This document summarizes a review article on the preparation of transdermal patches of curcumin using nanotechnology. It first introduces novel drug delivery systems and their necessity for herbal drugs like curcumin. It then discusses transdermal drug delivery systems, their advantages and disadvantages. The document outlines different approaches for herbal drug delivery including marketed transdermal patches. It describes the formulation of curcumin nanoparticle transdermal patches and discusses herbal excipients and their classification. Finally, it outlines the applications of turmeric patches and concludes the potential of curcumin nanoparticle transdermal patches to improve delivery of this herbal drug.

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2. Course Structure and Content For
PRACTICE SCHOOL (BP706PS)
B. Pharm Final Year (SEM VII)
DOMAIN – 14
NOVEL HERBAL DRUG DELIVERY SYSTEM
PREPARATION OF TRANSADERMAL PATCHES OF
CURCUMA BY NANOTECHNOLOGY
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3. A Review Article By
GHUGE SNEHAL VITTHAL
Final year B. pharmacy
(1952811823007)
Guided by
Dr. Anil G. Jadhav sir
Prof. Sagar. K. khokle sir
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4. Content
• INTRODUCTION
• NDDS- TRANSDERMAL DRUG DELIVERY SYSTEM
• ADVANTAGES AND DISAVDANTAGES OF TTDS
• HERBAL DRUG – CURCUMA
• APPROCHES IN NOVEL DRUG DELIVEREY SYSTEM -Marketed herbal transdermal patch
• TYPES OF NOVEL HERBAL DELIVERY SYSTEM
• NANOTECHNOLOGY
• FORMULATION OF TRANSDERMAL PATCH OF CURCUMIN NANO PARTICLE
• HERBAL EXCIPIENTS
• CLASSIFICATION OF HERBAL EXCIPIENTS
• ADVANTAGES AND DISAVDANTAGES OF HERBAL EXCIPIENT
• APPLICATION OF TURMERIC PATCH IN MANKIND DISORDER
• CONCLUSION
• REFRENCES
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5. INTRODUCTION
WHAT IS NOVEL DRUG DELIVERY SYSTEM ?
Novel drug delivery system is novel approach to drug delivery that combine
innovative , development , formulation, new technologies, novel
methodologies for delivering drug in the body safely to obtain desire
pharmacological action.
Necessity of NDDS in herbal drug
If we apply NNDS technology to herbal drug then it would help in
increasing efficacy and side effect of various herbal compounds and herbs
and this is basic sense behind incorporating NNDS in herbal medicine.
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6. Transdermal drug delivery system (tdds)
TDDS is type of non-invasive drugs administration system which is emerged as a
alternative drug delivery system to convention needle injection.
Its truly painless and attractive method among all drug delivery system due to its
ease of administration, very low rejection rate, greater results, super convection, and
easy patient handing.
TDDS is a painless method of delivering drug systemically by applying a drug
formulation into intact and healthy skin. A transdermal patch is a medicated
adhesive patch that is placed on the skin to deliver a specific dose of medication
through the skin and into the bloodstream.
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7. • For thousand of year, human civilization have applied various substances on skin as a
medical or cosmetic agent. It was until twentieth century when skin was used as drug
delivery route.
• The 1st transdermal system for systemic delivery a three day patch that delivers
scopolamine to treat motion sickness was approved for the use by united states in 1971.
• However, the routine use of transdermal delivery system only became a common practice
in later 20th century when delivery technology was developed to enable precise and
reproducible administration throughout the skin for systemic effect.
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8. Advantages of tdds
• Risk of inconveniences of iv therapy is avoided.
• Easy termination of therapy.
• Reduces dose frequency and predicts sustained and long duration of action.
• Self administration is possible.
• Enhance therapeutic efficiency by avoiding the peaks and through in systemic
drug level associated with conventional delivery.
• It gives better patient compliance due to elimination of multiple dosing intervals.
• fast effect due to elimination of 1st pass metabolism.
