Siew Hui Low has been selected as the training director of research studies for the newly created department of research studies. This department has been developed for the advancement of research methodology and techniques. Siew Hui Low's career has spanned decades with advanced knowledge and research on many topics that have been the focus of our industry and specifically our organization. Her promotion is a new era in the creation and development of this department and we look forward to Siew Hui Low's many insights.

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Contact
www.linkedin.com/in/siew-hui-low
(LinkedIn)
Top Skills
Stem Cell Transplant
Confocal Microscopy
Molecular & Cellular Biology
Languages
Malay (Full Professional)
Cantonese (Native or Bilingual)
Chinese (Native or Bilingual)
English (Native or Bilingual)
Honors-Awards
College Research Scholarship
2008-2010
Publications
Interleukins 4 and 13 Induce Exon
Skipping of Mutant Dystrophin
Pre-mRNA to Restore Dystrophin
Production
The satellite cell builds its nest under
Notch's guidance.
Myofiber-specific TEAD1
overexpression drives satellite
cell hyperplasia and counters
pathological effects of dystrophin
deficiency
Oesophageal and sternohyal muscle
fibres are novel Pax3-dependent
migratory somite derivatives
essential for ingestion
Exploiting CD34 myoblast
quiescence for the establishment of
minicircles and S/MAR containing
episomes in the place of antibiotic
selective pressure
SiewHui Low
Preclinical Scientist at AskBio
Durham
Summary
• Highly motivated research scientist with project and people
management experience
• Ph.D. in Biological Sciences with broad knowledge and extensive
experiences in life science disciplines
• Proficient in written and oral presentations, including 20+ research
papers and conference abstracts
• Extremely motivated, well-organized, and inquisitive self-starter
• Demonstrated determination, creativity and critical thinking in
multiple studies carried out simultaneously
• Team player with strong ability to work independently
• Authorized to work in the US for any employer
TECHNICAL SKILLS
• Cell Biology: mammalian cell and tissue culture; human muscle
xenograft, transfection and viral infection, stable cell line generation;
RNAi-mediated gene knockdown; proliferation, migration, and
invasion assays; immunostaining, confocal microscopy, flow
cytometry (FACS); single muscle fiber isolation; primary cell isolation
and manipulation
• Molecular Biology: plasmid and viral vector design, cloning, DNA/
RNA isolation and quantitation; PCR and qPCR, Next-Generation
Sequencing (NGS)
• Protein Biochemistry: recombinant protein expression (mammalian
cell lines), protein quantification by UV and BCA, SDS-PAGE,
immunoprecipitation, Western blotting, ELISA
• Animal biology: Perfusion, dissections, tissue preparation, cryo-
and paraffin section, histology; mouse care and husbandry, mouse
injection and gavage; stem cell transplantation
• Computer: Microsoft Office; FileMaker; FlowJo; FIJI; GraphPad
Prism; Vector NTI, online sequence analysis tools
Experience
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2.
AskBio
Preclinical Scientist
2018 - Present (4 years)
Carnegie Institution for Science
Postdoctoral Researcher
2011 - 2018 (7 years)
• Designed and conducted in pharmacological treatments to muscular
dystrophy mouse model and human myotonic dystrophy muscle cells for pre-
clinical studies
• Human muscle cells xenograft derived from patient specimens and tested
with different pharmacological treatment conditions for their growth both in vivo
and in vitro
• Generated skeletal muscle-specific CRE mice for conditional mutagenesis
• Mastered expertise in lineage analysis, skeletal muscle regeneration assays,
single myofiber culture, isolation of primary stem cells and assay development
and validation
• Coordinated with collaborating laboratories in studies on the characterization
of the mouse model of Duchenne muscular dystrophy and human myotonic
dystrophy muscle cells
• Trained lab members and collaborators in muscle single fiber isolation,
muscle primary cell culture and molecular biology skills
Royal Holloway, University of London
Laboratory Teaching Assistant
September 2007 - May 2010 (2 years 9 months)
Prepared, delivered and supervised undergraduate Biochemistry and
Chemistry laboratory courses.
University of Cambridge
Visiting Research Assistant
May 2008 - August 2008 (4 months)
• Performed and maintained TNGA mouse embryonic stem (ES) cell culture
• Prepared ES cells and P19OTOY cells for FACS analysis and sorting
• Cultured sorted ES cells and performed GFP, Nanog, Oct4 and Sox2 gene
expression analysis using immunostaining and PCR
Education
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3.
Royal Holloway, University of London
Doctor of Philosophy - PhD, Biological and Biomedical
Sciences · (2007 - 2011)
Royal Holloway, University of London
Master's degree, Biological and Biomedical Sciences · (2006 - 2007)
University of Bath
Bachelor of Science - BS, Biochemistry · (2003 - 2006)
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