HOCM SImulations using CFD and ANSYS
Hypertrophic Obstructive Cardiomyopathy and dynamic flow obstruction in left ventricle
Mitral valve leaflet motion
Systole and Diastolic mitral valve
Advanced Simulations of Hypertrophic Obstructive Cardiomyopathy in Human Hear...Can Ozcan
Surgeons, physicians and biomedical engineers need a model to better understand heart mechanics and develop solutions around it. Such modeling effort needs to incorporate multiphysics and nonlinearity where Ansys can help.
This presentation is a continuation of what has been done last year using simplified conditions. 3D two-way fully coupled fluid-structure interaction with viscoelastic valve motion in human heart left ventricle is resolved using realistic boundary conditions and material properties.
Can holds BS and MS degrees in Mechanical Engineering and currently a PhD candidate in Biomedical Engineering from Bogazici University Istanbul. He has been with Ozen Engineering since 2005, where he has been performing structural and fluid dynamics simulations using Ansys in various fields. Can is using Python heavily to develop solutions around Ansys products.
This presentation is given at Santa Clara Ansys Conference in 2014, where we have presented the viscoelastic modelling capabilities in Ansys and the basic requirements for such modelling. The presentation is simple and a good starting point to understand viscoelastic modeling in Ansys.
Surge Pressure Prediction for Running Linerspvisoftware
This white paper will review the engineering analysis behind trip operations for different pipe end conditions. The author will discuss the controlling parameters affecting surge pressure using SurgeMOD. There are 2 aspects of the surge and swab pressure analysis: one is to predict surge and swab pressure for a given running speed (analysis mode), while the other one is to calculate optimal trip speeds at different string depths without breaking down formations or causing a kick at weak zone (design mode). This article will address both issues. Examples of running liners in tight tolerance wellbore will be analyzed.
Valvula masoneilan handbook for control valve sizingJupira Silva
This document provides an overview of formulas and concepts for sizing control valves, including:
- Definitions of key terms like flow coefficient (Cv) and pressure recovery factor.
- Equations for calculating liquid and gas flow rates through valves.
- Factors that affect valve sizing like pressure drop, specific gravity, compressibility.
- Concepts like cavitation that must be considered to avoid valve damage.
- How to account for factors like pipe reducers that influence valve performance.
- Tables of constants to use with the provided equations depending on the system units.
The document is a reference for engineers, providing formulas, explanations of concepts, and considerations necessary to properly size
Flow analysis of butterfly valve using cfdeSAT Journals
Abstract
A butterfly valve is a type of control valve which is used for isolating or diverting the flow. The working mechanism takes place from the disc. Function is similar to that of a ball valve, which allows for quick close and open systems. Butterfly valves are selected because of their lower cost to other valves manufacturing techniques, also lighter in weight, meaning less support is required. Rotating disc is placed in the center of the valve body. Disc can be operated by either manual handle or electrical actuators of various torques. The close-off pressure acting on the disc is directly proportional to the in-line pressure in pipe. The valve is selected according to the pressure and torque and pipe diameter, which allows lowering the damage the valve in operation. Fluid flow is controlled through piping systems, which in turn are connected to the valves. The valve body comprises of disc, which also controls the flow of fluid through various angles of opening. The disc is connected in Centre through the stem which is connected to either handle or the rotating actuator. The design of the valve body and disc is of much important for linear or equal percentage flow. Nowadays the equal percentage flow is obtained by characterizing disc, which allows to maintain the equal percentage flow at different differential pressure across the pipe. Sometimes it becomes very critical to maintain the equal percentage flow; CFD can predict the flow performance and rate of discharge through the valve. This paper focuses on the study of 8”and 20” valves performance factors and results obtained by analysis as well as from the load bearing capacity of the valve However special thanks to Prof. Yogesh Dodia for his guidance to make this paper rational and justifiable. Keywords: Butterfly valve, CFD, Stress Analysis, orthogonal array, optimization.
Purge flow regulator and flow switchesKundan Gupta
This document discusses different types of flow controllers and flow switches. It describes a self-contained flow controller that uses a variable area flow meter combined with a differential pressure regulator to maintain a constant outlet pressure. It also discusses various types of flow switches, including folding paddle, thermal, bypass, and capacitor types. The thermal and capacitor types detect changes in temperature or dielectric constants to determine the presence or absence of flow. Flow switches are used to monitor if flow rates are above or below a certain threshold.
