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Aim To Perform Assay of
Ibuprofen Tablet
1
Aim To Perform Assay of Ibuprofen Tablet
-Pratik Terse
2
Requirement.
• Chemical: Ibuprofen tablets, 0.1 molar
Sodium hydroxide solution,
Phenolphthalein indicator, elcohol
• Glassware: Burette, conical flask, funnel,
beaker, Etc.
Aim To Perform Assay of Ibuprofen Tablet
-Pratik Terse
3
Ibuprofen molecular formula:
• C13H18O2.
Molecular weight:
• 206.28 g/mol
Category/ Uses:
• Analgesic, Antiinflamatory
Description:
• colorless, crystals or white crystalline powder, odorless or almost odorless.
Aim To Perform Assay of Ibuprofen Tablet
-Pratik Terse
4
Principal:
• Ibuprofen is a aryl acetic acid derivative non-
steroidal anti-inflammatory drug which is weakly
acidic in nature. It is estimated by alkalimetry.
The alcoholic solution of ibuprofen is titrated
against a standard solution of sodium hydroxide
using phenolphthalein as an indicator.
Aim To Perform Assay of Ibuprofen Tablet
 Reaction Mechanism:
-Pratik Terse
5
Aim To Perform Assay of Ibuprofen Tablet
-Pratik Terse
6
Carry out a blank titration.
Titrate with 0.1M NaOH using 0.2ml of Phenolphthalein indicator.
Weigh accurate quantity of powder equivalent to about 0.4 gram of ibuprofen and dissolve in 100 ml
of ethanol
Procedure extraction of ibuprofen: Weigh and powder 20 tablets
Procedure:
Aim To Perform Assay of Ibuprofen Tablet
 Calculation:
Sr. No Vol. of 0.1M NaOH
required for Sample
titration
Vol. of 0.1 NaOH
required for blank
titration
1 12 29
2 13 30
3 12 29
Average 12.33 29.33
-Pratik Terse
7
Aim To Perform Assay of Ibuprofen Tablet
-Pratik Terse
8
=87.67%
= 0.3507/0.4 × 100
% Purity= Calculated value of Ibuprofen/ Wt. of Ibuprofen× 100
Therefor 17 × 0.02063 = 0.3507
Total vol of 0.1 M NaOH = 29.33-12.33= 17ml
Total volume of 0.1 M NaOH required= Avg of Blank- Avg of Back
Means 1 ml of 0.1M NaOH = 0.02063 g of Ibuprofen.
Each mL of 0.1 Molar Sodium hydroxide is required for 0.02063 g of Ibuprofen.

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Aim To Perform Assay of Ibuprofen Tablet.pptx

  • 1. Aim To Perform Assay of Ibuprofen Tablet 1
  • 2. Aim To Perform Assay of Ibuprofen Tablet -Pratik Terse 2 Requirement. • Chemical: Ibuprofen tablets, 0.1 molar Sodium hydroxide solution, Phenolphthalein indicator, elcohol • Glassware: Burette, conical flask, funnel, beaker, Etc.
  • 3. Aim To Perform Assay of Ibuprofen Tablet -Pratik Terse 3 Ibuprofen molecular formula: • C13H18O2. Molecular weight: • 206.28 g/mol Category/ Uses: • Analgesic, Antiinflamatory Description: • colorless, crystals or white crystalline powder, odorless or almost odorless.
  • 4. Aim To Perform Assay of Ibuprofen Tablet -Pratik Terse 4 Principal: • Ibuprofen is a aryl acetic acid derivative non- steroidal anti-inflammatory drug which is weakly acidic in nature. It is estimated by alkalimetry. The alcoholic solution of ibuprofen is titrated against a standard solution of sodium hydroxide using phenolphthalein as an indicator.
  • 5. Aim To Perform Assay of Ibuprofen Tablet  Reaction Mechanism: -Pratik Terse 5
  • 6. Aim To Perform Assay of Ibuprofen Tablet -Pratik Terse 6 Carry out a blank titration. Titrate with 0.1M NaOH using 0.2ml of Phenolphthalein indicator. Weigh accurate quantity of powder equivalent to about 0.4 gram of ibuprofen and dissolve in 100 ml of ethanol Procedure extraction of ibuprofen: Weigh and powder 20 tablets Procedure:
  • 7. Aim To Perform Assay of Ibuprofen Tablet  Calculation: Sr. No Vol. of 0.1M NaOH required for Sample titration Vol. of 0.1 NaOH required for blank titration 1 12 29 2 13 30 3 12 29 Average 12.33 29.33 -Pratik Terse 7
  • 8. Aim To Perform Assay of Ibuprofen Tablet -Pratik Terse 8 =87.67% = 0.3507/0.4 × 100 % Purity= Calculated value of Ibuprofen/ Wt. of Ibuprofen× 100 Therefor 17 × 0.02063 = 0.3507 Total vol of 0.1 M NaOH = 29.33-12.33= 17ml Total volume of 0.1 M NaOH required= Avg of Blank- Avg of Back Means 1 ml of 0.1M NaOH = 0.02063 g of Ibuprofen. Each mL of 0.1 Molar Sodium hydroxide is required for 0.02063 g of Ibuprofen.