Novel drug delivery system (herbal) -:To acknowledge patient and doctor tu used widely herbal drug to greater therapeutic effect
To find out Niosomes in neem...
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Achalkumar chaudhari ppt
1.
2. Course Structure and content for
[ Practice school (BP706P) ]
Domain
Novel drug delivery system (herbal) NEEM
To identify neem Niosomes and acknowledge patient,doctor to use herbal
medicines Cause of there better therapeutic effects
3. A review article by,
Achalkumar v.chaudhari
PRN-1952811823014
Under guidence- sarvadnya mam
4. Abstract
Novel drug delivery system is a novel approach to drug delivery that addresses
the limitations of the traditional drug delivery systems. Our country has a vast
knowledge base of Ayurveda whose potential is only being realized in the
recent years. However, the drug delivery system used for administering the
herbal medicine to the patient is traditional and out-of-date, resulting in
reduced effi cacy of the drug. If the novel drug delivery technology is applied
in herbal medicine, it may help in increasing the effi cacy and reducing the
side effects of various herbal compounds and herbs. This is the basic idea
behind incorporating novel method of drug delivery in herbal medicines.
5. Control drug delivery
For many decades treatment of an acute disease or a chronic illness has been
mostly accomplished by delivery of drugs to patients using various
pharmaceutical dosage forms, including tablets, capsules, pills, suppositories,
creams, ointments, liquids, aerosols, and injectable as drug carriers. Even
today these conventional drug delivery systems are the primary
pharmaceutical products commonly seen in the prescription and over the
counter drug market place
6. Advantage
i] Patient Compliance: (patient acceptability)
Lack of compliance is generally observed with
1. Long term treatment of chronic disease.
2. Increase in number of doses.
3. Increase in side effects
The problem of lack of patient compliance can be resolved to some extent
7. Other advantage
Reduction in dosing frequency
Reduced fluctuations in circulating drug levels
Increased patient compliance and convenience
Avoidance of night time dosing
More uniform effect
Reduction in GI irritation and dose related (local and systemic) side effects
9. Other disadvantage
Ther disadvantages
High cost
Unpredictable and often poor invitro invivo correlation
Dose dumping
Reduced potential for dosage adjustment
Increased potential for first pass clearance and also of poor systemic availability.
10. Types of herbal Drug delivery system
Several approaches in case of new herbal drug delivery system
include different types of expressions such as mouth-dissolving
tablets, liposomes, phytosomes, pharmacosomes, museums,
nanoparticles, microspheres, transfersomes, ethosomes,
transdermal drug delivery system (TDDS), and proniosomes
11. Niosomes
Niosomes are multilamellar vesicles formed from nonionic surfactants of the
alkyl or dialkylpolyglycerol ether class and cholesterol. Earlier studies in
association with L’Oreal have shown that, in general, niosomes have
properties as potential drug carriers similar to liposomes. Niosomes are
different from liposomes in that they offer certain advantages over
liposomes.
12. Characteristics of Niosomes
Shape of niosomal vesicles is assumed to be spherical, and their mean
diameter can be determined by using laser light scattering method.[28] Also,
diameter of these vesicles can be determined by using electron microscopy,
molecular sieve chromatography, ultracentrifugation, photon correlation
microscopy and optical microscopy[29,30] and freeze fracture electron
microscopy. Freeze thawing of niosomes increases the vesicle diameter, which
might be attributed to a fusion of vesicles during the cycle.
13. Preparation
Niosomes are non-ionic surfactant vesicles which act as drug carrier systems. In the
present study, we carried preparation and evaluation of proniosomal gel of neem seed
oil. The proniosomal gel was prepared using span 40, soya lecithin and cholesterol, using
neem seed oil as the active pharmaceutical ingredient. Alcohol and phosphate buffer pH
7.4 were used in formulation as pharmaceutical excipients. The resulting formulations
were evaluated and observed by transmission electron microscopy. Evaluation of
formulation yielded optimum results like uniform size distribution 75-80% drug
entrapment and microbiological data. It is concluded that it is viable to prepare an
acceptable pronisomal gel of neem seed oil for therapeutic applications.
14. Function
Niosomal drug delivery is potentially applicable to many pharmacological
agents for their action against various diseases. It can also be used as vehicle
for poorly absorbable drugs to design the novel drug delivery system. It
enhances the bioavailability by crossing the anatomical barrier of
gastrointestinal tract via transcytosis of M cells of Peyer’s patches in the
intestinal lymphatic tissues
15. Nanoparticles
Nanoparticles are efficient delivery systems for the deliveryof both
hydrophilic and hydrophobic drugs. Nanoparticles are the submicron-sized
particles, ranging 10–1000 mm.The major goal behind designing nanoparticle
as a delivery arrangement is to control particle size, surface properties, and
release of pharmacologically active agents in order to achieve the
site-specific action of the drug at the therapeutically optimalrate and dose
regimen.
16. Mouth dissolving tablets
Asoka Lifescience Limited launched Res-Q, the world’s first
polyHerbal mouth-dissolving tablet, fast mouth-dissolving drug.
It induces a new drug delivery system that imparts increase
efficacy.In the Ayurvedic medicine segment, this is the inaugura
attempt to make medicines more effective in managing chronic
ailments. Res-Q is a polyherbal medicine highly effective for
lung problems and other respiratory ailments such as asthma.
17. Plants/constituents Therapeutic category Applications with respect to liposomal technology
Reference
Ampelopsin Anticancer Improved therapeutic efficact
Capsaicin Analgesic Prolong action, permeation enhancement Curcumin Anticancer Long systemic
residence time and high entrapment efficiency
Paclitaxel Anticancer pH sensitivity and improved entrapment efficiency
19. Conclusion
Herbal medications have been widely employed all over the globe since
ancient times and have been aacknowledgeby doctors and patients for their
better therapeutic value as they cause fewer adverse effects as compared
with modern medications. The drugs of Ayurvedic origin can be utilized in a
more upright course with enhanced efficacy by incorporatingin modern
dosage forms.