IRJET- A Review of Design and Analysis of Retainerless Dual Plate Check Valve...IRJET Journal
This document reviews the design and analysis of a retainerless dual plate check valve to reduce pressure loss and drag force. It discusses how modifications to the valve disc geometry can reduce the impact force when closing. Computational fluid dynamics (CFD) is used to evaluate the pressure loss coefficient and drag force coefficient at various openings and Reynolds numbers. The dual plate check valve is found to have lower pressure loss and drag force coefficients than other check valve designs. Finite element analysis is also used to analyze stress and deformation of valve components. The goal of improving the design is to reduce pressure loss and drag force for improved efficiency.
Performance Pulsation Control provides pulsation control products to improve pump performance and prolong pump life. Pulsation in reciprocating pumps negatively impacts efficiency and can cause piping vibration. Their dampeners and stabilizers reduce pulsation by 72% in some cases. Suction pulsation is a major problem that can increase cavitation 10x and reduce pump part life. Their suction stabilizers isolate the pump from pulsations in the suction line, reducing acceleration head loss and improving net positive suction head.
Advanced Simulations of Hypertrophic Obstructive Cardiomyopathy in Human Hear...Can Ozcan
Surgeons, physicians and biomedical engineers need a model to better understand heart mechanics and develop solutions around it. Such modeling effort needs to incorporate multiphysics and nonlinearity where Ansys can help.
This presentation is a continuation of what has been done last year using simplified conditions. 3D two-way fully coupled fluid-structure interaction with viscoelastic valve motion in human heart left ventricle is resolved using realistic boundary conditions and material properties.
Can holds BS and MS degrees in Mechanical Engineering and currently a PhD candidate in Biomedical Engineering from Bogazici University Istanbul. He has been with Ozen Engineering since 2005, where he has been performing structural and fluid dynamics simulations using Ansys in various fields. Can is using Python heavily to develop solutions around Ansys products.
This presentation is given at Santa Clara Ansys Conference in 2014, where we have presented the viscoelastic modelling capabilities in Ansys and the basic requirements for such modelling. The presentation is simple and a good starting point to understand viscoelastic modeling in Ansys.
Surge Pressure Prediction for Running Linerspvisoftware
This white paper will review the engineering analysis behind trip operations for different pipe end conditions. The author will discuss the controlling parameters affecting surge pressure using SurgeMOD. There are 2 aspects of the surge and swab pressure analysis: one is to predict surge and swab pressure for a given running speed (analysis mode), while the other one is to calculate optimal trip speeds at different string depths without breaking down formations or causing a kick at weak zone (design mode). This article will address both issues. Examples of running liners in tight tolerance wellbore will be analyzed.
Valvula masoneilan handbook for control valve sizingJupira Silva
This document provides an overview of formulas and concepts for sizing control valves, including:
- Definitions of key terms like flow coefficient (Cv) and pressure recovery factor.
- Equations for calculating liquid and gas flow rates through valves.
- Factors that affect valve sizing like pressure drop, specific gravity, compressibility.
- Concepts like cavitation that must be considered to avoid valve damage.
- How to account for factors like pipe reducers that influence valve performance.
- Tables of constants to use with the provided equations depending on the system units.
The document is a reference for engineers, providing formulas, explanations of concepts, and considerations necessary to properly size
Flow analysis of butterfly valve using cfdeSAT Journals
Abstract
A butterfly valve is a type of control valve which is used for isolating or diverting the flow. The working mechanism takes place from the disc. Function is similar to that of a ball valve, which allows for quick close and open systems. Butterfly valves are selected because of their lower cost to other valves manufacturing techniques, also lighter in weight, meaning less support is required. Rotating disc is placed in the center of the valve body. Disc can be operated by either manual handle or electrical actuators of various torques. The close-off pressure acting on the disc is directly proportional to the in-line pressure in pipe. The valve is selected according to the pressure and torque and pipe diameter, which allows lowering the damage the valve in operation. Fluid flow is controlled through piping systems, which in turn are connected to the valves. The valve body comprises of disc, which also controls the flow of fluid through various angles of opening. The disc is connected in Centre through the stem which is connected to either handle or the rotating actuator. The design of the valve body and disc is of much important for linear or equal percentage flow. Nowadays the equal percentage flow is obtained by characterizing disc, which allows to maintain the equal percentage flow at different differential pressure across the pipe. Sometimes it becomes very critical to maintain the equal percentage flow; CFD can predict the flow performance and rate of discharge through the valve. This paper focuses on the study of 8”and 20” valves performance factors and results obtained by analysis as well as from the load bearing capacity of the valve However special thanks to Prof. Yogesh Dodia for his guidance to make this paper rational and justifiable. Keywords: Butterfly valve, CFD, Stress Analysis, orthogonal array, optimization.
