1) Cancer may be best defined as a metabolic disease of the mitochondria rather than solely a genetic disease.
2) Therapies like calorie restriction and ketogenic diets that target energy metabolism can effectively manage tumor growth in mouse models and some human cases by lowering blood glucose and raising ketone levels.
3) A restricted ketogenic diet combined with other metabolic therapies may provide a novel non-toxic strategy for managing malignant cancers.
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention
Nota de prensa del convenio de colaboración que Fundación Banco Santander firmó el 4 de septiembre de 2013 con la Comunidad de Madrid para el desarrollo de los programas de educación y actividades para jóvenes del CA2M Centro de Arte Dos de Mayo.
Nota de prensa del convenio de colaboración que Fundación Banco Santander firmó el 4 de septiembre de 2013 con la Comunidad de Madrid para el desarrollo de los programas de educación y actividades para jóvenes del CA2M Centro de Arte Dos de Mayo.
Presentación del tema Servicios Bibliotecarios correspondiente a la cátedra Recursos de Información y Servicicos Bibliotecarios I de la carrera de Lic. en Bibliotecología de la Facultad de Humanidades y Ciencias Sociales de la Universidad Nacional de Misiones
Évaluation des activités anticancéreuses de quelques plantes utilisées dans ...Université de Dschang
Monsieur Tagne Simo Richard a soutenu sa thèse de Doctorat en Biochimie ce mercredi 13 avril 2016 dans la salle des conférences de l'Université de Dschang. A l'issue de la présentation et des échanges, le jury présidé par le Professeur Léon Tapondjou Azefack lui a décerné le titre de Docteur avec la mention très honorable à l'unanimité des membres.
Official Document of the Solar Policy of Uttar Pradesh 2013.
This document is not a work of Headway Solar (http://headwaysolar.com/) and it has been released here for the benefit of the general public.
Cloud computing is a big business and can be classified in two categories – consumer cloud and enterprise cloud. Although we are using cloud solutions, many still fail to understand the difference between consumer cloud and business cloud. This piece explains it all clearly.
Webwerks is a leading data center service provider since 1996 with data centers in 5 different geographical locations - (3 Data Centers in India and 2 in the US). IT Infrastructure offerings such as Cloud Platform, Dedicated Hosting, Virtual Private Servers and Colocation Services. 24x7 Rapid Action Support is bundled to support all our services.
Metastatic Breast Cancer and The Tumor MicroenvironmentAmandaRussell40
Dr. Cyrus M. Ghajar, Assistant Member PHS/Translational Research Program, Fred Hutchinson Cancer Research Center, will explain how microenvironments within distant tissues regulate dormancy and growth of disseminated tumor cells.
A normal cell can be transformed into a cancerous cell. Discuss the therapeutic strategies that are employed to target the cellular transformation process for cancer prevention and treatment.
Fishing Clues for the Efficacy of Chemotherapy Role of Fastingijtsrd
This Article is on how Fasting is effective in chemotherapy and how it prevents cancer. Fasting in disease intercept and treatment has recently become a popular topic and fasting is the part of most spiritual tradition in the world. Cell is the basic unit to the human body. Actually these cell division takes normally but due to some disturbance or mutation in cell it lead to cancer or tumor. chemotherapy is used to treat the cancer but it having the side effect. In this article we are describing about how cancer is prevented by fasting by different mechanism like Cellular fasting mechanism, Systemic changes by fasting, Mechanism of killing cancer cells in solid tumors by fasting and Autophagy Mechanism. Dr. C. Nithish | Dr. G. Ajith Kumar | Dr. P. Sravani ""Fishing Clues for the Efficacy of Chemotherapy: Role of Fasting"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23581.pdf
Paper URL: https://www.ijtsrd.com/medicine/other/23581/fishing-clues-for-the-efficacy-of-chemotherapy-role-of-fasting/dr-c-nithish
Cancer chemotherapy for medical studentstaklo simeneh
Cancer chemotherapy has been presented in detail for medical students. It can be used for other health students by modifying it based on their curriculum and time given.