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9. Disadvantages of tdds
• The main disadvantage of TDDS is that there are possibility of
skin irritation and sensitization.
• Drug with bigger particle size can’t be pass due to skins low
permeability limit.
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10. Herbal drug : Turmeric (curcuma longa)
Biological name : curcuma longa
Source: obtain from root of curcuma longa
Kingdom : plantae
Family: zingiberaceae
Chemical constituents : curcumin, volatile oil, curcumionids,
essential oil.
Biological activities: antioxidant, anti-inflammatory, anticancer,
antimicrobial, cardio protective.
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11. Challenges in upgrading and modification of herbal
formulation
There are mainly 3 challenges that’s must be overcome before promoting herbal
formulation:
• Quality issue: adulteration, wrong identification of plant, fauilty collection and
preparation and incorrect formulation are some factor which effect the quality of herbal
formulation.
• Processing and harvesting issue: poor agriculture, propagation method, harvesting
method, lack of process techniques leads to quality of herbal product.
• Quality control issue: poor quality control procedure, lack of GMP, lack of awareness
about guidelines between grower and manufacture.
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12. APPROCHES IN NOVEL HERBAL DRUG
DELIVERY SYSTEM
Marketed herbal transdermal patch
Given below are some herbal transdermal patches currently available in market.
Herbal transdermal
patch
Active ingredients Company Use
Antismoking patch –
nicoderm OQ
Nicotine Glaxosmithkline Quit smoking
Transdermal SCOP Scopolamine Novartis Prevent motion
sickness
Forest sap detox foot
patch
Tourmaline, chitosan,
pearl stone, wood
vinegar
Natural pharmacy Detoxification,
increase oxygen intake
Slimming patch –
hoodia+patch
Hoodia gordonni,
guarana, garcinia
combogia
Medex patches Weight control
Praan painplast Anelica dahuria,
rhizome zingerbis
Greatline impex Pain relief
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13. Different novel drug delivery system for
herbal drug
Liposomes
Niosomes
Trans
foursomes
Micro
emulsion
TYPES OF
NOVEL
HERBAL
DRUG
DELIVERY
SYSTEM
Ethosomes
Phytosomes
Microsphere
Nano
technology
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14. Nanotechnology
Nanoparticles used as drug delivery
vehicles are generally < 100 nm in at
least one dimension, and consist of
different biodegradable materials such as
natural or synthetic polymers, lipids, or
metals. Nanoparticles are taken up by
cells more efficiently than larger micro
molecules and therefore, could be used
as effective transport and delivery
systems. For therapeutic applications,
drugs can either be integrated in the
matrix of the particle or attached to the
particle surface.
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15. ADVANTAGES:
• Nanoparticles have the potential to cross the blood brain barrier, which
makes them extremely useful as a way to deliver drugs directly to the
brain.
• Maximum therapeutic effect with less side effect.
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16. Formulation of transdermal patch of
curcumin nano particle
Curcumin nanoparticle is formulated into transdermal patches using
combination of HPLC, EC, PVP polymer.
The transdermal patch were made which were of matrix diffusion
control system.
Studies show that curcumin has great solubility in ethanol.
The UV visible interaction studies show that there is no interacting
between the drug and polymer.
Among the various batches the uniformity weight and thickness indicate
that polymeric solution of the drug is well dispersed in the patches.
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17. HERBAL EXECIPENTS
EXCIPENTS:
Pharmaceutical excipient are substances that are included in
pharmaceutical dosage form not for their direct therapeutic
effect, but for the manufacturing, protect, enhance stability of
active ingredient.
Herbal excipient are naturally obtained and are toxic free, easily
available with low cost.
Eg of herbal excipients: natural dies, natural sweeteners, starch,
sucrose, gelatin.
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18. CLASSIFIACTION OF HERBAL EXCIPIENTS
BASED ON SOURCE :
• Marine origin/algal (seaweed) gums: agar, alginic acid, and laminarin.