Purge flow regulator and flow switchesKundan Gupta
This document discusses different types of flow controllers and flow switches. It describes a self-contained flow controller that uses a variable area flow meter combined with a differential pressure regulator to maintain a constant outlet pressure. It also discusses various types of flow switches, including folding paddle, thermal, bypass, and capacitor types. The thermal and capacitor types detect changes in temperature or dielectric constants to determine the presence or absence of flow. Flow switches are used to monitor if flow rates are above or below a certain threshold.
IRJET- A Review of Design and Analysis of Retainerless Dual Plate Check Valve...IRJET Journal
This document reviews the design and analysis of a retainerless dual plate check valve to reduce pressure loss and drag force. It discusses how modifications to the valve disc geometry can reduce the impact force when closing. Computational fluid dynamics (CFD) is used to evaluate the pressure loss coefficient and drag force coefficient at various openings and Reynolds numbers. The dual plate check valve is found to have lower pressure loss and drag force coefficients than other check valve designs. Finite element analysis is also used to analyze stress and deformation of valve components. The goal of improving the design is to reduce pressure loss and drag force for improved efficiency.
Performance Pulsation Control provides pulsation control products to improve pump performance and prolong pump life. Pulsation in reciprocating pumps negatively impacts efficiency and can cause piping vibration. Their dampeners and stabilizers reduce pulsation by 72% in some cases. Suction pulsation is a major problem that can increase cavitation 10x and reduce pump part life. Their suction stabilizers isolate the pump from pulsations in the suction line, reducing acceleration head loss and improving net positive suction head.
This document discusses the selection and use of check valves in pumped systems. It notes that check valves are commonly selected without considering their dynamic behavior, which can lead to check valve slam and damage. The document recommends performing a surge analysis to determine the maximum reverse velocity and fluid deceleration acceptable for a system. It provides data on the dynamic behavior of different check valve designs to help select a valve less likely to slam. The document emphasizes matching the selected check valve to the characteristics of the system to avoid issues from pressure transients.
Basic Fluid Dynamics - Control Valves Brannon Gant
Setpoint Integrated Solutions is a industry leader in providing control valve solutions across industry segments.
Brannon Gant - Regional Sales Manager
This contains a basic idea about viscosity measurement devices and their principles. Working, principle, construction, and advantages of rotating viscometer are described here.
The document summarizes the key aspects and findings of a master's thesis on analyzing pressure traces from a common rail diesel injection system to determine injected fuel mass. The thesis explored filtering approaches and modeling injections to predict mass from the pressure signal. Filtering was ineffective due to signal properties. Modeling injections as parametric profiles matched measurements well but could be improved by adding more physical details. Overall, the work established a foundation for predicting mass from pressure traces that warrants further refinement and algorithm development for online implementation.
Performance Pulsation Control specializes in the engineering, design, and manufacture of pulsation control devices. This presentation outlines the benefits of suction stabilizers in pulsation control.
Performance Pulsation Control specializes in the engineering, design, and manufacture of maintenance free and gas charge pulsation control devices. This presentation outlines basic pulsation control terminology.
Simulations of Hypertrophic Obstructive Cardiomyopathy (HOCM) in a Human Hear...Can Ozcan
HOCM is an inherited heart disease in which a portion of myocardium is thickened. It is the leading cause of sudden cardiac death in young athletes. Intevac and Ozen Engineering developed a parametric model of the left ventricle (LV) of a human heart coupled with the solid wall moition and viscoelastic valve motion in the framework of two-way fully coupled fluid-structure interactions. The model parametrically simulates varying LV dimensions and dimensions of cardiomyopathy thickening. For the first time, this model allows a realistic investigation of the transient effect of left ventricular outflow obstruction, assumed to cause systolic anterior motion of mitral valve leaflets.