How to Understand and Treat Cancer with Molecular MarkersSheldon Stein
How to Understand and Treat Cancer with Molecular Markers by Professor Serge Jurasunas, N.D., M.D. (Hom)
This is the first in a series of presentations on Naturopathic Oncology.
For More Information Visit: www.sergejurasunas.com
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. Cancer: A Metabolic Disease with Metabolic
Solutions
Thomas N. Seyfried
Boston College
2. Is the “War on Cancer”going well?
Data from American Cancer Society
3. Is cancer a nuclear
genetic disease or a
mitochondrial metabolic
disease?
Provocative Question
4. Current Dogma:
Cancer is a Genetic Disease
Cancer cells are the foundation of the disease; they
initiate tumors and drive tumor progression forward,
carrying the oncogenic and tumor suppressor mutations
that define cancer as a “Genetic Disease”.
Cell 144, March 4, 2011
6. Darlington, Brit. J. Cancer, 1948
“There can be no doubt that the cancer determinants arise as
mutant particles in the cytoplasm--that is, as plasmagenes.”
Findings are incompatible with the somatic
mutation theory of cancer
7. Tadpole cloned from nucleus
of frog
renal cell tumor
McKinnell et al Science 1969
Findings are incompatible
with the somatic mutation
theory of cancer
8. The capacity of embryonal carcinoma cells to form normally functioning adult
tissues demonstrates that conversion to neoplasia does not involve structural
changes in the nuclear genome.
Findings are incompatible with the somatic mutation
theory of cancer
9. Findings are
incompatible with the
somatic mutation
theory of cancer.
“Although medulloblastoma-
derived embryos aborted,
none exhibited uncontrolled
proliferation resembling
tumorigenesis”.
10. The presence of trisomy 8 and trisomy 11 in
embryonic mice cloned from a tumor
cell nucleus provide unequivocal genomic
evidence that the R545-1 NT ES cell was cloned
from a tumorigenic nucleus of the R545
tumor cell line.
Genes Dev. 2004 18: 1875-1885
Findings are incompatible
with the somatic mutation
theory of cancer
11. Role of the nucleus and mitochondria
in the origin of tumors
Seyfried, Cancer as a Metabolic Disease, 2012 John Wiley Press; Seyfried et al., 2014, Carcinogenesis
12. Microarray analysis showed that several oncogenic pathways observed
in cybrids with cancer mitochondria are inhibited in cybrids with
non-cancerous mitochondria.
Findings are incompatible with the somatic mutation
theory of cancer
13. If somatic mutations are not the origin of
cancer, then how do cancer cells arise?
14. Warburg Theory of Cancer
1. Cancer arises from damage to cellular
respiration.
2. Energy through fermentation gradually
compensates for insufficient respiration.
3. Cancer cells continue to ferment lactate in the
presence of oxygen (Warburg effect).
4. Enhanced fermentation is the signature
metabolic malady of all cancer cells.
Otto Warburg (Science, 24 February,1956)
17. Cancer as a Mitochondrial Metabolic Disease
Seyfried, Cancer as a Metabolic Disease, 2012 John Wiley Press; Seyfried et al., 2014, Carcinogenesis
18. If all cancers are a type of mitochondrial
metabolic disease, then what therapies
might be effective for managing tumors?
19. Calorie Restriction (CR): A Metabolic Cancer
Intervention
• Involves a total dietary restriction
• Differs from starvation
• Maintains minerals and nutrients
• Enhances mitochondrial biogenesis & OxPhos
• CR in mice mimics water-only therapeutic
fasting in humans
22. Calorie restriction reduces intracerebral growth
of the CT-2A astrocytoma
AL CR
40% CR initiated 3 days post-inoculation
23. 1. Anti-angiogenic
Mukherjee et al., Clin. Cancer Res., 2004
2.Anti-inflammatory
Mulrooney et al., PLOS One, 2011
3.Pro-apoptotic
Mukherjee et al., Brit. J. Cancer 2002
Anti-Tumor Effects of
Calorie Restriction
24. AL
CR
CR is anti-angiogenic in the CT-2A astrocytoma
Mukherjee et al, BJC
0
10
20
30
AL CR
Vessels/hpf
*
200 x
Factor VIII microvessels
25. CR is pro-apoptotic in the CT-2A astrocytoma
AL
CR 0
2.5
5
7.5
10
12.5
AL CR
ApoptoticIndex(%)
Mukherjee et al, BJC
*
400 x
*
TUNEL Staining
26. AL CR
Nuclear p-NF-κB (p65) (S-536)
Nuclear Histone H2B
AL
RelativeNuclearp-NF-κB
expression
CR
0.0
0.5
1.0
1.5
*
Calorie restriction targets NF-κB-mediated
inflammation
Mulrooney et al., PLoS One (2011)
CT-2A astrocytoma
36. Influence of raw KD-R on mast cell tumor in a dog
July 8, 2013 Sept 28, 2013
April 8, 2014
37. Can the KD-R be effective for the
metabolic management of malignant
brain cancer in patients?
