Siegfried has established a project group to implement Micro-Reactor Technology (MRT) into its platform to address reaction challenges like high pressure, low temperatures, and hazardous intermediates. MRT allows tight control of temperature, pressure, residence time and enables reactions beyond classical design. Siegfried offers MRT at the lab and pilot scale to provide customers opportunities to realize demanding chemical transformations.

1. Micro-Reactor Technology (MRT)
A continuous reactor system for intermediate and API synthesis

2. Temperature and pressure control
The small reactor volumes allow tight temperature control
and – if needed – an almost instantaneous temperature
jump of hundreds of degrees centigrade. A wide pressure
range can be easily used for chemical transformations. To
date the ranges explored extend from -60°C to +300°C
with pressures up to 100 bar / 1,450 psi. Extension of these
limits will be possible if deemed necessary.
Glass Reactor
Glass reactors tolerate a wide range of chemical
substances such as corrosive and acidic media.
A visual inspection of the reaction mixture and its flow
characteristics allows prompt interaction with the system
during the set-up phase and later on.

3. Mobile Unit
The mobile modular units offer the possibility to be used at
both locations: lab & kilo-lab alike. The same equipment &
parameter set can thereby be used for both development of
the process and subsequent kg production. As a result no
‘scale-up effects’ are envisaged.
Kilograms
Just let it run a couple of hours and you get your kilogram
quantities. Quality attributes of the product remain identical
at lab and kilo-lab. Variability all along the runs is minimized.
Schema Siegfried Examples
a. Aromatic boronic acid
b. Metalorganic reaction (double de-protonation)
c. Pinacolato-dichloromethylborane formation
d. Demethylation of MeO-Aryl
e. Nitration of an aromatic system
f. Epoxide opening with ammonia
g. Multi-step sequence; deprotonation,
silylation, alkylation, hydrolysis
h. α-Alkylation of a carboxylic acid
i. O-Nitration of an aromatic alcohol
j. Mono-nitration of an aliphatic diol
Nitration of an aliphatic alcohol
k. Ammonolysis of an ester
l. Oxidation with hydrogen peroxide

4. Process Analysis
The process can be monitored by temperature
probes and / or Raman probes as needed.
a. b. c. d. e. f.
O R R O
MgX DCM
OMe H
OH O R
Cl O R NH2
B
B(OH)2 Cl O OH
RO O NO2 OH
R'
OR CO2H Ary OH HO OH CO2R
RHN
(Cl)
O OMe
R' Cl
HO
RHN CO2H HO ONO2
Ary ONO2 CONH2
O Alk (Cl) O
g. h. i. j. k. l.

5. Siegfried Micro-Reactor Technology (MRT)
MRT equipment allows reactions beyond the classical design:
high pressure, low-temperature, tightly defined residence
times and hazardous intermediates are no longer obstacles for
industrial applications.
To address such reaction challenges Siegfried has established a pro-
ject group, implementing MRT into its technology platform.
MRT is now offered at lab and pilot scale, providing Siegfried’s
customers with the opportunity to realize the various demanding
chemical transformations they need.

6. Contact
If you are interested in how using MRT technology could solve your
chemical reaction challenges and bring value for your particular
projects please contact:
Siegfried Ltd
GERMANY A1
Untere Brühlstrasse 4 to Zürich
4800 Zofingen FRANCE Exit Zofingen
Switzerland Basel Zürich
A1 A1
A2
+41 62 746 12 12 Olten to Berne
Zofingen
Train
Tra
Lucerne
+41 62 746 12 58
n i
Process Development Berne
A1 A12 A2
Un
ter
www.siegfried.ch A2
Zofingen
eB
rü
hls
tra
sse
Geneva Lugano
Train
Station
FRANCE ITALY
to Lucerne