Manipulation of Water Hammer Problem by Modification of NRV ValveIDES Editor
Water hammer in piping systems produces large
dynamic forces which can damage the pipes and supports.
Therefore it is important to minimize the water hammer
effects on the piping system. In this work, a new method for
the reduction of water hammer by active measures is
described- that means the reduction of water hammer by
influencing the fluid dynamic conditions of the system. We
are concerned with the effects of the rapid valve closures in
pipes connected to wave reflection points. The energy is of
two kind’s Kinetic energy and Elastic energy. Both forms are
converted into pressure energy and the rapidity of the
conversion is of the utmost importance in terms of ensuring
damage that may result. Such energy dissipation in a
controlled non damaging way is discussed in this paper. The
latest outcomes of the research in this area are also discussed
with their failures in the implementation of these concepts in
industries, and the feasibility of our new method
This study evaluated three stent designs for treating patient-specific bifurcation aneurysm phantoms using angiographic imaging:
1) A "middle-flap wing stent" (Type 1) that covers the aneurysm ostium with a wing.
2) A "two-tapered-wing-ended stent" (Type 2) that creates a bridge across the aneurysm neck with short wings.
3) A modification of Type 1 where a standard stent anchors the wing tightly against the aneurysm (Type 3).
Angiography found that contrast inflow was reduced by 25% for Type 1, 63% for Type 2, and 88% for Type 3 compared to untreated phantoms.
The principles of vascular repair with sutures were established in the first decade of the 20th century by Alexis Carrel, who in 1912 was awarded the Nobel Prize for medicine for his work .Since then, technical refinements of suture materials have made possible surgical reconstruction of most arteries from the root of the aorta to microvascular anastomosis or repair of the smallest vessels, e.g., digital arteries or those on the surface of the brain.
1) The study investigated fluid dynamics of a ventricular assist device (VAD) called the Spiral Vortex (SV) VAD using laser Doppler anemometry while pumping a blood analogue fluid under physiological conditions.
2) The flow was dominated by an irrotational vortex that accelerated and precessed in phase with the pumping diaphragm, and two unexpected structures enhanced wall washing.
3) Under a weaning mode, the main vortex coherence degraded and recirculation was observed, indicating a need for anticoagulation in this mode. Turbulence increased with asymmetric diaphragm buckling in both modes.
The document discusses minimally invasive mitral valve surgery offered at Stanford Health Care, which uses a small right-sided incision rather than full sternotomy to access the heart, allowing for effective valve repair or replacement with benefits like less pain, shorter recovery time, and reduced complications compared to traditional open surgery. The techniques pioneered by Stanford surgeons for minimally invasive mitral valve surgery are described, including patient candidacy, surgical procedure details, and potential benefits over conventional open surgery.
Agenda
• Valve with moving components
• The Tesla Valve with no moving component
• Applications of Tesla Valve
• Fish ladders
• T-junction (medical application)
• Microfluidic mixing module
This document discusses balloon aortic valvuloplasty (BAV) as a treatment for aortic stenosis. It can be performed via either a retrograde or antegrade approach. The retrograde approach involves crossing the aortic valve from the femoral artery, while the antegrade approach involves transseptal catheterization from the femoral vein. Key steps for both approaches include rapid ventricular pacing to stabilize the heart during balloon inflation. The goals of BAV are to increase the aortic valve area and reduce pressure gradients. Complications can include hypotension, aortic regurgitation, and embolization of calcium deposits. BAV provides symptomatic relief but is usually not curative, as restenosis may occur.
Development of an Axial Flow Left Ventricular Assist Device (LVAD) from Incep...tmhsweb
1. The document discusses the development and clinical applications of axial flow left ventricular assist devices (LVADs) from their inception to help treat the increasing number of heart failure patients.
2. It describes the history and outcomes of various LVAD models used at the Methodist Hospital including the DeBakey-Noon VAD which was licensed from NASA and has been implanted in over 400 patients internationally.
