE
CONSTANTLY KEEPING EYE ON THE SOLAR
ACTIVITIES AND THOUGH NOT ACCURATELY, BUT,
ATLEAST THEY CAN GIVE PREDICTION OF SOLAR
STORMS WITH 50% ACCURACY.
11. How should we prepare
ourselves for such a catastrophic
event:1. WE SHOULD RESERVE EXTRA BATTERIES FOR
FLASHLIGHT AND RADIOS.
2. EXTRA GASOLINE SHOULD BE KEPT IN STOCK.
3. DURING A SOLAR FLARE ALERT USE OF ELEVATORS
SHOULD BE AVOIDED.
4. AIR TRAVEL SHOULD BE TOTALLY AVOIDED DURING
SOLAR EVENT.
5. BATTERY POWERED RADIO SETS SHOULD BE KEPT.
IT STILL WORKS DURING BLACKOUTS.
6. DISCONNECTING ELECTRONIC HOME APPLIANCES
SUCH AS TELEVISION,COMPUTERS etc.. INDUCED
VOLTAGE SPIKES DURING GEOMAGNETIC STORMS
DAMAGES ELECTRONIC EQUIPMENTS.
12. Conclusion
HAVING ANALYSED THE HARMS THAT CAN BE
CAUSED BY SOLAR FLARES, THE AIM NOW SHOULD
BE TO CONCENTRATE THE ELECTRICAL SETUP IN
SUCH A WAY THAT WOULD PREVENT THE COPPER
WIRES AND GRIDS FROM ITS EFFECTS. SINCE
SOLAR FLARES ARE NATURALLY OCCURING EVENTS,
WE CAN ONLY PREPARE OURSELVES TO OVERCOME
SUCH EVENTS IN OUR BEST POSSIBLE WAYS.