Clinical Question
38. The results showed that a ketogenic diet, which
reduced blood glucose and elevated blood
ketones, could provide long-term management in
two children with recurrent inoperable brain
tumors
42. How the standard of care can provoke
GBM growth and recurrence
eyfried et al., Lancet Oncology, 2010; Seyfried et al., Cancer Letters, 2014
Increases
Glutamine!
Increases
Glucose!
HCMV
infection
increases
use of
Glu & Gln
43. Overall survival for GBM using “Standard of Care”
Stupp et al., 2009 Lancet Oncology
A total of only
6 long-term
survivors out
of 532
irradiated
patients = 1.1%!
TMZ increases
Driver
mutations
Johnson et al.,
2014, Science
TMZ + Radiotherapy
44. Glucose (mmol)/Ketone (mmol) = GKI
The Glucose/Ketone Index Calculator:
A simple tool to help manage brain
cancer
Therapeutic efficacy is considered best with
index values approaching 1.0 or below
45. Influence of metabolic therapy alone on the G/K Index
in an adult patient with diffuse, infiltrative brainstem glioma
46. Calorie restriction reduces intracerebral growth
and the GKI in mice with the CT-2A astrocytoma
AL CR
GKI = 15.2 3.7
48. The Press-Pulse Paradigm: A Novel
Therapeutic Strategy for the Metabolic
Management of Cancer
1. Cyclic Energy Stress Targets Mutated Tumor Cells:
a. Calorie restricted ketogenic diet.
b. Calorie restricted raw vegan diet.
c. Hyperbaric oxygen therapy.
d. Non-toxic drugs.
Press
Pulse
49. Press-Pulse therapy using the KD-R with
the glycolysis inhibitor 2-DG for managing
n = 3-6/groupDose: 25 mg/kg BW Marsh et al., Nutrition & Met
50. Press-Pulse therapy using the KD with Hyperbaric
Oxygen for Systemic Metastatic Cancer in VM Mice
Poff, A., C. Ari, T. N. Seyfried, and D. P. D’Agostino (PLoS One, 2013)
SD
51. Influence of a restricted ketogenic diet on
brain metastases of the VM-M3 tumor cells:
Preliminary data
SD-UR KD-R (18% BW reduction)
55. Conclusion
1. Preclinical and case report studies indicate
that the restricted ketogenic diet (R-KD) can be
an effective non-toxic “metabolic therapy” for
managing malignant cancers in children and
adults.
2. The therapeutic effects of the R-KD against
cancer can be enhanced when combined with
drugs or HBO2T that also target energy
metabolism.
56. Acknowledgements
Purna Mukherjee, Ph.D.
Michael Kiebish, Ph.D.
Todd Sanderson, MD
Jeremy Marsh, MD
Weihua Zhou, MS
Giulio Zuccoli, MD
Miguel Sena-Esteves, Ph.D.
Laura Shelton, Ph.D.
Richard McGowan, S.J.
Roberto Flores
Angela Poff, Ph.D
Dominic D’agostino, Ph.D.
Linh Ta
Josh Meidenbauer
Tiernan Mulrooney
Joseph Maroon, MD
Funding: Amer. Inst. Cancer Res.,
National Cancer Institute,
Boston College Research
Fund.