3. The document outlines ongoing engineering improvements to LVAD designs through computational fluid dynamics and animal testing, including a smaller pediatric version, to provide longer and better quality of life support for heart failure patients.
The document provides an overview of transcatheter aortic valve implantation (TAVI), including a brief history of its development, descriptions of the Edwards Sapien valve and delivery systems, approaches for TAVI, and complications. It also discusses patient screening and risk stratification, as well as newer valve devices that are being developed.
A study on Nonlinear flow through an orifice metersunnynita
The document presents a study on nonlinear flow through orifice meters. It discusses:
- The working principle of orifice meters and factors that cause nonlinear flow
- Governing equations for modeling unsteady nonlinear flow through orifices
- A literature review of past studies on acoustic nonlinearity in orifices and CFD simulations of orifice flow
- Results of simulations showing the relationships between discharge, head, pressure gradient, and Forchheimer number
- Conclusions that the flow is affected by pressure gradient and fluid velocity, and that Forchheimer number is important for modeling nonlinear orifice flow
The Transradial technique is the true minimally invasive "Drive-through" approach to perform percutaneous coronary and peripheral angiograms and interventions.
Hemodialysis procedure dr. mohamed kamalFarragBahbah
This document discusses various types of vascular access for hemodialysis patients, including central lines, arteriovenous fistulas, and grafts. It notes that without adequate vascular access, hemodialysis efficiency is reduced and morbidity and mortality increase. Short-term catheters should only be used short-term, while long-term catheters require a plan for permanent access. Fistulas are the preferred permanent access but have high failure rates, especially in older patients and those with comorbidities. Early identification of failing fistulas allows for interventions like angioplasty and stent placement to salvage the access. Overall access-related problems account for half of hospitalizations in hemodialysis patients, emphasizing
This document summarizes the long-term outcomes of the Senning operation for repair of transposition of the great arteries (TGA). It discusses:
1) The Senning operation was initially developed as a complete repair for TGA but has fallen out of favor due to risks of right ventricular failure and arrhythmias. It is still used for anatomic repair of congenitally corrected transposition of the great arteries (CCTGA).
2) Long-term follow-up studies of Senning operations show risks of reduced exercise capacity, arrhythmias, and sudden death even in asymptomatic patients. Surgical re-intervention is also required in some cases due to complications.
3) While initial mortality
A rapid overview of indications to Mechanical Circulatory Support in the Acute and Chronic Setting of Heart Failure concluding with the new horizons in LVAD therapy and Heart Replacement.
This document discusses the selection and use of check valves in pumped systems. It notes that check valves are commonly selected without considering their dynamic behavior, which can lead to check valve slam and damage. The document recommends performing a surge analysis to determine the maximum reverse velocity and fluid deceleration acceptable for a system. It provides data on the dynamic behavior of different check valve designs to help select a valve less likely to slam. The document emphasizes matching the selected check valve to the characteristics of the system to avoid issues from pressure transients.
Basic Fluid Dynamics - Control Valves Brannon Gant
Setpoint Integrated Solutions is a industry leader in providing control valve solutions across industry segments.
Brannon Gant - Regional Sales Manager
This contains a basic idea about viscosity measurement devices and their principles. Working, principle, construction, and advantages of rotating viscometer are described here.
The document summarizes the key aspects and findings of a master's thesis on analyzing pressure traces from a common rail diesel injection system to determine injected fuel mass. The thesis explored filtering approaches and modeling injections to predict mass from the pressure signal. Filtering was ineffective due to signal properties. Modeling injections as parametric profiles matched measurements well but could be improved by adding more physical details. Overall, the work established a foundation for predicting mass from pressure traces that warrants further refinement and algorithm development for online implementation.
Performance Pulsation Control specializes in the engineering, design, and manufacture of pulsation control devices. This presentation outlines the benefits of suction stabilizers in pulsation control.
Performance Pulsation Control specializes in the engineering, design, and manufacture of maintenance free and gas charge pulsation control devices. This presentation outlines basic pulsation control terminology.