• Plant origin: pectin, starch, cardamom, vanilla
• Seed gums: guar gum, locust bean gum, starch, amylose, and cellulose
• Extracts: pectin, larch gum
• Tuber and roots: potato starch
• Animal origin: chitin and chitosan, chondroitin sulfate, and hyaluronic
acid;
• Microbial origin (bacterial and fungal): xanthan, dextran, curdian,
pullulan, Baker’s yeast glycan
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19. Based on their application and function in the drug:
• Binder – gum Arabic, gum tragacanth, methyl cellulose
• Diluents- starches, hydrolyzed starch, sugar alohol
• Lubricants- coconut oil
• Disintegrates- starch
• Polishing film-forming & coating agent- beewax , paraffin.
• Plasticizers- glycol, mannitol
• Coloring agent- carmine, annatto
• Suspending agent, preservatives, antioxidants etc
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20. ADVANTAGES OF HERBAL EXCIPENTS
• Natural excipients, all are obtained from the natural
resources. Hence, they are safe and biodegradable.
They do not affect the environment.
• Chemically, all of these natural/herbal excipients are
carbohydrates in nature. Hence natural excipients are
non-toxic compounds.
• Natural excipients are cheaper and their.
manufacturing cost is less than synthetic excipients.
• they do not show any adverse effects or side effect.
• Natural excipients are easily available from different
natural resources.
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21. DISADVANTAGES OF HERBAL EXCIPIENTS
• possibilities of microbial contamination.
• Herbal excipients have possibilities of heavy metal
contamination.
• Natural excipients production depends on environmental
conditions, regions and climates. Hence, the amount of different
natural excipients and percentage of constituents also varies in
different conditions.
• Slow process rate.
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22. Application of turmeric patch in mankind
disorder
• Antioxidant
Curcumin is an extremely potent lipid soluble antioxidant and has been
suggested to act through its pro-oxidant/antioxidant effects, because,
formation of ROS by curcumin and curcuminoids correlates with their
apoptotic activity on tumour cells.
• anti-inflammatory agent
Systemic inflammation has been associated with many conditions that affect
several systems, one of which is metabolic syndrome (MetS), which includes
insulin resistance, hyperglycaemia, hypertension, bad cholesterol (LDL), high
triglyceride levels and obesity, especially visceral. In this case, curcumin
improves insulin sensitivity, reduces the production of adipose tissue or fat
and lowers high blood pressure.
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23. Conclusion
Herbal medicine are employed all over globe and science ancient times it
have been acknowledged by doctor and patient for better therapeutic value
as they cause less side effect.
Nnds can be applied for herbal drug to get desire effect and less or no side
effect and to reduce repeated administration of drug.
Curcumin nanoparticles have been successfully formulated into transdermal
patches using combinations of HPMC and EC at various ratios. Curcumin can
be released from the transdermal patch and can be predicted that all
curcumin will be
released in 24 h. Curcumin can penetrate into the skin and formulating
curcumin nanoparticles.
Overall findings from this research show that the limitation of oral curcumin
administration can be solved by formulating curcumin into curcumin
nanoparticles transdermal patches, especially for inflammation therapy.
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24. Refrences
• Recent advances in transdermal drug delivery system: a review
Published: 28/july2021
https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-021-00226-6
• Transdermal patches: history, development, pharmacology
Published on: 18/march/2018
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403087/
• Transdermal drug delivery patches: a review
D. Prabhakar, J. Sreekanth, K.N.Jayaveera ,2013, 3(4), 213-221
https://jddtonline.info/index.php/jddt/article/view/590
• Article reviewing transdermal drug delivery system
published: jan-feb 2022
• Novel drug delivery system/ ppt / 2021
• Transdermal patch Wikipedia
https://en.wikipedia.org/wiki/Transdermal_patch
• Novel drug delivery system a book by Thakur publication
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25. THANK YOU!!
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