Simulations of Hypertrophic Obstructive Cardiomyopathy (HOCM) in a Human Hear...Can Ozcan
HOCM is an inherited heart disease in which a portion of myocardium is thickened. It is the leading cause of sudden cardiac death in young athletes. Intevac and Ozen Engineering developed a parametric model of the left ventricle (LV) of a human heart coupled with the solid wall moition and viscoelastic valve motion in the framework of two-way fully coupled fluid-structure interactions. The model parametrically simulates varying LV dimensions and dimensions of cardiomyopathy thickening. For the first time, this model allows a realistic investigation of the transient effect of left ventricular outflow obstruction, assumed to cause systolic anterior motion of mitral valve leaflets.
Manipulation of Water Hammer Problem by Modification of NRV ValveIDES Editor
Water hammer in piping systems produces large
dynamic forces which can damage the pipes and supports.
Therefore it is important to minimize the water hammer
effects on the piping system. In this work, a new method for
the reduction of water hammer by active measures is
described- that means the reduction of water hammer by
influencing the fluid dynamic conditions of the system. We
are concerned with the effects of the rapid valve closures in
pipes connected to wave reflection points. The energy is of
two kind’s Kinetic energy and Elastic energy. Both forms are
converted into pressure energy and the rapidity of the
conversion is of the utmost importance in terms of ensuring
damage that may result. Such energy dissipation in a
controlled non damaging way is discussed in this paper. The
latest outcomes of the research in this area are also discussed
with their failures in the implementation of these concepts in
industries, and the feasibility of our new method
This study evaluated three stent designs for treating patient-specific bifurcation aneurysm phantoms using angiographic imaging:
1) A "middle-flap wing stent" (Type 1) that covers the aneurysm ostium with a wing.
2) A "two-tapered-wing-ended stent" (Type 2) that creates a bridge across the aneurysm neck with short wings.
3) A modification of Type 1 where a standard stent anchors the wing tightly against the aneurysm (Type 3).
Angiography found that contrast inflow was reduced by 25% for Type 1, 63% for Type 2, and 88% for Type 3 compared to untreated phantoms.
The principles of vascular repair with sutures were established in the first decade of the 20th century by Alexis Carrel, who in 1912 was awarded the Nobel Prize for medicine for his work .Since then, technical refinements of suture materials have made possible surgical reconstruction of most arteries from the root of the aorta to microvascular anastomosis or repair of the smallest vessels, e.g., digital arteries or those on the surface of the brain.
1) The study investigated fluid dynamics of a ventricular assist device (VAD) called the Spiral Vortex (SV) VAD using laser Doppler anemometry while pumping a blood analogue fluid under physiological conditions.
2) The flow was dominated by an irrotational vortex that accelerated and precessed in phase with the pumping diaphragm, and two unexpected structures enhanced wall washing.
3) Under a weaning mode, the main vortex coherence degraded and recirculation was observed, indicating a need for anticoagulation in this mode. Turbulence increased with asymmetric diaphragm buckling in both modes.
The document discusses minimally invasive mitral valve surgery offered at Stanford Health Care, which uses a small right-sided incision rather than full sternotomy to access the heart, allowing for effective valve repair or replacement with benefits like less pain, shorter recovery time, and reduced complications compared to traditional open surgery. The techniques pioneered by Stanford surgeons for minimally invasive mitral valve surgery are described, including patient candidacy, surgical procedure details, and potential benefits over conventional open surgery.
Agenda
• Valve with moving components
• The Tesla Valve with no moving component
• Applications of Tesla Valve
• Fish ladders
• T-junction (medical application)
• Microfluidic mixing module
This document discusses balloon aortic valvuloplasty (BAV) as a treatment for aortic stenosis. It can be performed via either a retrograde or antegrade approach. The retrograde approach involves crossing the aortic valve from the femoral artery, while the antegrade approach involves transseptal catheterization from the femoral vein. Key steps for both approaches include rapid ventricular pacing to stabilize the heart during balloon inflation. The goals of BAV are to increase the aortic valve area and reduce pressure gradients. Complications can include hypotension, aortic regurgitation, and embolization of calcium deposits. BAV provides symptomatic relief but is usually not curative, as restenosis may occur.
Development of an Axial Flow Left Ventricular Assist Device (LVAD) from Incep...tmhsweb
1. The document discusses the development and clinical applications of axial flow left ventricular assist devices (LVADs) from their inception to help treat the increasing number of heart failure patients.
2. It describes the history and outcomes of various LVAD models used at the Methodist Hospital including the DeBakey-Noon VAD which was licensed from NASA and has been implanted in over 400 patients internationally.
3. The document outlines ongoing engineering improvements to LVAD designs through computational fluid dynamics and animal testing, including a smaller pediatric version, to provide longer and better quality of life support for heart failure patients.
The document provides an overview of transcatheter aortic valve implantation (TAVI), including a brief history of its development, descriptions of the Edwards Sapien valve and delivery systems, approaches for TAVI, and complications. It also discusses patient screening and risk stratification, as well as newer valve devices that are being developed.
A study on Nonlinear flow through an orifice metersunnynita
The document presents a study on nonlinear flow through orifice meters. It discusses:
- The working principle of orifice meters and factors that cause nonlinear flow
- Governing equations for modeling unsteady nonlinear flow through orifices
- A literature review of past studies on acoustic nonlinearity in orifices and CFD simulations of orifice flow
- Results of simulations showing the relationships between discharge, head, pressure gradient, and Forchheimer number
- Conclusions that the flow is affected by pressure gradient and fluid velocity, and that Forchheimer number is important for modeling nonlinear orifice flow
The Transradial technique is the true minimally invasive "Drive-through" approach to perform percutaneous coronary and peripheral angiograms and interventions.
Hemodialysis procedure dr. mohamed kamalFarragBahbah
This document discusses various types of vascular access for hemodialysis patients, including central lines, arteriovenous fistulas, and grafts. It notes that without adequate vascular access, hemodialysis efficiency is reduced and morbidity and mortality increase. Short-term catheters should only be used short-term, while long-term catheters require a plan for permanent access. Fistulas are the preferred permanent access but have high failure rates, especially in older patients and those with comorbidities. Early identification of failing fistulas allows for interventions like angioplasty and stent placement to salvage the access. Overall access-related problems account for half of hospitalizations in hemodialysis patients, emphasizing
This document summarizes the long-term outcomes of the Senning operation for repair of transposition of the great arteries (TGA). It discusses:
1) The Senning operation was initially developed as a complete repair for TGA but has fallen out of favor due to risks of right ventricular failure and arrhythmias. It is still used for anatomic repair of congenitally corrected transposition of the great arteries (CCTGA).
2) Long-term follow-up studies of Senning operations show risks of reduced exercise capacity, arrhythmias, and sudden death even in asymptomatic patients. Surgical re-intervention is also required in some cases due to complications.
3) While initial mortality
A rapid overview of indications to Mechanical Circulatory Support in the Acute and Chronic Setting of Heart Failure concluding with the new horizons in LVAD therapy and Heart Replacement.
This study evaluated a new minimally invasive technique for inserting an equine stented pulmonary valve through a right ventricular approach without using cardiopulmonary bypass. The valve consisted of an equine jugular vein sutured into a self-expanding nitinol stent with a sinus portion. In seven lambs, the valve was successfully inserted through a right minithoracotomy and released in the pulmonary position using a flexible hydraulic delivery system. At follow-up of up to six months, echocardiography showed the valves were well-positioned and functioning properly. Histological analysis demonstrated endothelialization of the valves. This new approach may provide an alternative to existing surgical and percutaneous pulmonary valve replacement methods.
Flow Like an Egyptian: The Basics of Open Channel FlowWalt Boyes
Ever since the time of the Pharaohs, we've been trying to accurately measure the flow of water in open channels-- like the Nile. Here's the basic scoop on how we do it.
Flow Control in a Diffuser at Transonic ConditionsJeremy Gartner
This document discusses an experimental study of flow control techniques in a transonic diffuser. A new diffuser design was created with an upper ramp and straight floor to decouple the secondary flow structures from separation. Different flow control actuators including steady and unsteady jets were tested at the ramp. The actuators were able to delay separation on the ramp and increase pressure recovery by up to 9.7% compared to the baseline case without flow control. Sweeping and pulsed jet arrays performed better than a two-dimensional jet when all were operated at their maximum mass flow ratios. The results provide insights into controlling flows in short inlet ducts used on aircraft.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.